excitatory synapse - docs.abcam.comdocs.abcam.com/pdf/biochemicals/excitatory-synapse.pdf ·...
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Ca2+ channel
Neurotransmitters
PiccoloBassoon
Actin
Actin
Synapticvesicle
Early endosome
ClathrinCa2+
Rab3
APC
PRA1
RIM
Eph
rinA
Eph
A
Eph
rinB
Eph
B
LAR
Net
rinG
NGL
Neu
rexi
nN
euro
ligin
LRR
TM
nCad
herin
SNAP25 SNAP25
Syntaxin SyntaxinSySMUNC18
MUNC13
SyntaxinS
NMUSynaptobrevin
Syn
deca
n
SSyntaxinSynaptobrevin
nCad
herin
CN
RC
N R
Syn
Cam
Syn
Cam
CASK
VelisMINT
PRA1
mGluR
ACh R
Kainate R
nnel
AMPA RNMDA R
Axonalguidance
Actinreorganization
Spinogenesis Synapse development,function, and plasticity
Neuronalsurvival
Receptortrafficking
Synapticsignaling
mGluR
PSD95
PSD95
PSD95
Fz RWNT
Homer
Homer
Cortacin
ProSAP/Shank
GSK3 β
Spectrin
AXIN
β CatAPC
Gi/o
Ca2+
Ca2+ channel
GDP
GTP
GTP
GDPGTP
GDP
Ca2+
UbUb
Ub
Ub
Ca2+
Ca2+
Ephexin1
Src
Vav2
Syntenin
TiamKalirin7
Src
CaM
Calcineurin
CaM
Src
2+
AKAP79/150
PKAAAA Calcineurin
AKAP79/150Src
PKAU
AAA Calcineurin
PP1
PRho
GRho
PRac
GRac
Kalirin7 CaMKII
DPRas
GRas
RASGRFNFAT
NFκB
CaMKKCaMKIBetaPIX
RAF
MEK
ERK
p190RhoGAP
GK
AP
/S
APA
P
A
MaGUK
Arc
b
SynG
ap Arc
Ub
CS
P α
SVOP
Rab5
/3A/
3B/3
C
SO
PSVO
SV2 (2A,2B,2C)
A/3B
SynapsinS
SynaptotagminSynptogyrin
SynaptobrevinSynptophysint
SCA
MPVti1a β
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Excitatory synapse
Discover more at abcam.com/biochemicalsProduced in collaboration with Paul L. Greer, Ph.D., Harvard Medical School
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Excitatory synapse related products from Abcam Biochemicals
Discover more at abcam.com/biochemicals
Product Biological description Purity Product code
Muscarinic Acetylcholine Chloride Endogenous neurotransmitter active at acetylcholine receptors - ab1204694-DAMP Muscarinic receptor antagonist >98% ab120144Pirenzepine dihydrochloride Selective M1 receptor antagonist >99% ab120153
Nicotinic (±)-Anatoxin A fumarate Potent nicotinic agonist >98% ab120013α-Bungarotoxin Subtype-selective α7 nAChR antagonist >99% ab120542Methyllycaconitine citrate α7-nicotinic receptor antagonist >98% ab120072PNU 282987 Selective α7 nAChR agonist >99% ab120558(+)-Tubocurarine ACh receptor antagonist >99% ab120073Vecuronium bromide Competitive nicotinic acetylcholine receptor (nAChR) antagonist - ab120536
Glutamate: broad spectrum/non-selective DL-AP4 Broad spectrum glutamate antagonist >99% ab120001L-Glutamate Excitatory neurotransmitter >99% ab120049Ibotenic acid Excitotoxic agonist >98% ab120041Kynurenic acid sodium salt Endogenous ionotropic / nicotinic antagonist; water soluble >99% ab120256
Glutamate: mGlu AMN082 dihydrochloride mGlu7 agonist >99% ab120011L-AP4 Selective group III mGlu agonist >99% ab120002(R,S)-CHPG Selective mGlu5 agonist >98% ab120039Cinnabarinic acid Endogenous mGlu4 selective agonist >98% ab120506(S)-3,5-DHPG Selective group I mGlu agonist >99% ab120007LY 341495 Potent, selective group II antagonist. Group III antagonist at higher concentrations >98% ab120199LY 367385 mGlu1a antagonist >99% ab120067(S)-MCPG Group I / II mGlu antagonist >98% ab120059mGlu Agonists Kit A collection of 7 agonists and modulators for a range of mGlu receptor subtypes - ab120321
Glutamate: mGlu (continued)mGlu Antagonists Kit A collection of 6 antagonists for mGlu receptor subtypes - ab120322MMPIP mGlu7 allosteric antagonist >98% ab120245MPEP hydrochloride Potent, selective mGlu5 antagonist >99% ab120008YM 202074 mGlu1 antagonist >98% ab120293
Glutamate: NMDA D-AP5 NMDA glutamate site antagonist >99% ab1200037-Chlorokynurenic acid sodium salt NMDA receptor glycine site antagonist; water soluble >99% ab120255(R)-CPPene Potent competitive NMDA antagonist >98% ab1202325,7-Dichlorokynurenic acid sodium salt NMDA receptor glycine site antagonist; water soluble >99% ab120254(+)-MK 801 maleate Non-competitive NMDA antagonist >99% ab120027NMDA Excitotoxic amino acid >98% ab120052UBP141 GluN2D (formerly NR2D) antagonist, with some subunit selectivity >98% ab120193
Glutamate: AMPA&Kainate (S)-AMPA AMPA agonist >98% ab120005CNQX disodium salt AMPA / kainate antagonist (water soluble) >99% ab120044GYKI 53655 hydrochloride Non-competitive AMPA / kainate receptor antagonist >99% ab120490Ionotropic Agonists Kit A collection of 8 agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. - ab120323Kainic acid Prototypic kainate receptor agonist >99% ab120100NBQX disodium salt AMPA / kainate antagonist (water soluble) >98% ab120046
Calcium channel ω-Agatoxin IVA Ca2+ channel blocker (P and Q type) >95% ab120210ω-Conotoxin GVIA Ca2+ channel blocker (N type) >96% ab120215SNX 482 R-Type Ca2+ (Cav2.3) channel blocker >96% ab120259Verapamil hydrochloride L-type Ca2+ channel blocker >99% ab120140
Pitstop 2™ clathrin inhibitor - World exclusive! (ab120687)
Novel, selective, cell membrane permeable clathrininhibitor. Competitively inhibits clathrin terminaldomain to selectively inhibit clathrin mediatedendocytosis (IC50 = 12 μM for inhibition ofamphiphysin association of clathrin terminal domain).Interferes with receptor mediated endocytosis, entryof HIV and synaptic vesicle recycling.
Featured products
Product Biological description Purity Product code
RuBi-Glutamate: A novel light-sensitive,caged ligand (ab120408)
• Activated by visible wavelengths of light• No need for harmful UV light or expensive quartz optics• Fast uncaging speeds - single photochemical step
Releases glutamate after one- or two- photon excitation.Can be used at low concentrations. Enablesphotoactivation of neuronal dendrites and circuits.Other caged compounds include RuBi-GABA (ab120409),RuBi-nicotine (ab120450) and RuBi-AP (ab120410)
Fluorescent false neurotransmitter - highlyefficient optical tracer of dopamine (ab120331)
Fluorecsent false neurotransmitter (FFN) acts as asubstrate for the synaptic vesicle monoamine transporter.
• Resolution seen at individual synaptic level• Concentration required does not interfere with
normal synaptic function• Compatible with GFP-based tags and other
optical probes