acquity arc system v1.65 driver pack release notes · contact waters technical service..... 22...

R E L E A S E N O T E S

ACQUITY, ACQUITY UPLC, Auto•Blend Plus, Connections INSIGHT, Empower, MassLynx, QDa, “THE SCIENCE OF WHAT’S POSSIBLE.” and

Waters are registered trademarks and ACQUITY Arc, eCord, SAT/IN, LAC/E32, and Q-Tof are trademarks of Waters Corporation.

All other trademarks are the sole property of their respective owners. Copyright 2015 Waters Corporation

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*716004392* *Rev.A*

ACQUITY Arc v1.65 Driver Pack

The ACQUITY® Arc™ v1.65 Driver Pack includes instrument drivers and firmware required to control the ACQUITY Arc™ system and detectors. The driver pack is compatible with Empower® software and MassLynx® software. See “What’s included in this release” for detailed information about the features included in the ACQUITY Arc v1.65 Driver Pack.

For instructions on installing the ACQUITY Arc v1.65 Driver Pack, see Installing the instrument control software.

For information regarding the configuration of Empower Enterprise networks, see Empower 3 Installation, Configuration, and Upgrade Guide.

Contents What’s included in this release ............................................................................. 3

System components and features .......................................................................... 3 Detectors ............................................................................................................ 4 Software functionality ........................................................................................... 5 Options ............................................................................................................... 5

ACQUITY Arc v1.65 Driver Pack contents ............................................................. 5 Instrument drivers and software components .......................................................... 6

Supported Waters software .................................................................................. 7 Compatibility Considerations for Empower Enterprise .......................................... 7

Where to install in Empower environments .............................................................. 9 Additional guidelines ............................................................................................ 9

Issues fixed in this release ................................................................................. 10 Known issues in this release .............................................................................. 12 Installing the instrument control software ......................................................... 16

Installing instrument control software from the DVD (not for a Citrix application server) ........................................................................17 Installation instructions using a downloaded executable file ......................................18

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Installing the instrument control software on an Empower Citrix server .....................19 Validation information .........................................................................................20 Using the Repair utility ........................................................................................20 Removing the instrument control software using the DVD ........................................20

Requalification guidelines .................................................................................. 21 Anti-virus considerations ................................................................................... 22 Contact Waters Technical Service ....................................................................... 22

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What’s included in this release The ACQUITY Arc v1.65 Driver Pack includes the instrument drivers, firmware, and utility applications necessary to support the ACQUITY Arc system.

System components and features

The core ACQUITY Arc system consists of the following components and features.

System components and features:

Component or Feature Description

Quaternary Solvent Manager-R (QSM-R)

The QSM-R allows you to mix and degas as many as four mobile phases. The flow rate range is 0.001 to 5.000 mL/min. The maximum pressure is 65,500 kPa (655 bar, 9,500 psi).

Sample Manager Flow Through Needle-R (SM FTN-R)

The SM FTN-R accommodates two vessel holders, in a variety of sizes, and supports needle injection volumes between 0.1 and 50 µL. Optionally, it can inject volumes as large as 1.0 mL. Optional temperature control is available, controlling the sample compartment temperature between 4 °C and 40 °C.

Column heating options The 30-cm Column Heater with Active Solvent Preheating (CH30-A, part number 186015045) offers these features:

• Control of compartment temperatures between 5 °C above ambient and 90 °C.

• A standard, active pre-heater (APH) assembly that heats the incoming solvent before it enters the column.

• Accommodation for LC columns of dimensions as large as 4.6-mm internal diameter (ID) and 30-cm long.

• eCord™ paperless tracking history of column usage. The 30-cm Column Heater (30-cm CH, part number 186017008) offers passive preheating that can operate as low as 5 °C above the ambient temperature, to 65 °C. An optional, 3-position, 9,500-psi column-selection valve is available. The 30-cm Column Heater/Cooler (30-cm CHC, part number 186017009) offers a 30-cm column heater/cooler option with passive preheating. The operating range of the passive pre-heater is the ambient temperature minus 15 °C to 65 °C or, alternatively, 4 °C to 65 °C (whichever is greater). A 3-position, 9,500-psi column-selection valve is available as an option. Tip: The Sample Manager FTN-R controls these modules; therefore, they do not have separate ICS or firmware. Restrictions:

• If your system configuration includes multiple column compartments, you can operate the system using only one column compartment at a time.

