acropolis jacob van klaveren

National Institutefor Public Healthand the Environment

ACROPOLIS

Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 2National Institutefor Public Healthand the Environment

• History and starting point

• Aims of ACROPOLIS

• Main overview (WPs)

• Project organisation

Contents

Jacob van Klaveren ACROPOLIS kick-off meeting 3National Institutefor Public Healthand the Environment

Starting point for ACROPOLIS

• An electronic platform for pan-European exposure modelling as created in SAFE FOODs

• Existing models like EuroPOEM, CONSEXPO, MCRA, IPRA

• EFSA opinions on cumulative risk assessment

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Aims of ACROPOLIS

• Improve cumulative exposure and hazard assessment

• Create new models for aggregated exposure assessment

• Setting up new toxicological testing for identifying synergistic effects

• To integrate cumulative and aggregated risk models

• Improve understanding of methodology of different stakeholders

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NLIT

SE

0.0

0.2

0.4

0.0 0.7 1.4 2.2 2.9 3.6-0.7-1.4-2.2-2.9-3.6

UK

MCRA-software

E-platform of databases (food and residue)

CZ

FR

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van der Voet & Slob (2007)

Toxicological BMD modeling

• Critical effect dose

• Number of experiments

• EFSA opinion BMD modeling

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Aggregated exposure assessment

Combine leading models in Europe(MCRA, EUROPOEM, ConsEXPO)

Case studies with two or more different routes of exposure

Validation of the model

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Mixtures and internal does

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Model and software development

Internet compatible model and data

• Test and justify underlying assumptions

• Scientific sound

• Reproducible and transparent (reference manual MCRA openly available)

• Include quantitative uncertainty analyses

• Data in connection with model available for stakeholders (including industry). Not the raw data.

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Risk based on Margin of Exposure

Be aware that safety factors are also modelled!

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Dissemination

• Training

• Stakeholder conferences

• Website and folders

• Scientific paper on stakeholders attitudes towards cumulative and aggregated exposure levels

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Stakeholders

• Industry

• Regulators

• EFSA and risk assessors at national level

• Risk Management

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ACROPOLIS PROJECT STRUCTURE

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External advisory board

EFSA (Luc Mohimont)

DG Sanco (Bas Drukker)

EPA (D. Miller will be asked)

Coordinator

- Further elaboration on case studies

- Overview needs of DG Sanco (risk managers)

- Fine-tune research needs of EFSA

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Scientific Advisory Board

WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof W. Steurbout, dr. D Hamilton), Greenpeace (dr. M. Krauter), Industry (Bayer, BASF, Syngenta)

- To convey relevant issues from a stakeholders perspective

- To bring in relevant expertise (e.g. from USA)

- Emerging issues in pesticide risk assessment

- Implementation of project outcomes at EU level

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Deliverables and milestones

A deliverable is a result that has to be produced

(e.g. a paper, a model, or any other result)

A milestone is something that you have to achieve before you can continue

All have to be done in time and as promised

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Project Management Team

• A representative of each beneficiary

• Stop-go decisions

• Contingency plan (coordinator)

• Financial issues as far as they deviate from proposal

• Gender issues

National Institutefor Public Healthand the Environment

MCRA model : https://mcra.rikilt.wur.nl/ EFSA opinion : EFSA website  RIKILT report

Thanks for your attention!

jacob.van.klaveren@rivm.nl