k10- plasmodium falc dan vivax
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Plasmodium spp.
Parasitology Dept.
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Malaria-endemic Areas 2000
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PlasmodiumsTerminology
PhylumApicomplexa
Subphylum Sporozoa
Class Telosporea
Subclass Hmosporina
Family Plasmodiid
Vectored primarily by femaleAnopheles
mosquito
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Anophelesvector of
Plasmodiums
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Sporogonous Cycle:
Mosquito Stages
Gametocytes
P. falciparum
P. vivax
P. ovale
P. malariae
Human Liver Stages
Exo-erythrocytic
(hepatic) Cycle:
Human lood Stages
Erythrocytic Cycle:
Malaria Lifecycle
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Plasmodium vivax
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Plasmodium vivaxGeneral
Synonims: Haemamoeba vivax,Plasmodium malariae tertiana
Prepatent period: 8-17 days (depends onthe number of inoculated sporozoits andstrain), usually 14 days
Prepatent period is also called biologicalincubation period: the period requiredsince sporozoits enter a human until it isdemonstrated in the blood stream
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Plasmodium vivaxMorphology in Stained Preparation
Ring form : blue-
stained ring of
cytoplasm with a redchromatin dot
Late ring form:
stippling (Schuffnersdots) appear, no
pigment yet
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Plasmodium vivaxMorphology in Stained Preparation
The early erythrocytic
trophozoit : blue-
stained cytoplasmwith a red chromatin
dot, stippling and
pigments appear,enlarged infected
RBC
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Plasmodium vivaxMorphology in Stained Preparation
Mature trophozoit: the
plasmodium enlarge,the sitoplasm becomes
irregular and larger
(amoeboid), stipplingand pigments (+)
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Plasmodium vivaxMorphology in Stained Preparation
Schizont: progressive
steps in division
(presegmenting)
Mature schizont: consist
of 8-24 merozoits,
usually 12-18
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Plasmodium vivaxMorphology in Stained Preparation
Macrogametocyte: female gametocyte,
stains deep blue, smaller nucleus,
chromatin is arranged in a compactmass near the periphery
Microgametocyte: male gametocyte,
stains pale blue, larger nucleus, thechromatin is irregularly situatedwithin
the cytoplasm
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Plasmodium vivaxMorphology of all stadiums
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Plasmodium falciparum
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Plasmodium falciparumGeneral
Synonims: Plasmodium tropica
Prepatent period: minimal 5 days,
average 8-12 days
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Plasmodium falciparumMorphology in Stained Preparation
Ring form: vary in
shape; doublechromatin, double
infection, accole
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Plasmodium falciparumMorphology in Stained Preparation
Trophozoit: rare in
peripheral blood afterhalf grown, infected RBC
is normal sized, stippled
(Maurers dots) and
pigmented
Note at the Maurers dots
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Plasmodium falciparumMorphology in Stained Preparation
Schizont: consist of 8-26 merozoits,
usually 8-18, rare in peripheral blood
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Plasmodium falciparumMorphology in Stained Preparation
Microgametocyte: sausage shape,chromatin diffuse, large nucleus
Macrogametocyte: longer and moreslender, central chromatin, pigment andnucleus more compact
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Plasmodium falciparumMorphology in Stained Preparation
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Plasmodium falciparumMorphology of all stadiums
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Pictures of P. falciparum
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Thank You
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