2017 sbir/sttr phase ii and pfi grantees conference abstract book · phase ii and pfi grantees...

1NATIONAL SCIENCE FOUNDATION

2017 SBIR/STTR Phase II and PFI Grantees Conference

Abstract Book

ATLANTA MARRIOTT MARQUISJUNE 5-7, 2017


COVER IMAGE CREDITS (left to right)

Farhang Wireless, Inc. NSF Award ID: 1632569STTR Phase II: Scalable Detector for Multiple-Input Multiple-Output (MIMO) Communication SystemsEight stream wireless testbed used in demonstrating the high spectral efficiency, high data rate, and low cost of the Markov Chain Monte Carlo (MCMC) MIMO technology.Image Credit: Farhang Wireless, Inc.

Spensa Technologies Inc. NSF Award ID: 1430996SBIR Phase II: A Multimodal Sensor Platform for Automated Detection and Classification of Pest InsectsImage Description: Z-Traps ready to deploy out to Z-Trap Network sites.Credit: Spectrum nonGMO Seed

Neural Analytics, Inc. NSF Award ID: 1556110SBIR Phase II: A Novel Non-Invasive Intracranial Pressure Monitoring MethodImage Description: The Lucid M1 transcranial Doppler Ultrasound System is indicated as an adjunct to the stan-dard clinical practices for measuring and displaying cerebral blood flow velocity within the major conducting arteries and veins of the head and neck. Additionally, the Lucid M1 System measures the occurrence of transient emboli signals within the blood stream.Credit: Neural Analytics, Inc.

ConsortiEX, Inc. NSF Award ID: 1660080SBIR Phase II: Development of a Track-and-Trace Medication Barcoded LabelImage Description: Phamacists utilize ConsortiEXs Assure-Trak IV Workflow system to produce compounded sterile preparations (CSPs) inside the clean room. (Assure-Trak IV Workflow system is a software solution utilized via a tablet mounted in the hood in the clean room to track the compounding process.)Credit: ConsortiEX, Inc.


INTRODUCTIONSmall Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) The SBIR/STTR program was conceived at the National Science Foundation (NSF) in 1976. Roland Tibbetts initiated an NSF program that would support the small business community with a specific objective to provide early-stage financial support for high-risk technologies with commercial promise. Today the government-wide program is administered by the Small Business Administration (SBA) and includes eleven federal departments that collectively award over $2.5 billion to small high-tech firms. The primary objective of the NSF SBIR/STTR Pro-gram is to increase the incentive and opportunity for small firms to undertake cutting-edge, high-risk, high-qual-ity scientific, engineering or science/engineering education research that would have a high-potential economic payoff if the research is successful.

The current portfolio of the NSF SBIR/STTR program covers a variety of technology topic areas:

Advanced Manufacturing and Nanotechnology (MN) Advanced Materials and Instrumentation (MI) Biological Technologies (BT) Biomedical Technologies (BM) and Smart Health (SH) Chemical and Environmental Technologies (CT) Educational Technologies and Applications (EA) Electronic Hardware, Robotics and Wireless Technologies (EW) Information Technologies (IT) Internet of Things (I) Other Topics (OT) Semiconductors (S) and Photonic (PH) Devices and Materials To learn more about NSF SBIR/STTR Program, visit our website at http://www.nsf.gov/eng/iip/sbir/

Partnerships for Innovation (PFI) Program The NSF Partnerships for Innovation (PFI) program is an umbrella for two complementary subprograms, Accelerat-ing Innovation Research (AIR) and Building Innovation Capacity (BIC). Overall, the PFI program offers opportuni-ties to connect new knowledge to societal benefit through translational research efforts and/or partnerships that encourage, enhance and accelerate innovation and entrepreneurship.

The PFI:AIR program supports research to overcome technology barriers or knowledge gaps in the transformation of fundamental science and engineering discoveries into market-valued solutions. The program provides funding for academic researchers to translate prior NSF-supported research discoveries toward commercial reality. Research-ers develop a proof of concept, prototype, or scale-up of the prototype that addresses real-world constraints and provides a competitive value in a potential application space. Some grantees have already formed a small business while others have been guided from the outset by business partners who are interested in commercializing their translated discoveries. All are interested in moving their technologies closer to commercial application, creating new partnerships, and learning about additional markets/applications where their technologies could be competitive. In addition, an important component of the AIR program is to offer an opportunity for post-docs and graduate stu-dents to engage in entrepreneurial and market-oriented thinking along with their traditional research experience.

To learn more about the PFI:AIR program, visit our website at https://www.nsf.gov/eng/iip/pfi/air-tt.jsp.

The PFI:BIC program supports academe-industry partnerships led by an interdisciplinary academic research team collaborating with a least one industry partner. In this program, there is a heavy emphasis on the quality, composi-tion, and participation of the partners, including their appropriate contributions. These partnerships focus on the inte-gration of technologies into a specified human-centered service system with the potential to achieve transformation-al benefits, satisfying a real need by making an existing service system smart(er) or by spurring the creation of an


entirely new smart service system. The selected service system should function as a test bed. PFI:BIC funds research partnerships working on projects that operate in the post-fundamental/translational space; grantees must be mind-ful of the state of the art and the competitive landscape. These projects require additional effort to integrate the technology into a real service system, incorporating human factors considerations to assure the systems efficacy. The research tasks in turn might spawn additional discoveries inspired by this interaction of humans with the technology.

To learn more about PFI:BIC program, visit our website at https://www.nsf.gov/eng/iip/pfi/bic.jsp.

