CancerResearchOFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH

October 15, 1993Volume 53 •¿�Number 20PP.4741-5065ISSN0008-5472 •¿�CNREA 8

Epidemiology Resources

•¿�The Tumor Virus Epidemiology Repository(TVER)contains sera and other biological samplesfrom more than 13,000 patients and controlsobtained in 12 countries. The TVERwas established primarily to support collaborative researchon the role of Epstein-Barr virus (EBV) in Burkitt's

lymphoma and related diseases. Sera characterized for human herpes virus 6 (HHV) antibodies arealso available. The TVERcollection is available fornew collaborative studies and some independentresearch. The most extensive collections are serumsamples from patients with Burkitt's lymphoma.

Contact: Dr PaulH. LevineViral Epidemiology BranchDCE, NCI, NIHExecutive Plaza North, Room 434Bethesda, MD 20892(301)496-8115

Cost: Free to CollaboratingInvestigators;Others: Dependent on Processing Time

•¿�The National Cancer Institute has availablethe Animal Morbidity/Mortality Survey of Collegesof Veterinary Medicine in North America (alsoknown as the Veterinary Medical Data Program).This registry of veterinary medical information represents patient data on animals seen at collaborating veterinary teaching facilities; 3 million hospitalepisodes have been abstracted and computerizedin a standardized record format. Disease information is coded using the scheme of the StandardNomenclature of Veterinary Disease andOperations. The computer tapes will be madeavailable upon request.

Contact: Dr. HowardM. HayesEnvironmentalEpidemiology BranchEPB, DCE, NCI, NIHExecutive Plaza North, Room 443Bethesda, MD 20892(301)496-1691

Cost: Inquire

•¿�Human fibroblast cultures from individuals athigh risk of cancer, selected members of cancer-prone families, and some normal family membersare available. The collection is historical withunknown viability and contamination status.Catalog of cell lines unavailable and followupon many individuals is unavailable. Informationrequests should include potential use of cultures.

Contact: Chief, Genetic EpidemiologyBranchDCE, NCI, NIHExecutive Plaza North, Room 439Bethesda, MD 20892(301)496-4375

Cost: Free to collaborating investigators.Others: $70/cell line.

•¿�The National Institute of Allergy and InfectiousDiseases and the National Cancer Institute havedeveloped a repository of biological specimensfrom homosexual men. The specimens werecollected through cooperative agreements withfive major U.S. universities for studies of thenatural history of acquired immune deficiencysyndrome (AIDS). Information about applyingfor collaborative use of these specimens isavailable from the NIAID Project Officer or theNCI Co-Project Officer.

Contact: Chief, EpidemiologyBranch,AIDSProgram, NIAID

CDC Bldg., Room 240National Institutes of HealthBethesda, MD 20892

or to ChiefExtramural Programs Branch, EBP,Division of Cancer Etiology, NCIExecutive Plaza North, Room 535Bethesda, MD 20892

•¿�The Epidemiology and Biostatistics Program ofthe National Cancer Institute has developed theObserved versus Expected (OIE) software systemwhich calculates: (1) the number of observedevents (e.g. cancer cases or deaths) in a studygroup at risk; (2) the number of expected events ina study group based on the rate of occurrence insome standard or referent population; (3) the ratioof observed to expected events; and (4) the significance of this ratio. The system is user friendly andcapable of executing a series of calculations bydifferent variables such as age, time group, dateof exposure, age at date of exposure, duration ofexposure, year relative to entry and cause of event.The 0/E System provides tables by race, sex anduser defined variables, allows user defined latencyintervals and accepts standard or user preparedrates. 0/E is written in COBOL and is exportableto most mainframes.

Contact: RuthWolfsonEpidemiology and Biostatistics

Program, DCE. NCI, NIHExecutive Plaza North, Room 443Bethesda, MD 20892(301)496-1691

Cost: Freeto investigatorsinterestedinepidemiologie research

•¿�The Epidemiology and Biostatistics Programof the National Cancer Institute (NCI) has developed an Occupational Mortality Analysis softwaresystem which calculates Proportionate MortalityRatios, Proportionate Cancer Mortality Ratios, orMortality Odds Ratios using occupational information on the death certificates from 24 states for1984-1989 The data were assembled througha collaborative effort involving the National Centerfor Health Statistics, the National Institute for

Occupational Safety and Health and NCI. The program is user friendly and allows analysis of data by(1) occupation, industry, or occupational/industrycombinations; (2) age group; (3) states or geographic regions; (4) race groups, (black andwhite); (5) sex, and (6) underlying causes ofdeath. The program is written in Wylbur CommandProcedures and is exportable to most mainframes.

