Ecole doctorale Biologie-Médecine

Programme 2016-2017

CancerSeptember 2016

• Prof. Dominique Belin, Dépt de Pathologie et immunologie,

• Prof. A.-­P. Sappino, Division d’Oncologie

• Proto-­oncogenes network (Tyrosine Kinases Abl, PML-­RAR, Ras)

• Tumor suppressor genes (p53, telomerase). Cell cycle (Retinoblastoma, cyclinsand cyclin inhibitors)

• Colon cancer (APC & familial polyposis, mismatch repair genes) and angiogenesis, Sonic Hedgehog and pancreas.

• Virus, bacteria and cancer. Metabolism, hepatocarcinoma and intestinal microbiota.

• Dates :

Tuesday 6, 13, 20 and 27th of September 2016, from 2.00 pm to 5.30 pm

MetabolismOctober 2016

ØORGANISERS: Mirko TRAJKOVSKI (MT)& Pierre MAECHLER (PM)

Thierry BRUN (TB) & Roberto COPPARI (RC) &

Valérie SCHWITZGEBEL (VS) & Michelangelo FOTI (MF)

ØFriday 07.10.2016 at 9.30am

ØSession 1: Human and mouse anatomy in the context of metabolism (2.5h, MT)

ØWednesday 12.10.2016 at 2pm

ØSession 2: The endocrine pancreas (3.5h, PM + TB)

ØTuesday 18.10.2016 at 2pm

Ø Session 3: Fat metabolism (3.5h, MT)

ØFriday 21.10.2016 at 1.30pm

Ø Session 4: Liver, muscle and brain (3h, RC +MF)

ØMonday 31.10.2016

ØSession 5: Clinical Overview on the Metabolic diseases. (VS)

Ø + oral exam by (MT) + (PM)

Cardiovascular Physiology and Disease January – February 2017

• Dr C. MONTESSUIT, Division of Cardiology;; Prof. Brenda KWAK, dept of Pathology• & Immunology, and Division of Cardiology;;• Dr Marie-­Luce PIALLAT, Dept of Pathology & Immunology;; • Dr Georg EHRET, Division of Cardiology.

• Tuesday January 10th 2017 : Christophe MONTESSUIT• Basics of heart physiology (lecture)• Tuesday January 17th 2017 : Christophe MONTESSUIT• Experimental models in cardiac research ( short lecture & TP Langendorff perfusion) • Tuesday January 24th 2017 : Brenda KWAK • Basics of Vascular physiology (lecture) • Tuesday January 2017 31rst : Brenda KWAK • Atherosclerosis (short lecture & TP histo-­pathology)• Tueday February 7th 2017 :Marie-­Luce PIALLAT • Cardiovascular pathology illustrated (short lecture & TP anatomo-­pathology)• Tuesday February 21rst 2017 : Georg EHRET • Cardiovascular Genomics

• TUESDAY 28 FEBRUARY 2017 : ORAL EXAM

• The module will take place upon a minimum participation of 5 students from 14 to 17h.

BACTERIOLOGY(from classical bacterial genetics

to modern medicine)

February 2017

• Profs. Patrick LINDER & Patrick VIOLLIER, Dépt of Microbiology & Molecular Medicine• Teachers are : Patrick VIOLLIER(PV), Thilo KOEHLER(TK), William KELLEY(WK), Patrick • LINDER(PL), Adriana RENZONI (AR) and proposed subjects are ( subjects may change, • accoording to speakers we will be able to attract for the seminars) :

• Two Component Systems, TCS (WK)• Toxin/antitoxin systems, (AR)• Cell envelope, peptidoglycan / cell division (PV)• Secretion, motility, conjugation (PV, TK)• Persistence, dormancy (PV, PL)• SOS, repair (PL)• Quorum sensing, single cell behavior (TK)

• The course will be held on Monday 30 January 2017, 06 February 2017, 13 February 2017,• 20 February 2017 from 14h to 16h. / ROOM A09.2525. • 27 February 2017, from 14h to 18h / EXAM / ROOM E07.3347 .• Discussion of a classic paper and a recent paper, one review for understanding.• The 4 courses will be combined with a Monday seminar

Medical GENETICSMarch 2017

• Prof. S. E. Antonarakis, Département de Médecine Génétique et Développement

• Prof. S. E. Antonarakis invites you to a first meeting on Friday 3rd of March 2017, from 2pm to 4pm, room E09.2753.A (ex 9078), 9e floor CMU.