The Conference The annual NSF SBIR/STTR Phase II and Partnerships for Innovation Grantee Conference provides an opportunity for small businesses that have received Phase II awards and academic faculty and students from the PFI program to share their technical and commercial achievements with each other, NSF staff and potential partners and investors. In the spirit of networking and resource sharing, we have designed this Abstract Book as a resource for conference attendees, potential investors, and strategic partners. We also hope to provide a snapshot of the cur-rent portfolio of these important programs. Industry and investor attendees are encouraged to use this resource to identify grantees of interest for one-on-one meetings onsite during the event and also to visit this page on our conference website for additional opportunities: http://www.nsfiipconf.com/2017sbirp2/industry-investors/.

WE HOPE YOU ENJOY THE CONFERENCE!


Abstract Table of ContentsADVANCED MANUFACTURING AND NANOTECHNOLOGY (MN) ............................................................................................20

Access Sensor Technologies ...................................................................................................................................................................................................21SBIR Phase II: Measuring Aqueous Metal Concentrations with the Chemometer .............................................................................................21

Air Squared, Inc. ......................................................................................................................................................................................................................22SBIR Phase II: Compact Torus-Shaped Organic Ranking Cycle for Distributed Solar Thermal Power Generation ..................................22

AnCatt Co. .................................................................................................................................................................................................................................23SBIR Phase II: Polyaniline Epoxy Primer with Related Topcoat: the Anticorrosion Coating System of a Barrier to Cations with a Barrier to Anions.............................................................................................................................................................................................................23

Atacama, Inc. ............................................................................................................................................................................................................................24SBIR Phase II: Second Skin: 3D Microfluidics-Enabled Technology for Perspiration Management .............................................................24

Branch Technology, LLC ..........................................................................................................................................................................................................25SBIR Phase II: Additive Manufacturing in Construction .........................................................................................................................................25

BTI Targetry, LLC ......................................................................................................................................................................................................................26SBIR Phase II: Boron Nitride Nanotube Cyclotron Targets for Recoil-Escape Production of Carbon-11 For PET/CT Medical Imaging ............................................................................................................................................................................................................................26

Carnot Compression, LLC.......................................................................................................................................................................................................27SBIR Phase II: Isothermal Gas Compression .............................................................................................................................................................27

Eclo, Inc. ......................................................................................................................................................................................................................................28SBIR Phase II: Footwear Fitting System for Online Retailers.................................................................................................................................28

Foundation Instruments ...........................................................................................................................................................................................................29SBIR Phase II: Evaluating the Feasibility of a Fully-automated, On-line, Real-time Analyzer for Simultaneous Determination of Individual THMs and HAAs ..........................................................................................................................................................................................29

Georgia Tech Research Corporation .................................................................................................................................................................................30PFI:BIC Next Generation Real-Time Distributed Manufacturing Service Systems Using Digital Process Planning and GPU- Accelerated Parallel Computing .................................................................................................................................................................................30

Graphene Frontiers, LLC ........................................................................................................................................................................................................32SBIR Phase II: Roll-to-roll Production of Uniform Graphene Films at Atmospheric Pressure and Low Temperature ................................32

Hummingbird Nano, Inc. .........................................................................................................................................................................................................33SBIR Phase II: Innovative Platform Technology for Rapid Three Dimensional Fabrication of Capillary Electrophoresis Chips: Phase II Proposal ...........................................................................................................................................................................................................................33

Intact Solutions ..........................................................................................................................................................................................................................34SBIR Phase II: Cloud-based Simulation Service for Makers .................................................................................................................................34

MagAssemble, LLC ..................................................................................................................................................................................................................35SBIR Phase II: Reducing Size and Cost of Optical Devices with Nanomanufacturing - a Novel use of Disk Drive Technology ...........35

Mark Miles Consulting, Inc. ....................................................................................................................................................................................................36SBIR Phase II: Solar Thermal Collector Using Advection Enhanced Nano-Porous Insulating Media ...........................................................36

Micro Laser Assisted Machining Technologies, LLC .........................................................................................................................................................37SBIR Phase II: Micro Laser Assisted Machining .......................................................................................................................................................37

MTPV, LLC ..................................................................................................................................................................................................................................38SBIR Phase II: Epitaxially Grown GaSb Thin Films on GaAs Substrates For Near-Field Conversion of Heat to Electricity .....................38

Nano Hydrophobics, Inc. ........................................................................................................................................................................................................39SBIR Phase II: Simple and Effective Fouling Release Coatings To Make Industrial Heat Exchangers More Energy Efficient .................39

Nanomaterial Innovation, Ltd. ..............................................................................................................................................................................................40SBIR Phase II: Carbide Bonded Graphene Coating for Enhanced Glass Molding ..........................................................................................40

NBD Nanotechnologies, Inc. ..................................................................................................................................................................................................41SBIR Phase II: Surface Coatings for Enhanced Efficiency of Industrial Condensers ........................................................................................41

Nova Photonics .........................................................................................................................................................................................................................42SBIR Phase II: Barrier Centrifuge for Aluminum Purification ................................................................................................................................42

PAX Scientific, Inc. ....................................................................................................................................................................................................................43SBIR Phase II: PAX Rotor Optimization for Flexible Micro-Hydro ......................................................................................................................43


PowerTech Water ....................................................................................................................................................................................................................44SBIR Phase II: Novel Cathode for Long-cycling Capacitive Deionization .........................................................................................................44

Purdue University .....................................................................................................................................................................................................................45PFI:BIC MAKERPAD: Cognitively Intuitive Shape-Modeling and Design Interface enabling a Distributed Personalized Fabrication Network. ...........................................................................................................................................................................................................................45