• The device can use either passive pre-heating or a column-selection valve, but not both.

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Component or Feature Description

System design To improve the usability of modules when they are stacked, new guides provide for the proper routing of inlet and outlet tubing. The guides are located on the right-hand side of the modules. In addition, the modules' chassis are fitted with new feet, cleats, and lugs, all of which ensure optimal alignment of stacked modules.

Detectors

The ACQUITY Arc system includes instrument drivers and instrument control software that enables control of the detectors in this system. The detectors listed below now have their own control panels, or updated versions similar to other ACQUITY detectors. You can control, configure, maintain, and troubleshoot them via the system console. The detectors also have the same system stacking capabilities, leak management, and waste management as other ACQUITY devices. Except the 2414 RI detector, each detector now has visual LEDs to indicate the Run, Power, and error states.

See also: www.waters.com for the detector specifications.

Detector Description

QDa® mass detector ACQUITY Arc system supports the QDa mass detector with or without an isocratic solvent manager. The ACQUITY QDa has been evaluated with ACQUITY Arc system with an existing version of the ACQUITY QDa instrument control software (ICS) 1.52.

2998 PDA detector The PDA detector has its own control panel and console pages. The inlet and outlet connections to the body and inlet tubing of the flow cell are optimized to minimize dispersion.

2489 UV/Vis detector The UV/Vis detector has its own control panel and console pages. The inlet and outlet connections to the body and inlet tubing of the flow cell are optimized to minimize dispersion.

2475 FLR detector The FLR detector has its own control panel and console pages. The inlet and outlet connections to the body and inlet tubing of the flow cell are optimized to minimize dispersion.

2414 RI detector The RI detector has its own control panel and console pages and this includes new features not available previously.

2424 ELS detector The ELS detector has its own control panel and console pages.

http://www.waters.com/

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Software functionality

The ACQUITY Arc system includes the following software functionality.

Functionality Description

Auto•Blend Plus™ Auto•Blend Plus supports the programming of gradients directly in terms of pH and percent (%) organic. It supports salt and pH gradients as well as pH and organic gradients.

Sample injection options Features include programmable needle-wash cycles, auto-dilution, and auto-addition.

Options

The ACQUITY Arc System offers these additional options.

Option Description

Heater/cooler assembly The Sample Manager FTN-R can include an optional heater/cooler assembly, to control the sample compartment temperature between 4 °C and 40 °C.

Hexane/THF adapter kit The Hexane/THF conversion adapter kit is suitable for normal-phase separations. It supports the use of tetrahydrofuran (THF), hexane, ethyl acetate, and acetone.

Solvent-selection valve The QSM-R can include an optional solvent-selection valve, which can accommodate as many as six solvents.

Leak detection The QSM-R, SM FTN-R, and CH30-A can detect leaks of at least 1.0 to 1.5 mL.

ACQUITY Arc v1.65 Driver Pack contents The ACQUITY Arc v1.65 Driver Pack DVD includes these items:

• All current instrument drivers and firmware files for ACQUITY Arc instruments and detectors

• Utilities for use with ACQUITY Arc systems • Waters Deployment Manager • Waters Console software

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Instrument drivers and software components:

Driver or software component

Part number

Software version (ICS)

Firmware version

Firmware Checksum

Quaternary Solvent Manager-R

186017000 1.65 1.65 0x7E9FD7DC

Sample Manager FTN-R with temperature control option

186017001 1.65 1.65 0xADA97897

Sample Manager FTN-R without temperature control

186017007 1.65 1.65 0xADA97897

2998 PDA Detector 186017003 1.65 1.65 0xEDD8EBF3

2489 UV/Vis Detector 186017002 1.65 1.65 0xBCED42B2

2475 FLR Detector 186017006 1.65 2.10 0xDBE4D721

2414 RI Detector 186017004 1.65 2.10 0x5038C65E

2424 ELS Detector 186017005 1.65 N/A N/A

ACQUITY QDa Detector 186006511 1.52.1803 N/A N/A

Isocratic Solvent Manager 186015019 1.65 1.65 0xB12ADF87

Deployment Manager N/A 3.1.200.1 N/A N/A

ICS Companion N/A 1.65.3899.0 N/A N/A

Columns Calculator N/A 1.60.1642.1 N/A N/A

Connections INSIGHT® N/A 3.2.82 N/A N/A

Waters Pump Control Software (WPC)

N/A 3.10 N/A N/A

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Supported Waters software The table below shows which Waters software operate with the ACQUITY Arc system.

