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National Institutefor Public Healthand the Environment
ACROPOLIS
Jacob van Klaveren
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• History and starting point
• Aims of ACROPOLIS
• Main overview (WPs)
• Project organisation
Contents
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Starting point for ACROPOLIS
• An electronic platform for pan-European exposure modelling as created in SAFE FOODs
• Existing models like EuroPOEM, CONSEXPO, MCRA, IPRA
• EFSA opinions on cumulative risk assessment
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Aims of ACROPOLIS
• Improve cumulative exposure and hazard assessment
• Create new models for aggregated exposure assessment
• Setting up new toxicological testing for identifying synergistic effects
• To integrate cumulative and aggregated risk models
• Improve understanding of methodology of different stakeholders
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NLIT
SE
0.0
0.2
0.4
0.0 0.7 1.4 2.2 2.9 3.6-0.7-1.4-2.2-2.9-3.6
UK
MCRA-software
E-platform of databases (food and residue)
CZ
FR
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van der Voet & Slob (2007)
Toxicological BMD modeling
• Critical effect dose
• Number of experiments
• EFSA opinion BMD modeling
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Aggregated exposure assessment
Combine leading models in Europe(MCRA, EUROPOEM, ConsEXPO)
Case studies with two or more different routes of exposure
Validation of the model
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Mixtures and internal does
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Model and software development
Internet compatible model and data
• Test and justify underlying assumptions
• Scientific sound
• Reproducible and transparent (reference manual MCRA openly available)
• Include quantitative uncertainty analyses
• Data in connection with model available for stakeholders (including industry). Not the raw data.
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Risk based on Margin of Exposure
Be aware that safety factors are also modelled!
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Dissemination
• Training
• Stakeholder conferences
• Website and folders
• Scientific paper on stakeholders attitudes towards cumulative and aggregated exposure levels
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Stakeholders
• Industry
• Regulators
• EFSA and risk assessors at national level
• Risk Management
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ACROPOLIS PROJECT STRUCTURE
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External advisory board
EFSA (Luc Mohimont)
DG Sanco (Bas Drukker)
EPA (D. Miller will be asked)
Coordinator
- Further elaboration on case studies
- Overview needs of DG Sanco (risk managers)
- Fine-tune research needs of EFSA
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Scientific Advisory Board
WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof W. Steurbout, dr. D Hamilton), Greenpeace (dr. M. Krauter), Industry (Bayer, BASF, Syngenta)
- To convey relevant issues from a stakeholders perspective
- To bring in relevant expertise (e.g. from USA)
- Emerging issues in pesticide risk assessment
- Implementation of project outcomes at EU level
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Deliverables and milestones
A deliverable is a result that has to be produced
(e.g. a paper, a model, or any other result)
A milestone is something that you have to achieve before you can continue
All have to be done in time and as promised
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Project Management Team
• A representative of each beneficiary
• Stop-go decisions
• Contingency plan (coordinator)
• Financial issues as far as they deviate from proposal
• Gender issues
National Institutefor Public Healthand the Environment
MCRA model : https://mcra.rikilt.wur.nl/ EFSA opinion : EFSA website RIKILT report
Thanks for your attention!