Redbud Labs, Inc. .....................................................................................................................................................................................................................46SBIR Phase II: Microfilm to Enable Enhanced Mixing in Low-resource Diagnostics .........................................................................................46

Robocasting Enterprises, LLC ................................................................................................................................................................................................47SBIR Phase II: High Efficiency Robocasting for Ceramic Product Application ..................................................................................................47

Rutgers University New Brunswick .......................................................................................................................................................................................48PFI:AIR-RA: Commercializing Pharmaceutical Process Modeling for Continuous Manufacturing ...............................................................48

Solution Deposition Systems, Inc. ..........................................................................................................................................................................................49SBIR Phase II: Low-Cost and Green Deposition of Multifunctional Oxide Films ..............................................................................................49

Spherical Block, LLC ................................................................................................................................................................................................................50SBIR Phase II: Topological Interlocking Manufactured Concrete Block .............................................................................................................50

Supercool Metals, LLC ............................................................................................................................................................................................................51SBIR Phase II: Economical Fabrication of Bulk Metallic Glass Sheets through Roll-Stretching .....................................................................51

ThermoAura, Inc. ......................................................................................................................................................................................................................52SBIR Phase II: Development and Manufacture of a New Class of High-figure-of-merit Bulk Thermoelectric Nanomaterials ..............52

Tivra Corporation ....................................................................................................................................................................................................................53SBIR Phase II: Ultra Low Defect Gallium Nitride Mediated by Metal Alloys .....................................................................................................53

Trustees of Boston University ................................................................................................................................................................................................54PFI:AIR - TT: Cost-Effective Membrane-Based Green Electrolytic Process for Solar and Semiconductor Grade Silicon Production ....54

University of California, San Diego....................................................................................................................................................................................55PFI:BIC: Smart Factories -An Intelligent Material Delivery System to Improve Human-Robot Workflow and Productivity in Assembly Manufacturing ..............................................................................................................................................................................................55

University of Florida ...............................................................................................................................................................................................................56PFI:AIR-TT: Scalable Hydrothermal Flow Manufacturing of High Value-Added Precision Nanoparticles .................................................56

University of Michigan, Ann Arbor......................................................................................................................................................................................57PFI:BIC - Cyber-Physical Service System for 3D-Printing of Adaptive Custom Orthoses .............................................................................57

V-Glass, LLC ..............................................................................................................................................................................................................................58SBIR Phase II: Ambient-Pressure Plasma Degassing for Low Cost Vacuum Glass ...........................................................................................58

Vistex Composites, LLC ...........................................................................................................................................................................................................59SBIR Phase II: Automation Enabled, Low-Cost, High-Volume Production of Advanced Composites ..........................................................59

WattGlass, LLC ........................................................................................................................................................................................................................60SBIR Phase II: High-Performance Self-Cleaning, Anti-Reflective Coating for Photovoltaic Glass ...............................................................60

XPEED Turbine Technology, LLC ...........................................................................................................................................................................................61SBIR Phase II: Aerodynamic Flow Deflector for Current and Future Wind Turbines to Increase the Annual Energy Production by 10% and Reduce the Levelized Cost of Energy by 8% ................................................................................................................................61

ADVANCED MATERIALS AND INSTRUMENTATION (MI) ............................................................................................................62

4 D Technology Corporation ................................................................................................................................................................................................63SBIR Phase II: High-Resolution Shop Floor Video-Rate Surface Metrology System .......................................................................................63

Akervall Technologies, Inc. .....................................................................................................................................................................................................64SBIR Phase II: High-performance Polymer Composites for Mouth Guards .......................................................................................................64

Akron Ascent Innovations .......................................................................................................................................................................................................65SBIR Phase II: Prototyping Reusable Dry Adhesives based on Scalable Fiber Spinning Technologies ........................................................65

Altaeros Energies, Inc. .............................................................................................................................................................................................................66SBIR Phase II: Ultra-light, Modular Wind Turbine ..................................................................................................................................................66

Bio-Adhesive Alliance, Inc. .....................................................................................................................................................................................................67SBIR Phase II: Production of Bio-adhesive from Animal Waste ..........................................................................................................................67

BioInspira, Inc. ...........................................................................................................................................................................................................................68STTR Phase II: SMART Colorimetric Sensor for Airborne Methane Detection ..................................................................................................68


bioMASON, Inc. .......................................................................................................................................................................................................................69SBIR Phase II: Efficacy of Scaled up Optimized Urease Producing Microorganisms for Manufacturing Biocement Binders towards a Viable Masonry Construction Material ..................................................................................................................................................69

Boston Electrometallurgical, Inc. ...........................................................................................................................................................................................70SBIR Phase II: A New Molten-Oxide Electrochemical Process for Producing Primary Iron and Ferrochromium ......................................70

BrightSpec, Inc. .........................................................................................................................................................................................................................71SBIR Phase II: A Programmable Residual Solvent Analyzer based on Fourier Transform Molecular Rotational Resonance (FT-MRR) Spectroscopy .................................................................................................................................................................................................71

CetoTech, Inc. ............................................................................................................................................................................................................................72SBIR Phase II: Manufacturing High Performance Natural Fiber Composites for Building Applications .....................................................72

Chirp Microsystems .................................................................................................................................................................................................................73SBIR Phase II: Ultrasonic 3D Rangefinding for Mobile Gesture Recognition ....................................................................................................73

Connora Technologies ............................................................................................................................................................................................................74SBIR Phase II: Sustainable Performance Composites for Energy Efficient Transportation Applications ......................................................74

