deducing local influence neighbourhoods in images using graph cuts ashish raj, karl young and...

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Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University of California at San Francisco, AND Center for Imaging of Neurodegenerative Diseases (CIND) San Francisco VA Medical Center email: [email protected] Webpage: http://www.cs.cornell.edu/~rdz/SENSE.htm http://www.vacind.org/faculty

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Page 1: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

Deducing Local Influence Neighbourhoods in Images Using Graph Cuts

Ashish Raj, Karl Young and Kailash Thakur

Assistant Professor of RadiologyUniversity of California at San Francisco, ANDCenter for Imaging of Neurodegenerative

Diseases (CIND) San Francisco VA Medical Center

email: [email protected]

Webpage: http://www.cs.cornell.edu/~rdz/SENSE.htmhttp://www.vacind.org/faculty

Page 2: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 2

San Francisco, CA

Page 3: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 3

Overview

We propose a new image structure called local influence neighbourhoods (LINs)

LINs are basically locally adaptive neighbourhoods around every voxel in image

Like “superpixels” Idea of LIN not new, but first principled cost

minimization approach Thus LINs allow us to probe the intermediate

structure of local features at various scales LINs were developed initially to address image

processing tasks like denoising and interpolation But as local image features they have wide

applications

Page 4: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 4

Local neighbourhoods as intermediate image structures

Pixel-level Neighbourhood-level

12

3

Region-level

Low level High level

Too cumbersomeComputationally expensive

Not suited for pattern recognition

Prone to error propagationGreat for graph theoretic and pattern recognition

Good intermediaries between low and high levels?

Page 5: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 5

Outline Intro to Local Influence Neighbourhoods How to compute LINs?

– Use GRAPH CUT energy minimzation Some examples of LINs in image filtering and denoising Other Applications:

– Segmentation– Using LINs for Fractal Dimension estimation– Use as features for tracking, registration

Page 6: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 6

Local Influence Neighbourhoods A local neighbourhood around a voxel (x0, y0) is the set of voxels “close” to it

– closeness in geometric space– closeness in intensity

First attempt: use a “space-intensity box”

Definition of , arbitrary Produces disjoint, non-contiguous, “holey”, noisy neighbourhoods! Need to introduce prior expectations about contiguity We develop a principled probabilistic approach, using likelihood and prior distributions

Page 7: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 7

Example: Binary image denoising

Suppose we receive a noisy fax:– Some black pixels in the original image

were flipped to white pixels, and some white pixels were flipped to black

We want to recover the original

input image

output image

Page 8: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 8

Problem Constraints

Our Constraints:1. If a pixel is black (white) in the original image,

it is more likely to get the black (white) label2. Black labeled pixels tend to group together,

and white labeled pixels tend to group together

original image

good labeling bad labeling(constraint 1)

bad labeling(constraint 2)

likelihood

prior

Page 9: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 9

Example of box vs. smoothness

Page 10: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 10

Example of box vs. smoothness

Page 11: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 11

A Better neighbourhood criterion1. Incorporate closeness, contiguity and smoothness assumptions2. Set up as a minimization problem3. Solve using everyone’s favourite minimization algorithm

– Simulated Annealing– (just kidding) - Graph Cuts!

A) Closeness: lets assume neighbourhoods follow Gaussian shapes around a voxel

Page 12: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 12

A) Closeness criterion in action

Page 13: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 13

B) Contiguity and smoothness

This is encoded via penalty terms between all neighbouring voxel pairs

p qG(x) = p,q V(xp, xq)

V(xp, xq) = distance metric

A) ClosenessB) Contiguity/smoothness

Define a binary field Fp around voxel p

s.t. 0 means not in LIN, 1 means in LIN

Bayesian interpretation: this is the log-prior for LINs

Page 14: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 15

Markov Random Field Priors

Imposes spatial coherence (neighbouring pixels are similar)

G(x) = p,q V(xp, xq)

V(xp, xq) = distance metric

pq

Potential function is discontinuous, non-convex Potts metric is GOOD but very hard to minimize

Page 15: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 16

Bottomline

Maximizing LIN prior corresponds to the minimization of

E(x) = Ecloseness(x) + Esmoothness(x)

MRF priors encode general spatial coherence properties of images

E(x) can be minimized using ANY available minimization algorithm

Graph Cuts can speedily solve cost functions involving MRF’s, sometimes with guaranteed global optimum.

Page 16: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

Graph Cut based Energy Minimization

Page 17: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 18

How to minimize E?

