9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 … · 2018. 4. 20. · 9.5...
TRANSCRIPT
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
0.98
1.70
1.72
1.73
4.33
4.34
4.36
7.26
8.22
9.2
1
2.0
4
2.0
0
0.8
8
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
29.81
29.94
41.58
67.54
76.84
77.16
77.48
91.77
163.28
Electronic Supplementary Material (ESI) for Chemical Science.This journal is © The Royal Society of Chemistry 2018
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
0.88
0.90
0.92
0.94
1.37
1.39
1.40
1.40
1.40
1.41
1.42
1.43
1.76
1.78
1.80
4.27
4.29
4.30
7.26
8.22
3.4
1
4.2
6
2.0
7
2.0
0
0.9
4
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
0.90
1.28
1.29
1.31
1.32
1.33
1.33
1.34
1.35
1.36
1.36
1.42
1.44
1.45
1.46
1.74
1.76
1.77
1.78
1.79
4.27
4.29
4.30
7.26
8.22
2.9
4
8.4
0
2.1
5
2.1
5
1.9
9
0.9
0
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
14.17
22.74
25.96
28.39
29.29
31.90
69.78
76.95
77.16
77.37
91.86
163.19
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.14
1.15
1.16
1.19
1.20
1.22
1.23
1.26
1.27
1.27
1.29
1.30
1.31
1.33
1.62
1.66
1.67
1.69
1.72
1.73
1.75
1.77
1.78
1.80
4.24
4.25
4.27
7.26
8.21
2.1
3
6.1
7
7.4
0
2.0
0
0.9
4
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
25.71
26.40
26.72
33.37
33.52
37.33
69.96
76.94
77.16
77.37
91.82
162.97
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.76
1.77
1.78
1.78
1.78
1.79
1.79
1.80
1.80
1.81
1.81
1.81
1.81
1.81
1.82
1.82
1.82
1.83
1.83
1.84
1.84
1.85
1.85
2.67
2.69
2.70
4.30
4.31
4.32
7.18
7.18
7.18
7.19
7.20
7.26
7.27
7.28
7.30
8.24
4.3
0
2.0
8
2.0
0
3.0
1
2.1
3
0.9
1
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
0.90
1.28
1.29
1.31
1.32
1.33
1.33
1.34
1.35
1.36
1.36
1.42
1.44
1.45
1.46
1.74
1.76
1.77
1.78
1.79
4.27
4.29
4.30
7.26
8.22
2.9
4
8.4
0
2.1
5
2.1
5
1.9
9
0.9
0
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
31.45
41.21
66.03
76.84
77.16
77.48
91.48
162.81
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 ppm
1.47
1.47
1.48
1.49
1.51
1.51
1.51
1.52
1.55
1.56
1.58
1.58
1.58
1.59
1.59
1.60
1.60
1.78
1.79
1.80
1.81
1.82
3.61
3.63
3.64
4.29
7.26
8.22
6.0
4
9.1
2
2.1
9
2.1
2
2.0
5
2.0
1
2.0
0
0.8
7
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 10 ppm
-5.17
18.43
22.43
26.08
28.23
32.48
63.01
69.64
76.95
77.16
77.37
91.80
163.11
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.21
2.11
2.13
2.14
4.22
4.39
7.26
8.31
9.1
4
2.0
5
2.0
2
2.0
0
0.8
9
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
27.26
27.82
38.83
60.77
65.92
76.95
77.16
77.37
91.48
162.83
178.36
11 10 9 8 7 6 5 4 3 2 1 ppm
1.81
1.81
1.81
2.38
2.39
2.41
3.67
4.29
4.30
4.32
7.26
8.26
4.4
0
2.1
4
3.1
3
2.0
0
0.9
9
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
21.50
27.80
33.57
51.64
69.05
76.84
77.16
77.47
91.60
162.98
173.77
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.84
1.85
1.85
3.74
3.76
3.77
4.32
7.26
7.70
7.71
7.71
7.72
7.83
7.84
7.84
7.85
8.25
4.1
9
2.0
0
2.0
1
2.1
4
2.1
6
0.9
6
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
25.34
25.93
37.70
68.90
76.95
77.16
77.37
91.65
123.38
132.29
134.07
163.02
168.50
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
9.48
25.91
76.95
77.16
77.38
82.01
92.36
162.77
1.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5 ppm
1.30
1.34
1.36
1.36
2.07
2.08
2.10
2.11
2.35
2.36
2.39
2.40
5.16
5.17
5.18
5.18
7.26
8.29
3.1
1
2.9
6
2.9
5
3.1
2
1.0
2
1.0
5
1.0
0
0.9
9
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.15
1.17
1.19
1.21
1.30
1.32
1.32
1.33
1.34
1.34
1.35
1.37
1.38
1.62
1.64
1.65
1.65
1.70
1.90
1.92
2.41
2.42
4.65
7.26
8.47
3.3
5
3.3
9
3.4
5
2.1
5
2.0
9
2.0
0
1.0
9
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
2.58
2.60
2.62
2.92
2.94
2.96
4.79
7.22
7.22
7.24
7.26
7.29
7.31
8.52
2.0
6
2.2
0
2.0
0
3.2
1
2.6
1
0.9
8
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
6.29
37.97
52.83
76.95
77.16
77.38
80.53
91.06
126.59
128.79
139.51
161.35
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
4.26
4.69
7.26
8.53
2.0
1
2.0
1
0.8
3
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 10 ppm
-0.52
56.64
76.48
76.95
77.16
77.37
90.88
160.91
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 ppm
0.06
0.89
1.84
1.85
1.86
1.87
1.88
1.89
2.34
2.35
2.36
3.71
3.72
3.73
4.75
7.26
8.48
6.1
7
9.3
2
2.2
7
2.2
4
2.1
7
2.0
0
1.0
8
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 10 ppm
-5.10
8.19
18.43
26.11
35.16
47.96
61.54
76.95
77.16
77.37
80.97
91.06
161.38
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.26
4.54
4.72
7.26
8.51
8.9
2
1.9
8
2.0
0
0.9
8
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 10 ppm
-3.05
27.36
39.18
72.81
76.95
77.16
77.38
90.87
161.24
176.49
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
2.69
2.70
2.71
4.01
4.02
4.04
4.78
7.26
7.71
7.71
7.72
7.72
7.83
7.84
7.84
7.85
8.51
2.1
5
2.1
9
2.0
0
2.1
6
2.1
1
0.9
9
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 10 ppm
-1.52
40.52
48.09
76.94
77.16
77.37
80.61
90.90
123.52
132.16
134.21
161.21
168.01
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.59
1.60
3.02
4.61
4.62
4.63
4.64
7.26
8.50
3.0
4
3.0
6
1.0
0
1.0
0
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
5.35
19.19
43.55
76.95
77.16
77.37
84.24
91.23
160.99
COSY
NOESY
Hb
Hb
Ha
Hc
Hc
Hb
Ha
Hc
Hc Hd
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.37
4.87
7.26
8.47
9.0
4
2.0
0
0.9
1
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
27.92
27.97
44.05
75.58
76.95
77.16
77.37
83.51
91.06
162.16
9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
1.11
4.05
4.05
4.06
4.07
4.39
4.40
4.40
4.42
4.65
4.66
4.67
4.68
7.26
8.35
9.2
9
0.9
9
1.0
0
1.0
0
0.9
6
190 180 170 160 150 140 130 120 110 100 90 80 70 60 50 40 30 20 ppm
27.26
27.82
38.83
60.77
65.92
76.95
77.16
77.37
91.48
162.83
178.36