Double Helix, LLC ....................................................................................................................................................................................................................75SBIR Phase II: Widefield Three-Dimensional Superresolution Microscopy Module .........................................................................................75

DropWise Technologies Corporation .................................................................................................................................................................................76SBIR Phase II: Anti-fouling Surface Modifications for Purification Membranes ...............................................................................................76

Essentium Materials, LLC ........................................................................................................................................................................................................77SBIR Phase II: High Performance Structural Composites with Cellulosic Nanoparticles .................................................................................77

Inprentus, Inc. .............................................................................................................................................................................................................................78SBIR Phase II: A Novel Method to Manufacture Ultra-Precise Diffraction Gratings for X-Ray Analysis and Imaging ...........................78

Invenio.........................................................................................................................................................................................................................................79SBIR Phase II: Dual-Wavelength Picosecond Fiber Laser Source for Label-Free Microscopy .......................................................................79

Lehigh University ......................................................................................................................................................................................................................80PFI:AIR - TT: Proof of Concept Low-cost Energy Efficient Multi-hazard Resistant Wall System ..................................................................80

LighTopTech Corporation .......................................................................................................................................................................................................81SBIR Phase II: Nondestructive/noninvasive Three-dimensional Imaging with Gabor-domain Optical Coherence Microscopy .............81

LumiShield Technologies, Inc. .................................................................................................................................................................................................82SBIR Phase II: A Cost-effective, Environmentally-responsible Alternative to Toxic Metal Coatings .............................................................82

Mallinda, LLC ............................................................................................................................................................................................................................83SBIR Phase II: Development of Advanced Composite Materials for Athletic Equipment ...............................................................................83

Massachusetts Materials Technologies, LLC ......................................................................................................................................................................84SBIR Phase II: Hardness Strength and Ductility Tester for Field Assessment of Structures .............................................................................84

Maxterial, Inc. ...........................................................................................................................................................................................................................85SBIR Phase II: Non-Stick / Easy-Clean Coatings for High Temperature Applications ...................................................................................85

Molecular Vista, Inc. ................................................................................................................................................................................................................86SBIR Phase II: Resonance Force Microscopy for Nanoscale Manufacturing Process Monitoring .................................................................86

Northeastern University .........................................................................................................................................................................................................87PFI:AIR - TT: Sustainable Permanent Magnets For Advanced Applications.......................................................................................................87

Polnox Corporation .................................................................................................................................................................................................................88SBIR Phase II: Development of Macromolecular Corrosion Inhibitors Based on Renewable Resources for Biolubricants and Lubricants .........................................................................................................................................................................................................................88

Rare Resource Recycling ........................................................................................................................................................................................................89SBIR Phase II: Sustainable Rare Earth Element Recycling from Neodymium Magnets ....................................................................................89

Renuvix .......................................................................................................................................................................................................................................90SBIR Phase II: High-Performance, Environmentally Friendly Polymer Systems for Paints and Coatings .....................................................90

Scuba Probe Technologies ....................................................................................................................................................................................................91SBIR Phase II: Encased Cantilevers for Ultra-Sensitive Force and Mass Sensing in Liquids ............................................................................91

Sigray .........................................................................................................................................................................................................................................92SBIR Phase II: Development of a Dual Energy Micro-focused X-ray Excitation Beam for Chemical Analysis and Materials Characterization .............................................................................................................................................................................................................92

Spectradyne, LLC .....................................................................................................................................................................................................................93SBIR Phase II:A Low-cost Instrument for Rapid Sub-micron Particle Size and Concentration Measurement ..............................................93


Spheryx, Inc. .............................................................................................................................................................................................................................94SBIR Phase II: Total Holographic Characterization of Colloids Through Holographic Video Microscopy ................................................94

Sunstrand, LLC ..........................................................................................................................................................................................................................95SBIR Phase II: Bamboo Fiber Processing for Use in Reinforced Composites .....................................................................................................95

Thermal Expansion Solutions, LLC ........................................................................................................................................................................................96SBIR Phase II: Zero Thermal Expansion Alloys For Lasers .....................................................................................................................................96

Trace-Ability, Inc. ......................................................................................................................................................................................................................97SBIR Phase II: Development of a Simple Device that Eliminates Bottlenecks in Radiopharmaceutical Production ...................................97

University of Connecticut .......................................................................................................................................................................................................98PFI:AIR - TT: A Hybrid Metal/Glass Composite System for Multihazard Resilient Bridge Columns ............................................................98

Xallent,LLC .................................................................................................................................................................................................................................99SBIR Phase II: Integrated Nano-Electro-Mechanical Scanning Probes for Failure Analysis of the 10-Nanometer Node and Beyond ......................................................................................................................................................................................................................99

BIOLOGICAL TECHNOLOGIES (BT) ............................................................................................................................................ 100

AmebaGone, Inc. .................................................................................................................................................................................................................. 101SBIR Phase II: Natural Biocides for Treating Bacterial Pathogens in Pome Fruits and Vegetable Crops ................................................101

Animated Dynamics, Inc. ..................................................................................................................................................................................................... 102SBIR Phase II: Development of a Microscope to Detect Cellular Motion in Three-dimensional Tissue .....................................................102

Ascent Bio-Nano Technologies, Inc. .................................................................................................................................................................................. 103STTR Phase II: Development of Bio-compatible and Bio-safe Cell Sorters ....................................................................................................103

Cairn Biosciences .................................................................................................................................................................................................................. 104SBIR Phase II: A Novel Multicolor Cell Line Engineering Platform that Enables High-throughput Microscopy-based Screening of Living cells for Drug Discovery ................................................................................................................................................................................. 104