• Courses from 2pm to 4pm, room E09.2753A, 9e floor on the followingdates :

• March 3, 2017 : Introduction Prof. S. E. Antonarakis

• March 7, 2017 : Genetic Variation Prof. E. Dermitzakis

• March 10, 2017 : Mendelian Disorders Prof. S. E. Antonarakis

• March 14, 2017 : Cytogenetics Dre F. Bena

• March 17, 2017 : Technology Dr. M. Guipponi

• March 21, 2017 : Comparative Genomics Prof. E. Zdobnov

• March 24, 2017 : Complex Disorders / Traits Prof. Dermitzakis

• March 28, 2017 : Epigenetics Prof. R. Murr

• March 31, 2017 : EXAM Prof. S. E. Antonarakis

Statistics course March-May 2017

• PD Christophe COMBESCURE, Service d’épidémiologie clinique, Direction médicale et qualité, HUG

• Prof. Thomas V. PERNEGER, Service d’épidémiologie clinique, Direction médicale et qualité, HUG

• The aim of this course is to provide to the students a general knowledge of statisticalinference, methods to describe data, to test hypotheses and to characterize associations between two variables. In addition to the theory, students will put into practice statisticalmethods with a statistical software and will conduct a critical appraisal of the statisticalmethodology in a selection of published articles.

• CONTACT : Thomas PERNEGER & Christophe COMBESCURE.The course will close with a maximum of 14 participants

Sessions(Room E.09.2753.A from 2.15pm to 5.15pm):

• Descriptive statistics and introduction to GraphPad (09.03.2017)• Statistical inference and confidence intervals (16.03.2017)• Basic principles of statistical hypothesis testing (06.04.2017)• Common statistical tests (20.04.2017)• Statistical power and sample size (27.04.2017)• Correlation and regression models (04.05.2017)• Reporting statistical analyses / Exam (11.05.2017)

CELL INTERACTION March – April 2017

• Dr. B. WEHRLE-­HALLER, Dépt. Physiologie Cellulaire & Métabolisme / • contact: bernhard.wehrle-­haller@unige.ch• Dr. S. Garrido-­Urbani, Dépt .de Pathologie et Immunologie;; Dr. L. Fontao, Dépt. de Neurosciences

Clinique & Dermatologie;; Dr. P. Soulie, Dépt. Physiologie Cellulaire et Métabolisme ;; Prof. Marc Chanson, Dépt. Physiologie Cellulaire et Métabolisme;; Prof. W. Kelley, Dépt. de Microbiologie.

• The course aims to introduce students to the biology of cell interaction, from pathogen-­host to cell-­cellcommunication, and from molecular and genetic factors to tissue function and disease. The course involves attending 6 sessions held in a three –week period, guided by experts in their respective fields.

• Each session lasts no more than 2 hours and is focused on discussing current knowledge and techniques used in studying cell interactions, using as reference pre-­assigned research articles relevant to the chosen topics (see below). It is essential for students to read the material before class and to actively engage in the discussions. Student evaluation is achieved through a 30 minutes oral examination and the format will be explained during the first session.