Graph cuts have proven to be a very powerful tool for minimizing energy functions like this one

First developed for stereo matching– Most of the top-performing algorithms for stereo rely

on graph cuts Builds a graph whose nodes are image pixels, and

whose edges have weights obtained from the energy terms in E(x)

Minimization of E(x) is reduced to finding the minimum cut of this graph

Page 18: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 19

Minimum cut problem

Mincut/maxflow problem:– Find the cheapest way to

cut the edges so that the “source” is separated from the “sink”

– Cut edges going from source side to sink side

– Edge weights now represent cutting “costs”

a cut C

“source”

A graph with two terminals

S T

“sink”

Page 19: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 20

Graph construction

Links correspond to terms in energy function Single-pixel terms are called t-links Pixel-pair terms are called n-links A Mincut is equivalent to a binary segmentation

I.e. mincut minimizes a binary energy function

Page 20: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 21

Table1: Edge costs of induced graph

n-links

s

tt-

link

t-link

Page 21: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 22

Graph Algorithm

Repeat graph mincut for each voxel p

Page 22: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 23

Examples of Detected LINs

Page 23: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 24

Results: Most Popular LINs

Page 24: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

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Filtering with LINs

Use LINs to restrict effect of filter– Convolutional filters:

– Rank order filter:

=

Page 25: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 26

Maximum filter using LINs

Page 26: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 27

Median filter using LINs

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EM-style Denoising algorithm

Likelihood for i.i.d. Gaussian noise:

Image prior:

Maximize the posterior:

Noise model: O = I + n

Page 28: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 29

Bayesian (Maximum a Posteriori) Estimate

Bayes Theorem:

Pr(x|y) = Pr(y|x) . Pr(x)

Pr(y)

likelihood

priorposterior

Here x is LIN, y is observed image Bayesian methods maximize the posterior probability:

Pr(x|y) Pr(y|x) . Pr(x)

Page 29: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

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EM-style image denoisingJoint maximization is challengingWe propose EM-style approach: Start with Iterate:

We show that

Page 30: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 31

Results: LIN-based Image Denoising

Page 31: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 32

Results: Bike image

Page 32: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 33

Table1: Denoising Results

Page 33: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

Other Applications of LINs

LINs can be used to probe scale-space of image data

– By varying scale parameters x and n Measuring fractal dimensions of brain images Hierarchical segmentation – “superpixel” concept Use LINs as feature vectors for

– image registration – Object recognition– Tracking

Page 34: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 35

Hierarchical segmentation

Begin with LINs at fine scale Hierarchically fuse finer LINs to obtain coarser LINS

segmentation

Page 35: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

How to measure Fractal Dimension using LINs?

How LINs vary with changing x and n depends on local image complexity Fractal dimension is a stable measure of complexity of multidimensional structuresThus LINs can be used to probe the multi-scale structure of image data

Page 36: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

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FD using LINs For each voxel p, for each value of x, n:

count the number N of voxels included in Bp

.CP1 CP2 ln x

ln N

extend to (x , n) plane

phase transition

Slope of each segment = local fractal dimension

Page 37: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 38

Possible advantages of LIN over current techniques

LINs provide FD for each voxel Captures the FD of local regions as well as global Ideal for directional structures and oriented

features at various scales Far less susceptible to noise

– (due to explicit intensity scale n which can be tuned to the noise level)

Enables the probing of phase transitions

Page 38: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 39

Possible Discriminators of Neurodegeneration

Fractal measures may provide better discriminators of neurodegeneration (Alzheimer’s Disease, Frontotemporal Dementia, Mild Cognitive Disorder, Normal Aging, etc)

Possibilities:– Mean (overall) FD -- D(0)– Critical points, phase transitions in (x, n) plane– More general Renyi dimensions D(q) for q ¸ 1– Summary image feature f() D(q)– Phase transitions in f()

Fractal structures can be characterized by dimensions D(q), summary f() and various associated critical points

These quantities may be efficiently probed by the Graph Cut –based local influence neighbourhoods

These fractal quantities may provide greater discriminability between normal, AD, FTD, etc.

Page 39: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

CIND, UCSF Radiology 40

Summary

We proposed a general method of estimating local influence neighbourhoods

Based on an “optimal” energy minimization approach

LINs are intermediaries between purely pixel-based and region-based methods

Applications include segmentation, denoising, filtering, recognition, fractal dimension estimation, …

… in other words, Best Thing Since Sliced Bread

Page 40: Deducing Local Influence Neighbourhoods in Images Using Graph Cuts Ashish Raj, Karl Young and Kailash Thakur Assistant Professor of Radiology University

Ashish RajCIND, UCSF

email: [email protected]

Webpage: http://www.cs.cornell.edu/~rdz/SENSE.htmhttp://www.vacind.org/faculty

Deducing Local Influence Neighbourhoods in Images Using Graph

Cuts