burphySTM815fhb

cupnecHPC(L)fhb

cupnecJMP134fhb

cupnecN1fhb2

cupnecN1fhb1

Tr Hp

NifA MarRs Rndes Sp Mδi Cd Mcc

Gt Tr Hp

Nat PG PH PI Jtp PK

HpHpCabefhRepNAD(P)H dh

Act PG PH PI PJ PK

NsrRHpCasTrGrkes

HpTr 3Imdh Hp

THp

HpHpHlnsph-ns T

rhilegUPM1137fhb

sinmel1021fhbNosY NosXNosL

NosFNosD

HpPCuep Hp

NosR NosZ

Hp TrcB Sox Tr Aep D2nd Aep

Hmsq Hmrr D2nd Tr

Figure S1

Gesto-Borroto et al.

(A)

Chr

n.i.

Chr

Chr

Pmd

n.i.

Pmd

Perll Hp Hp Pthie Hp T

Perll Hp Pthie T

NAD(P)Hnr

azodoeUFLA1-100sdgb

braelk587sdgb1braelk587sdgb2

braelk587sdgb3

braelkUSDA76sdgb1

braelkUSDA76sdgb2

Up

ABCtntsP3Bs

OxrNADbd/FAD bd Uadh

Pdmt Akr NADadh Gluc Nt

Pmbp

Hp Hp

Thir Hp Puf

tRNA-Thr Hp HpABCtsts

β-lac

Cd ABCtnts

Gluc Aldh

Pdmt

T Hp

braelkUSDA76sdgb3

PCuepUp

Tdsi BNRrld Omrp Puf

ABCtsts

Mtrk

(B)

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

braelkUSDA3254sdgb1

braelkUSDA3254sdgb2

braelkUSDA3254sdgb3

Mtrk

ABCtsts

Puf Omrp BNR/Asp br Tdsi Up Up PCuep

Hp

Hp

ATPase chrp Hp

Hp

T

THp

Hp

Hp

braelkUSDA3254sdgb4ABCtsts

Hp NADadh

Pmbp

Gluc

braelkUSDA94sdgb1

braelkUSDA94sdgb2

braelkUSDA94sdgb3

Pdmt Akr NADadh Gluc

Pmbp

ABCtnts

Hp

Perll Hp Pthie Hp

ABCtsts

Puf Omrp BNR/Asp br Tdsi Up Up PCuep

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

braelkUSDA3259sdgb1

braelkUSDA3259sdgb2

braelkUSDA3259sdgb3

braelkUSDA3259sdgb4

braelkWSM1741sdgb1

ABCtstsNADadh

Pmbp

Gluc Pc1,2dox

HpHp

ATPase chrpHp

HpT

Mtrk

ABCtsts

Puf Omrp BNR/Asp br Tdsi Up Up PCuep

Hp

Hp

THp

ABCtbcaats

Hp

Fthf

UIIIs Asp/Glu at

Up

NAD(P)Hnr

braelkWSM1741sdgb2

braelkWSM2783sdgb1

ABCtsts

Puf Omrp BNR/Asp br Tdsi Up Up

Pcd ABCtnts Uadh Gluc

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

braelkWSM2783sdgb2

braelkWSM2783sdgb3

brajap22sdgb

brajapin8p8sdgb

brajapis5sdgb

Rr

Sox PASf

Tr

Hp

PASd

Up TdsiBNR/Aspbr

Omrp Puf

ABCtsts

Tr

AnrABCtnts Nnt Gluc Akr

Ser/Thr pk FNt

ABCtntsHpAnr

Akr

AnrAkr

FNt Ser/Thr pk

ABCtntsHp

brajapUSDA4sdgb1

brajapUSDA4sdgb2

Akr Gluc UadhABCtnts

NAD(P)Hnr

Nnt

ABCtstsβ-lac

Puf Omrp Hp Up

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

Akr Gluc Nr Nr Nep

Akr Gluc Uadh

brajapUSDA6-7488sdgb1

brajapUSDA6-7488sdgb2

brajapUSDA6-8372sdgb2

brajapUSDA6-8372sdgb1

brajapUSDA38sdgb1

brajapUSDA38sdgb2

ABCtnts

Oxr

ABCtts

Puf Omrp Hp Tdsi

NADPHqr

ABCtsts

Puf Omrp BNR/Asp br Tdsi

ABCtntsNAD(P)H

nrNnt

NAD(P)Hnr

ABCtntsNnt Gluc AkrUadh

NADPHqr

ABCtsts

Puf Omrp BNR/Asp br Tdsi

NAD(P)Hnr

brajapUSDA122sdgb1

ABCtntsNnt Uadh Akr

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapUSDA122sdgb2

brajapUSDA123sdgb1

brajapUSDA123sdgb2

brajapUSDA124sdgb1

brajapUSDA124sdgb2

brajapUSDA135sdgb1

brajapUSDA135sdgb2

NAD(P)Hnr

ABCtntsNnt Uadh Akr

Ump Hp N-terdtmdHp

AnrABCtnts Nnt Gluc

Goxald Ptii L-2at4cah

ABCtnts

Puf Omrp Hp

Akr Gluc UadhABCtnts

NAD(P)Hnr

Nnt

Tdsi BNR/Aspbr

Omrp Puf

ABCtstsUp

Puf Omrp Up Up PCuepPtii Hp

ABCtsts

NAD(P)Hnr

brajapWSM1743sdgb

ABCtntsNnt Uadh Gluc

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapUSDA110sdgb1

brajapUSDA110sdgb2

brajapWSM2793sdgb1

brajapWSM2793sdgb2

ABCtntsNep Pnr NasA Akr

PCuepHp

ABCtnts

Hp

NAD(P)Hnr

ABCtntsNnt Uadh Gluc

ABCtsts

ABCtpts

Hp

Puf Omrp Hp

braelkWSM2783gcs

brajapin8p8gcs

ACoAdh

Dh

Pmp Up

2dhp2r Hp

Hp

tRNA-Arg

Tr

ABCtnts ECoAhyd

StHk Tr Hp

Tr Hp

Adsucl Amh cAMPbp

PASdSb/dgc ACoAs

(C)

n.i.

n.i.

