CLINICALRESEARCH

TRANSLATIONAL RESEARCH

Genomics & Proteomics

Bioprocessing

Chemical Synthesis

BIOTECHNOLOGYHEALTHCARESERVICES & DELIVERY

Molecular & Cell Biology

Bioengineering &Nanotechnology

Computational Biology

Industry Sectors

Industry Sectors

Bioimaging

Cohort Studies

Biomarkers

Stem

cells

Drug D

iscove

ryPHARMACEUTICALS MEDICAL TECHNOLOGY

Biomedical Cluster Map

MEaT = Medical Enginering and TechnologyIMCB = Institute of Molecular & Cell BiologyGIS = Genome Institute of SingaporeBTI = Bioprocessing Technical InstituteIBN = Institute of Bioengineering and NanotechnologyBII = Bioinformatics InstituteCMM = Centre for Molecular MedicineSICS = Singapore Institute for Clinical SciencesSBIC = Singapore Bioimaging Consortium

SIgN = Singapore Immunology NetworkSSCC = Singapore Stem Cell Consortium STN = Singapore Tissue NetworkSCS = Singapore Cancer SyndicateSCCS = Singapore Consortium of Cohort StudiesDPF = Data Privacy FrameworkBMS IF = Biomedical International FellowshipCSI = Clincian Scientist InvestigatorshipIRBs = Institutional Review Boards

Mission-oriented BENCH

INDUSTRY

Co-investment, VC funding

RISC grants, infrastructure, tax breaks

Pharma MEaT Biotech

Biologics (c

ells / v

accines)

Med tech

/ devic

es

Drug discove

ry & devt

Singapore Clinical Trials

• IMCB, GIS, BTI• IBN, BII, • CMM, SICS

Research Institutes

• SBIC• SSCC

• SIgN• Biomarkers

Research Consortia

Set up by A*STAR / BMRC

BEDSIDE

Clinical Research Programmes• Focus, strategyHuman Capital• Development, recruitment

Infrastructure• For Clinical Trials

Regulatory Framework• IRBs

DPF Office

MBBS PhD / BMS IF / CSI awards

Translational / Investigational

Medicine NMRC / HSA

Clinical Trials Overseas Clinical Trials

STNSCS

SCCS

Academic BENCH

NUS, NTU

ClinicalBIOMEDICAL RESEARCH

TranslationalBasic

Singapore Health Services• Singapore General Hospital• National Cancer Centre• National Heart Centre• Singapore National Eye Centre• KK Women and Children’s Hospital• National Neuroscience Institute

National Healthcare Group• National University Hospital• The Cancer Institute• Tan Tock Seng Hospital• Communicable Disease Centre• National Skin Centre

Extramural Grants

− Singapore Cancer Syndicate− Singapore Bioimaging

Consortium − Singapore Stem Cell

Consortium− Singapore Immunology

Network− Member of Intl Cancer

Biomarker Consortium

Singapore Institute for Clinical Sciences (SICS)

• Develop programmes in Translational Clinical Medicine

• Develop critical resources:- Singapore Tissue Network- Singapore Consortium of

Cohort Studies

• Develop Clinician Scientists:- Clinician Scientist

Investigatorship (CSI) Awards- PhD training for medical

doctors- Biomedical International

Fellowships

Ministry of Health HQ- Ethical regulations/framework for

clinical research e.g. IRBs

National Medical Research Council- Clinical research strategy- Grant management- Manpower development

Health Sciences Authority- Evaluation capabilities for new

technologies

Research Institutes

• Institute of Molecular & Cell Biology

• Genome Institute of Singapore

• Institute of Bioengineering & Nanotechnology

• Bioprocessing Technology Institute

• Bioinformatics Institute

UNIVERSITIES

Institute of Medicinal Biology (IMB)

− Singapore Oncogenome Group− Regenerative Medicine− Epithelial Biology

Consortia

SICS @ Kent Ridge- Genetic Medicine- Virology/Infectious Diseases

SICS @ Outram(2008-2010)− Cardiovascular Diseases− Eye Diseases

A*STAR Biomedical Research Council Ministry Of Health

Bench to Bedside to Industry Cycle

PHARMAINDUSTRY

BENCHKey performers:

research institutes, universities

BEDSIDEKey performers:

hospitals, specialist centres

Grow health services, public health research

Build critical mass of human capital , supernumerary to clinical service needs

Establish flagship programmes from bench-to-bedside (heart/ metabolic, neuro, cancer, eye, infectious disease)

Interaction strengthened by new entities arising from hospital-medical school partnerships

Develop strong investigational med capability

Be preferred site for early phase

clinical trials in Asia

Individual Research Grants

Exploratory/ Developmental Grants

Translational & Clinical Research Grant

Programmatic Grants

Strategic/ Programmatic

Investigator-led Research

Research Grants[Support research projects/ programmes]

Overall Grant/ Support Framework

Infrastructure[Devt support]

Strategic Research Infra[Research building, investigational med unit, animal facility]

Academic Research Organisation

Singapore Translational Research Investigatorship

Clinician Scientist Award

Talent Support[Salary support + research grants]

Incr

easi

ng s

enio

rity

and

supp

ort

Healthcare Research Scholarship

Development of Translational/Clinical Research (TCR ) Human Capital

A new pool of physicians scientists freed of clinical service obligations

Singapore Translational Research Investigatorship Award.