Cinder Biological, Inc. .......................................................................................................................................................................................................... 105SBIR Phase II: Improving Food Safety using Hyper-stable Enzyme Cleaning Products ...............................................................................105

Data2Discovery, Inc. ............................................................................................................................................................................................................ 106SBIR Phase II: Semantic Link Association Prediction for Phenotypic Drug Discovery ...................................................................................106

Elucid Bioimaging, Inc. ......................................................................................................................................................................................................... 107SBIR Phase II: Computer Aided Prognosis of Debilitating Disease.................................................................................................................. 107

Geneshifters, LLC .................................................................................................................................................................................................................. 108SBIR Phase II: New Dwarfing Genes to Improve Yield and Abiotic Stress Tolerance in Wheat ................................................................108

Glauconix, Inc. ....................................................................................................................................................................................................................... 109SBIR Phase II: Development of a High-Throughput Drug Screening System for Eye Diseases ..................................................................109

InnovaNutra ........................................................................................................................................................................................................................... 110SBIR Phase II: Encapsulation Solutions for Improving Stability and Delivery of Natural Food Ingredients ...........................................110

Lattice Automation, Inc. ....................................................................................................................................................................................................... 111SBIR Phase II: Fully Integrated Design and Automated Fabrication Services Software Platform for Engineering Living Systems ....111

Macromoltek .......................................................................................................................................................................................................................... 112SBIR Phase II: Automated Design Methods of Antibodies Directed to Protein and Carbohydrate Antigens .........................................112

Mission Bio, Inc. ...................................................................................................................................................................................................................... 113SBIR Phase II: Low-cost Detection and Enrichment of Nucleic Acids by Interfacing with Commercially Available Cell Sorters ..........113

MSTM, LLC .............................................................................................................................................................................................................................. 114STTR Phase II: Novel Ionization Process for Materials Characterization using Mass Spectrometry.........................................................114

PhylloTech, Inc. ....................................................................................................................................................................................................................... 115SBIR Phase II: Plant Bioproduction of Therapeutics and Antibodies for the Treatment of Ebola and Other Diseases .........................115

Plant Sensory Systems, LLC ................................................................................................................................................................................................ 116SBIR Phase II: Nutrient-Enhanced Soybean for Aquafeed ................................................................................................................................. 116

PureBiomass, LLC .................................................................................................................................................................................................................. 117SBIR Phase II: Large Scale Cultivation of Phytoplankton via Novel Photo-Bioreactor Technology .........................................................117

RedLeaf Biologics, Inc. ......................................................................................................................................................................................................... 118SBIR Phase II: Biomanufacturing Red Natural Food Dye ................................................................................................................................... 118

Solinas Medical, Inc.............................................................................................................................................................................................................. 119SBIR Phase II: Application of a Durable Self-sealing Material for Hemodialysis Blood Access ...............................................................119


Sonanutech, Inc. ..................................................................................................................................................................................................................... 120SBIR Phase II: Rapid Detection of Phages in Microbial Fermentation Processes ...........................................................................................120

SQZ Biotechnologies Company ........................................................................................................................................................................................ 121SBIR Phase II: Development of an Intracellular Delivery Platform for Accelerated Drug Discovery Using Genetically Engineered Human Immune Cells .................................................................................................................................................................................................. 121

TeselaGen, Inc. ...................................................................................................................................................................................................................... 122SBIR Phase II: An Intelligent Rapid Prototyping System for Synthetic Biology..............................................................................................122

Texas Tech University ........................................................................................................................................................................................................... 123PFI:AIR - TT: Design of Functionally-tested, Genomics-informed Personalized Cancer Therapy Drug Treatment Plans ......................123

Triton Animal Products ......................................................................................................................................................................................................... 124SBIR Phase II: Production of an Affordable Synthetic Colostrum Replacer in Edible Green Algae..........................................................124

UC2 .......................................................................................................................................................................................................................................... 125SBIR Phase II: Using Microbial Genetic Data to Improve Oil Production Efficiency and Reduce Environmental Impact ......................125

University of Maryland Baltimore County ..................................................................................................................................................................... 126PFI:AIR - TT: Using A. Niger as a Host to Express Recombinant Endolysin ....................................................................................................126

VariFAS Biorenewables, LLC .............................................................................................................................................................................................. 127SBIR Phase II: Novel Enzymes for Producing Homogeneous Preparations of Individual, Monounsaturated Industrial Fatty Acids ............................................................................................................................................................................................................................... 127

BIOMEDICAL TECHNOLOGIES (BM) AND SMART HEALTH (SH) .............................................................................................. 128

Acadia Harvest, Inc. ............................................................................................................................................................................................................. 129SBIR Phase II: Development of On-Land, Closed Containment Integrated Multitrophic Sustainable Aquaculture by means of Ecological Diversity. .................................................................................................................................................................................................... 129

Acadia Harvest, Inc. ............................................................................................................................................................................................................. 130SBIR Phase II: Developing Alternate Aquafeeds by Using Sustainable Methods of Bio-remediation of Seafood Residuals..............130

AivoCode, Inc. ........................................................................................................................................................................................................................ 131SBIR Phase II: A Novel Platform to Enable Directed Delivery of Therapeutics into Brain Injuries ............................................................131

Aperiomics, Inc. ...................................................................................................................................................................................................................... 132SBIR Phase II: Rapid Pathogen Diagnostics and Biosurveillance using Multiplexed High-throughput Sequencing ...............................132