Chr

Chr

n.i.

n.i.

brajapis5gcsrhietl8C3gcs

rhietlCFN42gcs1

rhietlCFN42gcs2

StHk Tr Hp

Tr Hp

Adsucl Amh cAMPbp

PASdSb/dgc ACoAs

Hp Hp

PtsNch

McpX1 HpRbsk

Def1 StdB Fmt TruA

DapE2 DadDHp

SecD1 Hp PKes

Hp

Pgt

Hp

McpE

CheA

CheW1

CheRch1

CheBch1

CheY2

CheD Hp FliF

rhietlCIAT652gcs1

Pmcp PDNArpRbsk

Def1 StdB Fmt TruA

DapE2 DadDHp

Ppsp

rhietlCIAT652gcs2

rhietlCIAT894gcs

SecD1 Hp PKes

Hp

Hp

Hp

McpE

CheACheW1

CheR1

CheB1

CheY2

CheD Hp FliFHp

Hp Hp Pgt

n.i.

n.i.

Chr

Chr

Chr

Chr

n.i.

rhietlCNPAF512gcs

rhietlGR56512gcs

rhileg128C53gcs1

rhileg128C53gcs2

PDNArp

Pdf PpspMet-

tRNAftPsp tRNApsI

Hp Sdapdsp

PDNArpSdapdsp Hp

PsI Met-tRNAft

Pnabp

Hp Pdf

Up McpSk

KeftKtsHp

Hp

Aaσrf

CheACheW1

CheR1

CheB1

CheY2

CheD

HpFliF

4a 4doxL-Arat

Ptr

Hp Pemp

rhileg248gcs1Pdmt Rsip NrpPtsN

Sk Up

Pdf

Pnabp

HpMet-

tRNAft PsI

Hp Sdapdsp Nstp

rhileg248gcs2

rhileg3841gcs1

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

AaσrfMcp

CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

Pmcp Rbsk PDNArp

PpdfPpsp

Fmt TruA

Ptmp DapE DapD

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

Chr

CheDrhileg3841gcs2

rhilegGB30gcs1

rhilegGB30gcs2

Ptep Ptmp Ptiesp Ptmp

HpCheX

CheY CheA CheWCheR CheBCheY Hp

FliF

Mcp Sk Up

PtmpHp

Met-tRNAft PsI

Hp Sdapdsp

KeftKtsHp

Rr

Aaσrf

CpHkCstpMcpCrrCheY

CpHpFliF

4a 4doxL-Arat

Ptr

Hp Pemp

rhilegPs8gcs1

rhilegPs8gcs2

Mcp Sk Up

Pdf Hp

Met-tRNAft PsI

Pnabp

T

Pemp Hp KeftKts 4a4doxL-Arat

RrMcp

CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

Ptr

rhilegTOMgcs1

rhilegTOMgcs2

Mcp Sk Up

Pdf Hp

Met-tRNAft PsI

Pnabp

Hp Sdapdsp Nstp

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

Chr

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

rhilegUPM1131gcs

rhilegUPM1137gcs1

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

rhilegUPM1137gcs2

SkUp

Pdf

Pnabp

HpMet-tRNAft

PsI

HpSdapdspNstp Mcp

PempHpKeftKts

Ptr

4a4doxL-Arat

Aaσrf

RrCpHkCstp

Mmcp

CrrRrCpHpFliF

Hp

rhilegVc2gcs1

rhilegVc2gcs2

Mcp Sk Up

Hp

Met-tRNAft PsI

Pnabp

Hp Sdapdsp Nstp

Pdf

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

rhilegVF39gcs1

rhilegVF39gcs2

SkUp

Pdf

Pnabp

HpMet-tRNAft

PsI

HpSdapdspNstp Mcp

KeftKtsHp

Rr

Aaσrf

CpHkCstpMcpCrrCheY

CpHpFliF

4a 4doxL-Arat

Ptr

Hp Pemp

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

rhilegVh3gcs1

rhilegVh3gcs2

rhilegWSM1455gcs1

SkUp

PdfHpMet-tRNAft

PsI

HpSdapdspNstp Mcp

Pnabp

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

DMT Rsip NrpPtsn

Sk Hp

Hp

Met-tRNAft PsI

Pnabp

Pdf

Hp Sdapdsp Nstp

rhilegWSM1455gcs2

rhilegWSM1481gcs1

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

DMT RsipNrpPtsn

Sk Up

HpMet-

tRNAft PsI

Pnabp

Pdf

Hp Sdapdsp Nstp

rhilegWSM1481gcs2

sinfreGR64gcs

Pemp Hp KeftKts

Ptr

4a4doxL-Arat

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliF

Hp

Rr

Aaσrf

CpHkCstp

Mmcp

CrrRrCpHpFliFABCtsts

SkHp Lr1e

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

sinfreHH103gcs

sinfreUSDA257gcs

sinmel1021gcs

Aaσrf

Rr CpHk Cstp

Mmcp

Crr Rr Cp Hp FliFABCtsts

Up Sk

ABCtstsLrm Pck Pup Prr CheA

CheW

CheR Crr

CheY

CheD Pup FliF

ABCtpts HpMcpE

Hp CheA

CheW1

CheR

CheY2

CheD

CheB Hp FliF

azodoeUFLA1-100thb1

azodoeUFLA1-100thb2

braelkWSM2783thb

braelkUSDA3259thb

DNA lig ABCtCots Up

RecR

CBSdcmp

DNAbp Hp DNApol III BsrpRNA

Dadtphh NTP-pphh

Pmscbe Dlh Hp

Act Tr Am PcthdHp

Fsnr

Hp

Gr Hp

Oxr NADbd/FADbd

Hp Pcbs

NIPSNAP

Pdthdsi

Ptr

Hp

Hp

Rrf2fp Hp

PcSETd

Hp

Hp Up

Lig α-β-diox

Hp

NIPSNAP

Pdthdsi

Ptr

Hp Rrf2fp Hp

PcSETd Up

Lig α-β-diox Hp IseppA

(D)

n.i.

n.i.

Chr

n.i.

n.i.

n.i.

n.i.

