hdaar 9806463 1. - science
TRANSCRIPT
Review ArticleIntelligent Shape-Morphing Micromachines
Qianying Chen ,1,2 Pengyu Lv ,1 Jianyong Huang ,1 Tian-Yun Huang ,1
and Huiling Duan 1,2
1State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Engineering Science, BIC-ESAT,College of Engineering, Peking University, Beijing 100871, China2CAPT, HEDPS, Peking University, Beijing 100871, China
Correspondence should be addressed to Huiling Duan; [email protected]
Received 23 December 2020; Accepted 11 April 2021; Published 12 May 2021
Copyright Š 2021 Qianying Chen et al. Exclusive Licensee Science and Technology Review Publishing House. Distributed under aCreative Commons Attribution License (CC BY 4.0).
Intelligent machines are capable of switching shape configurations to adapt to changes in dynamic environments and thus haveoffered the potentials in many applications such as precision medicine, lab on a chip, and bioengineering. Even though thedevelopments of smart materials and advanced micro/nanomanufacturing are flouring, how to achieve intelligent shape-morphing machines at micro/nanoscales is still significantly challenging due to the lack of design methods and strategiesespecially for small-scale shape transformations. This review is aimed at summarizing the principles and methods for theconstruction of intelligent shape-morphing micromachines by introducing the dimensions, modes, realization methods, andapplications of shape-morphing micromachines. Meanwhile, this review highlights the advantages and challenges in shapetransformations by comparing micromachines with the macroscale counterparts and presents the future outlines for the nextgeneration of intelligent shape-morphing micromachines.
1. Introduction
Intelligent machines refer to complex mechanical systemsthat can spontaneously adjust their configurations inresponse to specific external environments to carry outassigned tasks. Because of excellent environmental sensitivityand adaptability, they have distinctive contributions to manyengineering fields including soft robotics [1, 2], wearabledevices [3, 4], medical treatments [5, 6], and environmentengineering [7]. One of the most significant evaluation cri-teria for intelligent machines is the shape-morphing capabil-ity that would reflect the reconfigurability of the machines indifferent surroundings and further decide the properties andefficiency of functions. With the rapid development of smartfunctional materials [8â12], micro/nanofabrication technol-ogies [13â16], small-scale manipulation [17, 18], and actua-tion strategies [19â22], the shape-morphing performance ofintelligent machines has been greatly improved, which leadsmachines toward miniaturization, intellectualization, andmultiple functions. Therefore, intelligent micromachineshave been considered with feature sizes from several hundredmicrometers down to several micrometers. Intelligent micro-machines with programmable shape-morphing properties in
response to the change in external stimuli, such as acoustic[23, 24], optic [10, 25, 26], electro [27], thermal [12, 28],magnetic [29, 30], and chemical fields [31], are constantlybeing explored and created, which have important prospectson small-scale engineering applications, such as biomedicine[29, 32, 33], microfluid channels [34â36], and micromanipu-lators [37].
Recently, several reviews have made a systematic over-view of shape-morphing actuators or robots at microscales.Most of them focus on the progress in advanced materialsand fabrications for shape transformations. For example,Hines et al. [38] made a detailed overview of the soft actua-tors for small-scale robotics classified by different stimulusmethods and material types. Spiegel et al. [39] gave a reportfocused on advanced materials for microscale 4D printingand discussed the critical barriers in the material designand prospective applications. Moreover, Hu et al. [40]opened up another perspective involving soft micro/nanoro-botics with flexible components in terms of their architecturedesigns, fabrication methods, and actuation mechanisms.However, the core issue for the functionalities of intelligentmicromachines lies in how to design and realize the expectedshape morphing, which is usually affected by various internal
AAASResearchVolume 2021, Article ID 9806463, 16 pageshttps://doi.org/10.34133/2021/9806463
and external factors. A review on the shape-morphing char-acteristic of intelligent micromachines is still absent to date.This review makes a wide-ranging summary of principlesand methods for the construction of shape-morphingmachines at microscales, including the dimensions, modes,realizations, and applications of shape-morphing intelligentmicromachines, and highlights the uniqueness and potentialdifficulties by comparing them to the macroâs ones.
In Section 2, we present the shape-morphing dimensionsof intelligent micromachines, classified by the dimensionalfeatures before and after deformations. Further, the influ-ences of material selections, design methodologies, andmechanisms of shape-morphing modes are summarized inSection 3. Next, the effective control and actuation strategiesfor shape morphing of intelligent micromachines are dis-cussed in Section 4. Also, various applications of shape-morphing micromachines concerning their correspondingdimensions, modes, and realization methods are given inSection 5. Besides, the conclusions together with a broaderperspective for future researches about shape-morphingmicromachines are presented in Section 6.
2. Dimensions of Shape Morphing
The shape-morphing performance of intelligent microma-chines essentially reflects their spatio-temporal deformationability. Specifically, the shape-morphing process can beregarded as the fourth dimension related to time alongside thethree dimensions of space. Therefore, the shape-morphingdimensions, which contain the space and time dimensions,define the shape-morphing characteristics of micromachinesand present a worthwhile issue to be investigated. In general,the shape-morphing dimensions of intelligent micromachinesmainly depend on the fabrication methods because the struc-tural configurations and the deformation trends have beenalmost determined once the structures are formed.
Due to the development of micro/nanofabrication tech-nologies, the explorations to create shape-morphingmachines at small scales appear to be flourishing. As the fea-ture size decreases, however, the difficulty of fabrication forshape-morphing microstructures increases significantly. Ata smaller scale, higher positioning precision and forming res-olution are required during fabrication. In the former, subtleerrors in positioning will bring serious influences on theshape-morphing properties of printed structures. The latterdetermines the smallest feature size of the shape-morphingmicrounits, which is affected by some practical factors, suchas inevitable deformation of materials in the manufacturingprocess, external temperatures, fabrication speed, and settingtime. Furthermore, it is indispensable for achieving shapemorphing to require structural regulation during fabrication.For example, in the multimaterial fabrication mode, theregulation is focused on improving the bonding strengthand the deformation compatibility of different materialsat the interface; in the single-material-single-step mode,the whole rigid structures require the regulation on theclearance fit among different components, while the studyon the flexible structures is concentrated on regulating thematerial distributions to improve the deformation abilities.
Therefore, the fabrication of shape-morphing micromachineswith spatio-temporal coupling is a subject of multidisciplinary,concerning the micro-electro-mechanical system (MEMS),materials, optics, physics, and chemistry, which affects thedimension transformation performance of shape morphing.Here, we divide the dimension characteristics of shape-morphing micromachines into four categories, i.e., 1D-to-2D, 1D-to-3D, 2D-to-3D, and 3D-to-3D shape morphing.