System

Empower 2: base release to FR5, SPH, HF1

Empower 3: base release to SR2, HF2

MassLynx SCN 925

Stand-alone Waters Console

ACQUITY Arc System Yes Yes Yes No

See also: The ACQUITY Arc System Site Preparation Guide and the ACQUITY Arc System Installation Checklist for additional information about installing and configuring the ACQUITY Arc system.

Compatibility Considerations for Empower Enterprise

To ensure compatibility in Empower Enterprise environments, you must sometimes install additional drivers to control modules other than the ACQUITY Arc modules. These release notes include a table, below, to describe the compatibility of the ACQUITY Arc system components with systems supported by Waters Driver Pack 4 Supplemental Release 1 (DP4SR1).

Important: To ensure compatibility with the ACQUITY Arc v1.65 Driver Pack, Waters systems, that are not ACQUITY Arc systems, must be updated to DP4SR1.

Requirements:

• Install the ACQUITY Arc Driver Pack after all other driver pack and ICS installations are completed, including those produced by third-party vendors and supported by Empower.

• To facilitate compatibility between the ACQUITY Arc and DP4SR1 driver packs, ensure that the ICS and firmware versions installed on the same LAC/E™32 are consistent with the versions specified in the compatibility table, below.

Example: A LAC/E32 module with DP4SR1 installed can support an ACQUITY UPLC® H-Class QSM with ICS, version 1.65, and an ACQUITY Arc system. If the ACQUITY QSM ICS and firmware are earlier versions, they must be upgraded to version 1.65.

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Required ICS and firmware versions for compatibility with the ACQUITY Arc v1.65 Driver Pack:

Instrument Required ICS and Firmware (FW) Versions

Quaternary Solvent Manager-R ICS 1.65

FW 1.65

Sample Manager Flow Through Needle-R

ICS 1.65

FW 1.65

30-cm Column Heater N/A

30-cm Column Heater/Cooler N/A

30-cm Column Heater with Active Solvent Preheating

N/A

ACQUITY QDa Detector ICS 1.52

FW N/A

Isocratic Solvent Manager ICS 1.65

FW 1.65

2998 PDA Detector ICS 1.65

FW 1.65

2489 UV/Vis Detector ICS 1.65

FW 1.65

2475 FLR Detector ICS 1.65

FW 2.1

2414 RI Detector ICS 1.65

FW 2.10

2424 ELS Detector ICS 1.65

FW 1.65

2420 ELS Detector The 2420 ELS Detector is not supported with ACQUITY Arc Systems.

Requirement: Console software must be at version 1.65.

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Where to install in Empower environments

Where you install ACQUITY Arc v1.65 Driver Pack depends on the configuration of computers and instruments in your laboratory. Empower environments comprise three configurations:

• Standalone, Empower Personal workstations.

• One or more LAC/E32 modules connected to Empower clients in an Empower Enterprise system.

• One or more LAC/E32 modules connected to Citrix thin clients via a Citrix server in an Empower Enterprise system.

Requirements:

• You can install the ACQUITY Arc v1.65 Driver Pack on standalone workstations as desired.

• You can install the ACQUITY Arc v1.65 Driver Pack on LAC/E32 modules as desired.

• You must install the ACQUITY Arc v1.65 Driver Pack on Empower clients and Citrix servers connected to LAC/E32 modules running the ACQUITY Arc v1.65 Driver Pack.

Exceptions: Do not install the ACQUITY Arc v1.65 Driver Pack on Empower database servers or Citrix thin clients.

Additional guidelines

In an Empower client/server network, install the ACQUITY Arc v1.65 Driver Pack on all the Empower clients. You can maintain older instrument drivers on the LAC/E32 modules. Instrument drivers on a given LAC/E32 module, and firmware loaded on instruments connected to that module, must be from the same driver pack.

When you install the ACQUITY Arc v1.65 Driver Pack on your Empower clients, do not install the ACQUITY Arc v1.65 Driver Pack on your LAC/E32 modules as well, unless you plan to upgrade the firmware on instruments connected to those modules. For example, if you install DP4SR1 on a LAC/E32 module, the instruments connected to that module must run firmware that accompanies DP4SR1.