Hp

braelkWSM1741thb1

braelkWSM1741thb2

braelkUSDA94thb1

Hp

Hp StHk Rr Hp

Hp Ptr Hp

Amap Pmskp

Hp

GuaK

Up

Lig α-β-dioxHp

PcSETd

Mtd Hp Rrf2fpHp

Int

Hp

Hp

ABCtaats UpHp

Poxr

Hp Ptr

Pimp

Phyd LglUp

braelkUSDA94thb2

braelkUSDA3254thb

braelkUSDA76thb1

braelkUSDA76thb2

HpPcbs

NIPSNAP

Pdthdsi

Ptr

HpHp Rrf2fp

HpPcSETd

Hp Hp

Up

Lig α-β-diox

Hp Pcbs

NIPSNAP

Pdthdsi

Ptr

Hp

Hp

Rrf2fp Hp

PcSETd

Hp

Hp Up

Lig α-β-diox

ABCtaats HpUp Hp

Poxr

Hp Tr

Ptii

P3hyalks Phediox

TrRNApolσf

Pomp

Hp PcbsHp

Rrf2fp Hp Hp Lig α-β-diox

NIPSNAP

Pdthdsi

Ptr Hp PcSETd Tr

Hp

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

braelk587thb1

Ptr PdthdsiHp

TrHp Hp

HpPcSETd

Hp Hp

Tr

Lig α-β-dioxHp

braelk587thb2

brajap22thb1

Ptii

P3hyalks Phediox

Tr RNApolσf Pomp

AtCOdh Hp

PQQddh

RieskeFe-S p

3haCoAdh

Arr ABCttts

ABCttts

Hp

brajapUSDA122thb2AraCtDNAbd

brajap22thb2

brajap22thb3

brajapUSDA122thb1

Rr

Fer

Mglr

Tr

Hp

Pmscbe

Hp

Hp

Hp

Fsnr

Hp Fer

Ppphde

HpPuf NifZ

LRVp Fe-Scp

Ipfor NifBNifQ NifHFe/Znurp

L-Glns RieskeFe-S p

Tr

TrUp Tgle Shk

BCoAl Duf

Pmp Up

AtCOdh

PQQddh

RieskeFe-S p

3haCoAdhABCttts

ABCttts Hphat

FAD/FMNcdh

GlnS RieskeFe-S p

Tr PRCbd

Up Shk

BCoAl Phyd Duf BCoAdl

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapUSDA123thb1

Tr

AtCOdh

PQQddhRieskeFe-S p

HpbrajapUSDA123thb2

brajapUSDA124thb1

2,3dhy2,3dhybCoArce

Up Phyd BCoAl Hb

Shk

Pcbp

Tgle

KeftKtPcbp

Tr

AtCOdh

PQQddh

RieskeFe-S p

3haCoAdhABCttts

ABCttts Hphat

FAD/FMNcdh

Hp

brajapUSDA124thb2

brajapUSDA135thb1

brajapUSDA135thb2

brajapUSDA38thb1

Lip

Glns Glns

Tr

RieskeFe-S p

PRCbd

Shk

PhydBCoAl Duf BCoAdl

AtCOdh

PQQddh

RieskeFe-S p

3haCoAdh

ABCttts

ABCttts

HpHp

BCoAox BCoAdl Phyd BCoAl

ShK

Hp

AtCOdhHp

PQQddh

RieskeFe-S p

3haCoAdh

3haCoAdh Ptr Hp

Arr

Guf ABCttts

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapUSDA38thb2

BCoAdl Duf Phyd BCoAl

ShK

Hp

Tgle

KeftKtHp

PRCbd

Hp

brajapUSDA4thb2

brajapUSDA4thb1

AtCOdh

PQQddh

RieskeFe-S p

3haCoAdh

PhABCt

ABCttts

Hp Arr ABCttts Hp

PdmtHp Hp

UrSAMp

Abbmoxi

Ptr Metl

ABCtuts Adguac

brajapUSDA4thb3

brajapUSDA6-8372thb1

brajapUSDA6-7488thb1

brajapUSDA6-7488thb2

RieskeFe-S p Hp

BCoAl BCoAdlDufPhyd

ShKGlns

β kadptr PRCbd

3haCoAdh

RieskeFe-S p

Arr

GufABCttts

Goxald

Ptr PhABCt

Adh

AldhHp

Tr

PRCbd

KeftKt Hp

Tgle Hp ShK

ACoAs Hyd Duf BCoAdl

3haCoAdh

RieskeFe-S p

Arr

GufABCttts Ptr PhABCt HpHp

PQQddh Hp

AtCOdh

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapUSDA6-8372thb2

β kadptr

PRCbd

KeftKts Hp

Tgle Hp ShK

BCoAl Phyd Duf BCoAdl

