320

Filed Jul. 13, 1989.This invention relates to the identification, characterization, and sequencing of genetic sequences of human secretory granule proteoglycan peptide core protein, recombinant DNA clones directed against this sequence and against the sequence of the antisense RNA, and antobodies which recognize the native human secretory granule proteoglycan.

5171675

M A C R O P H A G E C O L O N Y S T I M U L A T I N G F A C T O R - £ 6 5

Douglas P Cerretti, Dirk M Anderson, Robert J Tushinski, Byron Gallis, David Cosman

A macrophage colony stimulating factor, M- CSF gamma, which is a primary translation pro- duct of an alternative mRNA splicing event and is a precursor to biologically active M-CSF. DNA sequences encoding M-CSF gamma and recombinant expression vectors comprising the DNA sequences.

5171677

R E C O M B I N A N T M A R E K ' S D I S E A S E V I R U S A N D P R O C E S S

F O R P R E P A R I N G T H E S A M E

Masash Sakaguchi, Hiroaki Maeda, Michitaka Yamamoto, Junichi Miyazaki, Kumamoto, Japan assigned to Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

A recombinant Marek's disease virus which comprises a Marek's disease virus genom and a DNA fragment incorporated therein, said DNA fragment being constructed by incorporating a promoter derived from an animal cell or an animal virus and a structural gene coding for an exogenous protein into a gene fragment derived from a Marek's disease virus, a process for pre- paring the same which comprises preparing a gene fragment wherein a structural gene coding for an exogenous gene is linked to the dow- nstream of a promoter derived from an animal cell or an animal virus, incorporating said gene fragment into a BamHl - H fragment ofa gene of a Marek's disease virus type I, and incorporating said fragment into a Marek's disease virus type I genome, and a multivalent live vaccine for birds comprising the same.

PATENT ABSTRACTS

5171684

B I O C O N V E R S I O N S C A T A L Y Z E D BY T H E T O L U E N E

M O N O O X Y G E N A S E O F P S E U D O M A N A S M E N D O C I N A

KR-1

Kwang-M Yen, Lawrence M Blatt, Michael Karl assigned to Amgen Inc

Disclosed and claimed are toluene mono- oxygenase (TMO) gene sequences from Pseudo- monas mendocina KR-I, TMO proteins encoded by these sequences, recombinant plas- mids containing such sequences, and micro- organism host cells containing such plasmids. A five-gene and six-gene TMO gene cluster encode proteins that are useful in a variety of bioconver- sions. In particular, the TMO gene cluster is use- ful for the preparation of p-hydroxyphenylacetic acid and indigo. In addition, the TMO gene cluster is useful for the degradative bioconver- sion of toxic compounds, such as trichloroethy- lene.

5171685

C L O N I N G O F T H E B A B E S I A B O V I S 60 K D A N T I G E N

Terry F McElwain, Stephen A Hines, Travis C McGuire, Guy Palmer, Douglas P Jasmer, David W Reduker, Will Goff, Lance E Per- ryman, William C Davis assigned to University of Florida; The United States of America as represented by the United States Department of Agricultu

The subject invention concerns the identifica- tion of novel merozoite surface proteins of Babesia bovis. Also disclosed are monoclonal antibodies to these proteins as well as genes which encode for the proteins. The invention fur- ther concerns the use of the novel proteins, recombinant DNA clones, and monoclonal anti- bodies in the detection, treatment, and pro- phylaxis of babesiosis.

5171839

N U C L E O T I D E A N D A M I N O A C I D S E Q U E N C E S O F P R O T E I N M T P 4 0

O F M. T U B E R C U L O S I S A N D S Y N T H E T I C P E P T I D E S D E R I V E D

T H E R E F R O M

Manuel E Patarroyo, Bogota, Colombia