huettlin laboratory and pilot units

Packaging Technology

Laboratory and Pilot UnitsMixing, Drying, Granulating, Coating

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2 | Laboratory and Pilot Units

Laboratory scale High-shear mixer granulator system Mixing, Granulating, Drying

When it comes to extremely homogeneous mixing results, granules of the highest quality and top production performance with short drying times, Hüttlin offers the right solution. With the Gentlewing bottom or top drive options, mixing and granulating enter new dimensions.

Gentlewing▶ Maximum mixing quality with minimum mechanical

stress on the product▶ Minimal wall caking due to very close clearances

between the product vessel and Gentlewing▶ Excellent discharge due to the Z-design of the

Gentlewing impeller▶ Effective drying without tilting or microwave t

echnology

SmartFlow▶ Highly-efficient gas distribution over 360° leads to

better drying homogeneity▶ Shorter drying times due to continuous, effective

strip gas feeding

Discharging▶ The discharge valve design enables uninterrupted

discharge, as the discharge velocity is not con-trolled by means of the valve, but by extremely low impeller speed


Laboratory and Pilot Units | 3

Maintaining a leading position in process engineering means enhancing the effi ciency and economy of processes. This starts with the fl uid bed and high-shear mixer granulator systems for laboratory scale applications, which off er the equivalent performance and system features of our production sized equip-ment. Hüttlin continues this design similarity with the pilot-scale systems, thereby off ering the best conditions for successful scale-up.

Gentlewing high-shear granulation technology

Bottom Drive Top Drive Z-shape impeller

Diskjet fl uid bed technology

Diskjet NexStep software

Exceeding expectations with innovative solutionsThe Hüttlin high-shear mixer granulator with bottom drive is the best choice for typical granulation applications in combination with a fl uid bed dryer.

The top-drive version satisfi es the highest of demands. UltraClean, SmartFlow, heating and vacuum unit with solvent recovery allows the HTG to extend up to a SinglePot unit or a high-containment unit.



The smallest high-shear mixer granulator with bottom drive and manual control system. The ideal solution for all laboratories in combination with the Mycrolab.

Mycromix

Container volume (litres) 0.5 / 1.0 / 2.5 / 5.0 / 10.0

Length (mm) 614

Width (mm) 632

Height (mm) 772

Electronic connection (kW) 2.5

Technical specifi cations are subject to change without notice

▶ Bottom Drive▶ Exchangeable container▶ Gentlewing▶ Chopper▶ For organic processes – option

Mycromix – Batch sizes ranging from 0.1 to 3.5 kg*

Left: Exchangeable Mycromix container

Right: Mycromix change mechanism

* at density 0.5 kg/l




Pilotmix – Batch sizes ranging from 3.5 to 60 kg*

Top or bottom drive: You decide which drive concept best meets your requirements. Either as a small production unit or as a step between laboratory and production, this product line off ers all advantages and features that are otherwise only available in

production scale. This applies also to the new UltraClean CIP concept and the option of modular extension up to the SinglePot version. Another ideal feature is the inline solution with the Pilotlab as a dryer.

25 75 100 150

Pilotmix T T B T B T B

Nominal size 25 75 100 150

Total volume (litres) 25 75 100 150

Electronic connection (kW)Ptot @ 50 Hz 8 13 13 16

Length L1 (mm) 1,000 1,450 – 1,500 – 1,800 –

Length L (up to wall; mm) 530 715 1,450 740 1,480 925 1,710

Width W (mm) 700 820 1,100 820 1,100 920 1,300

Height H1 (mm)** – – 2,200 – 2,310 – 2,450

Height H (mm)** 1,800 2,250 2,540 2,450 2,660 2,900 2,900

** depending on discharge container respectively discharge unit; Technical specifi cations are subject to change without notice

▶ Top Drive, Bottom Drive ▶ UltraClean design – option▶ SinglePot – option for Top Drive


Left:Pilotmix T

Right:Pilotmix B

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H1

H

W

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L1

W


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SinglePot – Drying kept simple

The Hüttlin SinglePot high-shear mixer granulators combine all the advantages of the top-drive design with the specifi c features of SmartFlow, UltraClean, product heating and vacuum drying with solvent recovery system. This concept meets the highest demands regarding process times, process quality and handling.