2.1. 1D-to-2D Shape Morphing. 1D-to-2D shape morphingoften happens in large-slenderness-ratio microrods with aflexible joint. The rods experience free 2D folding to angleswhen actuated by the relative motion of two rigid endsaround the joint. The length of the microrods is usuallyseveral micrometers while the diameter is generally at thenanoscale. Therefore, the major fabrication technology iselectrodeposition for the 1D-to-2D shape morphing, whichcan produce in situ metallic coatings on a conductive mate-rial under the action of an electric current. For example,Yoshizumi et al. [41] employed the electrodeposition methodto fabricate a 1D microrod with a nanometer-scale diameteras shown in Figure 1(a). In their work, silver, gold, and plat-inum were electro-posited in turn with the microtube tem-plate to form the microrod, and the length was tuned bythe electrodeposition duration. Besides, a flexible joint wasmade of a tubular polymer membrane consisting of bilayeredpolyelectrolytes, whose folding angle was controlled by exter-nal environments.
2.2. 1D-to-3D Shape Morphing. Li et al. [42] (Figure 1(b)) andJang et al. [43] extended the shape morphing dimension of1D microrods to 3D by increasing the number of flexiblejoints. They fabricated a fish-like 1D microstructure by usingsequential template electrodeposition with different mate-rials. Under the magnetic propulsion, the nickel segmentperiodically bent the body and caudal fin into a 3D shapeand realized oscillating swimming motions. With the samefabrication method, Ahmed et al. [23] and Gao et al. [44]realized 1D-to-3D shape morphing by increasing the lengthof the flexible part to a considerable value that is comparablein size to the rigid zone. Under the specific external stimuli,the 1D micromachine was triggered to realize 3D wave-likeshape morphing on its flexible part.
2.3. 2D-to-3D Shape Morphing. 2D-to-3D shape morphing isthe most common one because it enables various shape-morphing modes using some relatively simple fabricationmethods. 2D photolithography is the most popular fabrica-tion technology for manufacturing micromachines with the2D-to-3D shape-morphing function. Through adjusting thedegrees of photo-polymerization reaction on polymer chains,the distribution of crosslinking densities can therefore bedesigned. Jeon et al. [45], Na et al. [46], and Fusco et al. [6](Figure 1(c)) printed 2D-to-3D shape-morphing microstruc-tures with the aid of masks. The regions without masksobtained sufficient crosslinking while the ones under themasks received less. In this way, they could realize a pro-grammable photo-polymerization pattern. Martella et al.[47, 48] and Xiong et al. [49] adopted mask-free direct laser
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polymerization to fabricate microstructures, where the spa-tial distribution of crosslinking extents might be tunedthrough controlling the laser powers and the correspondingscan speeds.
Evaporation is another alternative effective fabricationmethod for 2D-to-3D shape-morphing micromachines.Zhang et al. [50] fabricated heterogeneous microbilayersthrough sequential Ti evaporation and Au nanocrystalspin-coating. After a ligand exchange process, the microbi-layers performed 2D-to-3D bending with an obvious curva-ture, while the ones without ligand exchange showedonly a slight curvature (Figure 1(d)). Moreover, Honscho-ten et al. [51] employed the plasma etching method toremove redundant regions, and only several narrow seg-ments were left as hinges on the 2D thin film for further pro-grammable 2D-to-3D shape morphing.
2.4. 3D-to-3D Shape Morphing. As one of the most challeng-ing tasks, 3D-to-3D shape morphing is highly desirable forsophisticated deformations toward potential engineeringrequirements. So far, several effective fabrication methodsfor 3D-to-3D shape morphing have already been proposed
due to the recent progress of micro/nanofabrication technol-ogies. Using 3D direct laser writing, Huang et al. [29](Figure 1(f)), Avci et al. [52], and Vizsnyiczai et al. [53] fab-ricated complex 3D micromachines with rigid independentcomponents. During the process of direct laser writing, thephoto-initiators of photoresist SU-8 absorbed photons andunderwent photochemical reactions to form a strong acid,which then catalyzed the crosslinking reaction in photoresistin the process of postdrying and heat preservation. The 3D-to-3D shape morphing was caused by relative motion controlamong different functional components.
However, the construction of 3D structures at microscalewith high shape-morphing freedoms posed challengesbecause of the lack of applicable materials and effectivemicrofabrication techniques. Jin et al. [54] developed anadvanced 4D direct laser writing strategy for reconfigurablecompound micromachines as shown in Figure 1(g). Theheterogeneous chemical and mechanical properties ofstimulus-responsive hydrogels were spatially distributed intohigh-resolution 3D structures by modulating the femtosec-ond laser parameters and finally realized 3D-to-3D shapemorphing at the microscale.
1D
Orig
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dim
ensio
n
2D
3D
2D 3D
Post-deformation dimension
Electrodeposition
Evaporation Etching
3D direct laser writing
Photolithography
(a) (b)
(d) (e)
(g)
Electrodeposition
4D direct laser writing
(f)
(c)
800 nm
500 nm
50 đm
200 đm
Electroplatingsolution
A.E. (Pt)
W.E. (Cu)
First step
Laser(I)
Au NCTiSi substrateDurimidePMGIThermal resist (c)
SCNâ
(d)(a)
(c)
LaserLP
đmax
Dehydration
MorphingPrinting
FEA10 mW 40 mW
â0.13
0.26
Gel precursor
Glass substrate
(d)
(b)
TiTiAu
Au
(II)SU-8SiO2Ni/Ti
Second stepw
R.E. (Ag/AgCl)H2O2 solution
Joint
V APt
AuAg
Ag
50 đm
Figure 1: Shape-morphing dimensions of intelligent micromachines: (a) electrodeposition for 1D-to-2D shape morphing [41]. Reproducedwith permission. Copyright 2017, American Chemical Society; (b) electrodeposition for 1D-to-3D shape morphing [42]. Reproduced withpermission. Copyright 2016, Wiley-VCH; (c) 2D photolithography for 2D-to-3D shape morphing [6]. Reproduced with permission.Copyright 2013, Wiley-VCH; (d) evaporation for 2D-to-3D shape morphing [50]. Reproduced with permission. Copyright 2018, Wiley-VCH; (e) etching for 2D-to-3D shape morphing [51]. Reproduced with permission. Copyright 2010, American Institute of Physics; (f) 3Ddirect laser writing for 3D-to-3D shape morphing [29]. Reproduced with permission. Copyright 2015, Wiley-VCH; (g) 4D direct laserwriting for 3D-to-3D shape morphing [55]. Reproduced with permission. Copyright 2020, American Association for the Advancement ofScience.
