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INSPIRE Taster Day Brochure

2015-2016

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INSPIRE is a scheme supported by the Academy of Medical Sciences and the Wellcome Trust aimed at getting medical, dental and veterinary students involved in academic research. The Universities of Bristol, Cardiff, Exeter and Plymouth are proud to have been awarded grants from this body to fund research Taster Days within prestigious research groups at the Universities. The relationships developed during these Taster Days will ideally lead to a funded INSPIRE vacation studentship (to be advertised later in the term) - and perhaps much more.

How to applyThis brochure contains details of the Taster Days being offered during 2015. Travel bursaries will be available to students wishing to travel to a Taster Day in a different university to their own. To apply for a 2015 Taster Day, please apply online via this link –

http://goo.gl/forms/ff6fHswZcg

The closing date for applications is October 23rd 2015 at 5pm

You will be notified if you application for a taster day was successful by the 6th November 2015.

We wish you the best of luck with your application and all future research endeavours.

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http://goo.gl/forms/ff6fHswZcg

The INSPIRE Scheme; a student’s FAQs and guide.

1. What’s the INSPIRE Scheme? The INSPIRE scheme is a programme run by the Academy of Medical Sciences, and supported by the Wellcome Trust, that aims to encourage and promote medical, dental and veterinary students to learn about and get involved in research at their own schools and elsewhere, both in the UK and abroad.http://www.acmedsci.ac.uk/careers/mentoring-and-careers/INSPIRE/The current programme will run for the next two years and is organised and co-ordinated between Cardiff, Bristol, Exeter and Plymouth schools to give students as much choice as possible for research placements and summer project opportunities. The timetable and deadlines for the scheme are at the bottom of the page.

2. How do I get involved? The major parts of the scheme are research ‘Taster days’ and summer project bursaries for students, but there are other events and programmes, such as showcase days, research conferences, a new student-led e-magazine and an intercalators’ conference. Check out your medical school’s INSPIRE website for details of events.

3. What are Taster Days? These are single day visits to a research provider’s lab or group to see research first-hand. The research taster days are advertised in October in a research booklet, students apply and then visit the labs for a day in November or December. Applications are made through a web-based system and you can apply and do more than one Taster day if you wish. Once allocated, both you and the provider will be contacted. You should then make direct contact with the provider to get more information and any background reading or arrangements for the day. As with any professional placement, if you cannot make the day, you MUST notify your provider. Student ‘no-shows’ discourage research providers from getting involved in future years!

5. What happens at the Taster day? These days are an opportunity for you to get to have find out about the research of the person you are visiting, also to consider whether you would like to apply for a summer project. Do some reading before you go and talk about the research with your provider and possible ideas and projects that would be suitable for a summer studentship. Ask them about the context of their research and why they do it!

6. What if I then want to apply for a summer studentship? Keep in contact with your provider and discuss what would make a good and do-able project within the 4-6 weeks of the project. The research proposal should be written by you; you will be sent the application forms. Bursaries are available from all 4 schools (£1000 for the successful students.) You do not have to apply for a project in the same place you have done your taster. See the deadlines below; no late applications will be accepted and the proposals are judged by a student/academic panel. After you finish your project you will be asked to write a short report; maybe even present your results at the research conference/showcase.

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http://www.acmedsci.ac.uk/careers/mentoring-and-careers/inspire/

7. Can I apply elsewhere for funding? Yes and it makes good sense to apply to more than one place. See the attached list of potential funders, but do note they will have different deadlines and conditions for their schemes.

Research Taster Booklet Released October 12th 2015

Closing Date for Applications October 23rd 2015

Students Notified of Taster Day Allocations

November 6th 2015

Taster Day Dates November 25th, Dec. 2nd and 9th 2015

Summer project application deadline 10th March 2016

Results for project applications 24th March 2016

Summer projects Summer 2016.

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University of Bristol Taster Days

MEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS

1)Research Group Name

Bacterial Infection Lab

Contact Dr Darryl Hill – Principal Investigator (PI)Location School of Cellular and Molecular Medicine, Biomedical Sciences Building,

University of BristolArea of Research

Bacterial infections of the respiratory tract which lead to localised or disseminated disease such as meningitis are a considerable health and financial burden globally. Our laboratory based research focuses on understanding the interplay between bacteria (mainly colonisers of the respiratory tract) and their human host during colonisation and progression of disease. By understanding key mechanisms used by bacteria to interact with human cells and tissues therapeutic targets can be identified.

Number of students and dates available

2 students on Wednesday 2nd or 9th of December


Brain Bladder Interactions

Contact Dr Thelma Lovick (PI)Location School of Physiology and Pharmacology, Biomedical Sciences Building,


Urge incontinence: “a sudden and compelling desire to void which is difficult to defer” is a relatively common condition, which is not adequately managed. It may arise, at least in part, due to dysfunction within the neuronal circuitry in the brain that controls bladder filling and emptying. Using rats as models the lab is investigating how lesions of groups of neurones the brain, of the type that occur in certain neurodegenerative diseases in humans, impact on 24h bladder function. We are also using rat models to investigate the potential of a closed loop pelvic nerve stimulator for controlling bladder function.


2 students on 2nd December and 2 students on 9th December

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Bristol Renal(Includes PIs: Prof Richard Coward; Prof Moin Saleem; Dr Seb Oltean; Dr Simon Satchell; Dr Becky Foster; Dr Natalie Finch)

Contact Prof Richard CowardLocation School of Clinical Sciences, Dorothy Hodgkin Building, University of BristolArea of Research

The molecular biology underlying kidney disease with a focus on the glomerulus. You will be given an overview of the research we perform and some “hands-on” experience of molecular biology techniques.


Up to 10 students on the 2nd of December.