You must perform upgrades on LAC/E32 modules and connected instruments at the same time, to ensure that instrument drivers and instrument firmware originate with the same driver pack. For example, if you install the ACQUITY Arc v1.65 Driver Pack on another LAC/E32 module, you must install the ACQUITY Arc v1.65 Driver Pack firmware for the instruments connected to that module.

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Issues fixed in this release The following table contains a list of the software problems fixed in this release. The software change request (SCR) numbers identify software issues that Waters personnel monitor within a system change request tracking tool.

Important: The fixes, for an existing 2424 ELS detector, are only available when you upgrade the firmware. To upgrade the 2424 firmware (not included in this driver pack), you must contact a Waters Service Representative.

SCR number

Instruments or software components Description

31122, 31123, 31124

2424 ELS, 2414 RI, and 2475 FLR detectors

Previously, user interface updates were slow when using centralized Citrix servers with geographically dispersed LAC/E32 servers. Now the user interface updates work correctly.

33152 2424 ELS detector The Normalize Unit diagnostic has been updated to accommodate more sensitive photomultiplier tubes (PMTs).

33238, 33291

2424 ELS, and 2414 RI detectors

Previously, on some Empower systems, the control panel appeared blank on the Run Samples screen. Now the control panel appears correctly on the Run Samples screen.

33364 2424 ELS detector The Rayleigh factor adjustment algorithm has been enhanced to better track lamp degradation.

32061 2489 UV/Vis detector Previously, the status panel was not visible after installation on some Empower systems. Now the status panel appears correctly.

32616 2489 UV/Vis detector Previously, an alarm would issue if the instrument was acquiring data while the data system was closed or in an error state. Now the instrument does not issue an alarm when acquiring data while the data system is closed or in an error state.

32617 2489 UV/Vis detector Previously, the stand-alone functionality using a contact closure inject start did not work. Now the stand-alone functionality using a contact closure inject start works correctly.

28308 2998 PDA detector Previously, when used with MassLynx systems, the instrument would report incorrect error messages following a Reset Communications. Now, following a Reset Communications, the instrument works correctly with MassLynx systems.

31320 2998 PDA detector Previously, the instrument would issue excessive lamp energy low warning messages. Now the instrument reports lamp energy low warning messages correctly.

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SCR number


31352 2998 PDA detector Previously, the detector could not be reset following a LAC/E32 reboot. Now the instrument can be reset after a LAC/E32 reboot.

32915 2998 PDA detector Previously, the instrument would issue excessive data buffer overrun alarms. Now the instrument issues data buffer overrun alarms correctly.

31228 2414 RI detector The front panel wavelength value has been removed.

31962 2475 FLR detector Previously, when a method was downloaded to the instrument, the detector would not clear alarms. Now the detector clears alarms when a method is downloaded to the instrument.

31993 2475 FLR detector The text for several alarm messages was updated to improve readability.

32023 2475 FLR detector Previously, the instrument would stop working when run in 3D scan mode. Now the instrument works correctly when run in 3D scan mode.

32260 2475 FLR detector Previously, the visual ID feature did not work correctly. Now the visual ID feature works correctly.

32905 2475 FLR detector Previously, alarms only appeared in English. Now the alarms have been translated to appear in the correct local language.

33259 2475 FLR detector Previously, when run in 2D mode with multiple channels selected, the detector stopped acquisition. Now acquisition runs in 2D mode with multiple channels selected.

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Known issues in this release The table below lists known software defects in the ACQUITY Arc v1.65 Driver Pack. Waters’ change request database uses the software change request (SCR) numbers in the left-hand column to track these issues.

SCR number


32509, 33339

QSM-R Rarely, the method editor can crash when you click to a different instrument method editor, and then you immediately click back again. Work-around: Reset the module, open the QSM-R method editor, and re-enter the parameter settings. Avoid clicking quickly between instrument method editors.

31749 SM FTN-R The Empower sample set cannot reach the four large vial positions, V:1 through V:4. Work-around: You can reference standard vials.

32547, 32556, 32557

SM FTN-R When performing load-ahead with auto-addition, the system uses the wrong Number of Samples value when loading the next samples. It uses the number of samples of the current injection and not the number of samples of the next injection, as it should. Currently, ICS/Empower does not send a complete set of samples for the next injection to be loaded ahead; rather, ICS/Empower sends only the first sample within the next set. The SM FTN-R then recognizes that the upcoming injection sample list does not match the current injection sample list, and it washes the needle, causing the loss of the sample drawn during the load-ahead phase. The injection time cannot be estimated correctly. Work-around: Do not use auto-addition with load-ahead.