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2.5. Section Summaries. With the development of micro/-nanofabrications, the configuration transforming of shape-morphing micromachines becomes more sophisticated;namely, the spatial dimension of micromachines before andafter shape morphing increases. Pioneering researchers haveproposed effective fabrication methods for 3D-to-3D shapemorphing, which greatly enriches the structure formsand shape-morphing patterns. However, multimaterialmicromachines, which allow the micromachines to havevarious desired shape-morphing performance, can onlybe fabricated for low dimensional shape morphing. There-fore, future studies can be focused on exploring the pro-grammable 3D-to-3D shape morphing of multimaterialmicromachines.
3. Modes of Shape Morphing
Shape-morphing modes describe the reconfiguration perfor-mance among different components or regions of intelligentmicromachines, which determine the configurations beforeand after the shape-morphing process and even influencethe functions. In general, the shape-morphing mode of themicromachines is related to their material properties, distri-butions of materials, and relative motions among differentcomponents.
In recent studies, almost all the shape morphing of intel-ligent micromachines exhibits simple and single modes com-
pared to the ones at the macroscale, as it is hard to realizerelatively complex shape-morphing modes at such a smallscale due to the limitation of fabrication resolution. Toensure the integrity of structures and functions for the intel-ligent micromachines, simple and single shape-morphingmodes have to be selected. Unfortunately, simple shape-morphing modes constrict the microstructures for largeand complex deformation and directly affect the functionsfor further applications.
In this section, the shape-morphing modes employed inintelligent micromachines are discussed. All the modes aredivided into three categories about material properties con-cerning rigid, rigid-flexible mixing, and flexible, which areassociated with the number of shape-morphing freedom ofthe intelligent micromachines.
3.1. Shape Morphing of Rigid Structures. For rigid microma-chines, shape morphing comes from relative motionsbetween different rigid components, where translating androtating are two main shape-morphing modes.
3.1.1. Translating. Huang et al. [29] proposed a rigidmicromachine consisting of a cylinder and a magneticscrew fabricated by using SU-8 photoresist which waslocally deposited with Ni/Ti nanometer-thin layers. Undereffective magnetic manipulations, the magnetic screw wasactuated by the external magnetic field and obtained lift
Flexible
Degree of freedom
1 2 3 Finite Infinite
Rigid
(a) Translating
(b) Rotating
Rigid-flexible
(c) Chaining (e) Swelling/shrinking
(g) Folding
(f) Bending
(h) Twisting
(i) Buckling (j) Moduling
30 đm
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T T T
Figure 2: Shape-morphing modes of intelligent micromachines: (a) translating [29]. Reproduced with permission. Copyright 2015, Wiley-VCH; (b) rotating [52]. Reproduced with permission. Copyright 2017, Wiley-VCH; (c) chaining [43]. Reproduced with permission.Copyright 2015, American Chemical Society; (d) mechanical driving [56]. Reproduced with permission. Copyright 2020, Springer Nature;(e) swelling/shrinking [36]. Reproduced with permission. Copyright 2019, The Royal Society of Chemistry; (f) bending [12]. Reproducedwith permission. Copyright 2019, Springer Nature; (g) folding [57]. Reproduced with permission. Copyright 2019, Wiley-VCH; (h)twisting [58]. Reproduced with permission. Copyright 2019, Springer Nature; (i) buckling [59]. Reproduced with permission. Copyright2010, The Royal Society of Chemistry; (j) modular assembling [60]. Reproduced with permission. Copyright 2019, Wiley-VCH.
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to translate along to the cylinder (Figure 2(a)). Since allthe components were rigid without local deformation, thecoordinate of an arbitrary point i on the mobile compo-nent mi after the rigid translating along vector Ă°tx, ty, tzĂcan be described as
mi = TMi, Ă°1Ă
where Mi is the initial coordinate and T is the translatingtransformation, which can be expressed as [61].
T tx, ty , tzďż˝ ďż˝
=
1 0 0 tx
0 1 0 ty
0 0 1 tz
0 0 0 1
2666664
3777775: Ă°2Ă
Employing Equations (1) and (2), one can calculate thearbitrary-point coordinate on the mobile component andconstruct the configuration of micromachines after shapemorphing.
3.1.2. Rotating.Avci et al. [52] designed an articulated micro-machine with a mobile head and a base. They realized a con-trollable out-of-plane rotational motion of the head under anoptical manipulation (Figure 2(b)) through applying suitablepower of optical tweezers. The coordinate of an arbitrarypoint i on the relative rotating component after relative rotat-
ing along an arbitrary axis A!Ă°Ax, Ay, AzĂ can be obtained by
mi = RAMi, Ă°3Ă
where the rotating transformation RA is [61].
RA θð Ă =c + 1 â cĂ° ĂA2
x 1 â cĂ° ĂAxAy â sAz 1 â cĂ° ĂAxAz + sAy
1 â cĂ° ĂAxAy + sAz c + 1 â cĂ° ĂA2y 1 â cĂ° ĂAyAz â sAx
1 â cĂ° ĂAxAz â sAy 1 â cĂ° ĂAyAz + sAx c + 1 â cĂ° ĂA2z
26664
37775,
Ă°4Ă
with θ the rotating angle around A!, c = cos θ, and s = sin θ.