Bristol Surgical Trials Centre(Includes Prof Jane Blazeby (PI); Dr Kerry Avery)

Contact Ms Kate TaylorLocation School of Social and Community Medicine, Whatley Rd, University of

BristolArea of Research

The Bristol Centre for Surgical Research is a multi-disciplinary collaboration aiming to transform patient care by increasing evidence-based surgery. The centre tackles key questions relevant to patients, clinicians and the NHS and is working to inspire and train a new generation of surgeons to undertake high quality research. We conduct research, including randomised controlled trials in surgery, with staff from a wide range of disciplines and surgical specialities. This includes expertise in trial design, consensus methods, qualitative research, medical statistics, evidence synthesis and surgery itself. Our research tackles key questions of relevance to patients, surgeons and to the NHS. This is an opportunity for students to ‘shadow’ the trials-related research processes by attending meetings where surgical trials are discussed.


2 students per research meeting.Research meeting dates:

By-Band-Sleeve Trial Executive Group meeting: 18/11/15 (10am, Level 7, BRI)

Bluebelle study Steering Committee meeting: 10/11/15 (Bristol – time and location TBC).

ROMIO study Trial Executive Group meeting: 04/11/15 (time and location TBC).

ConDuCT-II Hub for Trials Methodology Research outcomes theme meeting: 01/12/15 (11am-2pm, Bristol).

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Cell Biology Lab

Contact Professor David Stephens (PI)Location School of Biochemistry, Biomedical Sciences Building, University of BristolArea of Research

Lab based molecular cell biology research. We have two major inter-related projects:1. Molecular mechanisms of the dynein-2 cytoplasmic motor in cilia biology.2. Secretion of procollagen by the COPII vesicle trafficking system.The lab itself is using high-resolution light microscopy of living cells, notably live cell imaging, in 3D over time, to examine the organization and function of the mammalian secretory pathway both in healthy cells as well as in disease states. In this regard our work focusses on collagen secretion and the formation and function of primary cilia.For further details see: www.stephenslab.wordpress.com


Up to 2 on 25th November or 2nd December


Centre for Academic Primary Care

Contact Professor Debbie Sharp (PI)Location School of Social and Community Medicine, Canynge Hall/Oakfield House,


This is general practice/primary care research at its best! Answering questions of high importance to the NHS. Using a variety of different research methods. Please visit: www.bristol.ac.uk/primaryhealthcare/There will be a seminar with presentations from a variety of researchers in CAPC.


A group of not less than 6-8 students on either 25th November, 2nd December or 9th December

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http://www.stephenslab.wordpress.com/


Centre for Child and Adolescent Health, Paediatric CFS/ME

Contact Dr Esther Crawley (PI)Location School of Social and Community Medicine, Oakfield House, Oakfield

Grove, University of BristolArea of Research

Paediatric trials: Testing interventions, investigating trial design including recruitment and retention of children.Epidemiology using ALSPAC: MRC funded research using novel causal methodology.Qualitative research: the impact of CFS/ME on children and families; do children have a preference for treatment arm; how acceptable are trials/interventions; developing an outcome measure.Systematic reviews: Various systematic reviews investigating outcome, treatment, experience and treatment.The student(s) have the opportunity to take part in: qualitative analyses; data analyses techniques; trial design; how to interview children for qualitative research.


2 students on 25th of November or 2nd December


CRIC Bristol

Contact Dr Jade Thai (PI)Location School of Clinical Sciences, CRICBristol, 60 St Michael's Hill, University of


Clinical Applications of NeuroimagingFunctional brain mapping studies of healthy volunteers and clinical populations including Chronic Fatigue Syndrome and Multiple Sclerosis to investigate the impact of fatigue on brain function.


2 students on 2nd December

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Cystic Fibrosis Group

Contact Dr David Sheppard (PI)Location School of Physiology and Pharmacology, Biomedical Sciences Building,


This group investigates the cystic fibrosis transmembrane conductance regulator (CFTR). Mutations in CFTR cause the life-shortening genetic disease cystic fibrosis (CF). Lab-based research methods are used to explore CFTR structure and function, learn how CF mutations cause CFTR malfunction and investigate the mechanism of action of small-molecules that modulate CFTR activity. These small-molecules include drugs that target the root cause of CF by restoring CFTR expression and function and chemicals that inhibit CFTR function, which might be used to develop new therapies for secretory diarrhoea and autosomal dominant polycystic kidney disease.


2 students; date to be arranged with Dr Sheppard


Developmental Skeletal Biology

Contact Dr Chrissy HammondLocation School of Physiology and Pharmacology, Biomedical Sciences Building,


Regulation of cartilage and bone homeostasis in development and in disease


2 students on 2 of the dates (25th November, 2nd December and/or 9th December)


Diabetes and Metabolism

Contact Dr Kathleen Gillespie (PI)Location School of Clinical Sciences, Learning and Research Centre, Southmead

Hospital, University of BristolArea of Research

Combination of laboratory and population-based studies focused on prediction and prevention of type 1 diabetes. This involves detection of genetic markers and islet autoantibodies that predict future type 1 diabetes.


2 students on 2nd December or 9th December

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Fly Lab

Contact Dr James Hodge (PI)Location School of Physiology and Pharmacology, Biomedical Sciences Building,


We are interested in the molecular mechanisms and neural circuit changes that underlie behaviour. We are taking advantage of the fantastic genetic toolbox available in Drosophila to tackle this problem.We are studying age related memory decline and sleep disruption in Alzheimer and Parkinson’s models including the effect on neurodegeneration and movement.For more details see: http://www.bristol.ac.uk/phys-pharm/people/james-j-hodge/index.html


2 students on 25th November; 2 students on 2nd December; 2 students on 9th December


Glucocorticoid Lab

Contact Dr Becky Conway-Campbell (PI)Location School of Clinical Sciences, Dorothy Hodgkin Building, University of BristolArea of Research

Investigating the molecular, physiological and behavioural effects determined by normal and dysregulated glucocorticoid exposure.Glucocorticoids (GCs) regulate diverse physiological processes including metabolism and immune function, as well as stress responsiveness, cognitive processing and behavioural adaptation. Furthermore, chronic stress, and disease states such as arthritis, depression and sleep apnea are associated with significant alterations in the circadian GC profiles of patients. We use a range of techniques including cell culture, molecular techniques, histochemistry, imaging, in vivo models and behavioural testing,


3 students on any of the dates 25th November; 2nd December; 9th December

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IGFs and Metabolic Endocrinology Group (IMEG)

Contact Dr Claire Perks (PI)Location School of Clinical Sciences, Learning and Research Centre, Southmead


Laboratory based research.IMEG is focused on how nutrition and metabolism contribute to the development of major chronic disorders, such as cancer with a specific interest in the role of insulin-like growth factors. We particularly focus on breast and prostate cancer.


