evolution of ribosomes
DESCRIPTION
Evolution of ribosomesTRANSCRIPT
Evolution connection: RibosomesEvolution connection: Ribosomes
Ribosomes: An achilles heel for bacteria
Petri dish photo from CDC; researcher photo from CDC/Dr. U.P. Kokko; photo of various medicines from
National Institute of Health
Why don’t antibiotics like streptomycin harm our own cells?
Evolution connection: RibosomesEvolution connection: Ribosomes
Evolution connection: RibosomesEvolution connection: Ribosomes
Ribosomes evolved early in the history of life
All ribosomesshare:
• similar rRNA sequences
• small subunit that decodes mRNA
• large subunit that joins amino acids together
The ribosomeevolved back
here.
Evolution connection: RibosomesEvolution connection: Ribosomes
Ribosomes evolved early in the history of life
The ribosomeevolved back
here.
... and evolvedmodificationsas life’s lineagesdiversified.
Small evolutionary changes big impact
Evolution connection: RibosomesEvolution connection: Ribosomes
Streptomycin-like antibiotics bind to the ribosome
Antibiotic binds here and interferes with protein synthesis …
… but not in eukaryotic ribosomes.
A site antibiotic
ribosome
Evolution connection: RibosomesEvolution connection: Ribosomes
… because ofposition 1408In the small ribosomalsubunit.
Streptomycin-like antibiotics can’t bind to theeukaryotic ribosome …
G A
Evolution connection: RibosomesEvolution connection: Ribosomes
Streptomycin-like antibiotics can’t bind to the eukaryoticribosome …
Images provided by Joseph D. Puglisi.
Evolution connection: RibosomesEvolution connection: Ribosomes
But eukaryotic mitochondrial ribosomes are vulnerable.
G A
Mitochondrion
ribosomes
ReferencesReferences
Bokov, K., and Steinberg, S. V. (2009). A hierarchical model for evolution of 23S ribosomal RNA. Nature. 457: 977-980.
Lynch, S. R., and Puglisi, J. D. (2001). Structural origins of aminoglycoside specificity for prokaryotic ribosomes. Journal of Molecular Biology. 306: 1037-1058.
Pace, N. R. (1997). A molecular view of microbial diversity and the biosphere. Science. 276: 734-740.
Recht, M. I., Douthwaite, S., and Puglisi, J. D. (1999). Basis for prokaryotic specificity of action of aminoglycoside antibiotics. The EMBO Journal. 18: 3133-3138.
Selimoglu, E. (2007). Aminoglycoside-induced ototoxicity. Current Pharmaceutical Design. 13: 119-126.