Avitus Orthopaedics, Inc. .................................................................................................................................................................................................... 133SBIR Phase II: Development of a Minimally Invasive Device for Harvesting Autologous Bone Graft .....................................................133

Brigham Young University................................................................................................................................................................................................... 134PFI:AIR - TT: Robust High Porosity Filter for Circulating Tumor Cell Enrichment...........................................................................................134

BriteSeed, LLC ....................................................................................................................................................................................................................... 135SBIR Phase II: Label-free Imaging for Real-time, Intraoperative Blood Vessel Visualization ....................................................................135

Camras Vision, Inc. ............................................................................................................................................................................................................... 136SBIR Phase II: Adjustable Eye Pressure Control within an External Shunt .......................................................................................................136

Cardiac Motion, LLC ............................................................................................................................................................................................................ 137STTR Phase II: Development and Commercialization of a Wearable Long-term Monitor for Cardiac Arrhythmias ...........................137

Cognita Labs, LLC ................................................................................................................................................................................................................. 138SBIR Phase II: Handheld and Low-cost Pulmonary Function Testing Device using Smart Coherent Multi-signal Oscillometry Technique ....................................................................................................................................................................................................................... 138

ConsortiEX, Inc. ...................................................................................................................................................................................................................... 139SBIR Phase II: Development of a Track-and-Trace Medication Barcoded Label ..........................................................................................139

CONTINUUS Pharmaceuticals, Inc. .................................................................................................................................................................................. 140SBIR Phase II: Novel Pharmaceutical Manufacturing Technologies to Deliver more Affordable Medications to Patients Faster and with Better Quality ...................................................................................................................................................................................................... 140

Cornell University ................................................................................................................................................................................................................. 141PFI:BIC: Nutriphone: A Nanoparticle-based Optical Contrast Assay to Monitor Vitamin and Micro-nutrient Levels Using Smartphones ................................................................................................................................................................................................................. 141

Covaris, Inc. ............................................................................................................................................................................................................................ 142SBIR Phase II: Continuous Manufacturing of Nano- and Micron-particle Drugs Using Focused Acoustics .............................................142

DeviceFarm ............................................................................................................................................................................................................................ 143SBIR Phase II: A Medical Device based Treatment of Onychomycosis ...........................................................................................................143


Elidah, Inc. ............................................................................................................................................................................................................................... 144SBIR Phase II: Novel Treatment for Stress Urinary Incontinence ....................................................................................................................... 144

Esculon, LLC ............................................................................................................................................................................................................................. 145SBIR Phase II: Novel Device for Maintaining Continuous Fluid Drainage in Small-Bore Chest Tubes after Cardiothoracic Surgery .......................................................................................................................................................................................................................... 145

FlexDex, Inc. ........................................................................................................................................................................................................................... 146SBIR Phase II: Enhanced Dexterity Minimally Invasive Surgical Platform .......................................................................................................146

Guiding Technologies Corporation .................................................................................................................................................................................. 147SBIR Phase II: Using Data Mining to Optimally Customize Therapy for Individuals with Autism .............................................................147

Histogen, Inc. .......................................................................................................................................................................................................................... 148STTR Phase II: A Novel Wound Dressing for Infection Control and Tissue Regeneration ...........................................................................148

InnSight Technology, Inc. ...................................................................................................................................................................................................... 149SBIR Phase II: Novel, Point-of-service Device for use in Diagnosing the Severity of Anterior Eye Injures with an Objective Measure of the Ocular Tear Film ............................................................................................................................................................................. 149

LambdaVision, Inc. ................................................................................................................................................................................................................ 150SBIR Phase II: Design and Optimization of a Biocompatible Protein-Based Retinal Implant for the Treatment of End-Stage Retinal Degeneration .................................................................................................................................................................................................. 150

Lehigh University ................................................................................................................................................................................................................... 151PFI:AIR - TT: Proof of Concept Study and Scaleability of Injection Molded Nanostructured Biomedical Consumables .....................151

Lehigh University ................................................................................................................................................................................................................... 152PFI:AIR-TT: Preclinical Evaluation of Bioactive Tailored Amorphous Multiporous (TAMP) Powder for the Treatment of Dentin Hypersensitivity ............................................................................................................................................................................................................ 152

Liberate Medical, LLC ......................................................................................................................................................................................................... 153STTR Phase II: A Novel Abdominal Stimulator to Assist with Ventilator Weaning in Patients ...................................................................153

Madorra ................................................................................................................................................................................................................................. 154SBIR Phase II: Developing a Novel, Non-Hormonal Device for Vaginal Atrophy for Breast Cancer Survivors and Post- menopausal Women ................................................................................................................................................................................................... 154

Michigan State University .................................................................................................................................................................................................. 155PFI:BIC: iSee - Intelligent Mobile Behavior Monitoring and Depression Analytics Service for College Counseling Decision Support .......................................................................................................................................................................................................................... 155

Microdevice Engineering, Inc. ............................................................................................................................................................................................ 156STTR Phase II: Microdevice for Rapid Blood Typing without Reagents and Hematocrit Determination ..................................................156

Neural Analytics .................................................................................................................................................................................................................... 157SBIR Phase II: A Novel Non-Invasive Intracranial Pressure Monitoring Method ..........................................................................................157

Northwestern University ...................................................................................................................................................................................................... 158PFI:BIC - A Smart, Always-on Health Monitoring System .............................................................................................................................. 158

Pennsylvania State Univ University Park ........................................................................................................................................................................ 159PFI:AIR - TT: Continuous Urine Assay Instrumentation for Monitoring Kidney Function ..............................................................................159

