Team VOD

Vaso-Occlusion DetectionMatthew Plaisance

Madison McLeod

Francois Decuir

Uttam Dhodary

Deliverable

• Week 6 deliverable• Become familiar with sickle cell disease before the

immersion at St. Francis• Conduct research on sickle cell disease

Research

Treatment• Fluid therapy• Oxygen Therapy• Blood transfusions• Hydroxyurea

Research

How it occurs• Obstruction of a vessel by sickled erythrocytes.• Damaged endothelial walls of blood vessels• Leukocytes and platelets reducing the availability

of chemicals that dilate the vessel

Research

Frequency of occurrence• Varies from patient to patient• Anywhere from once a year to once a month

Research

Current methods of detection• X-Rays• MRI• CT

Research

Size of area affectedThe size of the area that can be affected by vaso-occlusion is unknown

Research

• Time it takes to clear Varies from patient to patient

• Can last from hours or days to weeks• Sustain episodes of vaso-occlusion can cause• Multiple Organ Failure• Bone Pain• Splenic Crisis

Research

Physiological implication of occurrence• Pain• Swollen hands and feet• Swollen spleen• Stroke• Pulmonary Hypertension• Abnormal Chest X-Ray• Low O2 levels• Infections

Deliverable

• Decide on a configuration for the arm band using a decision matrix

Decision Matrix Armband Configuration

Deliverable

• Construct a decision matrix to determine which type of LEDs and photodiodes to buy

Decision Matrix 780 nm

Decision Matrix 780 nm

• Results

Decision Matrix 940 nm

Decision Matrix 940 nm

Decision Matrix 660 nm

Decision Matrix 660 nm

Decision Matrix Photodiode

Decision Matrix Photodiode

Construct an Armband

LEDIR LEDPhotodiode

Construct an Armband

• Black nylon cloth• Adjustable for

varying arm size• 3 Emitters• 1 Detector

Pulse Oximeter Circuit

• Parts• Multivibrator(CD4047BE)• Binary counter (MM74HC393N)• 3-to-8 bit decoder (74F138PC)• Operational Amplifiers (LM324N and LM741CN)• Sample and Hold Chips (LF398N)• Data Acquisition (DAQ) (NI USB-6009)• Voltage Regulator (KMT15-51515)• LEDs (660 nm, 805 nm, 940 nm)• Photodiode (S6931-01)

Pulse Oximeter Circuit

Multivibrator

Binary Counter

Decoder

Inverter

QuadrupleOp-amp

Sample and Hold

Operational amplifier

Voltage Regulator

LabView

LabView