Contact: (To obtainthe programand relateinformation):

Mustafa Dosemeci, Ph.D.Occupational Studies SectionEBP, DCE, NCI, NIHExecutive Plaza North, Room 418Bethesda, MD 20892Phone: (301)496-9093Fax: (301)402-1819

(For questions concerning the nature and source ofthe occupational mortality data):

Jeff Maurer, M.S.Mortality Statistics BranchDivision of Vital Statistics, NCHS6525 Belcrest Rd., Room 840Hyattsville, MD 20782Phone: (301)436-8884Fax: (301)436-7066

Cost: Freeto investigatorsinterestedinoccupational epidemiologie research.

•¿�The Epidemiology and Biostatistics Program ofthe National Cancer Institute (NCI) has developeda computer-aided occupational and industrial codesearching program (CODESEARCH)which allowsthe code assigner to select appropriate codes fromexisting classification systems for job or industrialtitles from work histories of the study subjects. Theprogram is user friendly and allows searches fromfour occupational Classification Systems (1977Standard Occupational ClassificationManual [SOC];1980 SOC; 1970 Bureau of Census OccupationalClassificationSystem[BOCOC]; and 1980BOCOC,and four industrial classification systems (1972Standard Industrial Classification System [SIC];1987 SIC; 1970 Bureau of Census IndustrialClassification System [BOCIC]; and 1980 BOCIC).The program is written using PC-Clipper softwareand is exportable to most 486 PCs

Contact: MustafaDosemeci,Ph.D.Occupational Studies SectionEBP, DCE, NCI, NIHExecutive Plaza North, Room 418Bethesda, MD 20892Phone: (301)496-9093Fax: (301)402-1819

Cost: Freeto investigatorsinterestedin assignment of occupational andindustrial titles from work history data.

Chemical Resources

•¿�Analytical support for the collection,separation, and elucidation of environmentalcarcinogens including combustion and smokmg-related exposures. A contractor with experiencein the development of analytical methods for thedetermination of constituents of cigarette smokeand cigarette smoke condensâtes,and of specialtyinstrumentation for inhalation toxicology is availableto assist qualified investigators with particular interest in human and animal model exposure to environmental and sidestream smoke. An extensivechemical data base on smoke and smoke condensate components is available.

Contact: HaroldE. Seifried,Ph.D.Chemical and Physical

Carcinogenesis Branch, DCE, NCIExecutive Plaza North, Room 700Bethesda, MD 20892(301)496-5471(301) 496-1040 FAX

Cost: Inquire

•¿�Chemical Carcinogen Reference StandardRepository: Reference quantities of over 750 compounds are available. The newest additions aredilute aqueous standards of PAH deoxyguanosine-3'-monophosphates for Randerath KPpost labelling

assays. Other classes of available compounds are:fecapentaenes. food mutagens, polynucleararomatic hydrocarbons (PAH), PAH metabolites,radiolabeled PAH metabolites, nitrogen heterocy-cles, nitrosamines/nitrosamides, aromatic amines,aromatic amine metabolites, azo/azoxy aromatics,inorganics, nitroaromatics, pesticides, Pharmaceuticals, natural products, dyes, dioxins and chlorinated aliphatics. A number of radiolabeled PAHmetabolites and nitrosammes are also available.Data Sheets provided with the compounds includechemical and physical properties, analytical data,hazards, storage, and handling information.Catalog available upon request.

Contact: Manager. NCI ChemicalCarcinogen Repository

Midwest Research Institute425 Volker BoulevardKansas City, MO 64110(816)753-7600, Ext. 523(816)753-3664 FAX

Manager, NCI RadiolabeledChemical Repository

CHEMSYN Science Laboratories13605 W 96th TerraceLexena, KS66215(913)541-0525(913) 888-3582 FAX

Cost: Subjectto chemicalclasscodeand quantity (see catalog) includeshandling and shipping charges.

The Division ofCancer Etiology

National Cancer InstituteAnnounces to the Scientific Community the Availability of the FollowingResources/Services for Cancer Related Research As Noted Below:

Biological Resources

•¿�Cell Culture Identification Service. UsingIsozyme Analysis. Immunofluorescence andKaryotypic Analysis (Chromosome Banding).

Contact: Dr. Joseph KaplanChildren's Hospital of Michigan

3901 Beaubien BoulevardDetroit. Ml 48201(313)745-5570

Citing Contract #N01-CP-33063

Cost: Reasonable; inquire with specificrequests.