3.1.3. Combination of Translating and Rotating. Moreover,the combination of translating and rotating was employedto increase the total degrees of shape-morphing freedom ofrigid micromachines. Vizsnyiczai et al. [53] proposed a 3Dinterconnected micromotor including a ramp, an axis, anda rotor. Through the propulsion from bacteria, the rotorwas triggered to achieve a rotating motion around a fixed axisand a translating motion along the axis. Similar to the forego-ing analyses, the coordinate of an arbitrary point i on the rel-ative shape-morphing component after the shape morphingof rigid structures can be deduced by
mi =MMi, Ă°5Ă
where M is the transformation matrix of this shape morph-
ing, which is the product of the translating transformationand the rotating transformation, i.e.,
M = T tx, ty, tzďż˝ ďż˝
RA θð Ă: Ă°6Ă
3.2. Shape Morphing of Rigid-Flexible Hybrid Structures
3.2.1. Chaining. Concerning more degrees of freedom, achain-like shape-morphing mode was proposed with one orseveral flexible joints embedded into the rigid rods [41â43].Each flexible joint can provide two spatial rotational degreesof freedom due to its soft-material properties (Figure 2(c)).Therefore, the total degrees of freedom grow in multiplesof two as the number of joints increases. Moreover,inspired by the microorganisms, such as Escherichia coliconsisting of a rigid head and a flexible long tail, Ahmedet al. [23] and Gao et al. [44] demonstrated an advancedchaining shape-morphing mode with rigid-flexible mixingstructures for micromachines. The flexible sections experi-enced reconfiguration from a line to a rotating spiral dur-ing the swimming process. In this case, one can capturethe end-point coordinate of the j-th chaining rods aftershape-morphing (with the start-point of the first rod asthe origin) by
Oj!=
ă j
i=1ri sin θi cos Ďi
ă j
i=1ri sin θi sin Ďi
ă j
i=1ri cos θi
2666666666664
3777777777775
, Ă°7Ă
where j â ½1, nďż˝, n is the number of chains. riĂ°i = 1, 2,âŻ,nĂ,θi, and Ďi are the length, the zenith angle with z-axis, andthe azimuth angle with x-axis projecting in the xOy planeof the iâth chain, respectively. According to Equation (7), achaining rod with better shape-morphing ability can beachieved by increasing the number of flexible joints orexpanding the angle ranges. When nâ +â within afixed-length rod, the chaining rod turns to a completelyflexible rod with infinite degrees of freedom.
3.2.2. Mechanical Driving. Another shape-morphing modeof rigid-flexible hybrid structures is the mechanical driv-ing. Ma et al. [56] developed a programmable artificialmusculoskeletal system by combing a stiff SU-8 âskeletonâand a pH-responsive smart âmuscleâ into 3D microma-chines and demonstrated that the mechanical âskeletonâcould be driven by the âmuscleâ under specific pH stimuli(Figure 2(d)). The shape-morphing analysis of the mechani-cal driving is similar to the rigid-structure cases.
3.3. Shape Morphing of Flexible Structures. Flexible materialsprovide infinite degrees of freedom for shape morphing and
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construct multiple shape-morphing modes, which havebecome a research hotspot over the past decade.
3.3.1. Swelling/Shrinking. Swelling/shrinking is the simplestflexible shape morphing, which refers to a structure withhomogeneous material. The final configuration of the struc-ture is the similarity transformation of the initial one. There-fore, when the flexible structure undergoes homogeneousswelling or shrinking from the reference state xi to the cur-rent state XK , its deformation gradient S, which is definedas the partial derivative of xi concerning XK [62], i.e.,
S =âxi X, tĂ° ĂâXK
=
s 0 0
0 s 0
0 0 s
2664
3775, Ă°8Ă
where s is the swelling/shrinking ratio. Equation (8) con-structs a corresponding relationship between the referenceconfiguration and the current one, and thus, the shapemorphing configuration can be predicted when s is given.Hu et al. [36] fabricated a pH-sensitive cylindrical microflui-dic machine as shown in Figure 2(e), in which the structurecould be precisely controlled for uniform swelling or shrink-ing. Another pH-dependent swelling micromachine wasdemonstrated by Lee et al. [63], whose swelling performancewas tuned by the layer distance in the layer-by-layer lithogra-phy. Zeng et al. [64] printed a light-fueled cubic-shapemicromachine, which had ~20% contraction when it wastriggered by a focused laser beam.
3.3.2. Bending. Bending is a global shape morphing with asmooth curvature over the structure. The bending happenswhen there exists a strain mismatch along the thicknessdirection. Zhang et al. [50], Xiong et al. [49], and Hippleret al. [12] (Figure 2(f)) fabricated bilayer microbeams withlarge aspect ratios. The two layers were under differentdegrees of deformation, leading to the bending along thelength. However, the situations become distinct when thewidth is comparable to the length. Stoychev et al. [65]investigated the bending properties of rectangularbilayered thin films with different aspect ratios and relativethicknesses. It showed several bending directions, i.e.,long-side, all-side, diagonal, and mixing, which were dom-inated by the ratio of length to width. Relative energeticanalysis, finite-element modeling, and microscopy snap-shots with various bending directions were exhibited intheir work. Moreover, by programming the size and distri-bution of laser writing voxels or unilateral ultravioletexposure, Zhang et al. [66] and Jamal et al. [35] reporteda bending mode with stress gradients along the thicknessdirection. Further, various compound bending modes wereproposed by embedding bending units into local regions ofmicromachines for specific shape-morphing requirements[47, 54, 63, 67].
It is well-known that the curvature is the core parameterfor bending, which can be obtained by the classical theory ofTimoshenkoâs beam [68] based on the physical balance ofstructures and geometric coordination at the bilayer inter-face. For instance, the curvature Îş of the n-layer structurecan be solved as [67, 69, 70].
where Ei, ai, and Îľi represent the Youngâs modulus, thickness,and strain of the iâth layer, respectively. For the case ofbilayer beams (n = 2), the expression of curvature can besimplified as
Îş =1
a1 + a2â
6 Îľ2 â Îľ1Ă° Ă 1 + pĂ° Ă23 1 + pĂ° Ă2 + 1 + pqĂ° Ă p2 + 1/ pqĂ° ĂĂ° ĂĂ° Ă , Ă°10Ă
where p = a1/a2, q = E1/E2. It can be found from the abovetwo equations that the bending ability of microbeam canbe improved by increasing the difference between thestrains of two adjacent layers, decreasing the total thickness,or choosing suitable thickness ratios or Youngâs modulusratios, etc.
3.3.3. Folding. Folding is the localized bending in narrowdeformable regions of structures, which essentially behavesas hinges. Folding refers to a relative rotating around thehinge and finally exhibits an angular shape. Honschoten
et al. [51] fabricated a microstructure with a silicon nitridelayer and then created hinges by photolithography andplasma etching of the layer to a thinner thickness as thecrease for folding. Chen et al. [57] and Jin et al. [54] embed-ded narrow bilayer structures into micromachines for obvi-ously fixed-point folding (Figure 2(g)). In general, thefolding direction is predesigned, rather than random swingslike chaining. The folding angle θ is the key parameter forfolding, which is related to the curvature κ of the bendingpart. θ and κ satisfy the following geometric relation [71].
θ = Ď â ÎşL, Ă°11Ă
where L is the hinge length. Therefore, the folding abilitychanges with the bending deformation of the hinge.
3.3.4. Twisting. Twisting is another flexible shape-morphingmode, which can be viewed as generalized bending. However,the bending direction angle along with the long axis oftwisting is adjustable, and it finally exhibits a helix shape.
