gsk3 ikk igf-1r kinase inhibitors - cayman chemical
TRANSCRIPT
2022 2022WWW.CAYMANCHEM.COM WWW.CAYMANCHEM.COMCAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897
Kinase InhibitorsThe signal transduction pathways responsible for virtually every cell function in the body are built on a network of kinases. Because kinases are so acutely involved in the regulation of biological processes, the field of drug discovery endeavors to validate novel kinase targets for therapeutic intervention as well as to develop and improve target selectivity of modulatory small molecules. Use the signal transduction cascades inside this brochure to explore Cayman’s broad selection of inhibitors targeting specific nodes of the major kinase signaling pathways.
NF-кB
PARP Bcl-2 Bad
RAD514-3-3
c-Kit c-Met EGFR
PDPK1/PDK1
mTOR
DNA-PK
Wee1
S6KIKK
GSK3
PIP₃ DAGCa2+PTEN
PLC
PKC
JAK FAK
RSK MNK
HER2 FGFR IGF-1R CSF1R/Fms FLT3 ALK DDR1 EphB3
internalization and adaptor binding
MAP3Ks
MAP2Ks
MAPKs
proliferation glycolysis
apoptosis
translation
cell cycle
DNA damageDNA repair
Src
MEKK2/3
MEK5
Raf
MEK1/2
ERK1/2ERK5
PI3K
PKB/Aktp38JNK
ATM c-Abl
Aurora Plk CDK
AMPK
Chk1/2
KINASE SIGNALINGPATHWAYS
Kinase Network Map adapted from the Harvard Medical School LINCS Center
Kinases
Click on any of the kinases in the pathway to browsespecific inhibitors or visitwww.caymanchem.com/kinases to explore Cayman's entire catalog of more than 1,300 kinase inhibitors.
Second messengers
Hsp90
Ras
STAT
TSC
p53
Cdc25
MDM2
Related proteins Kinase Signaling Pathways Diagram Inside!
120301149813139
1001042211494
1208722143200561486117135
19420153441330814881
10009209
1311119157218131303221136
167331312313122
1001024610011251
1666713313172761729015115
1962633347222581827128927
2119321503167091798616613
1483317505177081364117329
1670711598176691209411609
104601000672710010399
1306718075
149321470818095
1001101118130
16986152797092032877
10010591
16499148701540618412
10010236
1538313310133111396481590
1738518193180991555317701
21482175421594618096
10010466
1159916999130341629270970
1697813643133461099714185
1149119178203512149017859
1917613602150151073513601
1977819374185161837117670
Item No.
Item No.
Item No.
Item No.
Item No. Item No.
Item No.
Item No.
Item No.
Item No.
Item No.
Item No. Item No. Item No.
Item No. Item No.
Item No. Item No.
Item No.
Item No.
Item No.Item No.Product Name
Product Name
Product Name
Product Name
Product Name Product Name
Product Name
Product Name
Product Name
Product Name
Product Name
Product Name Product Name Product Name
Product Name Product Name
Product Name Product Name
Product Name
Product Name
Product NameProduct NameBosutinibDasatinibImatinib (mesylate)NilotinibPonatinib
(R)-CrizotinibGolvatinibINCB 28060SU11274Tivantinib
CC-115Ku-0060648 NU 7026NU 7441PI-103
AZD 4547BGJ398JNJ-42756493PD 173074TAS 120
1-AzakenpaulloneBIOCHIR99021SB-216763TWS119
BMS 345541 (hydrochloride)IKK-16 (hydrochloride)IKK2 Inhibitor VIIMD 0354TPCA-1
BLZ-945EdicotinibKi20227PexidartinibPLX5622