•¿�Goat Antisera Against: Avian, Bovine, Feline,Murine, and Primate Intact Viruses and ViralProteins; Antibodies to Immunoglobulins for anumber of species. Preimmune Sera availablefor some Virus Antisera.

Contact: Alice K. Robison, Ph.D.BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden, NJ 08104(609) 966-8000(609) 342-8078 FAX

Citing Contract #N01-CP-15665

Cost: $75.00/5 ml. (Antisera)25.00/5 ml. (Preimmune Sera)65.00/100 ml. (Immunoglobulins)(Frozen Material)

•¿�Viruses: Avian, Feline, Murine, and PrimateViruses Produced in vivo and in vitro.

Contact: Alice K. Robison, Ph.D.BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden, NJ08104(609) 966-8000(609) 342-8078 FAX

Citing Contract #N01-CP-15665

Cost: Reasonable; inquirewith specificrequests.

•¿�Monoclonal Antibodies are available withspecificities for synthetic peptides representingthe amino acid sequences of the left end, rightend and active site of the oncogene productsof avian and mammalian retroviruses. Blockingpeptides are also available, as are a limitednumber of cell lines producing the monoclonalantibodies.

Contact: Alice K. Robison, Ph.D.BCB RepositoryQuality Biotech, Inc.1667 Davis StreetCamden. NJ 08104(609) 966-8000(609) 342-8078 FAX

Citing Contract #N01-CP-15665

Cost: Peptides —¿�$25.00/mg.Ascites Fluid —¿�45.00/ml.Cell Culture —¿�100.00/culture.

(Plus Shipping and Handling)

•¿�Human sera from donors with variousmalignancies (including nasopharyngealcarcinoma), non-malignant disorders,and from normal individuals.

Contact: Program Director, ResearchResources, BiologicalCarcinogenesis Branch,

DCE, NCI, NIHExecutive Plaza North, Room 540Bethesda, MD 20892(301)496-1951(301) 496-2025 FAX

Cost: Shipping and handling charges only.

•¿�The Division of Cancer Etiology's Registry of

Experimental Cancers announces the availability of 16 different study sets containing histologieslides of rodent tumors. The study sets, withaccompanying syllabi, illustrate a variety ofspontaneous and induced tumors, chiefly ofrats, mice, and mastomys. Each set is availableto cancer investigators worldwide, withoutcharge, for up to two months. Requests orinquiries should be addressed to:

Contact: Registry of Experimental CancersNational Cancer InstituteBuilding 41, Room D311NIH, Bethesda. MD 20892USA

Environmental Cancer•¿�NCI's Chemical Carcinogenesis Research

Information System (CCRIS) is available onlinethrough the National Library of Medicine's

Toxicology Data Network (TOXNET) system.Through an interagency agreement betweenNCI and NLM, the CCRIS database has beenbuilt and will be maintained and updated as oneof TOXNET's sponsored databases in the broad

areas of chemistry, toxicology, and hazardouswaste information. The CCRIS database contains evaluated data and information on carcinogens, mutagens, tumor promotors, cocar-cinogens, metabolites of carcinogens, andcarcinogen inhibitors derived from publishedreview articles, ongoing current awarenesssurvey of primary literature, NCI/NTP's short-and long-term bioassay studies, the IARCMonographs on the Evaluation of CarcinogenicRisk of Chemicals to Man, and special studiesand reports.

Contact: Dr. Thomas P. CameronOffice of the DirectorDivision of Cancer EtiologyNational Cancer InstituteExecutive Plaza North. Room 712Bethesda. MD 20892(301)496-1625

Cost: Inquire

•¿�The Special Assistant for EnvironmentalCancer, Office of the Director, announces theavailability of a limited number of copies of thefollowing publications, which have been prepared under contract to NCI:

Survey of Compounds Which Have Been Testedfor Carcinogenic Activity, PHS-149, 1987-1988and 1989-1990.

Contact: Dr. Thomas P. CameronOffice of the DirectorDivision of Cancer EtiologyNational Cancer InstituteExecutive Plaza North, Room 712Bethesda, MD 20892(301)496-1625

Cost: Inquire

•¿�TheNational Cancer Institute, along withthe National Institute of Environmental HealthSciences, the Centers for Disease Control, andthe Food and Drug Administration, has. formany years, supported a study by the MichiganDepartment of Public Health dealing with anaccidental exposure to polybrominatedbiphenyls.

