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Post on 22-Feb-2016
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Announcements
• Ch. 8 Part 2 Homework due today• Ch. 8 Part 3 Homework due Friday• Online quiz due at midnight TONIGHT• Lab tomorrow at 8 AM• Review Session: Tuesday March 4th at 9 AM
and 10 AM…Bring muddiest points
Bacterial GeneticsChapter 8 Part 3
Recap (2 Minutes)
What are the mechanisms by which bacteria can acquire new genes?
Answer:DNA-mediated transformation
TransductionConjugation
Revisiting Plasmids• Common to bacteria• Double stranded DNA• They have ori• Do not code information
critical to a cell’s life• Do provide an advantage
for certain environments• Vary in amount of genes
they carry: few to many• Narrow host range• Transferred by
conjugation• Resistance plasmid-
encode resistance to many antibiotics
Horizontal Gene Transfer: Chromosome Transfer
• Less common than plasmid transfer• Involves Hfr cells: High frequency
recombination• The plasmid integrates into the chromosome• So, part of the chromosome ends up getting
transferred to the F- cell
Horizontal Gene Transfer: Chromosome Transfer-Formation of Hfr Cell
Chromosome Transfer
Revisiting Transposons
• They can disrupt genes• They can also transfer genes from one
bacteria to another• 2 types: insertion sequence and composite
sequence
IS vs. Composite Transposons
The Role of Transposons In Antibiotic Resistance
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