2 students on 25th November


Neuroendocrinology Research Group(PI: Prof Stafford Lightman)

Contact Dr Francesca SpigaLocation School of Clinical Sciences, Dorothy Hodgkin Building, University of BristolArea of Research

Lab based research projects investigating the origin and regulation of glucocorticoids secretion in physiological and pathological conditions.The students may have the chance to observe a number of techniques including hormone assay, RNA extraction, RTqPCR and Western Blotting.


1 student on 25th November; 1 student on 2nd December; 1 student on 9th December


Neurology @ Southmead(Includes PIs: Dr Ali Bieneman; Dr Liz Coulthard; Dr Claire Rice)

Contact Dr Ali BienemanLocation School of Clinical Sciences, Learning and Research Centre, Southmead


There are several labs based at Southmead with an interest in the underlying mechanisms and treatment of various neurological disorders including: Dementia; Huntington’s Disease; Parkinson’s Disease; Multiple Sclerosis.


A group of up to 12 students on 2nd December 2-4pm.

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Neuroscience @ Physiology & Pharmacology(Including research from the labs of PIs: Prof Zaf Bashir; Dr Matt Jones; Dr Jack Mellor; Dr Tony Pickering; and Prof Clea Warburton)

Contact Dr Tony PickeringLocation School of Physiology and Pharmacology, Biomedical Sciences Building,


Featuring research groups using a wide range of approaches from synaptic and cellular to systems and behavioural neuroscience. As applied to investigate mechanisms of learning and memory, cognition, pain perception, neuromodulation and neural development working from the bench-side of the translational spectrum.(For more details see http://www.bristol.ac.uk/phys-pharm/)


Up to 12 students on 9th December


Paediatric Infection and Immunity

Contact Prof Adam Finn (PI) and Dr Begonia Morales-AzaLocation School of Cellular and Molecular Medicine / School of Clinical Sciences,

Biomedical Sciences Building, University of BristolArea of Research

Immunology and microbiology of upper respiratory tract infection in children with special reference to mechanisms of action of vaccines (which often work by reducing transmission by inducing mucosal immune responses). Immunological techniques used include primary human cell culture, flow cytometric immunophenotyping, proliferation assays and intracellular cytokine staining and immunoassays. As well as bacterial culture, real time quantitative polymerase chain reaction is used to detect both bacteria and viruses and the group recently began work on microbiomic analysis using 16S ribosomal sequencing techniques. The lab team is closely associated with a clinical studies and trials group based at the Children’s Hospital.


2 students on each day: 25th November; 2nd December; 9th December

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Regenerative Medicine Laboratories(Including PIs: Prof James Uney; Dr Liang-Fong Wong; Dr Oscar Cordero Llana)

Contact Dr Liang-Fong WongLocation School of Clinical Sciences, Biomedical Sciences Building, University of


Lab based research encompassing stem cell biology (e.g. culturing and study of stem cells for disease modelling), molecular and cell biology of neurodegenerative disease (e.g. investigating microRNAs in neural stem cells, drug screening in a cell model of Parkinson’s disease) and general neuroscience (e.g. visualising cell populations in transparent brains – CLARITY)


Possibly 2-3 students on 2nd December; 2-3 students on 9th December


Research into Safety & Quality Group (RiSQ) Group (Academic Centre of Women’s Health)(Including PIs: Dr Christy Burden; Prof Tim Draycott; Mr Dimitrios Siassakos;)

Contact Dr Christy BurdenLocation School of Social and Community Medicine, The Chilterns, Southmead


Professor Tim Draycott has particular expertise in outcome based research, multi-professional training for Obstetric Emergencies, team working and dashboards in maternity care including work in Global Heath.Mr Dimitrios Siassakos is a member of several international academic initiatives to improve the management of stillbirth and neonatal death through robust research. Current work includes commissioned projects for the Lancet stillbirth series, and research projects to inform Department of Health task groups, national guidelines, and NIHR-funded research.

Other areas of research include bariatric, maternal and reproductive medicine. The research study designs undertaken vary from clinical trials to mixed methodology & qualitative studies.


1 student on 25th November; 1 student on 2nd December; 1 student on 9th December

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DENTAL SCIENCE-FOCUSSED RESEARCH TASTERS


The Cleft Collective (Cleft lip and palate)

Contact Ms Nicola Stock ([email protected])

Location School of Oral and Dental Sciences, Oakfield House, Oakfield Grove, University of Bristol

Area of Research

We have recently established a national cleft lip and palate cohort study, which is the largest of its kind in the world. The long-term aims of the cohort study are to improve multidisciplinary cleft care and support by addressing three broad clinical/research questions: 1) What are the genetic and environmental causes of cleft? 2) What are the best treatments for cleft? 3) What is the psychological impact of cleft on the affected individual and the family? We are also running a large Speech and Language Study, as well as a number of smaller complimentary projects.


Up to 3 students; half a day; date to be confirmed


Dental Clinical Trials Unit

Contact Prof Nicola West (PI); Dr Maria DaviesLocation School of Oral and Dental Sciences, Bristol Dental Hospital, University of


The majority of our work involves the testing of newly developed products designed to improve dental conditions such as erosion or dental hypersensitivity. Testing may be in vitro (very new formulations) or by means of clinical trials which may be carried out in situ or in vivo. Efficacy of products is assessed using various measuring and imaging techniques such as profilometry and scanning electron microscopy.


