OR

INSULIN PLANT

PRESENTED BY :HARSHITA GUPTA

NATURAL PRODUCTS

NIPER AHMEDABAD,

GUJRAT.

COSTUS IGENUS

FLOW OF SEMINAR

INTRODUCTION DISTRIBUTION PHYTOCHEMISTRY BOTANICAL

DESCRIPTION BIOACTIVITY REFERENCE

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INTRODUCTION

Costus Igneus

Fiery Costus

Spiral flag Insulin plant

Chamaecostus cuspidatus

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Costus igneus a medicinal plant is a Magic Cure

for Diabetes.Insulin plant (Costus igneus) common name in Hindi is keukand and in Gujarati - pakarmula. In Marathi, Malayalam and Sanskrit is - pushkarmula and in Tamil is kostam.Family : Costaceae.Its leaves helps to build up insulin in the human body so it is commonly known as insulin plant in India.

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It is now accepted and used widely as an Ayurvedic medicinal herb.

Consumption of the leaves are believed to lower blood glucose levels.

Diabetics who consumed the leaves of this plant did report a fall in their blood glucose levels.

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Costus igneus is native to Southeast Asia, especially on the Greater Sunda Islands in Indonesia.It is a relatively new entrant to Kerala and India.This plant was grown in America and is becoming popular in India because of its medicinal chemicals.

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DISTRIBUTION

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C. igneus leaves

revealed that it is rich in

protein, iron, and

antioxidant components

such as ascorbic acid,

α‑tocopherol,

β‑carotene, terpinoids,

steroids, and flavonoids.

Methanolic extract was

found to contain the

highest number of

phytochemicals such as

carbohydrates,

triterpenoids, proteins,

alkaloids, tannins,

saponins, and flavonoids.

The ethanol extract

contained alkaloid also.

The major component of

the ether fraction was bis

(2’‑ethylhexyl)‑1,2‑benzen

edicarboxylate (59.04%)

apart from α‑tocopherol

and a steroid, ergastanol.

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PHYTOCHEMISTRY

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•Stem showed the presence of a terpenoid compound lupeol and a steroid compound stigmasterol.

•Bioactive compounds quercetin and diosgenin, a steroidal sapogenin, were isolated from C. igneus rhizome.

•phytochemical evaluation of Insulin plant revealed that the leaves contain 21.2% fibers. Successive extracts gave 5.2% extractives in petroleum ether, 1.06% in cyclohexane, 1.33% in acetone, and 2.95% in ethanol.

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CONT…..

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BOTANICAL DESCRIPTION

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A perennial,

upright,

spreading plant

reaching about

two

feet tall, with

spirally arranged

leaves and

attractive flowers.

Leaves- simple, alternate, entire,

oblong, evergreen, 4‑8 inches in

length.

Fruits- are inconspicuous, not

showy, less than 0.5 inch, and

green‑colored.

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Spiral flag grows in either full sun or

partial shade.

It needs fertile soil and ample moisture,

and is often planted near water.

The plant has no diseases are of major concern

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Growth and propagation

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BIOACTIVITY

Anti‑diabetic activity

Toxicity studyHypolipidemic

activityAnti‑cancer effect

Anti‑microbial activity

Antioxidant activity

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•In Ayurvedic treatment diabetes patients are advised to chew down the

Insulin plants leaves for a month.

•The patient has to take two leaves per day in the morning and evening for

one week.

The leaves must be

chewed well before

swallowing.

•After one week the patient should take one leaf each in the morning and

evening.

•This dosage should be continued for 30 days. Allopathic doctors too

recommend it and it is found to be effective in bringing blood sugar levels

under completely under control.

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ANTI-DIABETIC

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According to International Journal of Ayurveda Research a new study on Insulin plant

(Costus igneus) was published recently. The leaves of insulin plant (Costus igneus)

reduced the fasting and postprandial blood sugar levels, bringing them down towards

normal, in dexamethasone-induced hyperglycaemia in rats. Reduction in the fasting

and the postprandial blood sugar levels with leaves of insulin plant was comparable

with that obtained with Glibenclamide 500 µg/kg at 250 mg/kg/day and 500 mg/kg/day

of powdered leaves of the insulin plant(Costus igneus).

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Hardikar, M. R., Varma, M. E., kulkarni, A. A., Kulkarni, P. P. & Joshi, B. N.

2016. Elucidation of hypoglycemic action and toxicity studies of insulin-like

protein from Costus igneus. Phytochemistry, 124, 99-107.Kumudhavalli, M. & Jaykar, B. 2012. Evaluation of Antidiabetic activity of

Costus igneus (L) leaves on STZ induced diabetic rats. Der Pharmacia Sinica,

3, 1-4.Sataraddi, S. & Nandibewoor, S. 2012. Bio synthesis, characterization and

activity studies of Ag nanoparticles, by (Costus igneus) insulin plant extract.

Der Pharmacia Lettre, 4, 152-158.Ghaisas, S. M. 2011. Effect of insulin plant leaves on dexamethasone-

induced hyperglycemia. International journal of Ayurveda research, 2, 60.

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Krishnan, K., Vijayalakshmi, N. & Helen, A. 2011. Beneficial effects of

Costus igneus and dose response studies in streptozotocin induced diabetic

rats. International Journal of Current Pharmaceutical Research, 3, 42-6.

Krishnan, K., Vijayalekshmi, N. & Helen, A. 2011. Methanolic extract of

Costus igneus (NE Br) alleviates dyslipidemia in diabetic rats. Asian Journal

of Pharmaceutical and Clinical Research 4: 154-157.

Pazhanichamy, K., Aiswarya Devi, S., Jeba, S., Priya, G., Yogha, G.,

Manjula, K., Rajendran, K., Kumaran, S. & Eevera, T. 2011. The Efficacy of

Costus igneus Rhizome on Carbohydrate Metabolic, Hepatoproductive and

Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats. Journal of

Health Science, 57, 37-46.

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Vishalakshi Devi, D. & Urooj, A. 2010. Nutrient profile and antioxidant

components of Costus speciosus Sm. and Costus igneus Nak. Indian Journal

of Natural Products and Resources, 1, 116-118.

Vishnu, B., Naveen, A., Akshay, K., Sikarwar, M. & Patil, M. 2010. Antidiabetic

activity of insulin plant (Costus igneus) leaf extract in diabetic rats. Journal of

Pharmacy Research, 3, 608-611.

Mani, P., Kumar, R. A., Bastin, T. J., Jenifer, S. & Arumugam, M. 2010.

Comparative evaluation of extracts of C. igneus (or C. pictus) for

hypoglycemic and hypolipidemic activity in alloxan diabetic rats. International

Journal of Pharmacy and Technology, 2, 183-195.

Shetty, A., Choudhury, D., Nair, V., Kuruvilla, M. & Kotian, S. 2010. Effect of

the insulin plant (Costus igneus) leaves on dexamethasone-induced

hyperglycemia. International Journal of Ayurveda research, 1, 100-102.

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