Îş =6ân
i=1 2Eiai âiâ1j=1aj + ai/2Ă° Ă
ďż˝ ďż˝ân
k=1 Ekak âiâ1l=1 Îľl+1 â ÎľlĂ° Ă ââkâ1
l=1 Îľl+1 â ÎľlĂ° Ăďż˝ �� �� ďż˝
âni=1 Eiai ân
j=1Ejaj3 + 6 âiâ1j=1aj + ai/2Ă° Ă
ďż˝ ďż˝ân
k=1 Ekak ai â ak + 2 âiâ1l=1al ââkâ1
l=1 alďż˝ �� �� �� �� ďż˝ , Ă°9Ă
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Xu et al. [58] proposed a microdroplet-guided shape-morphing strategy of microstructures for programmabletwisting (Figure 2(h)). The twisting direction can be preciselycontrolled by selecting a trigger point of microdroplets.Mourran et al. [72] and Jeon et al. [45] fabricated twistingshape-morphing helixes by embedding specific-angle mis-matches between the principal axis of stress and the long axisof stripes.
The twisting configuration is characterized by the curva-ture κ and the pitch p [45, 73, 74], which are determined bythe thickness h, the width w, the angle between the twistingdirection, and the long axis θ. The design criterion andimproving strategy of twisting are similar to bending becauseit is a generalized bending. When θ = 0° or 90°, the twistingshape morphing degenerates into bending. For furtherquantitative analysis, two dimensionless parameters wereemployed by Jeon et al. [45] in a shape-morphing phase dia-gram, i.e., the dimensionless helix pitch ~p = κp and thedimensionless width ~w =w
ffiffiffiffiffiffiffiÎş/h
p, which can systematically
capture the twisting rules for further tuning and optimizing.
3.3.5. Buckling. Buckling of structures with periodic andregular array patterns appears when the top and bottomsurfaces of a membrane structure experience differentialdeformations. Wang et al. [75] and Hendricks et al. [59](Figure 2(i)) realized programmable buckling in thin filmswhen they exerted compressive or tensile deformations onsubstrates. The related physical mechanism, control, and pre-vention strategies were also proposed in their investigations.Buckling of the film happens when the strain reaches thefollowing critical strain Îľc [76, 77].
Îľc =14
3�Es�Ef
� �2/3
, Ă°12Ă
where ďż˝E = E/Ă°1 â ν2Ă, E and ν are Youngâs modulus andPoissonâs ratio, respectively. The subscripts f and s repre-sent the film and the substrate, respectively. Therefore, it iseasier to realize buckling by decreasing the ratio of ďż˝Es toďż˝Ef , leading to a smaller Îľc. Moreover, the wavelength Îť
and the amplitude A of the buckling pattern can be quantifiedas [59, 76, 77]
Îť = 2Ďdďż˝Ef3ďż˝Es
� �1/3
, Ă°13Ă
A = dÎľ
Îľcâ 1
ďż˝ ďż˝1/2, Ă°14Ă
where Îľ and d are the applied strain and the thickness of themembrane, respectively. And thus, the buckling configura-tion can be predicted and further tuned.
3.3.6. Modular Assembling. When the micromachine isassembled by a series of identical shape-morphing modules,it can produce modulated structural transformations. Themodular structures have distinctive advantages to achievecomplex and programmable deformation, which is an alter-
native strategy to break the limitation of single and simpledeformation of the current intelligent micromachines. Zhouet al. [60] explored the pattern buckling modular assemblingwith 2 Ă 3 and 3 Ă 3 arrays (Figure 2(j)). They furtherlyfound that the buckling direction failed to adopt the desiredshapes when there exhibited opposite-direction modulesinserted into the center of the row. Jamal et al. [35]fabricated 3D microstructures with interconnected modularshape-morphing segments. This periodic pattern had versa-tility in self-assembling geometries. Cui et al. [30] also intro-duced the modular assembling strategy in their structuraldesign of shape-morphing micromachines. They demon-strated assemble modular units for encoded morphing infor-mation into the letter of the alphabet and finally obtained abird-shaped micromachine with complex and variousmotions. Huang et al. [55] extended the dimension ofmodular units into 3D, proposing a programmable modulardesign for constructing sophisticated 3D-to-3D shape-morphing microstructures by assembling 4D microbuildingblocks. A microscale transformer was fabricated and devised,capable of changing from a racecar to a humanoid robot. Quet al. [78] fabricated 3D microlattices with shape-morphingmodular units and obtained 3D metamaterials with tunablethermal-expansion coefficients.
In practice, the well-established Denavit-Hartenbetgparameters are utilized for structural design and kinematicanalysis of modular assembling [55]. The relative movementallowed at the junction is quantified by a transformation ½Zi�,whereas the dimensions of each link are defined by a separatetransformation ½Xi�. In this context, the transformation of theend of n building blocks is then described as
T½ ďż˝ = Z1½ ďż˝ X1½ ďż˝ Z2½ ďż˝ X2½ �⯠Znâ1½ ďż˝ Xnâ1½ ďż˝, Ă°15Ă
where
Zi½ ďż˝ = Transzi diĂ° ĂRotzi θziďż˝ ďż˝
, Ă°16Ă
Xi½ ďż˝ = Transxi Ri,i+1Ă° ĂRotxi Îąi,i+1Ă° Ă, Ă°17Ădi, θzi , Ri,i+1, and Îąi,i+1 are the DH parameters, which may beimplemented into the modular assembling system for kine-matic shape-morphing predictions and optimizations. Like-wise, Huang et al. [55] demonstrated that the DH matrixcan be employed to facilitate the inverse and forward designof complex and arbitrary modular assembling cases.
3.4. Section Summaries. Intelligent micromachines haveprovided unique and various shape-morphing modes nomatter in rigid, rigid-flexible, or flexible materials. How-ever, they still have their challenges in further microma-chine design. Shape-morphing modes of rigid structures,i.e., translating and rotating or their mixing, have advan-tages in precise relative motion control among compo-nents because of their limited shape-morphing degrees offreedom. Nevertheless, the limitations of the freedomdegree hinder the development towards multiple andsophisticated functions. Moreover, rigid microstructureshave poor environmental and mechanical compliance,
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which is not suitable for applications in biomedical engi-neering. For rigid-flexible chaining micromachines, theembedded flexible joints bring real-time dynamic configu-rations transforming following the external environment.It greatly improves environmental compliance and adapt-ability. However, the random shape-morphing propertyincreases the difficulty in control. The shape-morphing anal-yses on the flexible structures encounter many bottlenecksin recent years because of the infinite degrees of freedomand nonlinear deformation properties, such as the construc-tions of soft-material constitutive models, the analysis ofinterface mismatching, and the influence of size effects.