1-2 students; date to be confirmed

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mailto:[email protected]

Research Group Name

Oral Nanoscience Group

Contact Dr Michele Barbour (PI)Location School of Oral and Dental Sciences, Bristol Dental Hospital, University of


The Oral Nanoscience group is interested in the exploitation of nanoscience and nanotechnology in dental materials and oral care products. We are particularly interested in antimicrobial technologies, and have recently developed a novel nanoparticulate form of chlorhexidine. We are currently engaged in investigation of the properties of this new material and its application in materials such as glass ionomers, bonding materials and toothpastes. We are laboratory-based and very interdisciplinary; current and recent group members have first degrees which include chemistry, biomaterials science, biomedical science, engineering, physics and microbiology as well, of course, as dentistry. You can expect to spend your time in the lab working with our chlorhexidine nanoparticles and investigating how these might be applied in the oral environment.


2 students on a date in November/December.

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VETERINARY SCIENCE-FOCUSSED RESEARCH TASTERS


Academic Renal Unit

Contact Dr Natalie Finch (PI)Location School of Veterinary Sciences / School of Clinical Sciences, Dorothy

Hodgkin Building, University of BristolArea of Research

Lab-based research on kidney disease. The research is focussed on glomerular endothelial cells.


2 students on 25th November; 2 students on 2nd December (this session will be combined with an overview of research from several member of the Bristol Academic Renal Unit)


AMR Force

Contact Dr Kristen Reyher (PI)Location School of Veterinary Sciences, Dolberry Building, Langford, University of


We are a group of veterinarians and researchers interested in decreasing antimicrobial use while improving animal health through a plurality of approaches. We have strong links and collaborations with social scientists along with a track record of influencing behaviour change in animal welfare as well as national welfare control programmes on farms. We currently are involved at a high level in influencing the use of medicines on farms in the UK and have for the past five years been conducting medicines audits within our practice and reducing the use of higher level medicines on our farms. We have expertise in policy-making as it relates to animals and their welfare, and experience in using participatory approaches to develop policy with policy-makers, vets and farmers and dealing with a multitude of different farming styles and attitudes.Farm-based with subsequent lab and office-based analyses.


5 students. Tuesday 1st December afternoon

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Research Group Name

Anaesthesia and Analgesia Research Group

Contact Dr Jo Murrell (PI)Location School of Veterinary Sciences, Langford (Wellcome Lab), University of


We conduct clinical type research studies to investigate fundamental pain mechanisms or the efficacy of different analgesics in clinical pain states. The research is therefore animal based, with the majority carried out on client owned animals and involves direct interactions with the animals to assess pain.


2 students. Date to be arranged with Dr Murrell.


Animal Welfare and Behaviour

Contact Prof David Main (PI)Location School of Veterinary Sciences, Dolberry Building, Langford, University of


The Animal Welfare and Behaviour groups undertakes both fundamental and applied research in a range of species including farm, companion, equine and laboratory animals. Some of the work is undertaken at Langford whilst many studies are conducted on commercial farms and home environments. The research themes include understanding animal behaviour, cognition, emotion; companion animal behaviour; welfare on farm and implementation of welfare solutions.


Students may be able to experience specific taster experiences offered by individual members of the group (see other details) or a more generic session covering a range of research on afternoon 2nd December



Contact Dr Jo Edgar (PI)Location School of Veterinary Sciences, Langford, University of BristolArea of Research

Research project on the use of natural maternal behaviour to improve welfare in farmed chickens. The project may involve work with chickens here at Langford, or on-farm study, depending on the chosen days. It will involve behavioural observations and tests on chicks and pullets, to assess their welfare.


1 student; date is dependent on when next study begins but can be discussed nearer the time.

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Research Group Name


Contact Prof Christine Nicol (PI)Location School of Veterinary Sciences, Langford, University of BristolArea of Research

It is essential that animal welfare indicators are valid – they should measure something that matters to the animal, rather than being chosen arbitrarily. Students will see ongoing experiments with laying hens, developing new methods of validating a range of measures against hens’ own preferences and emotions.




Bone Mechanobiology Group

Contact Prof Jo Price (PI)Location School of Veterinary Sciences, Southwell St, University of BristolArea of Research

My research group seeks to decipher the mechanisms by which mechanical loading leads to structurally appropriate bone mass and architecture and to establish why these mechanisms fail with ageing and after the menopause. Our research is laboratory based and we use both in vivo (mouse) and ex vivo models.


Two students on 9th December


The Bristol Cats Study – Animal Welfare and Behaviour

Contact Dr Jane Murray (PI)Location School of Veterinary Sciences, Dolberry Building, Langford, University of


The Bristol Cats Study is a longitudinal study that enables the collection of prospective data that are used for a range of epidemiological studies. The taster day would involve students gaining experience of working with data that are collected (e.g. owner-completed questionnaires, veterinary histories) and the administration that is involved in running this project.



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Research Group Name

Equine Pain

Contact Ms Veronica Roberts (PI)Location School of Veterinary Sciences, Langford Equine Hospital, University of


Trigeminal-mediated headshaking in horses. This is a neuropathic facial pain syndrome. Developing a human neuropathic pain management technique on horses.


2-4 students. Date to be arranged with Veronica Roberts (depends on cases).


Feline Infectious Diseases

Contact Dr Séverine Tasker (PI)Location School of Veterinary Sciences, Churchill Building, Langford, University of


This group is involved in the laboratory investigation of feline infectious agents. A primary interest is haemotropic mycoplasmas (haemoplasmas), which are bacterial agents that can induce haemolytic anaemia in a range of host species. Most of our studies centre on the feline haemoplasmas but we have carried out research on other haemoplasma species including canine, rodent and human species. We also work on feline coronavirus (FCoV) infection, a virus that can cause feline infectious peritonitis (FIP). Current research involves the development of reliable diagnostic tests for FIP, deriving genome sequences of field coronavirus isolates and identification of feline coronavirus host receptors.