brajapWSM1743thb2

brajapWSM1743thb1

3haCoAdh

RieskeFe-S p

ABCttts Hp

PQQddh

AtCOdh Hp

ABCttts

Omrp

Hp

RieskeFe-S p GlnsHp

β kadptr PRCbd

Shk

BCoAl BCoAlPhyd

3haCoAdh

brajapWSM2793thb1

brajapWSM2793thb2

brajapWSM2793thb3

brajapin8p8thb1

RieskeFe-S p

Guf ABCtttsAtCOdh Hp PhABC t

Arr

PtrHp

RieskeFe-S p

Tr PRCbd

Up

AraCDNAbp

Tgle Shk

BCoAl BCoAdlDufPhyd

Lgl

Hp

CoenzF420 Hp Hp PtrMetl

Ptr AraCDNAbp

UrSAMp

3haCoAdh

RieskeFe-S p

ABCttts

AtCOdhHpHp ABCttts Hp

PQQddh

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

brajapin8p8thb2

2,3dhy2,3dhybCoArce

Phyd BCoAl

Shk Tgle RieskeFe-S p UpTr

Tr

L-Glns

brajapis5thb1

brajapis5thb2

3haCoAdh

RieskeFe-S p

ABCtttsAtCOdh HpHp

ABCttts

Hp

PQQddh

2,3dhy2,3dhybCoArcePhydBCoAl

ShkTgleRieskeFe-S p Up Tr

Tr

L-Glns

brajapUSDA110thb

mescicWSM1271thb

mescicWSM4083thb

PGlns Pdiox

Tr Hp

PGloxa Ptr Racbe

ACoAs Phyd Hp ECoAhyd

Puf

Tgap

Puf

Tef Hp Puf

tRNA-Trp

PptTt/atf Rp

GTPase tef Ppep tRNA-Trp

Tr

ABCtaatsGly/Daaox

mescicCMG6thb

PptRp

GTPase tef Ppep

tRNA-Trp

Up Tt

n.i.

n.i.

n.i.

Chr

Chr

n.i.

n.i.

meslotR7Athb

meslotR88bthb

meslotUSDA3471thb1

EamAltfUp

Pmp Tef Ppep

Hp

tRNA-Trp

Up Ppt Tt/atfRp

EamAltfUp

Pmp Tef Ppep

tRNA-Trp

Up PptTt/atfRp

cAMPbp

Up Hp

Psazu

UpNr

UpHp CpphIIIox

cAMPbp

Hp

Ccox

meslotUSDA3471thb2

meslotCJ3symthb

RpTt/atf

tRNA-Trp

Ppt PpepTef

RpTt/atf

tRNA-Trp

Ppt Up GTPase tefPpep

meslotNZP2037thb1

meslotNZP2037thb2Pmp PsazuHcp

Tr

Dnr Up

EamAltfUp

Pmp Tef Ppep

Hp

tRNA-Trp

Up PptTt/atfRp

GAFdcp Up HpHp

Hp Up

ChapGrol

CochapGroES

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

meslotMAFF303099thb

rhietlCFN42thb1

Tgap

Hp

Tuf Hp Hp

tRNA-Trp

Tl TatpRp

PABCtHp

Mi2dh Tmup

Pmv/ertmp

Ptr

Hp

PblrpHp

Hts

Pmp Hp

rhietlCFN42thb2

rhietlCIAT652thb1

rhietlCIAT652thb2

rhietlKim5thb

Pta

Ptr Pact

Phyd

Acamhy

DNArrp

Ppep Hp

Hp Phyd

RpTif

PABCt Hp

Hcmp ThuBch

Pmv/e rp

Ptr

AbbmoxiHp

Pmp Hp

Hts

Ptr

Pta

Pact

Phacdhhyd

AphA RecX Ppep Hp

Ptglcp Phyd

TifRp

Hp

Ptefp Tr

Ptmp

rhietl8C3thb Hp

n.i.

Chr

Chr

Chr

Chr

n.i.

n.i.

Hp

rhietlIE4771thb

rhietlCIAT894thb

Tr

Tr

rhietlBrasil5thb

rhietlCNPAF512thb

rhileg3841thb1

rhileg3841thb2

rhilegWSM1455thb1

Hp Ppep

Up Ppep DNArtr Acpaahyd

Phacdhhyd

Pact Ptr

Pta

PtmcABCtPtmp

PGFO/IDH/MocAfox Ptcp

Ptefp

Ptr

Ptmp

HpHp

Htp

Ptr

Ptr Pact

Phacdhhyd

Pacpaahyd

Ptr Ptmp Ptmp

Hp

TifRp

PheS

ABCtmdtsHp

Pdh Tup Ccdt Tr

Usmp

UebexpsHp TonBfp Hp

Htp

rhilegWSM1455thb2Pta

Ptr Pact

Hacdhhyd

Hdac Hp Ppep Hp

Ppp Phyd

TifRp

PheS

n.i.

n.i.

n.i.

n.i.