4. Realizations of Shape Morphing
Another important factor worth considering is the realiza-tion method of shape morphing, which denotes the actuationand control strategies to exhibit specific deformation and fur-ther locomotion of intelligent micromachines. In comparisonwith shape-morphing modes discussed in Section 3, whichsummarizes the initial and final configurations designaccording to the material properties, this section is focusedon the dynamic process of shape morphing.
It is generally known that the intelligent machines inthe macroscale have various actuation and controlmethods for shape morphing, which could be classifiedinto four types according to the energy transformationmodes: (1) hydraulic drive, which can realize high accu-racy control using the incompressibility of liquid; (2)pneumatic drive, which has large actuation speed becauseof the small viscosity of compressed air and large flowrate; (3) motor drive, a current mainstream driver withconvenient energy transfer and quick signal transforma-tion; and (4) advanced drive, utilizing magnetostrictiveeffect, piezoelectric effect, or electrostatic drive of materialsand some smart materials, like shape memory alloy andultrasonic-/optical-/magnetic-response materials. The func-tion conditions and requirements of machines should becomprehensively considered in the process of selectingthe specific actuation and control modes. However, asthe size decreases to the micrometer scale, alternative actu-ation and control modes become much rarer. Because it isdifficult to construct and assemble complex and completecontrol systems in micromachines. Therefore, it becomesfeasible to utilize the advanced driven strategy to realizeshape-morphing control and untethered actuation. Never-theless, it is difficult to achieve independent deformationcontrol in different microregions, because most of thestimuli-response microstructures undergo shape morphingunder uniform external fields. Therefore, it is still a greatchallenge to acquire accurate and independent shape-morphing control on different compounds of intelligentmicromachines, further constricting programmable loco-motion and complex functions. Moreover, the responsespeeds for the material deformation, and the componentmovement is of positive correlation with the feature sizeof the structures. The shape-morphing response becomesfaster on intelligent machines as the size decreases, whichincreases the difficulty in the effective control of the
shape-morphing process. It is known from the law ofmomentum conservation that breaking symmetry and thencreating asymmetry is an essential method to realize func-tional shape morphing of intelligent micromachines. Here,we divide the asymmetric factors into two categories, i.e.,external asymmetry and internal asymmetry.
4.1. External Asymmetry
4.1.1. Asymmetric Stimulus. The external asymmetry involvesthe external factors responsible for shape morphing, themost important of which is the asymmetric stimulus. Itcreates spatial variability of the ambient environmentfor the intelligent micromachines, which could triggerorientable or sequential shape morphing of structures.Since the surface tension dominates rather than thebulk force at the small scale, capillarity becomes aneffective mechanism to trigger shape morphing [58,79â81]. Utilizing the capillary forces, Honschoten et al.[51] developed an origami-based technique for planermicrostructures folding into 3D objects (Figure 3(a)).After droplets were dropped on one side of the struc-tures, asymmetric surface tension promoted folding dueto the spontaneous evaporation of water. The corre-sponding theoretical model was put forward to describethe elasto-capillary interaction of the shape-morphingprocess and the folding tuning method. On the otherhand, diffusion emerges as the spatial-temporal variabil-ity of solvents in solution. Though it is a random andunpredictable process in a static fluid, the diffusion pathcould be artificially controlled when the velocity of thefluid is greater than the diffusion speed. Chen et al.[57] proposed a shape-morphing realization strategy totrigger a series of microcrawlers walking along a prede-signed diffusion path (Figure 3(b)). Through controllingof injecting directions and rates of the alkaline solutioninto the acidic solution, the trajectories of neutralizationreaction could be manipulated. Subsequently, the micro-joints of the microcrawlers deformed in sequence andbrought the asymmetric dynamic frictions between feet andsubstrates, which thus realized directional locomotion.Mourran et al. [72] proposed a similar diffusion-path-control strategy but focused on temperature diffusion to real-ize the dynamic asymmetry in the shape morphing.
4.1.2. Asymmetric Boundary. The boundary asymmetry isanother external asymmetric factor. If we define the asym-metric stimuli discussed in Section 4.1.1 as the dynamicexternal factor, the asymmetric boundary could beregarded as the static one. Although boundaries constrainthe deformation and locomotion of intelligent microma-chines near the wall, it could also be employed to createasymmetric situations for the realization of shapemorphing.
In nature, some microorganisms control their swimmingdirections by utilizing the constraints from fixing flagella.Inspired by nature, Mourran et al. [72] achieved a lineartranslocation of the oscillating microhelices instead of a rota-tional motion when they approached a wall as shown in
8 Research
Figure 3(c). Meanwhile, the microhelices could obtain a loco-motion speed comparable to some helical bacteria. Zeng et al.[64] drove a microwalker on the substrates with predesignedpatterns. Owing to the shear off anisotropy, the walker
experienced shape-morphing locomotion with preferreddirections and final exhibited various motion modes, includ-ing random walking, directional walking, rotating, and evenjumping (Figure 3(d)).
Asymmetric stimulus
Asymmetric triggering timeAsymmetric boundary
Asymmetric response
(a)
(c) (d)
1
1
2
0.0 s
+39.8 s+18.8 s
+8.5 s2
+51.4 s
+27.9 s
3
t = 6 s t = 3 s
Translation
t = 0 s
3
4
4
5
5
6
6
(b)
(c)
(d)
(e)
(f)
(g)
External Internal
30 đm
50 Îźm
30 đm
50 đm
20 đm
đ
đ
đc đđw
ww
w ww
0 s 5 s 9 s
0 s 1.2 s 2 s
11.7 s
7.2 s
5.9 s
4.1 s
2.7 s
0.0 s
Designmodel
MLB
Not symmetricmovement sequence
H2O H2O2 H2OBeâ
H+
BLB
10 đm
Pt
Pt
Au
Au
Ag
Ag
Magnetic propulsion
Ni
Ni
Catalytic propulsion
PtNi
AuAg
Asymmetry
2eâ
Figure 3: Shape-morphing realizations of intelligent micromachines: (a) [51] and (b) [57] asymmetric stimulus. Reproduced withpermissions. Copyright 2010, American Institute of Physics and Copyright 2020, Wiley-VCH, respectively; (c) [72] and (d) [64]asymmetric boundary. Reproduced with permissions. Copyright 2016, Wiley-VCH and Copyright 2015, Wiley-VCH, respectively; (e) [44]and (f) [48] using asymmetric response. Reproduced with permissions. Copyright 2011, Wiley-VCH and Copyright 2017, The RoyalSociety of Chemistry, respectively; (g) asymmetric triggering time [57]. Reproduced with permission. Copyright 2020, Wiley-VCH.