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Research Group Name

Mucosal Immunology Lab

Contact Prof Mick Bailey (PI)Location School of Veterinary Sciences, Churchill Building, Langford, University of


We carry out primarily lab-based studies on the impact of early life, particularly colonisation with commensal bacteria, on development of the mucosal immune system. We use pigs primarily, because they are agricultural species as well as good models for humans. In addition, we work on swine influenza and on pig-as-biomedical-model, particularly transplantation.


2 students, ideally together, on any of the days (25th November, 2nd December or 9th December)


Mucosal Microbiology Group

Contact Dr Tristan Cogan (PI)Location School of Veterinary Sciences, Churchill Building, Langford, University of


Lab-based research on the cause and control of zoonotic diseases in animals and humans, especially Campylobacter, E. coli and Leptospira. Current projects cover pure, applied and clinical research. The group also contains a commercial diagnostic laboratory for veterinary samples.Current highlight areas are the diagnosis and epidemiology of Leptospira infections in dogs in the UK; the prevalence of antibiotic resistance in E. coli and where resistant strains can be found in the environment; intervention strategies to prevent Campylobacter infections of chickens and improve human health.


Up to 3 students on each of the 3 dates (25th November, 2nd December, 9th

December).

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Research Group Name

“Puppies of our Time”: dog cohort study

Contact Dr Rachel Casey (PI)Location School of Veterinary Sciences, Dolberry Building, Langford, University of


“Puppies of our Time” is a longitudinal study in which puppies are recruited before 16 weeks of age and followed through life. The project enables the collection of prospective data that are used for a range of epidemiological studies. The taster day would involve students gaining experience of the various aspects of the project, including owner, breeder and vet recruitment, questionnaire development, discussion about measuring a range of health and behaviour outcomes, and some experience of data handling.


4 students on 2nd December.


Spinal Cord Regeneration Lab

Contact Dr Nicolas Granger (PI)Location School of Veterinary Sciences, Langford and Biomedical Sciences Building,


Research type: clinical research.My research focuses on the development and testing of cellular therapies for spinal cord injury repair. I focus on the use of olfactory ensheathing cells and I am interested in optimizing this cell transplant population by: (i) engineering cells to express molecules improving their migration and integration within sites of spinal cord injury; (ii) designing new methods of cell protection for efficient in vivo delivery, such as delivering cells within hydrogels. To assess cell efficacy, I work on the canine spontaneous model of spinal cord injury and use advanced imaging techniques, kinematic and electrophysiology.



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Research Group Name

Sustainable Livestock Systems

Contact Prof Michael Lee (PI)Location Rothamsted Research, North Wyke, Okehampton, Devon, EX20 2SBArea of Research

Sustainability of grazing livestock systems – the use of a BBSRC National capability to measure the true impact (emissions, animal health) and value (economic and social) of different ruminant livestock production practices


A mini bus full of students between 9-11th November


Veterinary Parasitology and Ecology

Contact Dr Eric Morgan (PI)Location School of Veterinary Sciences, Life Sciences Building, University of BristolArea of Research

Parasites remain one of the most important constraints to animal health, welfare and productivity. A detailed understanding of the biology, ecology and epidemiology of parasites, in association with the hosts they inhabit, is essential to allow acceptable levels of control to be achieved. We conduct laboratory and field based research on the dynamic interactions between host and parasite populations, and its manipulation to achieve sustainable control. Applications include the practical diagnosis, epidemiology and control of parasites of veterinary importance.


2 students on 25th November; 2nd December; 9th December


Wooldridge T-cell Immunology Lab

Contact Prof Linda WooldridgeLocation School of Veterinary Sciences, Biomedical Sciences Building, University of


The group works on cytotoxic T-cells and the role that they play in controlling viral infection and the natural eradication of cancer. The group is also interested in the role that T-cells play in autoimmune disease. We study human and animal disease including recently initiated studies on feline coronavirus and neuroinflammatory disease in dogs.


2 students – date to be confirmed

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Cardiff University Taster DaysMEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS


Diabetes/metabolism

Contact Prof Colin DayanLocation Infection and Immunity, Cardiff University, C2 Link, Heath Park, UHW,

CF14 4XNArea of Research

Protecting beta cells from immune destruction in type 1 diabetes - laboratory and clinical studies. To introduce students into the different project in the group - developing new ways to induce immune tolerance with a "diabetes vaccine", how we develop early phase clinical trials and studies on large cohorts of children with type 1 diabetes.


4 students on 25th November 2015, 2nd December 2015, or 9th December 2015


Immunology

Contact Prof Paul MorganLocation Infection and Immunity, Cardiff UniversityArea of Research

Biomarkers and their measurement. See and learn how biologically important molecules relevant to disease are measured and how these measurements help predict disease.


4 students on 25th November 2015, 2nd December 2015, or 9th December 2015

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Psychiatry

Contact Prof George KirovLocation Psychiatry, Cardiff UniversityArea of Research

Identifying new copy number variations in schizophrenia. The students will observe our work on the analysis of genetic data from several thousand cases and controls. The subjects have already been genotyped, so the work will be done in offices, in front of computers. The students will be able to familiarise themselves with some of the pitfalls and biases that can occur in research settings of this type, the statistical methods we use and the process of writing papers.


2 students on 25th November 2015 or 9th December 2015


Viral Immunology

Contact Dr Eddie WangLocation Infection & Immunity, Cardiff UniversityArea of Research

Modulation of host immunity by human cytomegalovirus. Introduce human cytomegalovirus as a pathogen and its use in research as a paradigm for immune evasion, which has aided our understanding of the host immune system. Demonstrate assays used in our research.