32661 SM FTN-R Problems can occur when the dilution option is used in conjunction with a pre-sample air gap:

• The pre-sample air gap is dispensed with a portion of the dilution volume.

• The dilution volume is reduced by the size of the air gap when dispensed into the sample.

Work-around: Avoid adding an optional pre-sample air gap when using the dilution option.

33265 SM FTN-R Drawing an air gap that exceeds the syringe capacity causes a failure. Some functions allow the sample syringe to perform multiple draws, to aspirate the desired volume:

• Dilution operation • Large post-sample air gap

Example: For a 100-µL syringe and a 250-µL extension loop, if you select a pre-sample air gap of 5 µL (optional), a sample of 75 µL, and a post-sample air gap of 25 µL (larger than the default setting), an error occurs.

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SCR number


Work-around: When specifying a pre-sample air gap and a post-sample air gap for a sample, ensure that the syringe is large enough to contain the total.

32864 Citrix environment

Installing updated drivers for 2414, 2475, and 2424 detectors in a Citrix environment, without updating the LAC/E32 nodes for any existing systems, is not supported. Work-around: If you install these drivers, you must also update the LAC/E32 nodes for any existing systems.

31736 2475 FLR detector

Existing 2475 ICS methods are not compatible with all languages. Work-around: If you want to use a method that was created in the released 2475 ICS in a different language, you must install the new ICS, open the method in the language in which it was created, and then save the method. The saved method is compatible with all languages.


On detectors with the older 161-charge amperage, when you start the detector and then perform the “manual shift calibrate”, the reference offset is calculated incorrectly. The value corrects itself on startup, so the issue occurs only after a “manual shift calibrate”. This value is not stored as part of the method.


When a module’s interactive display page controls the system, and an Empower sample set is started, the sample set immediately stops and a “Run aborted” message appears. Work-around: Click the module page in the console, and then click Control > Reset module.

31746, 31758

2424 ELS detector

In the MassLynx Inlet Configuration Detector dialog box, two ELS detectors can appear, but one is obsolete. The MassLynx Inlet Configuration Detector dialog box includes an outdated driver, “Waters 2424”. Work-around: When configuring the MassLynx inlet and a 2424 detector is connected, ensure that you select “2424 ELS Detector” in the Detector Configuration dialog box, not “Waters 2424”.

32372 2424 ELS detector

The updated driver for the 2424 does not work unless the same ICS version is installed on both the client and server. Work-around: Choose one of the following:

• Don't update to version 1.65, and continue operating without a console and control panel.

• Update both the client and server to version 1.65, to gain a console and control panel. Note that the LAC/E32 must also be updated with the latest infrastructure and driver.

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SCR number


33630, 33631

2424 ELS detector

When you create methods specifying alarm limits for a drift tube or an external column heater, the sample run can start while the temperature is outside the temperature band. Reason: The 2424 firmware waits for up to an hour for the temperature to get within the alarm band. Nevertheless, it does not prevent an injection from starting if the temperature is outside the band. If the temperature is not reached before acquisition begins, a warning is entered in the log.

31750 2414 RI detector

In 410 mode, the firmware displays the method filter time of 0.2 as 0.0.

31230 2414 RI detector in 410 emulation mode

The sensitivity setting in an Empower instrument method affects negative peaks, but it does not appear to affect positive peaks (communication through Ethernet). Reason: In 410 emulation mode, firmware does not allow the legacy Millennium data to be negative. When the sensitivity is increased (greater than or equal to 64), the range is reduced, and you are more likely to see negative saturation of data. Changing the polarity to the opposite value or reducing the sensitivity allows you to utilize a larger range and alleviate the clipping behavior. Work-around: Switch the polarity.

31754 W410 RI detector

During the upgrade of a W410 RI detector, the Autoloader application does not select the 2414 Detector [V2.10].sft file automatically. Work-around: When using Autoloader to upgrade a W410 detector, select the 2414 Detector [V2.10].sft file.

32880 MassLynx with eSAT/IN™

If the project Acqudb folder does not contain a Default.esat method, new eSAT/IN methods cannot be created. Work-around: A Default.esat method is provided in the Default project when MassLynx is installed. Copy it to any new project that does not have this file.

