ANTI-AGING
citrustemTM
Orange stem cells
Organizes the inner structure of the skin for a younger appearance
www.provitalgroup.com
Orange stem cells. Organizes the inner structure of the skin for a younger appearance
citrustemTM
What are plant stem cells?They are undifferentiated cells that have the capacity to regenerate the whole plant.
Its use is a very sustainable way to obtain the benefits of plants because you don’t need to cultivate them, no land, no pesticides, less water is needed, and they are absolutely traceable and available at convenience.
citrustemTM, obtained from orange stem cells with anti-aging effect, is the first
launching of Provital Stem Cells Collection
Skin aging and orderAs skin ages, collagen and elastin fibers, that form the extracellular network, become disordered, unstructured and sparse.
The dermis loses density and skin shows aging signs:
The microrelief structure becomes more anisotropic resulting in a loss of softness and velvety touch.
The skin elasticity decreases and wrinkles appear.
Keeping the skin inner structure organized is essential for a younger
looking skin
citrustemTM
Organizes and redensifies the dermis structure.Restores the extracellular network improving cells adhesion.Recovers the quality of a young skin.
...The architect of skin
Orange stem cells
Cell Treatment % vs. Control
P17-NHDF
100
108
111
123
Control
citrustemTM (0.03%)
citrustemTM (0.1%)
citrustemTM (0.3%)
P17-NHDF
P17-NHDF
P17-NHDF
P17-NHDF
ANTI-AGING
In vitro efficacy
All these genes are related to quality and structure of extracellular matrix:
Improvement of extracellular matrix structure
Elastin: the most important protein for good skin appearance.
Collagen VI: cell adhesion properties and a diverse range of extracellular matrix protein binding activities.
ADAM metallopeptidase: facilitates collagen function and assembly.
Gene % vs. Control
ADAM metallopeptidase with thrombospondin type 1 motif, 2
Elastin
245
251
Collagen, type VI, alpha 1 239
TGK is an essential enzyme for the epidermis. An increase in its synthesis means better assembly and organization of epidermal structures:
Stimulation of TGK production in the epidermis
Aged fibroblasts increase their proliferation capacity with citrustemTM.
The synthesis of collagen and other key elements of the extracellular matrix grow.
Stimulation of fibroblasts proliferation
citrustemTM
(0.03%)CONTROL
TGK
INC
REA
SE
VS. C
ON
TRO
L
600500400300200100
0
citrustemTM
(0.1%)citrustemTM
(0.3%)
KERATINOCYTE CULTURES
In vivo efficacy
The stratum corneum is more cohesive, with fewer scales.
The skin is smoother and recovers its velvety touch.
Desquamation regulation
Product T0 % increase
5.95
17.50*
11.6*
4.20
4.00
Placebo
citrustemTM (3%)
citrustemTM - placebo
T56
4.45
4.70
The improvement on the microrelief is the visible result of an organized and better structured dermis.
Microrelief improvement
Product T0 % increase
0.09
10.15*
10.1*
0.633
0.613
Placebo
citrustemTM (3%)
citrustemTM - placebo
T56 - T0
0.001
0.062
T56
0.634
0.675
T0 T56
With citrustemTM, the skin will recover the biological elasticity that had 12 years ago.
Biological elasticity Ur/Uf (R7) by Cutometer®
(*) statiscally significant
20 women between 41 and 55 years old, who used a 3% formula of citrustemTM, compared with a placebo formula. Applied twice a day for 56 days.
Viscous liquidWhite - pale yellow color
Aqua (Water), Sodium Hydroxide (10%)E
Glyceryl Caprylate, Glyceryl UndecylenateD
Bentonite, Xantham GumAcrylates/C10-30 Alkyl Acrylate CrosspolymerSimmondsia Chinensis (Jojoba) Seed Oil
C
B CyclopentasiloxaneOleyl ErucateDimethicone, Polysilicone-11Oleth-20Tocopherol
Deion Ster. WaterGlycerinAqua (Water), Citric Acid (10%)Pentylene Glycol
A
INCI / PCPC
RECOMMENDED DOSE
SOLUBILITY
APPEARANCE
2 - 4 %
Soluble in aqueous solutions
citrustemTM, obtained from orange stem cells, organizes, restores and redensifies the dermis structure to recover the quality of a young skin
PROPERTIES
Orange stem cells. Organizes the inner structure of the skin for a younger appearance
citrustemTMANTI-AGING
cosmetic applications
Technical specifications Formulation
• Global anti-aging lines• Cosmetic products for skin rejuvenation• Anti-aging preventive cosmetics• Cellular regenerator• Intensive facial treatments• Treatment make-up
citrustemTM 72800 Ageless Restructuring Serum
Parfum (Fragrance)G
citrustemTMF
0.68
0.90
1.000.304.00
8.001.002.003.000.20
69.123.000.152.50
% (w/w)
0.15
4.00
V01-2013