3 students on 9th December 2015


College of Biomedical and Life Sciences

Contact Dr Kathryn TaylorLocation School of Pharmacy and Pharmaceutical Sciences, Cardiff UniversityArea of Research

Discovery of Zinc Signalling Mechanisms in Breast Cancer. To discover what we mean by zinc signalling and find out how zinc transporters are important for breast cancer spread


4 students on 25th November 2015, 2nd December 2015 or 9th December 2015

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Psychiatric genetics

Contact Dr Maria NiarchouLocation Institute of Psychological Medicine and Clinical Neurosciences, Cardiff

UniversityArea of Research

Exploring the role of Copy Number Variants in learning disability and psychopathology in children. Results from the Experiences of CHildren with cOpy number variants (ECHO) study. A considerable number of studies have recently shown that specific Copy Number Variants (CNVs, deletions or duplications of genetic material) increase risk of development of psychiatric disorder. However, there is high variability in the phenotypic outcomes of these CNVs and insight is very limited regarding the mechanisms involved. The main focus of my research group is to examine the phenotypic outcomes of individuals with Copy Number Variants in order to obtain a better understanding of these issues. We conduct detailed cognitive, psychiatric and genetic assessments over time of individuals with high-risk CNVs, including children and adolescents with 22q11.2 Deletion Syndrome (22q11.2DS). The aims of the taster day are to provide an overview of the ECHO study, describe the assessments and data collection and discuss the ECHO study findings.


2 students on 2nd December 2015 or 9th December 2015


Neurology/Immunology

Contact Dr Mark WillisLocation Institute of Psychological Medicine & Clinical Neuroscience, Cardiff

UniversityArea of Research

CD8 T cells in multiple sclerosis. To experience the laboratory environment and the interface with clinical medicine. I am a clinical research fellow in neurology working on the role of CD8 T cells in multiple sclerosis. My work involves patient recruitment and sample collection (cerebrospinal fluid) through to the use of cutting edge laboratory techniques. I benefited from time in the lab as a medical student and am keen to introduce others to this exciting environment and the role of a clinical academic.


2 students on 2nd December 2015

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Child Psychiatry

Contact Dr Stephen CollishawLocation Psychological Medicine and Clinical Neuroscience, Cardiff UniversityArea of Research

Child and adolescent psychiatry research taster day. The aims of the taster day are to provide an opportunity to find out more about our research. This focuses on child and adolescent mental health. Our main areas of interest are: child and adolescent depression, ADHD and other developmental difficulties. We use a variety of strategies to better understand these problems including epidemiology, genetics and neuroimaging as well as cognitive, behavioural and clinical assessment. We also have an interest in translating these findings into improved patient care, for example by developing online education packages for young people with depression.


4 students on 25th November2015 or 2nd December 2015


Cancer biology

Contact Dr Tracey MartinLocation C&G, Cardiff UniversityArea of Research

Tight junction as regulators of Cancer metastasis. To see how Cell function assays, Molecular biology and protein analysis can investigate Cancer metastasis.


4 students on 25th November2015


Diabetes

Contact Prof F. Susan WongLocation IMEM, Cardiff UniversityArea of Research

Can autoantibody secreting cells be detected in Diabetes?Introduction to some laboratory techniques used in investigation of autoimmune diabetes.


2 students on 25th November2015

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Diabetes


Genetic analysis of DNA by PCR.Introduction to some laboratory techniques used in investigation of autoimmune diabetes.




Diabetes


Introduction to some laboratory techniques used in investigation of autoimmune diabetes.




PET/CT imaging / Radiochemistry

Contact Dr Stephen PaisleyLocation PETIC, Cardiff UniversityArea of Research

Behind the scenes introduction to the facilities and research at PETIC (the Positron Emission Tomography Imaging Centre. PETIC runs the national clinical diagnostic service for PET/CT in Wales and has an active many research projects in PET tracer development. We will provide a behind the scenes introduction to the facilities required for PET imaging (clinical and pre-clinical imaging).


4 students on 25th November 2015, 2nd December 2015 or 9th December 2015

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Bone Biology

Contact Dr Bronwen EvansLocation IMEM, Cardiff UniversityArea of Research

How does mechanical loading of bone prevent osteoporosis?




Ionic Cell Signalling

Contact Dr David EdwardsLocation IMEM, Cardiff UniversityArea of Research

Forming myocytes from pluripotent stem cells


4 students TBC


Infection and Immunity

Contact Prof Tim WalshLocation Infection and Immunity, Cardiff UniversityArea of Research

Superbugs: what they are and what they do!



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University of Exeter Taster DaysMEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS


Child Mental Health

Contact Prof Tamsin FordLocation Institute of Health Research , University of Exeter, South Cloisters, St.

Luke’s CampusArea of Research

Factors influencing childhood psychiatric disorder, mental health and well-being, including interventions. We are currently running one randomised controlled trial, a systematic review and a number of observational studies




Primary Care

Contact Prof John CampbellLocation Institute of Health Research, University of Exeter, Smeall Building, St.

Luke’s CampusArea of Research

Primary care clinical research




Medical Imaging

Contact Prof Karen KnappLocation Medical Imaging, University of Exeter, South Cloisters, St. Luke’s CampusArea of Research

We utilise medical imaging to study musculoskeletal disease processes and investigate how to optimise imaging. We undertake experimental work through to clinical research involving both patients and volunteers.