The Gentlewing along with the SmartFlow continuous strip gas feeding system replaces expensive, high-maintenance

accessories such as tilting options or microwave technology with short drying times.

The wall installation enables true separation of the GMP and technical areas. All drives and supply lines can be serviced without having to enter the GMP area. Combined with the UltraClean concept, it provides a high-containment system which meets the very latest demands.

SmartFlow: 360° strip gas feeding

UltraClean metal fi lter

Heated jacket

Heated impeller shaft

Heated lid

SmartFlow, 360° strip gas feeding

Discharge valve

Gentlewing

Chopper

Temperature measurement

Cleaning nozzles

Filter

Condensation unit

Vacuum pump

Video camera

SinglePot▶ Excellent drying times without complicated

concepts such as tilting or microwave technology

▶ Containment ready with only minimal additional features

SmartFlow▶ Highly effi cient gas distribution over 360°

for considerably higher drying homogeneity▶ Shorter drying times due to continuous,

eff ective strip gas feeding

Discharge valve▶ The discharge valve design enables

uninterrupted discharge, as the discharge velocity is not controlled by means of the valve opening, but by extremely low impeller speed

UltraClean ▶ The fi rst CIP concept, which signifi cantly

reduces cleaning times and ensures highest cleaning quality

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CIP (Cleaning in Place) is only achieved in many of today’s systems at the price of extremely long cleaning times, mainly caused by the slow drainage of the cleaning medium through the fi ne metal fi lter mesh. With UltraClean, Hüttlin off ers a concept, which signifi cantly reduces cleaning times while ensuring perfect cleaning

results. The newly developed metal fi lters with opening mechanism enable actual draining of the clean gas side and fast drying.

Combined with retractable cleaning system and the GMP-compliant design of all Hüttlin devices, the UltraClean version ensures fast and effi cient CIP cleaning, which is also aff ordable.

▶ Top Drive, Bottom Drive, SinglePot

▶ Metal fi lter ▶ CIP Cleaning

UltraClean – This is how CIP works

Product overview / dimensionsHigh-shear mixing and granulation technology Fluid bed technology

Bottom Drive Top Drive Dryer, Granulator, Coater

Lab Mycromix Solidlab 1

Solidlab 2

Pilot Pilotmix 25T *

Pilotmix 75T * Pilotlab S *

Pilotlab L *

Pilotmix 150T *

UltraClean Pilotmix 25TUltraClean *

Pilotmix 75TUltraClean * Pilotlab S *

Pilotlab L *

Pilotmix 150TUltraClean *

SinglePot

SinglePot 25 SinglePot 25UltraClean



* Can be confi gured as a granulation line; Technical specifi cations are subject to change without notice



Only a technological leader creates innovative solutionsThe higher your requirements for drying, granulation and coating/layering are, the more you benefit from the Hüttlin fluid bed technology. The spraying system with the three-component nozzle generates homogeneous granules and excellent coating. The patented process gas distributor plate prevents adhesion of the product and offers the best conditions for reliable and reproducible processes.

Fluid bedDiskjet▶ Homogeneous airflow ensures optimum exchange

of substance and energy, the tangential air outlet puts less strain on the filter system

▶ Best product mixing results due to controlled and uniform process air distribution

▶ Process times can be significantly reduced

Dynamic filter▶ Continuous filter cleaning speedily re-routes

the particles to the process▶ Various filter materials can be selected

to suit the respective processes Three-component nozzle

▶ Extremely low spraying losses due to the spray nozzle arrangement in the distribution plate

▶ Homogeneous granulates, after-treatment with a sieve mill is no longer necessary

▶ Excellent coating quality and gentle handling of the product during coating

▶ Very short granulation and coating times

NexStep▶ Process development and optimization in

the laboratory scale and reliably applied in the production scale via NexStep

▶ Scale-up without intermediate steps

Fluid bed systemsDrying, Granulating, Coating

Customize your lab

With the modular Solidlab Technology you are able to run eight solid processes – just as you like.