The Michigan Long Term PBB Study is a well-maintained longitudinal database on 4,000participants from rural farms in Michigan.This group was exposed to polybrominatedbiphenyls through consumption of contaminatedfarm animals and food products. The cohort wasenrolled and characterized in 1975-76, establishing a database containing demographic,health history, medical condition, reproductivehistory, blood and tissue analyses, and chemical/environmental exposure information. Majorlife events—birth, death, cancer and majorillnesses have been confirmed and updatedannually. The project is currently completing adetailed recharacterization of all cohort membersand their children. This longitudinal database isavailable for collaborative research investigatingbiological and human health outcomes fromhalogenated biphenyl exposure.

Contact: Dr. Harold E. B. HumphreyMichigan Department of

Public HealthDivision of Health Risk Assessment3423 North Logan, P.O. Box 30195Lansing, Ml 48909(517)335-8350

Cost: Free to qualified investigators.

AMERICAN ASSOCIATION FOR CANCER RESEARCHSCIENTIFIC CONFERENCES: 1993-1994

NOVEMBER 7-11, 1993Molecular Approaches to

Cancer ImmunotherapyChairperson: Ralph A. Reisfeld, San Diego, CAGrove Park Inn, Asheville, NC

NOVEMBER 9-13, 1993Interactions of Cancer Susceptibility

Genes and Environmental CarcinogensJoint Meeting with International Agency for

Research on Cancer (IARC)Chairpersons: Frederick P. Li, Boston, MA, and

Ruggero Montesano, Lyon, FranceIARC, Lyon, France

DECEMBER 5-9, 1993Cell Signalling and Cancer Treatment

Joint Meeting with British Association forCancer Research and EuropeanOrganisation for Research and Treatmentof Cancer (PAMM Group)

Chairpersons: Garth Powis, Tucson, AZ;Paul Workman, Macclesfield, England

El San Juan Hotel, San Juan, PR

JANUARY 17-22, 1994Risk Assessment in Environmental

CarcinogenesisCo-Sponsored by the

Environmental Mutagen SocietyChairpersons: PhilipC. Hanawalt,Stanford,CA;

James A. Swenberg, Chapel Hill, NCWhistler Resort and Conference Center, Whistler,

B.C., Canada

JANUARY 31-FEBRUARY 5, 1994Molecular Genetics of Progression

and MetastasisChairperson: Lance A. Liotta, Bethesda, MDBig Sky Resort, Big Sky, MT

FEBRUARY 19-24, 1994Cancer: Perturbations in Cell Cycle

Control and Genomic IntegrityChairpersons: Thea D. Tlsty, Chapel Hill, NC;

Lawrence A. Loeb, Seattle, WABanff Springs Hotel, Banff, Alberta, Canada

MARCH 5-11,1994Growth Factors, Development, and CancerJoint Meeting with Friedrich Miescher-lnstitutChairpersons: HaroldL. Moses,Nashville,TN;

BerndGroner,Basel,SwitzerlandCongressCenter, Interlaken,Switzerland

APRIL 10-13, 199485th Annual Meeting

Chairperson: Karen S. H. Antman, New York, NYMoscone Convention Center, San Francisco, CA

OCTOBER 16-20, 1994Transcriptional Control of Cell Growth

and DifferentiationChairpersons: Eric N. Olson, Houston, TX; Bruce

M. Spiegelman, Boston, MAChatham Bars Inn, Chatham (Cape Cod), MA

NOVEMBER 7-11, 1994Modern Developments in Cancer

TherapeuticsJoint Meeting with Academia SinicaChairperson: Yung-chi Cheng, New Haven, CTAcademia Sinica, Taipei, Taiwan, R.O.C.

AACR members will receive brochures on theabove special conferences as soon as they areavailable. Nonmembers should call or write:

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 •¿�215-440-9313 (FAX)

CANCER:PERTURBATIONSIN CELLCYCLECONTROLANDGENOMICINTEGRITY

AnAACRSpecialConferenceinCancerResearchCo-SponsoredbytheNationalCancerInstituteof Canada

February19-24,1994BanffSpringsHotel

Banff,Alberta,Canada

CONFERENCE CHAIRPERSONS

TheaD.Tlsty / ChapelHill,NCLawrenceA. Loeb/ Seattle,WA

PROGRAM COMMITTEE

Philippe Gros / Montreal,Canada Michael Smith / Vancouver,Canada

SCIENTIFIC PROGRAM

KeynoteAddressManfredEigen/ Gottingen.Germany

ModulatorsofGrowthandDevelopmentJ. MichaelBishop/ SanFrancisco,CAHaroldWeintraub/ Seattle.WATomCurran/ Nutley.NJ

