ammonia in ugi reactions — four-component versus six-component couplings

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2005 Multicomponent reactions O 0359 Ammonia in Ugi Reactions — Four-Component versus Six-Component Cou- plings. — Ugi reactions using ammonia are less predictable than reactions with amines because side reactions such as six-component couplings [(V), (VII)] can occur. These side reactions can be suppressed or favored by choice of appropriate reaction condi- tions. — (PICK, R.; BAUER, M.; KAZMAIER*, U.; HEBACH, C.; Synlett 2005, 5, 757-760; Inst. Org. Chem., Univ. des Saarlandes, D-66123 Saarbruecken, Germany; Eng.) — R. Staver 32- 071

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Page 1: Ammonia in Ugi Reactions — Four-Component versus Six-Component Couplings

2005

Multicomponent reactionsO 0359 Ammonia in Ugi Reactions — Four-Component versus Six-Component Cou-

plings. — Ugi reactions using ammonia are less predictable than reactions with amines because side reactions such as six-component couplings [→(V), (VII)] can occur. These side reactions can be suppressed or favored by choice of appropriate reaction condi-tions. — (PICK, R.; BAUER, M.; KAZMAIER*, U.; HEBACH, C.; Synlett 2005, 5, 757-760; Inst. Org. Chem., Univ. des Saarlandes, D-66123 Saarbruecken, Germany; Eng.) — R. Staver

32- 071