International and Singaporean Senior Physician Scientist awards

(15 per year)Similar to Howard Hughes Medical Institute award –

full salary and lab support for 5 years)

Clinician Scientist Award.

Young Singapore Physician Scientist awards (70 per year)

Full salary and an internationally competitive research grant for 3 years

Bench to Bedside Research Funding Programs

Funds for teams of basic and clinical scientists

Translational/Clinical Research (TCR) flagship Awards

Targeted research programs in each of the following therapeutic areas: cancer, neuroscience, cardiovascular/

metabolism, infectious diseases, opthalmology –

S$25 M over 5 years for each program

Infrastructure to support TCR

*Academic Medical CentersAMCs established through union of

medical school and tertiary hospital under a common governance

*Investigational Medicine UnitsClinical research units (2)

for early in man clinical investigation – S$20 M each

*Singapore Clinical Research InstituteTrans-Singapore clinical research

organisations to support therapeutic trials sponsored by pharmaceutical companies

– S$6 M per annum

Institute of Medical Biology (IMB)

Executive Director: Prof Birgit Lane

IMB studies the mechanisms of human disease in order to discovernew and effective therapeutic strategies for an improved quality of life.

Translational ResearchFrom Bench to Bedside

Research Areas:• Singapore Oncogenome Project• Papilloma Virology• Epithelial Biology• Developmental and Regenerative

Biology• Regenerative Medicine• Stem Cell Biology• Mesenchymal Stem Cells

Singapore Institute for Clinical Sciences (SICS)

Executive Director: Prof Judith Swain

Using innovative approaches and technologies to enable the efficient and effective study of human health and diseases

Translational ResearchFrom Bench to Bedside

Research Areas:• Genetic Medicine• Hepatic Diseases• Metabolic Diseases

SICS is headquartered at Biopolis, with labs both at: • The Brenner Centre for Molecular Medicine • Nanos @ Biopolis

Experimental Therapeutics Centre (ETC)

Chief Executive Officer: Prof Sir David Lane

Translational ResearchFrom Bench to Bedside

• Build up capabilities and resources required for early stage drug discovery and development

• Help advance the drug candidates to a stage that is considered commercially more attractive to industry

2001

Dr Edison LiuExecutive Director,

GIS

2002

Dr Yoshiaki ItoPI, IMCB

2003 2004 2005 2006

Sir David LaneExecutive Director, IMCB & Executive

Dy Chmn (BSTG), BMRC

Dr Birgitte LaneExecutive

Director, IMB

Dr Neal Copeland & Dr Nancy Jenkins

PIs, IMCB

Dr Phil InghamPI, IMCB

Dr Jean Paul Thiery

PI, IMCB

Dr Edward HolmesExecutive Dy Chmn

(TCSG), BMRC & Chmn, NMRC

Dr Judith Swain

Executive Director, SICS

Dr Philippe KourilskyChairman, SIgN

Dr Axel UllrichDirector, SOG Lab

Sir George RaddaChairman, SBIC

Dr Jackie YingExecutive

Director, IBN

When physician-scientists Judith Swain and Ed Holmes take up their posts in Singapore…, they will join a star-studded community at one of the world’s most rapidly developing biomedical research centres. …they are the latest of many Western scientists who have headed for the impressive facilities of the tiny city-state.

Naturejobs, 5 Jul 06

Attracting International Talent (Whales)

MITPhysics

(Malaysia)

Human Capital: International Guppies

StanfordChemical Engineering

(Shanghai)

MITBio Engineering

(Hong Kong)

MITChemical Engineering

(Germany)

StanfordComputer Science

(India)

MITChemical Engineering

(Vietnam)

RockefellerBacteriology

Human Capital: Singapore Guppies

StanfordBiochemistry

StanfordBiochemistry

Medicine/PhDDuke

Medicine/PhDCamrbidge, London

Computer ScienceCarnegie-Mellon

NSS(BS) - 3 yrs

231*AGS - 4 yrs

193 at partner

universities

NSS(PhD) - 4-5 yrs

193**

overseas72 Completed

PhDs***

Nurturing & Developing Human Capital689 Potential and Completed PhDs

IFCorrect as at 24th September 2007*Of which, 68 BS and 1 MBBS are NSFs.**Includes 1 GMS (MD-PhD) scholar.***Includes scholars who are currently attached pending PhD conferment (NUS & NTU takes up to 9 months for conferment.)

458

Completed