32386 System Plates and racks are not installed if the user configures the Waters Pump Control (WPC) software. WPC is required if using the QDa with an ISM and QSM-R. Work-around: Configure QSM-R first so that MassLynx software installs the plates and racks, and then configure WPC.

1. Install drivers for ISM, QSM-R and WPC. 2. In MassLynx software, on the Inlet Method screen,

select Tools\Instrument Configuration. 3. On the Inlet Configuration screen, click Configure. 4. On the Welcome to the Inlet Configuration Wizard

dialog box, click Next. 5. On the Select Pump screen, select Quaternary

Solvent Manager-R, and click Next. 6. On the Select Auto Sampler screen, select Sample

Manager FTN-R, and click Next.

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SCR number


7. On the Select Detectors screen, select a detector or detectors, and click Next.

8. On the Configure Communications screen, configure the instruments, and click Next.

9. Click Finish. 10. On the Inlet Configuration screen, click Finish. 11. Verify that the C:\MassLynx\Plates folder contains 22

files. 12. Verify that the C:\MassLynx\Racks folder contains 6

files. 13. In MassLynx software, on the Inlet Method screen,

select Tools\Instrument Configuration. 14. On the Inlet Configuration screen, click Configure. 15. In the Welcome to the Inlet Configuration Wizard

dialog box, click Next. 16. On the Select Pump screen, select Waters Pump

Control, and click Next. 17. On the Select Auto Sampler screen, select Sample

Manager FTN-R, and click Next. 18. On the Select Detectors screen, select a detector or

detectors, and click Next. 19. On the Configure Communications screen, configure

the instruments, and click Next. 20. Click Finish. 21. On the Inlet Configuration screen, click Finish.

33546 System When you open and then close Run Samples for a system, then add an instrument to the system, the control panel of the newly added instrument is disabled and its status is not connected. Work-around:

1. Add a new instrument to the system. 2. Restart the PC. 3. Open Run Samples for the system. The new

instrument’s control panel appears in Run Samples.

32909 30-cm CHC If the 30-cm CHC icon does not appear in the sample manager FTN-R instrument panel during initialization, perform the following steps:

1. Power-off all devices. 2. Power-on the column compartment and other

dependent devices. 3. Power-on the sample manager FTN-R.

Tip: When a sample manager has dependent devices such as a column compartment, always power-on the dependent devices before the sample manager.

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SCR number


32610, 32896, 33564

Console plots Occasionally, when you zoom into a Console plot and then zoom out, the plot trace can become distorted, or the wrong data appear in the plots. However, the plot data stored on the hard drive remain intact. Work-around: To refresh the plots and correct the display,

click Full View , and then click Realtime , which enables real-time plotting.

Installing the instrument control software Important:

• Upgrading the 2414 firmware erases the settings in the NVRAM. You must reenter the serial number for your instrument and optimize the lamp. In the console software, select Troubleshoot > Optimize Lamp.

• To upgrade the 2424 firmware (not included in this driver pack), you must contact a Waters Service Representative. The upgrade erases the settings in the NVRAM. In addition to reentering the settings, the Waters Service Representative must perform a PMT calibration.

You can install the instrument control software as follows:

• From the DVD provided with this document.

• From the Waters Web site, which requires a support plan. Visit http://www.waters.com/waters/home.htm, and then click Services & Support > Support > Software Downloads.

• As a silent or push installation. See Chapter 4 of the Driver Pack 4 Installation and Configuration Guide 715004344 (on the ACQUITY Arc system documentation CD) and apply the instructions to an ACQUITY Arc system controlled by the ACQUITY Arc v1.65 Driver Pack.

After you launch the Deployment Manager, select Install/Upgrade, and confirm that you have read the recommendations in the release notes and accepted the license agreement. Then select one of two installation options.

Installation option Description

Typical (recommended) Install the contents of the ACQUITY Arc v1.65 Driver Pack in its entirety.

Custom (advanced) Select which instrument drivers to install or upgrade.