Chr

Chr

n.i.

n.i.

rhilegUPM1131thb1Phts

HpUpHp

Uebexps

Usmp

Tr

Mtccd

Tup Pdh

PufABCtmdts

rhilegUPM1131thb2

rhilegUPM1137thb1

rhilegUPM1137thb2

rhilegVF39thb1

Pta

Ptr Act

Hacdhhyd

Dac Up Ppep Up

Ppp Phyd

TifRp

PheS

Phts

HpUp

Uebexps

Usmp

Tr

Mtccd

Tup Pdh

PufABCtmdts

TonBfp Hp

PheS TifRp

Phyd Ppep

Up Ppdmt

Hacdhhyd

DacUp

Pta

PtrAct

Phyd Ppp Hacdhhyd Pta

PheS TifRp

Up Ppdmt DacUp PtrAct

rhilegVF39thb2

HpUpHp

Uebexps

Tr

Mtccd

Tup Pdh

PhtsUsmp

rhilegGB30thb1Phts

HpUp

Uebexps

Usmp

TrMtccd

Tup Pdh

PufABCtmdts

Hp

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

rhilegGB30thb2Phyd Ppp

TifRp

Up Ppdmt

rhileg248thb1

rhileg248thb2

rhilegVc2thb1

Hts

Hp

Uebexps

Usmp

Tr

Mtccd

TupPdh

PufABCtmdts

TonBfpHpT Up

Pta

Ptr Act

Hacdhhyd

Dac Up Ppdmt Up

Ppp Phyd

TifRp

PheS

GIIci

Hts

HpUebexps

Usmp

TrMtccdTupPdh TonBfpHp Up

rhilegVc2thb2

rhilegVh3thb1

rhilegVh3thb2

GIIci

Hp Up Ppdmt Up Dac

Hacdhhyd

Act Up Ptr

Pta

RpLrp Tif

Phyd Ppp

Up Ppdmt

Hacdhhyd

DacUp

Pta

PtrAct

Hp Up

Uebexps

Usmp

Tr

Mtccd

Tup Pdh

PufABCtmdts

TonBfp Hp

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

Phts

rhileg128C53thb1

RpLrp Tif Up Ppdmt DacUp PtrAct

Phyd Ppp Hacdhhyd Pta

rhileg128c53thb2 Hts

Hp

Uebexps

Usmp

Tr

Mtccd

TupPdh

Puf

TonBfpHp UpHp Pimp

rhilegPs8thb2

rhilegTOMthb1

rhilegTOMthb2rhilegWSM1481thb1

rhilegPs8thb1Phts

Hp Up

Uebexps

Usmp

Tr

Mtccd

Tup Pdh

PufABCtmdts

TonBfp Hp Pimp

Hp

Hp Ppdmt

Hts

HpUebexps

Usmp

Tr

Mtccd

TupPdh

PufABCtmdts

HpUp

Pta

Ptr Act

Hacdhhyd

Dac Up Ppdmt Up

Ppp Phyd

TifRp

PheSLrp

Hts

HpUebexps

Usmp

Tr

Mtccd

TupPdh

PufABCtmdts

Up

rhilegWSM1481thb2

Ptr Act Dac Up Ppdmt Up TifRp

PheSLrp

Pta Hacdhhyd Ppp Phyd

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

n.i.

rhilupHPC(L)thb1

rhilupHPC(L)thb2

sinfreHH103thb

Ser/Thrpk

Ppep

TifRp

Up

Est ABCtsts

Tr

Pdlh

Act Hp

NTPpph Pheh Allam

Tr Up Hp

Usmp Hp Nuct Phmm

Sucgbtp

Hp

UDPhxt

ABCtpts Zn-ddp

Up

Mtccd Tr

Usmp

Uebexps

HpUp

TonBfp

Hp

Hts ABCthts

sinfreGR64thb

sinfreUSDA257thb

sinmel1021thb1

ABCtpts Zn-ddp

Up

Mtccd Tr

Usmp

Uebexps TonBfp

Hts ABCthts

HpUp Hp

Dpbpp Up

Hp Plipp

Qacrp Ptr

Pup

Pup

Htp Hbpp

DppB2 DppA2 Pdpp

EmrE

Hp

NtrPNtrR1

Hp

Hp

Hp Phts

n.i.

n.i.

n.i.

n.i.

n.i.

Chr

sinmel1021thb2

PpbpPABCtp

AsfB

Por Hp PGlns Hp

HpPABCtbcaats

burphySTM815thb1

burphySTM815thb2

HSerdh Thrs Mocsdp

Moptcf

MoaE Tr ClpB

Hp PDNAup

P Hp

LemAfpHp

Hp Ptmp

Smdrp

Tr

cupnecJMP134thb

cupnecHPC(L)thb

LysRc Ptmp Puf

Pspp

Puf

Hp TetR

Dacgk

Gt Mphest

DacgkGtMphest Tr Hp

HpHp

cupnecN1thb1cupnecN1thb2

CitA PM38 Tr

Excsr Hp SDR

SufA SufB SufC SufD

SulTfABCt

Pmobp Hp LolE Hp

LOGfp TrDacgk

MgtA Hp Act

Chr

Chr

Chr

Chr

n.i.