TumorSuppressorGenesCarolL.Prives' NewYork,NYMaryClaireKing/ Berkeley,CA

EndogenousSourcesof DNADamageLawrenceA.Loeb/ Seattle,WATomasLindahl/ Herts.EnglandCurtisC.Harris/ Bethesda.MDMiroslavRadman/ Paris.France

Responsesto DNADamageAlbertJ. Fornace,Jr./ Bethesda,MDMichaelB.Kastan/ Baltimore.MDSaraLavi/ TelAviv.Israel

Controls on Genomic IntegrityTheaD.Tlsty/ ChapelHill,NCJoyceL.Hamlin/ Charlottesville,VACarolW.Greider/ ColdSpringHarbor,NYRandalN.Johnston/ Calgary.Canada

GeneticIntegrityandCarcinogenesisTakashiSugimura/ Tokyo,JapanJoe W. Gray / San Francisco,CAGlennaBurmer/ Seattle,WA

CellCycleRobertA.Weinberg/ Cambridge,MAJeanY.J.Wang/ LaJolla,CA

TerminalArrestJ. Carl Barrett/ ResearchTrianglePark,NCJudithCampisi/ Berkeley,CAEileenWhite/ Piscataway,NJ

Applicants are encouraged to submitabstracts for poster presentation.

Application Deadline: December 3,1993

InformationandApplicationFormsAmerican Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)

AACR SPECIAL CONFERENCE INCANCER RESEARCH

MolecularApproachesto CancerImmunotherapy

November7-11,1993TheGroveParkInn,Asheville,NorthCarolina

CONFERENCE CHAIRPERSON

RalphA. Reisfeld/ LaJolla,CA

SCIENTIFIC PROGRAM

KeynoteAddressGiorgioTrinchieri/ Philadelphia,PA

MonoclonalAntibodiesfor TumorTherapyAlanN.Houghton/ NewYork,NYAlbertF. LoBuglio/ Birmingham,ALIraPastan/ Bethesda,MDDavidA. Scheinberg/ NewYork,NY

Genetically Engineered AntibodiesStephenD.Gillies/ Lexington,MAJeffreySchlom/ Bethesda,MDRichardP.Junghans/ Boston,MASherieL. Morrison/ LosAngeles,CACliveWoodhouse/ MountainView,CA

Gene Therapy of CancerJamesJ. Mulé/ PaloAlto,CADrewM.Pardoll/ Baltimore,MDDavidT. Curiel/ ChapelHill,NCPatrickHwu/ Bethesda,MDElizabethJaffee/ Baltimore,MD

CytokinesinTumorTherapyStevenGillis / Seattle,WARolandMertelsmann/ Freiburg,GermanyRonaldLevy/ Stanford,CATerryStrom/ Boston,MA

Tumor Antigens Recognized by T-CellsOliveraJ. Finn/ Pittsburgh,PAPerA. Peterson/ LaJolla,CAMartinA. Cheever/ Seattle,WAMichaelT. Lotze/ Pittsburgh,PA

Antibodies as ImmunogensSoldanoFerrane/ Valhalla,NYDorothéeHerlyn/ Philadelphia,PAKennethFoon/ Lexington,KYAlanN.Houghton/ NewYork,NY

Future of Cancer ImmunotherapyIsaiahJ. Fidler/ Houston,TXPaulM.Sondel/ Madison,WlIrwinD.Bernstein/ Seattle,WAEugenieS.Kleinerman/Houston,TX

Applicants are encouraged to submit abstractsfor poster presentation.

InformationandApplicationForms

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483

215-440-9300 215-440-9313 (FAX)

AN AACR SPECIAL CONFERENCE IN CANCER RESEARCH

GROWTH FACTORS,DEVELOPMENT,AND CANCERCo-Sponsoredby the FriedrichMiescher-lnstitut

March5-11,1994CongressCenter,Interlaken,Switzerland

Supportedin Partby a GenerousGrantfrom the SwissCancerLeague

CONFERENCE CHAIRPERSONS

HaroldL.Moses/ Nashville,TNBerndGroner/ Basel,Switzerland

PROGRAM COMMITTEE

MaxM.Burger/ Basel,SwitzerlandTomCurran/ Nutley,NJRikDerynck/ SanFrancisco,CANancyE.Hynes/ Basel,Switzerland

