accurate and exact cnv identification from targeted high-throughput sequence data
DESCRIPTION
Accurate and exact CNV identification from targeted high-throughput sequence data. 出處: BMC Genomics 2011 報告人:嚴孝昇. OUTLINE. Background CNV MicroArray Methods & Results Conclusions. Background. CNV. Background. MicroArray. Background. Background. - PowerPoint PPT PresentationTRANSCRIPT
Accurate and exact CNV identification from targeted high-throughput sequence data
出處: BMC Genomics 2011
報告人:嚴孝昇
OUTLINE
Background CNV MicroArray
Methods & Results Conclusions
Background
CNV
Background
MicroArray
Background
Background
Green – DNA from reference sample hybridized to target DNA
Red – DNA from test sample hybridized to target DNA
Yellow – DNA from both samples hybridized equally to target DNA
Background
Methods & Results
Methods
Methods & Results
Methods & Results
Results
Methods & Results
Methods & Results
Methods & Results
Methods & Results
Conclusions
Estimate absolute copy Robust, simple to implement
Conclusions
優點: 方法易用,可利用已知資料進行驗證。
缺點: 各家MicroArray晶片設計不同。 對未知基因序列斷點,僅能預測無法驗證。
對本人研究影響: 可多方對 CNV驗證。 可提出準確 CNV位置供實驗驗證。
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