Phase Diagnostics, Inc. ......................................................................................................................................................................................................... 160SBIR Phase II: A Handheld, One Step Paper-Based Device for Rapid Self-Testing of Sexually Transmitted Infections .......................160

Phi Optics, Inc......................................................................................................................................................................................................................... 161SBIR Phase II: Quantitative Phase Imaging for Life Sciences ............................................................................................................................ 161

Phytoption, LLC ...................................................................................................................................................................................................................... 162SBIR Phase II: New Ingredients Technology to Enhance the Safety, Quality, and Value of Active Substances for Pharmaceuticals, Food, and Personal Care ........................................................................................................................................................................................... 162

Protein Dynamic Solutions, LLC .......................................................................................................................................................................................... 163SBIR Phase II: Novel, Accurate and Reproducible Platform for the Developability Assessment of Protein Therapeutics ....................163

Radial Analytics, Inc. ............................................................................................................................................................................................................ 164SBIR Phase II: System for Patient Risk Stratification through Electronic Health Record Analytics .............................................................164

Rivanna Medical ................................................................................................................................................................................................................... 165SBIR Phase II: Safe, Portable, Non-ionizing Bone Imaging with an Ultrasound-based X-ray Replacement Device ..............................165

Roundtable Analytics, Inc. ................................................................................................................................................................................................... 166SBIR Phase II: Data-Driven Decision Support Services for Emergency Department Operations ...............................................................166


Sense Diagnostics, LLC ......................................................................................................................................................................................................... 167SBIR Phase II: Novel Device for Monitoring Brain Hemorrhage using Radio Waves .................................................................................167

Shasqi, Inc. .............................................................................................................................................................................................................................. 168SBIR Phase II: Biomaterials and Chemistry to Enhance the Delivery of Medicines in the Body .................................................................168

SiMPore, Inc. ........................................................................................................................................................................................................................... 169STTR Phase II: Development of Ultrathin Nanomembranes for Home-based Hemodialysis.......................................................................169

Sintact Medical Systems, LLC............................................................................................................................................................................................. 170SBIR Phase II: Development of a Barrier Film to Prevent Post-operative Internal Scarring .......................................................................170

Sonavex, Inc. .......................................................................................................................................................................................................................... 171SBIR Phase II: Automatic Vascular Flow Reconstruction with Adaptive Three-Dimensional Doppler Ultrasound....................................171

SonoVol, LLC .......................................................................................................................................................................................................................... 172SBIR Phase II: Developing a New Platform Technology for 3D Ultrasound Imaging .................................................................................172

Springbok, Inc. ....................................................................................................................................................................................................................... 173SBIR Phase II: A Non-invasive Image-based Skeletal Muscle Analytics Tool .................................................................................................173

Stasys Medical Corporation .............................................................................................................................................................................................. 174SBIR Phase II: Development of a Rapid Assay for the Personalized Assessment of Clot Dysfunction due to Trauma..........................174

TAO Connect, Inc................................................................................................................................................................................................................... 175SBIR Phase II: An Intelligent Mental Health Therapy System ............................................................................................................................. 175

Texas A&M Engineering Experiment Station ................................................................................................................................................................ 176PFI-AIR-TT: Wearable Sleepwear for Quantitative Prognostication and Noninvasive Therapy of Obstructive Sleep Apnea ...........176

Texas A&M Engineering Experiment Station ................................................................................................................................................................ 177PFI:AIR-TT: Self-adaptive Growing Rod for the Treatment of Pediatric Scoliosis .........................................................................................177

University of Arizona ........................................................................................................................................................................................................... 178PFI:BIC Making Full Use of the High-Resolution Image Capability of Smartphones to Collect Data through Ophthalmic Devices for Smart Mobile- and Tele-Health ........................................................................................................................................................... 178

University of California, Irvine .......................................................................................................................................................................................... 179PFI:AIR - TT: Integrated Microfluidic System for Cell Separation and Enrichment .......................................................................................179

University of California, Los Angeles .............................................................................................................................................................................. 180PFI:BIC Human-Centered Smart-Integration of Mobile Imaging and Sensing Tools with Machine Learning for Ubiquitous Quantification of Waterborne and Airborne Nanoparticles ............................................................................................................................ 180

University of Cincinnati, Main Campus ........................................................................................................................................................................... 182PFI:AIR - TT: Developing an Engineering Prototype for Ultra-Low-Cost Blood Coagulation Diagnostics Using Paper-based Microfluidics .................................................................................................................................................................................................................. 182

University of Colorado at Denver, Downtown Campus .............................................................................................................................................. 183PFI:AIR - TT: Proof-of-concept Fiber-based Miniature Multiphoton Microscope using Adaptable Optics ..............................................183

University of Illinois, Urbana-Champaign ...................................................................................................................................................................... 184PFI:BIC - Pathtracker: A Smartphone-based System for Mobile Infectious Disease Detection and Epidemiology ................................184

University of Maryland Baltimore County ..................................................................................................................................................................... 186PFI:AIR - TT: RestEaze: Accessible Measures of Leg Movements during Rest and Sleep ............................................................................186

University of Mississippi, Medical Center ....................................................................................................................................................................... 187PFI:AIR - TT: Thermally Targeted Biopolymers for the Delivery of Anticancer Drugs ..................................................................................187

University of South Florida ................................................................................................................................................................................................. 189PFI:AIR - TT: Enhancing the Balance and Control of Crutch Walking Using a Novel Crutch Tip .............................................................189