Basic Unit

Outlet air

Inlet air

MonoblocCombi Module



Drum coaterSpray gun▶ Anti-bearding systems with superior spray pattern▶ Enhanced droplet performance▶ Tool free, GMP compliant design▶ Low profi le shape with integral connections

for reduced airfl ow turbulence▶ Retro-fi t capability to upgrade existing coating

equipment

Interchangeable Drums The Manesty Drum Coater has the ability to change pan sizes/diameters, which makes it ideal for use in the development of products with small production batches and the confi dence of scale-up to larger production size coaters.

Open SurfaceThe fully perforated side-vented coater drum and cabinet design allows highly eff ective drying capacity in the process without the need to use high drying temperatures eliminating lower process effi ciencies (spray drying) and detrimental thermal stresses on the product.

Drum coater

SugarCoating

FilmCoating

Com-pression

Fluid bedcoatingGranulationDosing Mixing

Fluid bed module Coater module

Drying Mixing



Solidlab 1 – Batch sizes ranging from 0.05–1 kg*

Testing feasibilityThe Solidlab 1 laboratory machine processes batch sizes from 0.05 to 1 kilograms and is the equivalent for the highest performance in the smallest space. The plant supports you in developing your products and in examining your recipes. All important parameters and results are recorded by the software, and changes are documented. This makes the Solidlab 1 the ideal solution for your feasibility studies.

Fast conversionThe fl uid bed or the coating module can be easily assembled in the base unit. Both are operated via a joint, integrated air treatment and control system. A conversion to either module is possible in only a few steps.

The advantages of your Solidlab at a glance:

▶ Up to eight functions in one device▶ Modular layout, compact design ▶ Common control software Provicon▶ Joint air treatment and sensor technology▶ Open recipe creation and management ▶ Reproducible and controllable results▶ High planning fl exibility, many available

options

Exchange of fl uid bed and drum coater module in just a few steps

Mixing ●

Drying ●

Granulating ●

Powder Coating ●

Pellets Coating ●

Tablet Coating ●

Tablet Sugar Coating ●

Blending ●

Solidlab 1fl uid bed module

Solidlab 1drum coater module

L W

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Fluid Bed Drum Coater

Solidlab 1 Multi Mix insert Drum Coater

H

L W



Fluid Bed Solidlab 1

options

Fluid Bed

Working volume max. (litres) 2 0.5 1.5 0,8 1.5

Working volume min. (litres) 0.4 0.1 0.5 0.25

Working Capacity max. (kg) 1* 0.25* 1.2** 0.65**

Working Capacity min. (kg) 0.2* 0.05* 0.4** 0.2**

Air flow (m3/h) 70 70 70 70 –

Max. inlet air temperature °C 80 80 80 80 –

Dimensions 1,100 x 730 1,100 x 730 1,100 x 770 1,100 x 770 1,100 x 770 L x W x H (mm) x 1,010 x 1,010 x 1,010 x 1,010 x 1,010

Weight (kg) 205 205 240 240 240

optional drum

optional product container

Drum CoaterDrum Coater Drum Coater

optional Multi Mix insert

* ρ= 0.5 kg/l ** ρ= 0.8 kg/l



Solidlab 2 Fluid Bed Fluid Bed Drum Coater Drum Coater

Working volume max. (litres) 24 2 16 24/8/4/2

Working volume min. (litres) 2 0.5 5 7.2/2.4/1.4/0.75

Working Capacity max. (kg) 12* 1.0* 12.8** 19.2/6.4/3.2/1.6**

Working Capacity min. (kg) 1* 0.25* 4** 5.8/1.9/1.1/0.6**

Air flow (m3/h) 600 50 600 600

Max. inlet air temperature (°C) 80 80 80 80

Dimensions L x W x H (mm) 860 x 860 x 1,980 860 x 860 x 1,980 1,130 x 1,000 x 1,991 1,130 x 1,000 x 1,991