Jean-PierreMach/ Epalinges,SwitzerlandLynnM.Matrisian/ Nashville,TNJohnMendelsohn/ NewYork,NY

SCIENTIFIC PROGRAM

SpecialLecturesHaraldzurHausen/ Heidelberg,GermanyWalterJ. Gehring/ Basel,Switzerland

PositiveandNegativeGrowthFactorsandTheirReceptorsRikDerynck/ SanFrancisco,CAYosephYarden/ Rehovot,IsraelHaroldL. Moses/ Nashville,TNNancyE.Hynes/ Basel,Switzerland

Receptor-AssociatedKinasesandPhosphatasesAnthonyJ. Pawson/ Toronto,CanadaSaraA. Courtneidge/ Heidelberg,GermanyBenjaminG.Neel/ Boston,MAErnstHafen/ Zurich,Switzerland

SignalTransductionIncludingTargetsforTherapyGeorgeThomas/ Basel,SwitzerlandUlf R.Rapp/ Frederick,MDFrankP.McCormick/ Richmond,CA

TranscriptionFactorsandHomeoboxGenesTomCurran/ Nutley,NJRobertEisenman/ Seattle,WAFritsMeijlink/ Utrecht,TheNetherlands

Tumor Suppressor GenesStephenH.Friend/ Cambridge,MABernardM.Mechler/ Heidelberg,GermanyDavidP.Lane/ Dundee,Scotland

Cell-Cell InteractionsPeterHerrlich/ Eggenstein,GermanyWalterBirchmeier/ Essen,GermanyPatriciaS.Steeg/ Bethesda,MDRudolphL Juliano/ChapelHill,NC

Cell-Matrix Interactions and ProteasesJeanPaulThiery/ Paris,FranceRuthChiquet-Ehrismann/ Basel,SwitzerlandLynnM.Matrisian/ Nashville,TN

TargetedTherapyIncludingImmunotherapyJohnMendelsohn/ NewYork,NYBerndGroner/ Basel,SwitzerlandMichaelBlaese/ Bethesda,MDCorneliusJ.M.Melief/ Leiden,TheNetherlands

ApplicationDeadline:December1, 1993

InformationandApplicationForms

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)

INTERACTIONS OFCANCER SUSCEPTIBILITY GENES

AND ENVIRONMENTAL CARCINOGENS

Joint Meeting Organized by theAmerican Association for Cancer Research (AACR)

and the International Agency for Research on Cancer (IARC)

Supported by Generous Grants from theNational Institute of Environmental Health Sciences

The Commission of the European CommunitiesLa Ligue Nationale Contre Le Cancer

November 9-13,1993Lyon, France

CONFERENCE CHAIRPERSONSFrederickP. Li / Boston,USA

RuggeroMontesano/ Lyon,France

PROGRAM COMMITTEE

KarlK.Alitalo/ Helsinki,FinlandJ.CarlBarrett/ ResearchTrianglePark,USAValerieBeral/ Oxford,EnglandDirkBootsma/ Rotterdam,TheNetherlandsCurtisC.Harris/ Bethesda,USAHenryC.Pitot/ Madison,USA

BruceA.J. Ponder/ Cambridge,EnglandCarmenSapienza/ LaJolla.USATakashiSugimura/ Tokyo,JapanLorenzoTomatis/ Lyon,FranceLeeW.Wattenberg/ Minneapolis,USAI. BernardWeinstein/ NewYork,USA

SCIENTIFIC PROGRAM

OpeningLecturesLeeW.Wattenberg/ Minneapolis,USALorenzoTomatis/ Lyon,FranceCurtisC.Harris/ Bethesda,USAManfredF.Rajewsky/ Essen,Germany

GeneticInstabilityKariK.Alitalo/ Helsinki,FinlandThierryHeidmann/ Paris,FranceTheaD.Tlsty/ ChapelHill,USA

ExperimentalModelsof GeneticSusceptibilityJ. CarlBarrett/ ResearchTrianglePark,USAHenryC.Pitot/ Madison,USABernardM.Mechler/ Heidelberg,GermanyLauriAaltonen/ Helsinki,Finland

DNADamageand RepairDirkBootsma/ Rotterdam,TheNetherlandsJohnM.Essigmann/ Cambridge,USAMutsuoSekiguchi/ Fukuoka.Japan

Mechanismsof TransgenerationalCarcinogenesisCarmenSapienza/ LaJolla,USAJohnCairns/ Oxford,EnglandUlrikeWintersberger/ Vienna,AustriaDavidMalkin / Toronto,CanadaChristopherJ. Kemp/ Glasgow,Scotland

HumanCancersFrederickP.Li / Boston,USAValerieBeral/ Oxford,EnglandBruceA.J. Ponder/ Cambridge,EnglandNeilE.Caporaso/ Bethesda,USAGilbertM.Lenoir/ Lyon,France

Markersof IndividualExposureRuggeroMontesano/ Lyon,FrancePeterA. Cerutti/ Epalinges,Switzerland

Opportunitiesfor PreventionI. BernardWeinstein/ NewYork,USA

Applicants are encouraged to submit abstractsfor poster presentation.

