copyright (c) by w. h. freeman and company 17.3 the rough er is an extensive interconnected series...
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Copyright (c) by W. H. Freeman and Company 17.3 Overview of the secretory pathway Figure cisternal progressionTRANSCRIPT
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17.3 The rough ER is an extensive interconnected series of flattened sacs
Figure 17-11
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17.3 Secretory proteins are found in the ER lumen immediately after synthesis
Figure 17-12
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17.3 Overview of the secretory pathway
Figure 17-13
cisternalprogression
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17.3 Many experiments on the secretory pathway have relied on cells specialized for the secretion of certain proteins
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Box 4.5
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17.3 Analysis of yeast mutants defined the major steps in the secretory pathway
Figure 17-14
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Fig. 4.13
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Fig. 4.14
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17.4 A signal sequence on nascent secretory proteins targets them to the ER and then is cleaved off
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17.4 The cotranslational import of proteins into the ER is studied with microsomes
Figure 17-15
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17.3 Some acronyms
SRP - signal recognition particle Particle made of 1 RNA and six proteins which binds the signal sequence on newly made proteins
SRP receptor - ER protein which binds SRPTRAM - translocating chain-associated
membrane (also translocon) takes the protein across the ER membrane
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17.4 Two proteins initiate the interaction of signal sequences with the ER membrane
Figure 17-16
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17.4 Structure of the signal recognition particle (SRP)
Figure 17-17
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17.4 Polypeptides move through the translocon into the ER lumen
Figure 17-18
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Fig. 4.15
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17.4 GTP hydrolysis powers protein transport into the ER in mammalian cells
Figure 17-20
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17.5 Topologies of some integral membrane proteins synthesized on the rough ER
Figure 17-21
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Fig. 4.17
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17.5 Most nominal cytosolic transmembrane proteins have an N-terminal signal sequence and an internal topogenic sequence
Figure 17-22
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17.5 A single internal topogenic sequence directs insertion of some single-pass transmembrane proteins
Figure 17-23
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17.5 Multipass transmembrane proteins have multiple topogenic sequences
Figure 17-24
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17.5 After insertion into the ER membrane, some proteins are transferred to a GPI anchor
Figure 17-25
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17.5 After insertion into the ER membrane, some proteins are transferred to a GPI anchor
Figure 17-25
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17.6 Post-translational modifications and quality control in the rough ER
Newly synthesized polypeptides in the membrane and lumen of the ER undergo five principal modifications Formation of disulfide bonds Proper folding Addition and processing of carbohydrates Specific proteolytic cleavages Assembly into multimeric proteins
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17.6 Disulfide bonds are formed and rearranged in the ER lumen
Figure 17-26
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Fig. 4.18
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17.6 Correct folding of newly made proteins is facilitated by several ER proteins
Figure 17-27
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17.6 ER-resident proteins often are retrieved from the cis-Golgi
Figure 17-29
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17.7 Different structures characterize N- and O-linked oligosaccharides
Figure 17-30
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17.7 The immediate precursors in the synthesis of oligosaccharides are nucleoside diphosphate or monophosphate sugars
Figure 17-31
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17.7 Specific sugars are linked by specific glycosyltransferases
Figure 17-32
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17.7 Sugar nucleotides and free nucleotides are exchanged by antiporters in the ER membrane
Figure 17-33
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17.7 ABO blood type is determined by two glycosyltransferases
Figure 17-34
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17.7 ABO blood groups
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17.7 A common preformed N-linked oligosaccharide is added to many proteins in the rough ER
Figure 17-35
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17.7 Addition and initial processing of N-linked oligosaccharides in the rough ER
Figure 17-36
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Fig. 4.27
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Fig. 4.20
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Fig. 4.28
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Fig. 4.22
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Box 4.4
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Fig. 4.23Developing wheat endosperm
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Fig. 4.24
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Fig. 4.25
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Fig. 4.29extensin
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17.7 Modifications to N-linked oligosaccharides are completed in the Golgi complex
Figure 17-38
Oligosaccharides may promote folding and stability of glycoproteins
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Golgi and post-Golgi protein sorting
Sequences in the membrane-spanning domain cause the retention of proteins in the Golgi
Different vesicles are used for continuous and regulated protein secretion
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17.10 Components that participate in budding of coated vesicles
Figure 17-51
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Figure 17-60
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17.10 A clathrin-coated pit on the cytosolic face of the plasma membrane
Figure 17-35
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17.10 Structure of a clathrin-coated vesicle
Figure 17-53
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17.10 Model for formation of a clathrin-coated pit and selective incorporation of integral membrane proteins
Figure 17-54
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17.10 GTP hydrolysis by dynamin is required for pinching off of clathrin-coated vesicles
Figure 17-55
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17.10 COP I vesicles mediate retrograde transport within the Golgi and from the Golgi back to the ER
Figure 17-56
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17.10 Model for formation of COP I-coated vesicles
Figure 17-58
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17.10 Specific fusion of intracellular vesicles involves a conserved set of fusion proteins
Figure 17-59
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Box 4.6B