The rough ER gets its name from the presence of ribosomes, which makes the surface look bumpy and is mainly composed of flattened sacs.

Ribosomes are small circular structures that control protein synthesis.

Rough ER

Flattened Sacs

The function of the rough ER is protein synthesis. During protein synthesis, the ribosomes on the

rough ER create new proteins. The ER then folds them properly and sorts them according to their function and destination.

As protein synthesis increases the rough ER expands, providing more surface area for ribosomes to spread out and create more proteins.

The rough ER carries out its protein folding activity deep within the cisternal space.

Most proteins produced by ribosomes of the rough ER are destined for secretion out of the cell.

you wouldn't have the following:- transmembrane receptors - digestive enzymes- production and storage of glycogen and steroids

because they are involved in the transport of proteins.

Fibrinogen storage disease is a form of Endoplasmic Reticulum Storage Disease. (ERSD)

It’s the accumulation of proteins destined for secretion.

It’s permanent and affects mainly the rough endoplasmic reticulum (RER).

The rough ER is not easily visible with a light microscope, but it can be seen with an electron microscope.

Rough ER seen through the Electron MicroscopeElectron Microscope

The rough ER is so named because it has an abundance of _______________ on it.

A.Golgi bodies B.MitochondriaC.LysosomesD.Vesicles E.Ribosomes