gen path case study

8/8/2019 Gen Path Case Study

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Gen Path Groupmates:

Please answer the questionnaire assigned to you. Encode your answers in theword document format and send it to this email address: [email protected] e-mail your work on Friday Sept 10, 2010 or early morning on Saturday, Sept11,2010. This will be presented in Class on Sept 13, 2010.

Thank you and hoping for your immediate response. God bless and have ahappy long vacation.

P.S.:Please answer the questionnaire thoroughly. If theres any problem please

notify me. =)tnx!_____________________________________________________________________________Assignments of topics are in Alphabetical Order

Learning Objectives:

Neoplastic Lung Disease

1. (Pelinio, Katrina)Describe the Cell Types present in the various parts of the

Tracheo-bronchial tree. Be familiar with the various forms of cellular

differentiation and their possible relationship to specific types of lung cancer.

2. (Quinones, Aiza Maria) Describe the relationship between lung cancer and

cigarette smoking and other environmental hazards (including radon, etc.)

3. (Reyes, Joseph Ian) Describe the four major histologic forms of lung cancer

and their biological behavior patterns (relative to prognosis and therapy).

Understand the importance of distinguishing non small cell lung carcinomaand small cell lung carcinoma.

4. (Rubia) Describe the usual histologic sequence of the development of lung

cancers.

Have an appreciation that lung cancers arise through a series of molecular

events, and that some of these may be of diagnostic and prognostic

importance.

5. (Saengkla, Kattalee) Describe the common location, typical histology,

clinical manifestations, and cell of origin of bronchial carcinoid. Is its etiology

related to smoking?

6. (Siega, Lilbert) Know that the lung and pleura are common sites of

metastatic spread of tumors arising elsewhere. What tumors frequently,

metastasize to the lungs.

7. (Sordilla, Raezel) Pleural disease. List the important cause of serous and

inflammatory effusions in the pleural space.
mailto:[email protected]:[email protected]


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8. (Sy, Alvin) Describe the major primary tumor of the pleura and the

environmental agent associated with it. What is the role of smoking in

asbestos-induced lung cancer and mesothelioma?

Lesions of the Upper Respiratory Tract

1. (Tahil, Samir) Describe salient clinical and morphologic features of

nasopharyngeal angiofibroma, lymphoepithelioma, vocal cord polyps,

laryngeal squamous papilloma, laryngeal squamous carcinoma.

Reporters: TIGLAO, VILLANUEVA

CASE STUDTY: SCENARIO

A Chain smoker, 48 yrs old insurance company executive was referred to an

endocrinologist with complaints of increasing facial hair, a florid complexion,weight gain, depression, and a productive cough. Levels offree cortisol in his

urine were very greatly increased. X-rays of his skull indicated that the pituitary

fossa was of normal size. However, a chest X-ray demonstrated a large mass in

the right lung and he was sent to the chest clinic. Bronchoscopy revealed focal

areas of thickening in the right upper and middle lobe bronchus. Several biopsies

were obtained and a specimen of bronchial washing was sent for cytological

examination. The tumor cells were relatively small, tightly clustered, and had

inconspicuous nucleoli . Electron microscopic examination revealed that some of

the tumor cells contained a few small dense core granules in the cytoplasm.

Immunohistochemical stains indicated that the cells stained positive for ACTH

and calcitonin. Bone scans and biopsies were obtained. The patient was treated

with combination chemotherapy. Within 8 weeks, the large mass was no longer

evident on X-ray and his original symptoms had almost completely disappeared.

Urine cortisol levels returned to normal levels. However, after three months

he returned, complaining ofsevere headaches. A lumbar puncture was performed

and cells similar to those identified in the bronchial wash specimen were

present. Despite further chemotherapy, his condition progressively declined and he

died six weeks later. At autopsy multiple body sites were involved with tumor.

Microscopic examination of the metastases revealed tumor containing multiple

forms of differentiation including small cell, squamous cell, and adenocarcinoma

elements.

1. (Tripop) Discuss the clinicpathology correlation of this case.

2. (Villamor, Ralph) Give the differential diagnosis

3. (Villamor,Karen) What is the most likely diagnosis?


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4. (Werajong, Obunpun and Ma. Theresa Stephanie) Discuss the

Management.

gen path case study

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