Dimensions (swivelled out) L x W x H (mm) 1,372 x 860 x 1,980 1,372 x 860 x 1,980 1,862 x 1,913 x 1,991 1,862 x 1,913 x 1,991

Weight (kg) 600 600 800 800

location options

optional product container

optional drums

process room

process room

The advantages of your Solidlab at a glance:

▶ Up to eight functions in one device ▶ Modular layout, compact design ▶ Common control software Provicon▶ Joint air treatment and sensor technology▶ Open recipe creation and management ▶ Reproducible and controllable results▶ High planning flexibility, many available

options

Easy scale-upThe Solidlab 2 laboratory machine handles batch sizes from 0.25 to 12 kilograms in laboratory scale. The different modules use a common periphery and are constructed like full scale production machines. This enables an easy scale-up of all production parameters.

Combi ModuleThe fluid bed and the coater are both operated via a Combi Module with common software. This significantly reduces the need for operative personnel and training. The joint air treatment is located in the technical room, which not only contains the Monobloc but also the switchboard, and enables a space-saving layout.

The control via HMI (Human Machine Interface) eases operation and reduces the training required for personnel.

* ρ= 0.5 kg/l ** ρ= 0.8 kg/l

Solidlab 2 – Batch sizes ranging from 0.25 –15 kg*

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2–24

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1,130 x 1,000 x 1,991 875 x 750 x 1,466

1,862 x 1,913 x 1,991

800 100

Drum Coater Combi Modul

optional Multi Mix insert

process room

Options▶ Variable drum inserts ▶ Smaller fl uid bed material containers▶ WIP (Wash-in-Place)▶ Air humidifi er and dehumidifi er▶ Active de-dusting unit

Fluid Bed Drum Coater Multi Mix insert Drum Coater

Mixing ●

Drying ●

Granulating ●

Powder Coating ●

Pellets Coating ●

Tablet Coating ●

Tablet Sugar Coating ●

Blending ●

Solidlab 2

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L L

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The Pilotlab can be used as a small-size production unit or as an intermediate step from laboratory towards production. The reduction kit assures highest

▶ 10 bar shock-resistant as standard▶ Process air equipment and circuit cabinet with integrated PLC for separate installation


Pilotlab – Batch sizes ranging from 4 to 50 kg*

fl exibility to the Pilotlab, ranging from 4 to 50 kg. Another ideal feature is the inline solution with the Pilotmix high-shear mixer/granulator.

From left to right:▶ Dynamic fi lter lowered ▶ mobile container▶ Pneumatic discharging system


2950

1840 1660


S LPilotlab

Container volume (litres) 75 100

Air fl ow (m3/h) 500 1,000

Diff erential pressure (Pa) 16,000 16,000

Heating capacity (kW) (Δtmax = 75°C) 35 35

Steam consumption (kg/h @ 3 bar) 59 59

Compressed air consumption (Nm3/h @ 6 bar) 130 150

Number of spray nozzles 2 3

Electrical connection (kW) 30 30

Dimensions L x W x H (mm) 1,840 x 1,600 x 2,950 1,840 x 1,660 x 2,950

Weight of Pilotlab (kg) 1,400 1,400

Weight of air handling (kg) 555 550

Weight of fan (kg) 500 500

Weight of controller (kg) 380 380

Technical specifi cations are subject to change without notice


Hüttlin GmbHA Bosch Packaging Technology Company

Hohe-Flum-Straße 4279650 Schopfheim GermanyPhone +49 7622 6884-0Fax +49 7622 [email protected]

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Bosch Packaging Technology Ltd.

Kitling Road Knowsley Merseyside, L34 9JS Great BritainPhone +44 151 547 8000Fax +44 151 547 [email protected]


huettlin laboratory and pilot units

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