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Cognitive and Behavioural Neurology

Contact Dr Sharon SavageLocation Institute of Health Research, University of Exeter, College House, St Lukes

CampusArea of Research

Cognitive and Behavioural Neurology




Medical Statistics

Contact Dr Fiona WarrenLocation Primary Care, University of Exeter, Smeall Building, St Lukes CampusArea of Research

Medical Statistics


4 students on 25th November 2015


Molecular Genetics

Contact Dr Lorna HarriesLocation IBCS, University of Exeter, RILD building, RD7E siteArea of Research

My group are interested in gene expression and gene regulation, particularly in how these mechanisms can influence human diseases. We are a lab-based group, engaged in basic science research to uncover the molecular causes of chronic diseases including diabetes, dementia and ageing itself. The work uses both population-level analysis, and also focused in vitro work to assess cause and effect and define mechanism. Current projects include analysis of deregulation of splicing during human ageing, functional analysis of genetic variants associated with type 2 diabetes and assessment of the effect of endocrine disrupting chemicals on gene expression or gene regulation


4 students on 25th November 2015

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Mental Health Research Group

Contact Prof Rose McCabeLocation Institute of Health Research, University of Exeter, College House, St Lukes


Communication is at the heart of all healthcare delivery. It is the means through which diagnosis is reached and treatment is delivered. In mental health care, it takes centre stage in the absence of physical signs and symptoms. Moreover, the quality of healthcare professional-patient communication influences treatment outcomes. We will introduce you to key topics and methods in the study of communication (using real life video recordings of doctor-patient communication in the treatment of psychosis, depression and dementia), including our application of novel methods such as 3D motion capture, see http://www.youtube.com/watch?v=VxKYrZWSPJA&feature=c4-overview&list=UUD7C4mz9mrgkY4chpS419dQ.




Suicide and Self Harm Research

Contact Dr Christabel OwensLocation Institute of Health Research, University of Exeter, College House, St Lukes


Qualitative research, exploring suicide and self-harm from the perspective of those who are caught up in them




Cell Biology

Contact Dr David AllardLocation IBCS, University of Exeter, Medical School Building, St Lukes CampusArea of Research

Tumour microenvironment


4 students on Wednesday 25th November, 2nd December or 9th December

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Implementation Science

Contact Dr Mark PearsonLocation Institute of Health Research, University of Exeter, South Cloisters St Lukes


We talk a lot about evidence-based practice but how much clinical practice is actually evidence-based? Our group brings together clinicians, managers, and researchers to improve care by ensuring research and practice inform each other


5 students on Wednesday 25th November


Child Health

Contact Dr Katrina WyattLocation Institute of Health Research, University of Exeter, South Cloisters St Lukes


Development and evaluation of complex programmes to change behaviour, including RCTs, intervention mapping and implementation design .


5 students on Wednesday 9th December


Respiratory Medicine

Contact Dr Chris ScottonLocation IBCS, University of Exeter, Medical School Building, St Lukes CampusArea of Research

Lung disease, particularly lung fibrosis. Our group is trying to unravel the cell and molecular mechanisms underlying the development of lung disease, with a view to identifying novel therapeutics, including regenerative medicine approaches.



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Monogenic diabetes research group

Contact Dr Elisa De FrancoLocation IBCS, University of Exeter, RILD buildingArea of Research

Genetic and genomic approaches to the identification of the genetic causes of neonatal diabetes and hyperinsulinism.


4 students on Wednesday 2nd December

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Plymouth University Taster DaysMEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS


Neurodevelopment and CNS repair

Contact Dr. Torsten Bossing and Dr Claudia BarrosLocation School of Biomedical and Healthcare SciencesArea of Research

Understanding the workings of the human central nervous system (CNS) with its millions of neurons generating trillions of connections is a formidable challenge. Fortunately, to uncover the basic rules, we can turn to simpler organisms. I am making use of the simple fruit fly Drosophila to study evolutionary conserved mechanisms in CNS development and disease. Using classical genetics, molecular biology, transgenics and micromanipulation I study the embryonic development of the CNS to understand how damage in the CNS can be repaired. I also investigate the transcriptional program ensuring the correct formation of neural networks


1 student on Wednesday 2nd December


Basic pathology of disorders of human nervous system

Contact Dr Aditya ShivaneLocation Department of Cellular & Anatomical Pathology, Derriford HospitalArea of Research

Neuropathology is a highly specialized branch of histopathology which deals with the gross and microscopic analysis of tissues of the nervous system. Neuropathologists therefore aid clinicians in arriving at a diagnosis. We are a small team of two neuropathologists and four biomedical scientists incorporated in a larger histopathology department. We collaborate with the neurosciences team in the Peninsula School of Medicine and Dentistry on various research projects (eg. tumours of the CNS, Parkinson disease). The aim of this taster session is to give you an insight into the basics of neuropathology.



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Genetic Toxicology and Ecotoxicology Research Group

Contact Prof. Awadhesh Jha and Dr Deepu OommenLocation Plymouth University; Biological SciencesArea of Research

Our group works on different aspects of mutagenesis and carcinogenesis, with particular reference to elucidation of molecular mechanisms of DNA damage/ repair in a range of normal (e.g. cells of nervous origin) or tumor cells (viz. ovarian and lung cancer cells) following exposure to anti-tumor drugs or environmental agents (e.g. engineered nanoparticles).




Hepatology Research Group

Contact Dr Dan FelmleeLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

Hepatitis C virus (HCV) infects 3% of the global population and transmitted through contaminated blood products. The majority of those infected carry a chronic infection that leads to liver disease and hepatic cancer. Our group previously studied of a cohort of individuals that were exposed to HCV, but amazingly cleared the virus without showing antibody evidence of exposure. Genetic studies of this population reveal unique alleles in a region of anti-viral genes that may enable these individuals to escape infection. We will pursue this investigation by identifying other differences in sequence and testing our findings functionally in cell culture models.


2 students on Wednesday 2nd December or 9th December

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Neurobiology

Contact Dr Wai-Ling KokLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

The debilitating movement symptoms in patients with Parkinson’s disease (PD) are primarily caused by the death of dopaminergic neurons. Understanding why these neurons die or do not function properly may lead to new therapies for PD. Mitochondria, the powerhouses of the cell, are highly dynamic and they undergo frequent changes in shape, size, number and location. These dynamic processes can be controlled by mitochondrial fission and fusion. Manipulating these processes has considerable potential for treating human neurological conditions. One primary interest of this laboratory is to develop therapeutic strategy for PD by targeting mitochondrial fusion/fission.