Information and Application Forms

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483(215)440-9300 (215) 440-9313 (FAX)

RISKASSESSMENTIN ENVIRONMENTALCARCINOGENESIS

AnAACRSpecialConferenceinCancerResearchCo-SponsoredbytheEnvironmentalMutagenSociety

Supported by a Generous Grant from theNational Institute of Environmental Health Sciences

January17-22,1994WhistlerResortandConferenceCentre

Whistler,BritishColumbia,Canada

CONFERENCE CHAIRPERSONS

PhilipC. Hanawalt/ Stanford,CAJamesA. Swenberg/ ChapelHill,NC

PROGRAM COMMITTEE

JohnAshby/ Macclesfield,England WilliamH.Farland/ Washington,DCCarolJ. Henry/ Sacramento,CA B.Singer/ Berkeley,CAThomasR.Skopek/ ChapelHill,NC RogerW.Wiseman/ ResearchTrianglePark,NCBarryW.Glickman/ Victoria,Canada

SCIENTIFIC PROGRAM

SpecialLecturesJamesA.Swenberg/ ChapelHill,NCPaulKleihues/ Zurich,Switzerland

CriticalEventsin HumanCarcinogenesisHelmutBartsch/ Lyon,FranceMonicaHollstein/ Lyon,France

MolecularEpidemiologyandBiomarkersofExposureJohnD.Groopman/ Baltimore,MDFredF.Kadlubar/ Jefferson,ARFredericaPerera/ NewYork,NYDavidH.Phillips/ Sutton,England

GeneticPredispositiontoCancerNormanR.Drinkwater/ Madison,WlF.PeterGuengerich/ Nashville,INMarkSkolnick/ SaltLakeCity,UTRogerW.Wiseman/ ResearchTrianglePark,NC

MutationalSpectrafor EnvironmentalCarcinogenesisRichardJ.Albertini/ Burlington,VTJohnA.Meddle/ Toronto,CanadaAlainR.Sarasin/ Villejuif,FranceThomasR.Skopek/ ChapelHill,NC

EndogenousFactorsFung-LungChung/ Valhalla,NYPhilipC.Hanawalt/ Stanford,CABarbaraSedgwick/ PottersBar.EnglandStevenR.Tannenbaum/ Cambridge.MA

ScientificBasisof ExtrapolationIJohnAshby/ Macclesfield,EnglandFrederickA.Beland/ Jefferson,ARAnthonyB.DeAngelo/ ResearchTrianglePark,NCRolfSchulte-Hemmann/ Vienna,Austria

ScientificBasisof ExtrapolationIISamuelM.Cohen/ Omaha,NEGeorgeW.Lucier/ ResearchTrianglePark,NCLawrenceJ. Marne«/ Nashville,TNB.Singer/ Berkeley,CABernardS.Strauss/ Chicago,IL

BiologicallyBasedRiskAssessmentandPublicPolicyRoryConolly/ ResearchTrianglePark,NCWilliamH.Farland/ Washington,DCCarolJ.Henry/ Sacramento,CASureshMoolgavkar/ Seattle,WA

Applicants are encouraged to submitabstracts for poster presentation.

Application Deadline: November 1, 1993

InformationandApplicationFormsAmerican Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)

MOLECULARGENETICS OF TUMOR PROGRESSIONAND METASTASIS

An AACRSpecialConferencein CancerResearch

Supportedby GenerousGrants from the Steiner Foundation

January31- February5,1994BigSkyResort,BigSky,Montana

CONFERENCE CHAIRPERSON

Lance A. Liotta / Bethesda,MD

PROGRAM COMMITTEE

EricR.Fearon/ NewHaven,CTPatriciaS.Steeg/ Bethesda,MD

WilliamG.Stetler-Stevenson/ Bethesda,MDDennisJ. Slamon/ LosAngeles,CA

SCIENTIFIC PROGRAM

ModelSystemsIsaiahJ. Fidler/ Houston,TXAllenShearn/ Baltimore,MDElizabethJ. Luna/ Shrewsbury,MAConnieCepko/ Boston,MASusanMackem/ Bethesda,MDGregoryR.Dressler/ Bethesda,MDAnnF.Chambers/ London,Canada

KeynoteAddressMarcE.Lippman/ Washington,D.C.