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4.2. Internal Asymmetry. The internal asymmetric factorscome from the intrinsic attributes of intelligent microma-chines, such as the material properties and structure configu-rations, which are also influenced by the fabricationtechniques.
4.2.1. Asymmetric Response. When different regions ofintelligent micromachines are triggered by different defor-mation degrees or stimuli, the whole micromachines real-ize asymmetric-response shape morphing [43, 47â50, 54,57, 69]. For example, Gao et al. [44] reported a synthetichybrid wire-shaped motor at the microscale. It consisted ofa flexible, a catalytic-response, and a magnetic-response seg-ment. When it was immersed in the hydrogen peroxide solu-tion, the catalytic segment triggered the decomposition ofhydrogen peroxide, and simultaneously, the magnetic-response segment was driven under the rotating magneticfield, leading to a wire-to-helix reconfiguration and breakingthe symmetry of structures for further movements(Figure 3(e)). Different from the multimaterial or multisti-muli strategy for an asymmetric response, Martella et al.[48] focused on the use of light to activate liquid crystallineelastomers for nonreciprocal motion. Double stripes withdifferent mixture properties were employed for intelligentmicromachines as shown in Figure 3(f), which provided dif-ferent degrees of shape morphing and finally realized non-symmetric rapid movement driven by the light within thetime scale of seconds.
4.2.2. Asymmetric Triggering Time. Asymmetric triggeringtime is an effective internal asymmetric factor for the realiza-tion of shape morphing. Chen et al. [57] found a sequentialdeformation effect of pH-response bilayer beams at themicroscale. The layer with dense crosslinking density wastriggered ahead of the loose one in response to the changein the ambient solution from acidic to alkaline and inducedsequential swelling between two layers of the microbeam.This asymmetric triggered effect brought multimode shapemorphing to the micromachines and was finally used in themorphing-driven locomotion of microcrawlers (Figure 3(g)).
4.3. Section Summaries. Micromachines are still posing bigchallenges in sophisticated and sequential shape-morphingactuation and control of different functional regions due tothe small size. The use of asymmetry provides a promisingway to realize shape-morphing micromachines. In futureresearch, new asymmetric mechanisms of shape morphingshould be explored and applied to intelligent micromachines.Moreover, hybrid asymmetric factors should be combinedfor more diverse shape morphing.
5. Applications of Shape-Morphing Micromachines
The shape-morphing performance offers the ability of multi-ple reconfigurations for intelligent micromachines and con-tributes to various applications in the engineering fields. Incomparison with the macroscale shape-morphing machinescapable of realizing complex shape-morphing configurations
via precise programming for intriguing applications [22, 82â84], the shape-morphing intelligent micromachines can onlyproduce relatively simple shape-morphing patterns due tothe limitations of fabrication technologies and control strate-gies. But intelligent micromachines have advantages in fastshape-morphing response, low actuation strength, and con-venient in-mass control due to their small volumes, high flex-ibility, and strong adaptability. Therefore, they have uniquepotential applications especially in small-scale or narrowspaces like microfluidic channels [35, 36], biochips [85],and blood vessels [54]. For example, Huang et al. [29] pro-posed an intelligent micromachine capable of actively carry-ing out tasks of targeted and triggering delivery of particles,biological materials, and even smaller micromachines undershape morphing driven by magnetic fields. This microtran-sporter can be used to access remote places of the body formedical treatment. Hu et al. [36] reported a shape-morphing microfluidic machine by integrating a pH-sensitive microring array into a microchannel. The machinecould trap particles of different sizes in a multifiltering way.These microrings have potential applications in microobjectmanipulation and single-cell biology analysis.
However, there still faces many inevitable challenges asthe feature size decreases to microscale, including the mate-rials selections, fabrication technologies, structural design,actuation method, and control strategies. The research onthe shape-morphing micromachines is still in its infant stageas it involves an emerging and complex interdisciplinary sub-ject. Most current shape-morphing micromachines couldonly perform fundamental shape morphing to achieve singleand simple functions.
Here, we list eight types of applications of intelligentmicromachines which are divided into motion- and target-based micromachines, as shown in Figure 4. The motion-based micromachines include microswimmers for swimmingin the liquid [23, 30, 41â44], microcrawlers for substratelocomotion [57, 64], microjumpers for jumping [64, 86],and micromotors for marching [52, 53, 58, 87], while thetarget-based micromachines include microvalves for valvecontrol of microchannels [35, 36], microstents for extendingvessels [54, 88], microgrippers for drugs catching [26, 47, 49,56, 66], and microcarriers for drug carrying and delivery [29,89, 90]. Each application is summarized and marked withits common strategies according to the shape-morphingdimension, shape-morphing modes, and realization methodsdiscussed above, together with their advantages and limita-tions (see Table 1 for details).