University of Southern California ..................................................................................................................................................................................... 190PFI:AIR - TT: Wireless Implantable Pressure Sensor for Continuous Monitoring of Chronic Disorders ...................................................190

University of Texas, Austin .................................................................................................................................................................................................. 191PFI:AIR - TT: A Novel Bimanual Upper-body Exoskeleton for Stroke Therapy ..............................................................................................191

University of Washington ................................................................................................................................................................................................... 192PFI:BIC - Smart Laser-Based Imaging and Optical Spectroscopy System: Optical Quantification of Bacterial Load, Oral Health Surveillance, and caries Prediction. ......................................................................................................................................................................... 192

Vanderbilt University ........................................................................................................................................................................................................... 194PFI:AIR - TT: External Stents to prevent vein failure in dialysis grafts ............................................................................................................. 194


Vaxess Technologies, Inc. .................................................................................................................................................................................................... 195SBIR Phase II: A New Approach to Developing a Heat-stable Rotavirus Vaccine .......................................................................................195

CHEMICAL AND ENVIRONMENTAL TECHNOLOGIES (CT) ....................................................................................................... 196

Amriton, LLC ........................................................................................................................................................................................................................... 197SBIR Phase II: Regenerable Adsorbent Filter for Water Purification ..............................................................................................................197

Colorado School of Mines ................................................................................................................................................................................................. 198PFI:BIC: Self-Correcting Energy-Efficient Water Reclamation Systems for Tailored Water Reuse at Decentralized Facilities ...........198

Cycladex................................................................................................................................................................................................................................. 200SBIR Phase II: An Economic, Sustainable, Green, Gold Isolation Process .......................................................................................................200

Duke University ...................................................................................................................................................................................................................... 201PFI:BIC - A Smart, Flexible, Large-Scale Sensing and Response Service System (LASSaRESS) for Monitoring and Management of Ground, Air and Waterborne Contaminants ................................................................................................................................................... 201

Ecovia Renewables, Inc. ....................................................................................................................................................................................................... 202SBIR Phase II: Efficient Production of a High Performance and Eco-Friendly Superabsorbent Microbial Biopolymer for Hygiene Applications .................................................................................................................................................................................................................. 202

EIE Materials, Inc. .................................................................................................................................................................................................................. 203SBIR Phase II: Novel Compositions for Narrow Bandwidth Light Emitting Diode Phosphors ......................................................................203

framergy, Inc. ......................................................................................................................................................................................................................... 204SBIR Phase II: A Novel Metal-Organic Framework Material for the Separation and Recovery of Unprocessed Natural Gas During Oil and Gas Production ................................................................................................................................................................................ 204

Glucan Biorenewables, LLC................................................................................................................................................................................................ 205SBIR Phase II: Catalytic Conversion of Lignocellulosic Biomass into Furfural and Dissolving Pulp using Green Solvents ...................205

Ground Fluor Pharmaceuticals, Inc. .................................................................................................................................................................................. 206SBIR Phase II: PET Radiotracer Synthesis ............................................................................................................................................................... 206

Kepley Biosystems, Inc. ........................................................................................................................................................................................................ 207SBIR Phase II: A New Sustainable Crustacean Bait ............................................................................................................................................. 207

Loci Controls, Inc. ................................................................................................................................................................................................................... 208SBIR Phase II: Automatic Control of Landfill Gas Collection ............................................................................................................................ 208

Mango Materials .................................................................................................................................................................................................................. 209SBIR Phase II: A Novel Biodegradable Biopolymer from Waste Methane Gas ...........................................................................................209

Membrane Technology & Research, Inc. ....................................................................................................................................................................... 210STTR Phase II: New Perfluorodioxolane- and Perfluorodioxane-based Copolymer Membranes for Gas Separations ........................210

Ohio State University .......................................................................................................................................................................................................... 211PFI:AIR - TT: Towards Commercialization of Potassium-Oxygen Batteries: Solving Safety Challenges .................................................211

Oklahoma State University ................................................................................................................................................................................................ 212PFI:AIR - TT: Transitioning Explosive Sensing Technology to the Marketplace ..............................................................................................212

Picoyune, LLC ......................................................................................................................................................................................................................... 213SBIR Phase II: Inline Plasmonic Mercury Monitors for Natural Gas Processing ............................................................................................213

PolyDrop ................................................................................................................................................................................................................................. 214SBIR Phase II: Porous Conductive Polymer Nanostructures as Antistatic Additives for Coatings and Plastics ........................................214

PolymerPlus, LLC.................................................................................................................................................................................................................... 215STTR Phase II: Nanofiber Fabrication via Melt Coextrusion for Fuel Filter Membranes .............................................................................215

Precision Polyolefins, LLC..................................................................................................................................................................................................... 216SBIR Phase II: Commercially Viable Ton-Scale Production of Stereoblock Polypropylene Thermoplastic Elastomers and XPURE Oils ................................................................................................................................................................................................................................. 216

Protabit, LLC ........................................................................................................................................................................................................................... 217STTR Phase II: Development of a Computational Protein Engineering Platform and its Application to Methane Activating Enzymes ....217

Proton Energy Systems, Inc. ................................................................................................................................................................................................ 218SBIR Phase II: Hydrogen Bromine Electrolysis for Highly Efficient Hydrogen-Based Energy Storage and High Value Chemical Applications .................................................................................................................................................................................................................. 218

Provivi, Inc. .............................................................................................................................................................................................................................. 219SBIR Phase II: Enzymatic Synthesis of Insect Pheromones ..................................................................................................................

2017 sbir/sttr phase ii and pfi grantees conference abstract book · phase ii and pfi grantees...

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