سيتوكينات cytokines

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  • :

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  • Cytokines 2015-2016

    :

    COLONY STIMULATING FACTORS: ............................................................. 8

    INTERLOKINES (IL) : .................................................................... 9

    INTERFERON : ......................................................................... 41

    TUMOR NECROSIS FACTOR: ......................................... 02

    00 ................................................................................................ :

    ": "Cytokines and inflammation

    :

  • Cytokines 2015-2016

    :

    .

    . 011

    Jack/Stat pathway

    .

    :

    81 8 -0

    . -2

    . -3

    Synergistically -4

    . Antagonistically

    :

    :

    source : ) ) ) (monocytes

    function : ) )

    intercellular action: .

    :

    .

    Differentiation.

    Chemotaxis.

    Cytotoxicity.

  • Cytokines 2015-2016

    IL-6 .

    :

    Innate immunity :

    Macrophages

    Endothelial cells

    Fibroblasts

    Adaptive immunity :

    T lymphocytes

    Macrophages

    NK cells

    Cytokines

    Growth

    factors .

    T cells Locally

    APCs

    .

    Lymphokines

    IL 1 Monokines

  • Cytokines 2015-2016

    Monocytes

    Monokine IL - 2 T cell

    growth factor Lymphokine

    .

    Repair

    IL

    IL 1

    IL 6

    Stromal cells . IL -1

    IL 1

    .

    Tumor Necrosis Factors

    . Lymphotoxin TNF Cachetin TNF -

    .

  • Cytokines 2015-2016

    Chemokines

    "

    Homing

    "

    . CX3C C CC CXC

    " "

    .

    :

    Tyrosine kinases .

    :

  • Cytokines 2015-2016

    :

    autocrine : .

    )( : paracrine .

    )( : endocrine .

    ..

  • Cytokines 2015-2016

    : Pleiotropy :

    : Redundancy

    Synergy :

    Antagonism :

    Cascading :

    .sequentially ..

  • Cytokines 2015-2016

    0591 " "

    .

    " " : 0599

    .

    0599 MIF

    .

    "" 0595

    ." "

    "".

  • Cytokines 2015-2016

    :

    .

    .

    .

    colony stimulating factors:

    colony stimulating factors

    , Erythropoietin .

    G-CSF .

    (Granulozyt Colony-Stimulating Factor (

    .

    . MDS

    G-CSF

    GM-CSF TH .

    M-CSF ""

    https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%81%D9%8A%D8%B1%D9%88%D9%86https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%81%D9%8A%D8%B1%D9%88%D9%86https://ar.wikipedia.org/w/index.php?title=%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%8A%D9%83%D9%8A%D9%86&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%8A%D9%83%D9%8A%D9%86&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D9%85%D8%B9%D8%A7%D9%85%D9%84_%D8%AA%D8%AD%D9%81%D9%8A%D8%B2_%D9%85%D8%B3%D8%AA%D8%B9%D9%85%D8%B1%D8%A9_%D8%AE%D9%84%D8%A7%D9%8A%D8%A7&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D9%85%D8%B9%D8%A7%D9%85%D9%84_%D8%AA%D8%AD%D9%81%D9%8A%D8%B2_%D9%85%D8%B3%D8%AA%D8%B9%D9%85%D8%B1%D8%A9_%D8%AE%D9%84%D8%A7%D9%8A%D8%A7&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D9%85%D8%B9%D8%A7%D9%85%D9%84_%D9%86%D8%AE%D8%B1_%D9%88%D8%B1%D9%85&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D9%83%D9%8A%D9%85%D9%88%D9%83%D9%8A%D9%86&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D9%83%D9%8A%D9%85%D9%88%D9%83%D9%8A%D9%86&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=G-CSF&action=edit&redlink=1https://ar.wikipedia.org/wiki/%D9%86%D8%AE%D8%A7%D8%B9_%D8%A7%D9%84%D8%B9%D8%B8%D8%A7%D9%85

  • Cytokines 2015-2016

    Interlokines (IL) :

    .

    TNF- IL-6 IL-1

    .

    -01) IL-6

    02 M . 0111 (

    .TNF- Interleukin 1 Interleukin-6

    0-

    .

    :

    -

    0- .

    .

    IL-1

    2-

    .

    2-

    .

    IL-2

    3-

    .

    IL-3

    https://ar.wikipedia.org/w/index.php?title=%D8%AE%D9%84%D9%8A%D8%A9_%D9%88%D8%B1%D9%85&action=edit&redlink=1https://ar.wikipedia.org/w/index.php?title=%D8%AE%D9%84%D9%8A%D8%A9_%D9%88%D8%B1%D9%85&action=edit&redlink=1https://ar.wikipedia.org/wiki/%D8%AF%D8%B1%D8%AC%D8%A9_%D8%A7%D9%84%D8%AD%D8%B1%D8%A7%D8%B1%D8%A9https://ar.wikipedia.org/wiki/%D8%AF%D8%B1%D8%AC%D8%A9_%D8%A7%D9%84%D8%AD%D8%B1%D8%A7%D8%B1%D8%A9https://ar.wikipedia.org/wiki/%D9%85%D9%88%D9%84https://ar.wikipedia.org/wiki/%D9%85%D9%88%D9%84

  • Cytokines 2015-2016

    .

    . IgG4 IgE

    .03-

    IL-4

    . IL-5

    .

    . IL-6

    .

    1-

    CD4-ve CD8-ve .

    . 1-

    IL-7

    .

    .

    IL-8

    .IL-9

    .TH2 TH0

    . TH1

    .

    01-

    TGF beta .

    IgA .

    IL-10

  • Cytokines 2015-2016

    IL-11 . 9- .

    .

    IFN gamma

    . ADCC

    . TH1 CD4

    IL-12

    (IL-1b, IL-6, TNFa, IL-8 . LPS(

    . CD23

    .anti-CD40 anti-Ig IgG4 IgM IgE

    IL-13

    .

    . IL-14

    IL-15 . 2-

    .

    ) +CD4

    (.

    IL-16

    +CD4

    ( GM-CSF, IL-1beta and TNF alpha )

    .

    IL-17

    . Th2

    IFN-gamma

    . Th1 02-

    IL-18

    IL-19 . 01-

  • Cytokines 2015-2016

    01-

    . IL-20

    IL-21 . 01-

    . 01- IL-22

    02-

    .IL-23

    IL-24 . 01-

    Th1/Th2

    Th2 IL-4, IL-5 IL-13. IL-25

    IL-26 . 01-

    .

    Th1 CD4

    .

    IL-27

    .

    25- 28-

    .

    IL-28 , IL-

    29

    - P28

    21. IL-30

    . .

    .

    .

    IL-31

    . IL-32

  • Cytokines 2015-2016

    . 0-

    . IL-33

    CSF-1. IL-34

    .

    . 01

    IL-35