Chr

Chr

Abbreviations for predicted polypeptides:

2,3dhy2,3dhybeCoArce, 2,3 dihydro 2,3 dihydrobenzoyl CoA ring cleavage enzyme;

2dhp2r, 2 dehydropantoate 2 reductase; 3haCoAdh, 3 hydroxyacyl CoA dehydrogenase;

3imdh, 3-isopropylmalate dehydrogenase; 4-a4-dox-L-arat, 4-amino 4-deoxy-L-arabinose

transferase; Aaσrf, Anti anti σ regulatory factor; Abbmoxi, Antibiotic biosynthesis

monooxygenase; ABCtaats, ABC type amino acid transport system; ABCtbcaats, ABC

type branch chain amino acid transport system; ABCtCots, ABC type Co transport system;

ABCthts, ABC type hemin transport system; ABCtmdts, ABC type multidrug transport

system; ABCtnts, ABC type nitrate transport system; ABCtpts, ABC type peptide

transport system; ABCtsts, ABC, type sugar transport system; ABCtts, ABC type

transport system; ABCttts, ABC type tungstate transport system; ABCtuts, ABC type

uncharacterized transport system; Acamhyd, acetyl aminohydrolase; ACoAdh, acylCoA

dehydrogenase; ACoAs, AcetylCoA synthetase; Acpaahyd, acetylpolyamine

aminohydrolase; Act, acetyl transferase; Adguac, adenylate and guanylate cyclase; Adh,

alcohol dehydrogenase; Adsucl, adenylosuccinate lyase; Aep, arabinose efflux permease;

Akr, aldo/keto reductase; Aldh, aldehyde dehydrogenase; Allam, allantoate

amidohydrolase; Am, amidase; Amap, Addition module antidote protein; Amh,

amidohydrolase; Anr, Assimilatory nitrate reductase; AphA, acetylpolyamine

aminohydrolase protein; AraCtDNAbp, AraC type DNA binding protein; Arr, Arsenate

reductase; AsfB, putative ferredoxin protein; Asp/Gluat, Asp/Glu amidotransferase;

AtCOdh, aerobic type carbon monoxide dehydrogenase; ATPase chrp, ATPases involved

in chromosome partitioning; BCoAdl, benzoyl CoA dihydrodiol lyase ; BCoAl, benzoate

CoA ligase; BCoAox, benzoyl CoA oxygenase, βkadptr, β ketoadipate pathway

transcriptional regulator; βlac, β lactamase; BNR/Aspbr, BNR Asp box repeat; BNRrld,

BNR repeat like domain; BsrpRNA, bacterial signal recognition particle RNA; Cabefh, Ca

binding ef-hand; cAMPbp, cAmp-binding protein; Cas, Ca sensor; CBS-dcmp, CBS-

domain containing membrane protein; Ccdt, cation/cationic drug transporter; Ccox,

cytochrome oxidase; Cd, catechol 1,2-dioxygenase; ChapGrol, chaperonin Grol; CheA,

chemotaxis two component sensor histidine kinase protein; CheBch1, protein glutamate

methyltransferase; CheD, chemotaxis protein; CheRch1, chemotaxis methyltransferase

protein; CheW1, chemotaxis signal transduction protein; CheY2, chemotaxis two

component response regulator protein; CitA, citrate proton symporter; ClpB, ATP

dependent chaperone; CochapGroES, co-chaperonin GroEs; CoenzF420, coenzyme

F420; Cp, chemotaxis protein; CpHk, chemotaxis protein histidine kinase; CpphIIIox,

coproporphyrinogen III oxidase; Crr, Chemotaxis response regulator; Cstp, chemotaxis

signal transduction protein; D2nd, dioxygenase related to 2-nitropropane dioxygenase;

Dac, deacetylase; Dacgk, diacylglycerol kinase; Dadtphh, diadenosine tetraphosphate

hydrolase; DapD, N-succinyltransferase protein; DapE, putative succinyl diaminopimelate

desuccinylase protein; DapE2, succinyl diaminopimelate desuccinylase protein; Def1,

Peptide deformylase protein; Dh, dehydrogenase; Dlh, dienelactone hydrolase; DMT, DMT

(drug/metabolite transporter) superfamily permease; DNAbp, DNA binding protein,

DNAlig, DNA ligase; DNApolIII, DNA polymerase III; DNArrp, DNA repair regulator

protein; DNArtr, DNA repair transcriptional regulator; Dnr, dissimilatory nitrite reductase;

Dpbpp, dipeptide binding periplasmic protein; DppA2, putative dipeptide binding

periplasmic protein; DppbB2, putative dipeptide transport system; Duf, domain of

unknown function; EamAltf, EamA like transporter family; ECoAhyd, enoyl CoA hydratase;EmrE,

transmembrane protein; Est, esterase; Excsr, extracytoplasmic solute receptor;

FAD/FMNcdh, FAD/FMN containing dehydrogenase; Fe/Zn urp, Fe/Zn uptake regulation

protein; Fer, ferredoxin; Fe-Scp, Fe-S cluster protein; Flif, flagellar M-ring protein; Fmt,

formyltransferase protein; FNt, formate/nitrite transporter; Fsnr, ferredoxin subunit of

nitrite reductase; Fthf, formyltetrahydrofolate; GAFdcp, GAF domain containing protein;

GIIci, group II catalytic intron; Glns, Gln synthetase; Gluc, gluconolactonase;

Gly/Daaox, Gly/D amino acid oxidase; Goxald, glyoxalase like domain; Gr, glutathione

reductase; Grkes, glutathione-regulated K-efflux system; Gt, glycosyl transferase;