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Installing instrument control software from the DVD (not for a Citrix application server)

To install the instrument control software from the DVD:

1. Exit all applications, and restart the computer.

2. Power-on all modules in the system.

3. Log on as a local administrator.

4. Insert the DVD into the drive.

5. Navigate to the DVD drive, and then run Setup.exe.

6. On the Deployment Manager Welcome page, click Next.

7. Click Install / Upgrade.

8. Select “I have read the product release notes”, and then click Next.

9. Select “I agree to the License terms and conditions”, and then click Next.

10. Select Typical (recommended).

11. If you do not want to install Connections INSIGHT, clear “Connections INSIGHT”, and then click OK.

Tip: For ACQUITY Arc systems controlled by MassLynx software, the QDa detector does not appear in the Deployment Manager. You must select the module during the MassLynx software installation.

12. Review the list of modules to install or upgrade, and then click Next, to start the installation and deployment operation.

Note: It can take several minutes for installation to complete.

Tip: If you click Stop , the Deployment Manager completes the current module’s installation, and then stops.

13. Click Finish.

Result: The Autoloader launches and lists the modules that require firmware updates.

Tip: To locate the firmware file for a specific module, point to the module name.

14. Click Load Firmware, to install the latest firmware.

Important: To avoid corrupting the firmware, do not cycle power to any module until all firmware loads.

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Tip: You can run the Autoloader separately from the Deployment Manager, from one of the following locations:

• For Empower systems: C:\Empower\Instruments\Firmware • For MassLynx or non-Waters data systems on 32-bit computers:

C:\Program Files\Waters Instruments\Firmware • For MassLynx or non-Waters data systems on 64-bit computers:

C:\Program Files (x86)\Waters Instruments\Firmware

15. After all firmware loads, cycle power to all modules, as prompted in the Autoloader, and then click Close.

16. If the system includes a QDa detector, cycle power to it.

17. Restart the computer.

Installation instructions using a downloaded executable file To install the instrument control software using a downloaded executable file:




4. Navigate to the executable file you downloaded from waters.com, and then double-click it.

5. Click Unzip to extract the installation files.

6. Browse to the extracted file location, and then double-click the setup.exe file to begin the installation using Waters Deployment Manager.


8. Click Install / Upgrade.

9. Select “I have read the product release notes”, and then click Next.

10. Select “I agree to the License terms and conditions”, and then click Next.

11. Select Typical (recommended).

12. If you do not want to install Connections INSIGHT, clear “Connections INSIGHT”, and then click OK.

Tip: For ACQUITY Arc systems controlled by MassLynx software, the QDa detector does not appear in the Deployment Manager. You must select the module during the MassLynx software installation.

13. Review the list of modules to install or upgrade, and then click Next, to start the installation and deployment operation.

Note: It can take several minutes for installation to complete.

Tip: If you click Stop , the Deployment Manager completes the current module’s installation, and then stops.

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14. Click Finish.

Result: The Autoloader launches and lists the modules that require firmware updates.

Tip: To locate the firmware file for a specific module, point to the module name.

15. Click Load Firmware, to install the latest firmware.

Important: To avoid corrupting the firmware, do not cycle power to any module until all firmware loads.

Tip: You can run the Autoloader separately from the Deployment Manager, from one of the following locations:

• For Empower systems: C:\Empower\Instruments\Firmware • For MassLynx or non-Waters data systems on 32-bit computers:

C:\Program Files\Waters Instruments\Firmware • For MassLynx or non-Waters data systems on 64-bit computers:

C:\Program Files (x86)\Waters Instruments\Firmware

16. After all firmware loads, cycle power to all modules, as prompted in the Autoloader, and then click Close.

17. If the system includes a QDa detector, cycle power to it.

18. Restart the computer.

Installing the instrument control software on an Empower Citrix server

To install the instrument control software on an Empower Citrix server:





5. Put the Citrix server in Install mode by opening a command prompt and typing “Change user /install”.

Result: An advisory appears: “User session is ready to install applications”.

6. Browse to the root of the media, and double-click the setup.exe file to begin the installation using Waters Deployment Manager.

7. Follow the prompts to complete the installation.

8. Put the Citrix server in Execute mode by opening a command prompt and typing “Change user /execute”.

Result: An advisory appears: “User session is ready to execute applications”.

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Validation information

After you install or uninstall the ACQUITY Arc v1.65 Driver Pack on a qualified system, Waters recommends determining your requalification needs in accordance with your laboratory’s standard operating procedures.

If this is an initial installation in a GxP-regulated environment, perform a full qualification of Empower software.

Waters recommends that you run the Verify Files utility or the ConnectionsAQT for Empower IQ and review the resulting file for an entry that states “No installation changes were detected.”