ColonCancerEricR.Fearon/ NewHaven,CTStanleyR.Hamilton/ Baltimore,MDBernardLevin/ Houston,TXLi-KuoSu/ Baltimore,MDRaymondL White/ SaltLakeCity,UT

MelanomaWallaceClark/ Kennebunk,MERobertS.Kerbel/ Toronto,CanadaIanR.Hart/ London,EnglandGarthL.Nicolson/ Houston,TXGeorgeF.VandeWoude/ Frederick,MD

Breast/OvarianDennisJ. Slamon/ LosAngeles,CAEddieReed/ Bethesda,MDMinaJ. Bissell/ Berkeley,CALarryNorton/ NewYork,NYLynnM.Matrisian/ Nashville,TN

ProstateJohnT. Issacs/ Baltimore,MDDonaldS.Coffey/ Baltimore,MDLelandW.K.Chung/ Houston,TXMarkE.Stearns/ Philadelphia,PAWalterBirchmeier/Essen,Germany

GenomicInstabilityandRepairVilhelmA.Bohr/ Baltimore,MDRuthJ. Muschel/ Philadelphia,PACarloM.Croce/ Philadelphia,PACarolW.Grieder/ ColdSpringHarbor,NY

MetastasisSuppressionPatriciaS.Steeg/ Bethesda,MDWilliamG.Stetler-Stevenson/ Bethesda,MDPaulB.Fisher/NewYork,NYUrsulaGunthert/ Basel,SwitzerlandAminFazilli/ Cambridge,MA

ClinicalApproachesto CancerProgressionLanceA.Liotta/ Bethesda,MDJohnR.Murphy/ Boston,MAIngegerdHellstrom/ Seattle,WAVictorLing/ Toronto,CanadaEliseC.Kohn/ Bethesda,MDKennethW.Culver/ DesMoines,lA

ApplicationDeadline:December6, 1993

Informationand ApplicationForms

American Association for Cancer ResearchPublic Ledger Building620 Chestnut Street, Suite 816Philadelphia, PA 19106-3483215-440-9300 215-440-9313 (FAX)

COVER LEGEND.

CancerResearch

We are pleased to feature on this issue's cover

Margaret L. Kripke, President of the American Association for Cancer Research for 1993-1994. She comesto this position not only with a stellar research record,but also with an extraordinary record of service to theAssociation and the journal Cancer Research. A nativeCalifornian and a graduate of the University of California at Berkeley, Dr. Kripke received an A.B. and M.A.in Bacteriology in 1965 and 1967, respectively, and aPh.D. in Immunology in 1970. She is now Vivian L.Smith Professor and Chairperson, Department ofImmunology, University of Texas M. D. AndersonCancer Center, Houston, Texas. She joined this institution in 1983 after two years of postdoctoralwork at Ohio State University, Columbus, Ohio;

three years at the Department of Pathology at theUniversity of Utah College of Medicine, Salt LakeCity, Utah; and eight years as Director of Immunologyand Cancer Biology at the NCI-Frederick CancerResearch Facility, Frederick, Maryland.

Her research focuses on the immunology of the skinand skin cancers, and the interactions between ultraviolet light and the immune system. Her pioneering workin these areas has contributed greatly to our understanding of the potential harmful effects of ultraviolet radiation on immune responses. She has published well over200 original research papers and reviews and has written and edited several books on these subjects. She hasdevoted her time generously to advisory committees,study groups, and boards dealing with scientific policiesand the disbursement of research funds and awards, aswell as to numerous committees for the Association. Inaddition, she is a member of the Executive Committeeof the Science Advisory Board of the EnvironmentalProtection Agency and the Board of Scientific Counselors for a division of the National Cancer Institute,and has served on many editorial boards, including thatof Cancer Research. Dr. Kripke has received manyprestigious awards, has given honorary lectureshipsthroughout the world, and has held offices in manyscholarly societies. Her positions on government boardsdealing with the environment and environmental car-cinogenesis reflect the tremendous influence she bringsto the implementation of national environmental policies and actions.

We are indebted to Dr. Kripke and the M. D.Anderson Cancer Center for providing background information and the cover photograph.

Sidney Weinhouse