GTPase tef, GTPase translation elongation factor; Guak, guanylate kinase; Guf, glycerol

uptake facilitator; Hacdhhyd, haloacid dehydrogenase hydrolase; Hbpp, hemin binding

periplasmic protein; Hcmp, hypothetical conserved membrane protein; Hcp, hybrid

cluster protein; Hdac, histone deacetylase; Hlnsph-ns, histone like nucleoid-structuring

protein H-NS; Hmrr, heavy metal response regulator; Hmsq, heavy metal sensor

quinase; Hp, hypothetical protein; Hphat, histidinol phosphate aminotransferase;

HSerdh, homoserine dehydrogenase; Htp, hemin transport protein; Hts, Hemin transport

system; Hyd, hydrolase, Int, integrase; Ipfor, indol pyruvate ferredoxin oxidoreductase;

IseppA, intracellular septation protein A; Jtp, J transmembrane protein, KeftKts, kef type

K transport system; L-2at4cah, L-2-amino-thiazoline-4-carboxylic acid hydrolase;

LemAfp, LemA family protein; Lgl, lactoylgluthathione lyase; L-Glns, L-Gln synthetase;

Ligα-β-diox, lignostilbene α-β-dioxygenase; Lip, lipase; LoGfp, LoG family protein;

LolE, ABC transporter; Lr1e, L-rhamnose 1-epimerase; Lrp, long range pseudoknot;

LRVp, LRV protein; LysR, regulatory protein; MarRs, transcriptional regulator; Mcc,

muconate and chloromucanate cycloisomerase; Mcp, methyl accepting chemotaxis

protein; McpE, methyl accepting chemotaxis protein; McpX1, methyl accepting

chemotaxis protein; Metl, methylase; Met-tRNAft, Methionyl tRNA formyltransferase;

Mglr, monothiol glutaredoxin; MgtA, mannosyltransferase; Mi2dh, myoinositol 2-

dehydrogenase; Mmcp, methylase of methyl accepting chemotaxis protein; MoaE,

molybdopterin biosynthesis protein; Mocsdp, Mo cofactor synthesis domain containing

protein; Moptcf, molybdopterin converting factor; Mphest, metallophosphoesterase;

Mtccd, membrane transporter of cation and cationic drugs; Mtd, methyltransferase

domain; MtrK, methylthioribose kinase; Mδi, muconolactone δ-isomerase; NADadh,

NAD dependent aldehyde dehydrogenases; NAD(P)Hnr, NAD(P)H nitrite

reductase; NAD(P)Hdh, NAD(P)H dehydrogenase; NADPHqr, NADPH quinone

reductase; NasA, nitrate reductase; Nat, N-acetyltransferase; Nep, nitrite extrusion

protein; NifA, transcriptional regulator; NifB, responsible for formation of a functional Mo-

Fe nitrogenase; NifH, Mo nitrogenase iron protein subunit; NifQ, responsible for

formation of a functional Mo-Fe nitrogenase; NifZ, nitrogenase Mo-Fe maturation protein;

NIPSNAP; Nnt, nitrate/nitrite transporter; NosD, periplasmic Cu-binding precursor;

NosF, Cu-ABC transporter; NosL, N2O reduction; NosR, regulatory protein for N2O

reductase; NosX, N2O reduction; NosY, N2O metabolic protein; NosZ, nitrous oxide

reductase precursor; Nr, nitrite reductase; NrpPtsN, nitrogene regulatory protein PtsN;

NsrR, transcriptional regulator; Nstp, N-succinyltransferase protein; Nt, nitrate transport;

Nterdtmd, N-terminal double transmembrane domain; NTPpph, NTP

pyrophosphatase; NTP-pphh, NTP pyrophosphohydrolases; NtrP, nitrogen regulatory

protein; NtrR1, nitrogen regulatory protein; Nuct, nucleotidyltransferase; Omrp, outer

membrane receptor protein; Oxr, oxidoreductase; OxrNADbd/FADbd, oxidoreductase

NAD binding domain/FAD binding domain; P3Bs, precorrin 3B synthase; P3hyalks, Poly

(3-hydroxyalkanoate) synthetase; PABCt, probable ABC transporter; PABCtbcaats,

Putative ABC type branch chain amino acid transport system; PABCtp, putative ABC

transport protein; Pacpaahyd, Putative acetylpolyamine aminohydrolase; Pact, probable

acetyltransferase; PASd, PAS domain; PASdsb/dgc, PAS domain S-box/diguanylate

cyclase; PASf, PAS fold; Pblrp, putative bleomycin resistance protein; Pc1,2dox,

protocatequate 1,2 dioxygenase; Pcbp, predicted cobalamin binding protein; Pcbs,

protein involved in cellulose biosynthesis; Pcd, protocatechuate 3,4 dioxygenase; PcK,

putative carbohydrate kinase; PcSETd, protein containing SET domain; Pcthd, protein

containing a thioredoxin domain; PCuep, putative copper export protein; Pdf, peptide

deformylase; Pdh, putative dehydrogenase; Pdiox, probable dioxygenase; Pdlh,

predicted dienelactone hydrolase; Pdmt, permease of the drug/metabolite transporter;

PDNArp, putative DNA recombination protein; PDNAup, putative DNA uptake protein;

Pdpp, putative dipeptidase protein; Pdthdsi, predicted dithiol-disulfide isomerase;

Pemp, protein export membrane protein; Perll, predicted enzyme related to

lactoylglutatione lyase; PG, general secretion pathway proteins; PGFO/IDH/MocAfox,

PGFO/IDH/MocA family oxidoreductase; PGloxa, probable glyoxalase; PGlns, probable