3 students on Wednesday 25th November or 2nd December


Collaboration for the Advancement of Medical Education Research and Assessment (CAMERA)

Contact Dr Julian Archer and Dr Sam Regan de BereLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

CAMERA brings together academic researchers, medical professionals, educators and policy makers interested in the improvement of healthcare through evidence-based education.We focus on assessment and its impact across the continuum of medical education from student selection to professional regulation. We have a high profile in educational, regulatory and clinical literatures. We work closely with key national institutions including the GMC and other regulators, the Health Foundation, the Department of Health and the National Institute of Health Research (NIHR). Our findings inform debate, policy and practice at local, national and international levels.

Population-based research using various qualitative and quantitative methodologies


3 students on Wednesday 25th November, 2nd December 9th December

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Neurobiology- Understanding tumours of the nervous system.

Contact Professor David Parkinson

Location Peninsula University Peninsula School of Medicine and DentistryArea of Research

Schwann cells are the glial cells of the peripheral nervous system and provide the myelin that allows the rapid propagation of action potentials. The loss of the tumour suppressor protein Merlin leads to the formation of schwannomas in patients. My lab studies the biology of these tumours using both primary human schwannoma cells and transgenic mouse models to understand the changes in cell signaling that underlie the uncontrolled proliferation of Schwann cells lacking Merlin.Please see Doddrell et al (2013), Brain 136: 549-63 for details of the kinds of research we do.Research type: Lab based project.


2 students on Wednesday 25th November and 2 students on 9th December


Medical microbiology

Contact Dr Mat Upton

Location Peninsula University Peninsula School of Medicine and DentistryArea of Research

Lab based, medical microbiology and bacterial genomics

My group is investigating the pathogenesis, epidemiology and genomics of uropathogenic E coli (UPEC), which are the leading cause of urinary tract infection. We are developing and commercializing rapid diagnostic assays for UPEC.

We also carry out discovery of novel antibiotics. Lead compounds are being developed towards clinical use for therapy of infections caused by antibiotic resistant Gram-positive bacteria, including MRSA.



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Clinical neurobiology

Contact Prof Oliver Hanemann and Dr Sara FerlugaLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

Meningiomas are slow growing tumours of the meninges. There is no treatment available after resection other than radiation-therapy; therefore it is a great medical need to find new drugs to treat these patients. We want to identify meningioma diagnostic, predictive or prognostic biomarkers. In particular, we will analyse the phosphoproteome from meningiomas with different genotype: phosphoproteins present in all samples are indicative of common upregulated pathways that could possibly be targeted. The final goal of this project is the identification of the best suitable drug, already in clinical trial or general practice, to target common up-regulated pathways in meningioma patients.




Translational neurobiology

Contact Prof Robert FernLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

We are interested in injury to the developing white matter of the brain, which is selectively damaged in cases of cerebral palsy; we also study stroke injury in the brain. Projects can use electrophysiology, electron microscopy or immuno-staining to examine an aspect of cellular injury. This is a lab based project although there is potential for projects using CT data from stroke patients.



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Peripheral nerve regeneration group

Contact Dr Xin-peng DunLocation Peninsula University Peninsula School of Medicine and DentistryArea of Research

The peripheral nervous system differs from the central nervous system in that it is capable of remarkable regeneration after injury, but this astonishing regenerative capability is limited after transection injury due to the loss of the integrity of the original axonal paths necessary for highly efficient and accurate regeneration. In order to understand the molecular mechanisms contributing this regenerative failure, our group is currently using global and conditional gene knockout mouse as our research models to study the role of several transcription factors, canonical MAPK signalling pathways and axonal guidance molecules in peripheral nerve repair.

Research type: Lab based project.



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DENTAL SCIENCE-FOCUSSED RESEARCH TASTERS


Dental and Oral Research Group

Contact Dr. Bing HuLocation Peninsula Schools of Medicine & DentistryArea of Research

The current research topics (research lab based) of my group include:

1. The molecular mechanism in controlling epithelial stem cell fate both in development and in cancer;

2. The role of mesenchymal-epithelial interactions in organogenesis and cancer initiation.




Tissue Engineering

Contact Dr. Vehid SalihLocation Peninsula Schools of Medicine & Dentistry- Dental SchoolArea of Research

This research is totally laboratory-based and involves a variety of research methods including 2D and 3D cell culture, a variety of microscopy, basic molecular biology, ELISA, Histology, Flow Cytometry, Materials Testing and Biochemical assays. My current research combines both 2D and 3D cell culture methods to develop in vitro models and assays for diseases of the oral tissues, in particular the oral mucosa. The work also encompasses oral tumours and mimicking infection of in vitro mucosa to understand the microbial and tissue interactions. I am also interested in standardizing in vitro assays for tissue engineered scaffolds.


3 students on Wednesday 2nd December

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Contact Dr. Svetislav ZaricLocation Peninsula Schools of Medicine & Dentistry- Dental SchoolArea of Research

Lab based and clinical research.My research interests include microbiology of periodontal diseases, host-pathogen interactions, Toll-like receptors signalling, immunopathogenesis of chronic inflammation and mechanisms involved in the resolution of inflammatory response (endotoxin tolerance). I am particularly interested in the chemical composition of Porphyromonas gingivalis LPS, with regards to its lipid-A structure and sialylation, and in consequences these changes have on the host’s immune response. Another area of my research interest are molecular and cellular mechanisms responsible for tissue injury during inflammation, identification of therapeutic targets for resolution of inflammation and oral-systemic health connection.


5 students on Wednesday 25th November



Contact Dr Louise BelfieldLocation Peninsula Schools of Medicine & Dentistry- Dental SchoolArea of Research

Macrophages play a vital role in the orchestration of immune responses to pathogenic stimuli. My research interests lie in how normal macrophage differentiation and function may be altered in oral diseases, particularly periodontal disease and oral cancer. Current research projects include:

- Porphyromonas gingivalis induced macrophage effector functions and their influence on osteoclast activity in periodontal disease

- Development of an in vitro, 3-D model of the oral mucosa to study oral cancer and stromal cell interactions

- Development of an in vitro, 3-D model of the oral mucosa to study host-pathogen (biofilm) interactions.

Research type: Lab based project.Number of students and dates available


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