6. Summaries and Perspectives
In nature, shape morphing is an important factor to figureout the life and the inanimate and is endowed on the intelli-gent micromachines. In this review, we briefly summarize therecent progress on the shape morphing of micromachinesfrom four perspectives: (1) the dimension of shape morph-ing, which emphasizes the dimension transformation beforeand after shape morphing; (2) the modes of shape-morphing,which is concentrated on the styles of shape morphingrelated to the material properties and the deformation
10 Research
freedom; (3) the realization methods of shape morphing,which describes the strategies for actuation and control bycreating asymmetry on micromachines; and (4) the applica-tions of shape morphing, in which the common applicationsof shape-morphing micromachines are discussed. All theseperspectives point out the significance and indispensabilityof shape-morphing abilities in intelligent micromachinetoward engineering applications, such as targeted drug deliv-ery and release [91, 92], disease diagnosis and treatment [93],
environmental monitoring [94], and intelligent microfluidicchips [34]. Although great progress has been achieved inthe shape-morphing micromachines, there inevitably existcertain difficulties. For example, it still requires higher fabri-cation precision and stronger structure forming regulationfor high-dimension shape morphing. Moreover, the currentshape-morphing modes are quite simple and single. Micro-machines with large and complex shape morphing are stillabsent. Besides, the realization methods of shape morphing
Microcrawler
Microjumper
Micromotor
Microstent
Microgripper
Microcarrier
10 đm500 nm
100 đm20 đm50 đm
30 đm
20 đm
(a)
1 đm
Ni
2.4 s
1.2 s
0.0 s
Au
Ppy
(b)
(e)
(c)
(d)
Ti/Cr/Pt
t = 3.6 s
(e) pH < 9
10 đm 15 đm
50 đm 50 đm
50 đm
(c)
i ii iii
iv v vi
(a)
(d)
(b)
50 đm
5 đm
(f)
(g)
(b) (c)
Closed
B
B
B
Open
Fully-loaded Release Empty
(h)
Microswimmer Microvalve
Motion-based Target-based
Figure 4: Applications of shape-morphing micromachines. (aâd) Motion-based micromachine. (a) Microswimmer [23]. Reproduced withpermission. Copyright 2016, American Chemical Society; (b) Microcrawler [64]. Reproduced with permission. Copyright 2015, Wiley-VCH; (c) Microjumper [86]. Reproduced with permission. Copyright 2010, The Royal Society of Chemistry; (d) Micromotor [58].Reproduced with permission. Copyright 2019, Springer Nature. (eâh) Target-based micromachine. (e) Microvalve [36]. Reproduced withpermission. Copyright 2019, The Royal Society of Chemistry; (f) Microstent [88]. Reproduced with permission. Copyright 2019, Wiley-VCH; (g) Microgripper [66]. Reproduced with permission. Copyright 2019, American Chemical Society; (h) Microcarrier [29].Reproduced with permission. Copyright 2015, Wiley-VCH.
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Table1:Asummaryof
theshape-morph
ingcharacteristicsof
micromachineswithdifferentapplications.
Dim
ension
ofshapemorph
ing
Mod
esof
shapemorph
ing
Realizations
ofshape
morph
ing
Advantages
Limitations
Refs.
Motion-basedmicromachines
Microsw
immer
(i)1D
â2D
(ii)1D
â3D
(i)Chaining
(ii)Mod
ular
assembling
(i)Asymmetricstim
ulus
(ii)Asymmetricrespon
se
(i)Sm
allsize
(ii)Highprop
ulsive
forces
(iii)
Goodfluid
adaptability
(i)Singlesw
imming
posture
[23,30,41â44]
Microcraw
ler
(i)2D
â3D
(ii)3D
â3D
(i)Sw
ellin
g/shrink
ing
(ii)Fo
lding
(iii)
Bending
(i)Asymmetricstim
ulus
(ii)Asymmetricboun
dary
(iii)
Asymmetricrespon
se(iv)
Asymmetrictriggering
time
(i)Fastlocomotionspeed
(ii)Con
trollabletrajectory
(iii)
Goodterrain
adaptability
(i)Singleandsimplegait
[57,64]
Microjumper
(i)3D
â3D
(i)Sw
ellin
g/shrink
ing
(ii)Buckling
(i)Asymmetricstim
ulus
(ii)Asymmetricboun
dary
(iii)
Asymmetricrespon
se
(i)Fastsnap-throu
ghspeed
(ii)Highpo
wer
density
(i)Hardto
repeat
continuo
usly
[64,86]
Micromotor
(i)2D
â3D
(ii)3D
â3D
(i)Translating
(ii)Rotating
(iii)
Bending
(i)Asymmetricstim
ulus
(ii)Asymmetricrespon
se
(i)Fastactuationspeed
(ii)Tun
ablemoving
direction
(i)Needspecificactuation
fuel
[52,53,58,87]
Target-basedmicromachines
Microstent
(i)3D
â3D
(i)Sw
ellin
g/shrink
ing
(ii)Fo
lding
(iii)
Bending
(i)Asymmetricrespon
se(i)Largeextend
ingdegree
(ii)Fastrespon
sespeed
(i)Weakbearingcapacity
[54,88]
Microvalve
(i)2D
â3D
(ii)3D
â3D
(i)Sw
ellin
g/shrink
ing
(ii)Mod
ular
assembling
(i)Asymmetricrespon
se
(i)Fastrespon
sespeed
(ii)Reversiblesw
itching
(iii)
Precise
particle
selection
(i)Onlyforregular-shaped
particles
[35,36]
Microgripper
(i)2D
â3D
(ii)3D
â3D
(i)Bending
(ii)Mechanicald
riving
(i)Asymmetricrespon
se(i)Precise
objectgrasping
(ii)Site-specificreleasing
(i)Und
esired
adhesion
betweenthegripperand
objects
[26,47,49,56,66]
Microcarrier
(i)3D
â3D
(i)Translating
(ii)Rotating
(iii)
Bending
(i)Asymmetricstim
ulus
(ii)Asymmetricrespon
se
(i)Con
trollableparticles
collectingand
releasing
(ii)Narrowgap
transporting
(i)Com
plex
control
strategy
[29,89,90]
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are rare at the microscale compared to the macroscales,which increases the difficulty in accurate and programmablecontrol.
As the development trend of the current technologies ismoving to high precision, high efficiency, miniaturization,and intellectualization, intelligent micromachines, especiallythose with the shape-morphing performance, have alreadybecome a focus on small-scale research. Predictably, withthe development of 4D microprinting technology, the recon-figuration dimension of shape-morphing micromachines willbe concentrated on 3D to 3D, which facilitates complex anddiverse structure assembling and shape morphing. Modulardesign strategies may be a new direction towards achievinglarge, complex, and programmable shape morphing in thefuture. Furthermore, more asymmetric factors, includinginternal factors from the materials or external ones fromthe environments, should be explored to extend the realiza-tion approaches of shape morphing. With an effective combi-nation of several asymmetric factors, the intelligentmicromachines are on track to achieve precise and alterna-tive shape-morphing control of different regions or furtherto realize independent parallel control of a single microma-chine and swarm collaboration of several micromachines.Inspired by current-related research, one should take intoaccount more applications concerning shape-morphingmicromachines, such as location tracking by visual monitor-ing [95, 96], multiple interaction or cooperation betweenindividuals [97â99], and information perception, data stora-ge/processing, and feedback [100]. The shape-morphinganalysis provides a brand-new view to investigate intelligentmicromachines. Despite it has many difficulties and limita-tions at the microscale, the prospects of intelligent shape-morphing micromachines are promising.
Conflicts of Interest
The authors declare no conflicts of interest.
Acknowledgments
This work was supported by the National Natural ScienceFoundation of China (grant nos. 91848201, 11521202,11988102, 11872004, 11802004, and 11702003) and theBeijing Natural Science Foundation under grant no. L172002.
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