Gln synthetase; Pgt, putative glycosyltransferase protein; PH, general secretion

pathway proteins; PhABCt, phosphate ABC transporter; Phacdhhyd, putative haloacid

dehydrogenase hydrolase; Phediox, phenylpropionate dioxygenase; Pheh,

phenylhydantoinase; PheS, phenylalanyl-tRNA synthetase; Phmm,

Phosphomannomutase; Phts, putative hemin transport system; Phyd, predicted

hydrolase; PI, general secretion pathway proteins; Pimp, predicted integral membrane

protein; PJ, general secretion pathway proteins; PK, general secretion pathway proteins;

PKes, putative K efflux system; Plipp, putative lipoprotein; PM38, peptidase M38;

Pmbp, periplasmic molybdate-binding protein; Pmcp, probable methyl accepting

chemotaxis protein; Pmobp, periplasmic molybdate binding protein; Pmp, predicted

membrane protein; Pmscbe, predicted metal sulfur cluster biosynthetic enzyme; Pmskp,

plasmid maintenance system killer protein; Pmv/erp, probable methyl viologen/ethidium

resistance protein; Pmv/ertmp, probable methyl viologen/ethidium resistance

transmembrane protein; Pnabp, predicted nucleic acid binding protein; Pnr, putative

nitrite reductase; Pomp, predicted outer membrane protein; Por, putative

oxidoreductase; Poxr, predicted oxydereductase; Ppbp, putative periplasmic binding

protein; Ppdf, putative peptide deformylase; Ppdmt, predicted permease of the

drug/metabolite transporter; Ppep, putative permease protein; Ppp, predicted

periplasmic protein; Ppphde, predicted pyridoxal phosphate dependent enzyme; Ppsp,

probable plasmid stabilization protein; Ppt, preprotein translocase; PQQddh, PQQdependent dehydrogenase; PRCbd, PRC barrel domain; Psazu, Pseudoazurin; PsI,

Pseudouridylate synthase I; Psp, plasmid stability protein; Pspp, probable signal

peptide protein; Pta, probable transcriptional activator; Ptcp, putative transporter

component protein; Ptefp, putative transmembrane efflux protein; Ptep, putative

transmembrane exporting protein ; Ptglcp, putative transglutaminase-like cysteine

peptidase; Pthie, predicted thioesterase; Ptiesp, putative transmembrane ion efflux

system protein; Ptif, putative transcriptional initiation factor; Ptii, putative translation

initiation inhibitor; PtmcABCt, putative transmembrane component ABC transporter;

Ptmp, putative transmembrane protein; Ptr, probable transcriptional regulator; PtsNch,

protein N(pi)-phosphohistidine-sugar phosphotransferase; Puf, protein of unknown

function; Pup, putative uncharacterized protein; Qacrp, quaternary ammonium

compound resistance protein; Racbe, regulator of the catabolism of benzoate; RbsK,

ribose kinase protein; RecR, recombination protein; RecX, DNA repair transcriptional

regulator; Rieske FE-Sp, Rieske Fe-S protein; RNApolσf, RNA polymerase σ factor;

RNDes, RND efflux system outer membrane lipoprotein; Rep, regulatory protein; Rp,

ribosomal protein; Rr, response regulator; Rrf2fp, Rrf2 family protein; Rsip, ribosomal

subunit interfase protein; Sdapdsp, succinyl diaminopimelate desuccinylase protein;

SDR, short chain dehydrogenase; SecD1, translocase; Ser/Thrpk, ser/thr protein

kinase; Shk, shikimate kinase; Sk, sugar kinase; Smdrp, small multidrug resistance

protein; Sox, Sulfite oxidase; Sp, secretion protein; StdB, plasmid stability protein;

StHk, signal transduction histidine kinase; Sucgbtp, succinoglycan biosynthesis

transport protein; SufA, iron sulfur cluster assembly transcriptional regulator; SufB,

iron sulfur cluster assembly protein; SufC, iron sulfur cluster assembly protein; SufD,

iron sulfur cluster assembly protein; SulTfABCt, SulT family ABC transporter; T,

transposase; Tatp, transcription antitermination protein; Tdsi, thiol-disulfide isomerase;

Tef, translation elongation factor; TetR, regulatory protein; Tgap, Transglycosylase

associated protein; Tgle, Transglutaminase like enzyme; Thir, thioredoxin reductase;

Thrs, threonine synthase; ThuBch, myoinositol dehydrogenase; Tif, translation

initiation factor; Tl, translocase; Tmup, trehalose maltose utilization protein; TonBfp,

TonB family protein; Tr, transcriptional regulator; TrcB, thiosulfate reductase

cytochrome B; tRNA-Arg; tRNApsI, RNAt pseudouridine synthase I; tRNA-Thr; tRNA-

Trp; TruA, tRNA pseudouridine synthase; Tt, transcriptional termination; Tt/atf,

transcriptional termination/antitermination factor; Tuf, elongation factor, Tup, trehalose

utilization protein; Uadh, Uncharacterized anaerobic dehydrogenase; UDPhxt, UDP

hexose transferase; Uebexps, uncharacterized enzyme involved in biosynthesis of

extracellular polysaccharides; Ullls, uroporphyrinogen lll synthase; Ump,

uncharacterized membrane protein; Up, uncharacterized protein; UrSAMp,

uncharacterized radical SAM protein; Usmp, uncharacterized small membrane protein;

Zn-ddp, Zn-dependent dipeptidase.