FLT3 Inhibitor IIIGilteritinib PacritinibQuizartinibUNC2025
AG-1024BMS 754807LinsitinibNVP-AEW541 (hydrochloride)Picropodophyllotoxin
BaricitinibCP 690,550FilgotinibLestaurtinibRuxolitinib
DoramapimodPD 169316SB 202190SB 203580VX-745
BX-795BX-912GSK2334470KT 5720UCN-01
BYL719CAL-101LY294002TGR-1202Wortmannin
A-443654Akt Inhibitor VIIIAZD 5363GDC-0068ML-9
Calphostin CGö 6976Gö 6983LY333531 (hydrochloride)Staurosporine
BI-2536BI-6727GSK461364ON-01910 (sodium salt)TAK-960
BentamapimodJNK Inhibitor VJNK Inhibitor VIIIJNK Inhibitor XVISP 600125
AZD 6244BIX02189PD 0325901TrametinibU-0126
AZD 8055PP242RapamycinTorin 1Torin 2
AZD 7762CCT241533 (hydrochloride)LY2603618LY2606368PF-477736
AMG 900MLN8237PF-03814735Phthalazionone pyrazoleZM 447439
AP26113CeritinibCH5424802PF-06463922TAE684
Abl Family & Bcr-Abl
c-Met
DNA-PK
1554421107191661829819173
Item No. Product NameFR180204GDC-0994SCH 772984Ulixertinib (hydrochloride)XMD8-92
ERK FGFR Family
GSK3 IKKs
CSF1R/Fms
1149216237104831316611493
Item No. Product NameAfatinibAZD 9291ErlotinibGefitinibLapatinib
EGFR/ErbB/HER Family
FLT3
IGF-1R
JAK Family
p38 MAPK
PDPK1/PDK1 PI3K PKB/Akt
PKC
2108914244131981149713338
Item No. Product NameCGP 77675 (hydrate)PP1 (Src Inhibitor)PP2SaracatinibSU6656
SrcPlks
JNK MEK
mTOR
1470710009197
162731514928459
Item No. Product NameDinaciclibFlavopiridol (hydrochloride)PD 0322991 (hydrochloride)Ro 3306Senexin B
CDKs Chk1/2
AuroraALK (Anaplastic Lymphoma Kinase)Simplify Screening and Hit-SeekingKinase Screening Library (96-Well)Item No. 10505
Comprehensive Kinase Screening LibraryItem No. 28940
· Consists of two plates with ~160 selective and non-selective kinase inhibitors
· Includes inhibitors of lipid, receptor and non-receptor tyrosine, serine/threonine, and dual specificity kinases
· Targets include the ROCK, ALK, GSK3, PKC, PDGFR, VEGFR, Src, MAPK, CDK, and PI3K families, among many others
· Contains more than 850 kinase inhibitors, providing greater coverage of individual kinases, kinase isoforms and mutants, and kinase families
KINASE RESOURCE CENTER Browse more than 1,300 kinase inhibitors
Find tools and resources for inhibitor selectionwww.caymanchem.com/kinases
2022 2022WWW.CAYMANCHEM.COM WWW.CAYMANCHEM.COMCAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897
NF-кB
PARP Bcl-2 Bad
RAD514-3-3
c-Kit c-Met EGFR
PDPK1/PDK1
mTOR
DNA-PK
Wee1
S6KIKK
GSK3
PIP₃ DAGCa2+PTEN
PLC
PKC
JAK FAK
RSK MNK
HER2 FGFR IGF-1R CSF1R/Fms FLT3 ALK DDR1 EphB3
internalization and adaptor binding
MAP3Ks
MAP2Ks
MAPKs
proliferation glycolysis
apoptosis
translation
cell cycle
DNA damageDNA repair
Src
MEKK2/3
MEK5
Raf
MEK1/2
ERK1/2ERK5
PI3K
PKB/Aktp38JNK
ATM c-Abl
Aurora Plk CDK
AMPK
Chk1/2
KINASE SIGNALINGPATHWAYS
Kinase Network Map adapted from the Harvard Medical School LINCS Center
Kinases
Click on any of the kinases in the pathway to browsespecific inhibitors or visitwww.caymanchem.com/kinases to explore Cayman's entire catalog of more than 1,300 kinase inhibitors.
Second messengers
Hsp90
Ras
STAT
TSC
p53
Cdc25
MDM2
Related proteins