• « Adhesion, Integrins and Signaling », Dr. B. Wehrle-­Haller• « Tight Junctions : a Dynamic Fence », Dr. S. Garrido-­Urbani• « Epithelium-­SubstrateAdhesion », Dr. Lionel Fontao• « Direct Communication : Gap Junctions », Prof. M. Chanson• « From Cells to Tissues », Dr. P. Soulie• « Bacterial Interactions », Prof. W. Kelley

• SCHEDULED DATES: Friday 24.03.2017 / Wed. 29 March 2017 / Friday 31 March 2017/ • Wed. 5 April 2017 / Friday 07.04.2017 /12 April 2017 from 14pm to 16pm• (CMU/Room 5000)

• ORAL EXAM : for the 26 or 27 April 2017

HISTOLOGYApril-May 2017

• NB: THIS MODULE IS NOT OPENED TO MD-­PhD STUDENTS

• Number of students : 18 max

• Contact : Dre Marie-­Luce BOCHATON-­PIALLAT, (MLBP) Dpt of Pathology and Immunology

• Prof. M. Foti (MF) Dpt of Cellular Physiology and Metabolism;; Dre P. Soulié (PS) Dpt of Cellular Physiology and Metabolism;; Dre J. Perrin-­Simonnot (JPS) Dpt of Cellular Physiology and Metabolism;; Dre. S. Clément(SC) Dpt of Clinical Pathology;; Dr J-­C Tille(JCT) Dpt Clinical pathology

• HISTOLOGY (2 sessions): study of primary tissues(epithelium, connective tissue, muscles, vessels, nervous tissue, lymphoid tissue) and some representive organs.

• HISTOPATHOLOGY (2 sessions): study of the main concepts of general pathology (cell death: necrosis and apoptosis, inflammation, tissue repair, tumor) and some representive organs with typicalpathological alterations.

• HISTOLOGY AND RESEARCH (2 sessions): study of different microscopic approaches (optical, immuno-­fluorescence, confocal and electron microscopy) and their applications in research(autoradiography, in situ hybridization, immunohisto/cytochemistry, live imaging).

• NB : PhD students are required to attend all sessions.

• Introduction : MLBP/PS – Monday April 24, 2017

• Session 1 : PS/JPS-­Tuesday April 25, 2017

• Session 2 : PS/JPS -­ Friday April 28, 2017

• Session 3 : JCT-­Thursday May 4, 2017

• Session 4 : JCT-­Monday May 8, 2017

• Session 5 : MLBP/SC-­Wednesday May 10, 2017

• Session 6 : MF-­Friday May 12, 2017

• ORAL EXAM : will be organized from Thursday May 18 to Wednesday May 24, 2017.

VIROLOGYMay-June 2017

• Dr. D. Garcin, Dépt de Microbiologie et Médecine Moléculaire

• Virus cycle (entry, replication, budding…)

• RNA viruses : genetic variability, quasi-­species, adaptation and evolution..

• Anti-­viral innate immunity, detection, interferon system and viral counter measures.

• An introductory course in each topic, articles to read and present, discussions, criticalanalysis (sort of «battle» over the article J).

• 4 sessions of 3 to 4 hours plus one session for the exam.

• The course will be held on:

• Monday May 8 2017 : Introduction virology–introduction viral cycle.

• Monday May 15 2017: Viral cycle (presentation 3 publications) – Introduction quasi-­species

• Monday May 22 2017: Quasi-­species (presentation 3 publications)– Introduction innate immunity

• Monday May 29 2017 : Innate immunity (presentation 3 publications)

• Monday JUNE 12 2017 :EXAM

• Location : Room MIMO 7172, 7ème floor from 2pm to 6pm

Developmental BiologyMay-June 2017

• Prof. P. Herrera, Dr. F. Thorel (dépt. de médecine génétique & développement CMU).

• M.N. Steiner, Service de Transgénèse (cours pratique sur la production de souris transgéniques).

• Transgenics and mouse molecular genetics

• Sex determination

• Regenerativemedicine : ES and IPS cells;; cell reprogramming

• Pancreas developmentand regeneration

• Courses will be held on, in English,

• EveryWednesday of

• May (31.05.17) & June (07/14/21.06.2017);; room 9112C, from2pm to 5pm.

• (4 sessions)

• EXAM DATE TO CONFIRM

• The course will only take place with a minimum of 4 and a maximum of 12 students.

• Attendance at all sessions ismandatory