A 20-Year Legacy

GENESIS™ II Total Knee System20 Years of pioneering solutionsFor over 160 years, Smith & Nephew has transformed the medical industry with continued innovation, supporting healthcare professionals to enable better outcomes for patients around the globe. The GENESIS II Total Knee laid the foundation for Smith & Nephew’s knee legacy over 20 years ago.

1856Thomas James (T.J.) Smith opens shop in Hull, England 1896

Horatio Nelson Smith (nephew) entered a partnership in forming T.J. Smith and Nephew

1978Richards Medical Company (RMC) Total Knee System introduced

1986Smith & Nephew, Plc. acquires Richards Medical Company

1928EUROPLAST™ introduced making Smith & Nephew a household brand in the United Kingdom

1934Richards Manufacturing Company founded in Memphis, TN

1991OXINIUM™ Oxidized Zirconium Technology first patented, US Patent #5037488

1997First GENESIS II Knee implanted with OXINIUM 2000

Global orthopaedic sales exceed $500M

1856

1962Richards annual sales exceed $1M

1914WWI – propelled the expansion of wound dressings and staff grows from 50 to 1200

2008VERILAST™ Technology OXINIUM + XLPE = VERILAST

2004Minimally Invasive Surgery (MIS) Instruments for GENESIS II

2005LEGION™ Revision Knee (RK)

GENESIS II SPC (Symmetric Posterior Condyles)

2009LEGION CR Porous CoCr

2010VISIONAIRE™ Patient Matched Instrumentation 2011

New Global Orthopaedic Headquarters established in Memphis, TN

2012LEGION Hinge Knee (HK)

2012Acquisition of LifeMod, the leading provider of biomechanical human body simulation tools and services

2015Acquired BlueBelt Technologies and NAVIO™ Robotic Assistance for Partial and Total Knee Systems

2014Partnership with OrthoSensor® and VERASENSETM Sensor Assisted Surgery for Total Knee Systems

2015Over 1 million OXINIUM implants sold worldwide

2013LEGION Narrow CR and PS

2014JOURNEY II CR

2010Received clearance for 30-year wear claim for LEGION Knee and VERILAST Technology*

Global orthopaedic sales exceed $2B

GENESIS II CR and PS High Flex Inserts

JOURNEY™ Bi-Cruciate Stabilized Knee System

2007Smith & Nephew Gender Knee System claim

2009 JOURNEY BCS Knee System cleared for normal knee kinematics

2005Engineering Materials Achievement Award presented to Smith & Nephew for OXINIUM Oxidized Zirconium

Smith & Nephew is only orthopaedic company to win this award. Past recipients include GE, DuPont, IBM, Texas Instruments, Dow Corning and Northrup Grumman

1mm increment inserts launched for LEGION and GENESIS II

JOURNEY II BCS

1988 GENESIS Total Knee System

1984Richards acquires Dyonics and celebrates 50 years in orthopaedics with sales that exceed $100 million for the first time

TRICON-M™ Total Knee System was introduced

1996GENESIS II Total Knee System introduced at AAOS in Atlanta, GA

M/L Width-2mm each side

A global success story Over the past 20 years GENESIS II knees have been sold in more than 45 countries, impacting almost one and a half million patients worldwide. Key elements of the GENESIS II design have become standard and inherent to all Smith & Nephew knees. Born from GENESIS II was the LEGION™ Total Knee System, including Revision & Hinge and the JOURNEY™ II Total Knee System, including PFJ, UNI & XR. All can be traced back to GENESIS II design principles. GENESIS II laid the groundwork for all Smith & Nephew knee designs – past, present and future.

* The LEGION Primary CR Knee System completed 45 million cycles of in vitro simulated wear testing, which is an estimate of 30 years of activity. Other LEGION VERILAST™ Primary Knee Systems underwent similar lab testing comparable to industry standards. The results of in vitro wear simulation testing have not been proven to quantitatively predict clinical wear performance. Also, a reduction in total polyethylene wear volume or wear rate alone may not result in improved clinical outcomes as wear particle size and morphology are also critical factors in the evaluation of the potential for wear mediated osteolysis and associated aseptic implant loosening. Particle size and morphology were not evaluated as part of the testing.

Smith & Nephew, Inc.7135 Goodlett Farms ParkwayCordova, TN 38016USA

Telephone: 1-901-396-2121Information: 1-800-821-5700Orders and Inquiries: 1-800-238-7538

www.smith-nephew.com

™Trademark of Smith & Nephew. All Trademarks acknowledged.©2016 Smith & Nephew, Inc.06428 V1 06/16

Over 1.4M GENESIS™ II knees have been implanted in over 45 countries worldwide