Note: The date displayed when Verify Files (IQ) runs always reflects the previous installation. See the Empower.log file for the complete history.

Using the Repair utility

The Repair utility corrects known installation and compatibility problems involving installation artifacts caused by nonstandard installers or older Waters instrument-control software.

To run the Repair utility:

1. Run Setup.exe on the DVD, to open the Deployment Manager.

2. Click Next.

3. Click Repair.

Removing the instrument control software using the DVD To remove the instrument control software using the DVD:




4. Navigate to the DVD drive, and run Setup.exe.


6. Click Remove.

7. To remove instrument control software for all modules, do as follows:

• Click Typical. • To prevent the removal of Connections INSIGHT, clear “Remove

Connections INSIGHT”, and then click OK. • Review the list of modules, and then click Next, to remove the instrument

drivers.

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8. To remove instrument control software for selected modules, do the following:

• Click Custom. • Select the modules, and then click Next. • Review the list of modules, and then click Next, to remove the selected

instrument drivers.

9. Click Finish.

10. When prompted to restart the computer, click Yes.

Requalification guidelines

The ACQUITY Arc v1.65 Driver Pack includes instrument driver software and firmware used on your laboratory instruments, servers, and workstations. As with any change in a regulated environment, follow your organization's standard operating procedures for managing software changes.

This update has been designed not to alter the physical specifications of the instrument(s) or system(s), and Waters believes that methods run and data generated on instruments before and after the update will be identical.

However, after a risk based review of the changes detailed in the release notes, users in a regulated environment may need to consider and document what, if any, requalification of the instrument modules, the chromatographic system, and/or the Chromatographic Data System (CDS) are required by their own change control SOPs.

Use the appropriate qualification methods outlined below to verify installation and correct operation:

To confirm that the driver pack installation has not negatively affected any critical system functions, and that the new files have loaded properly, you may consider performing a software Installation Qualification (IQ). To confirm the firmware files installed on the modules are correctly installed, compare the checksum values in the product release notes to the checksum values displayed in the console.

To confirm an instrument's operation with the newly loaded driver software and firmware, you may consider performing an Operational Qualification (OQ) for the updated instrument or system.

To confirm performance, control, and communications of the instruments in your system, you should consider conducting a Performance Qualification (PQ) (user or vendor PQ) or System Suitability test.

Where multiple identical systems are involved, a risk based approach to qualification activities may be an important consideration.

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Requalifying the instrument driver software, firmware, and hardware when upgrading is covered under the Total Assurance Plan with System Qualification Option in the following cases:

• During yearly requalification under the plan. • If loading this release is required for operation of a new module or

system, where qualification of the new module or system is covered under the plan.

Requalification of the CDS software and computers after a driver upgrade may or may not be included in Assurance Plans from the CDS vendor.

Review your Total Assurance Plan to determine which services are covered, and which are not covered. For situations not covered under the plan, Waters can still perform the qualification, but additional charges apply.

Anti-virus considerations If you are using real-time virus scanning, exclude the data system and instruments folders and sub-folders as shown below. Some real-time virus scanners can mistake normal data acquisition and instrument control for virus activity and thus interfere with proper operations. Full-system scans and live updates can be network-intensive, disk-intensive, and CPU-intensive, and they can also interfere with normal data acquisition. Schedule scans and updates for idle times when data acquisition does not occur.

Exclude these folders:

• For Empower 2 and Empower 3 installations, the Empower installation folder, usually “C:\Empower”, and its sub-folders.

• For MassLynx installations, • “C:\Program Files\Waters Instruments”, and its sub-folders (“C:\Program

Files (x86)\Waters Instruments” on 64-bit machines). • the MassLynx installation folder, usually “C:\Masslynx”, and its sub-

folders. • For standalone console software and other third party installations,

“C:\Program Files\Waters Instruments”, and its sub-folders (“C:\Program Files (x86)\Waters Instruments” on 64-bit machines).

Certain anti-virus program features like “intrusion prevention” and “tamper protection” can also interfere with normal operation. Disable them as well.

Contact Waters Technical Service If you are located in the USA or Canada, report malfunctions or other problems to Waters Technical Service (800 252-4752). If you are located elsewhere, phone the Waters corporate headquarters in Milford, Massachusetts (USA), or contact your local Waters subsidiary. Our Web site includes phone numbers and e-mail addresses for Waters locations worldwide.

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