i...3,3'- $:' . .-4,4'- >7 / 27 =j,?, >( ::) ch, (c"n,nh,ci), casn0....
TRANSCRIPT
3,3'- $: ' . .-4,4'- >7 / 27 =J, ?, >( ::)
cH, (c"n, NH, ci),
CAS N0. 104-14-4
8!' ;, 0.005mg/m'
,,,, i . -.,,,- ,,Cl
,#
i. !i : L, {t,! ti!j, . Et""
3,3'->? ? n n -4.4'-:;7 / :, 7z. =iu?t ' >' (4,4'-
/ + v y t:'>< (2-? 0 0 7=. 1j >.), :$ (4-7 /-3-?'
o 0 7 =..=/L, ) ?t ?' > , MOCA, ,t ,,. 7 >,, !;1~1',
MBOCA !: R - ~) lt, ; .:1' 267.17, ry&. titl @>*:V. i 3
,*t::U:@)!i . j, J!:. :1.26, *, 98~108t:. i :i, F'tE 74z
} >,, / +)L-.:.+i, 4>. } >., .7' } 'j> t j* 0 7 >, $, /
+),,*/!,/. 7 S l*, :.? / ;f. J!, x/L, ;1;:4. $,, 1,1=t;'; - , } JL
J. y , ,.:>{t'>., ,z. / -/v!. ja;iil'j :; 7k!c7t<j .
2 . ts {i ti:);li;6sl-a)
;;t:U:;;h 2:ijt:Ut , (MBOCA35 %, t4 u z. f-v >- >$A:>
Y',..- } 65%) @) 2 ii!E@>}1 !1 t'ililt! ittly. ,. ,? v .:*'
7, z.;> >!. } ?-! 1i, !{b 1 (*' u ? y .'Aj;U), ,..*49;- >., jtj
l *5 J: U'.:. ilt, ' :.,'> P ' >'i !@{b 1, *1rt'1 =, '> P
' ' "' ~ '; > } !;gii;f{t: ".
3. q&. JD!, f& t, ; Ft
' ,? } 1=* . !i! - L i=* .'.", . @>!3: 2: A, !:':b*j;j:!#it
{ 3ji tL, ii! 4:, 4811f;tHlt 1= 1t !g }: A. !:'b* (49~69%)
*s J: U, Fi!. (24~29%) q"1=j;FtlL tL. :;, b* 481if'115t 1=.!s
v*t , 2 %b<fif!.;; f:a L t v. i::.'i> v F @>!t. 1 jlc25mg@)MBOCA :. 2411 1tit :&i L t:*!$- ."'1*, 2i3 itit@)*j40%75t!&llX *Li::. 1 !$s J: U21;FtlLl*
* . t! 4 -1=tb, <:i < 24R&:llffi;!P, 1=!& ! :@)29%;b*$6;b*
,, 12%:b*Fj!. 75. !,;HFil! tL6 bt 72U&:llai t'{i 59%7bt4!,l, , !. ;i :tF L t v. i;:. : i:: FR. . MBOCA@> 5 *> * ;:{b @)
MBOCAld:0 .1%i;!Tti. ;t, o i:z.
MBOCA;!f4F-'i> .y } @)ER;rp i= j, :ioj;
@)f'qaf!i ;bt ;3!F L t v* , ib* -@>:}< j*i*{ ;!t!1 @>t!i at>
.6, V. 1;t ?'/1, ,' D 7 U;:*j! 't*:?:'d> * i::". .>! + 1, ' >' tSt' tL
i::7 / ?0 n 7=. /-),@)61ia tj! .{*;{)j*:!" tLtv*. ,
*< 5t,g!s{1, @)MBOCA!*!:! 4F- @> i %!;!~Ftt>o i::".':> v F ! ? n /-A :.!:R\*i;= i" uitro ! tl*, N-
hydroxy-MBOCA, N-nitroso-MBOCA, 5-hydroxy-
MBOCA, .is ,k U, / + u >FiE@>;4< !{1, L i::4 ;!t!1*i, 5, t- 'i;,
,,, ly* ;:, 4, .
IOmg@)"C-MBOCA ! 4 5t!=fi , 1!&ti:6i' (iv) L i::i; ;. 2:
!;:li;1. t:aii (pc) !, i=! .!: t .@)1 1 !:; Fti&, b*jt, t;
t'Ltv. . ,". iv;1 - 1 tlt*6 - : 5 ~ 6 1 ft5'Cm. rpb. ,
MBOCA*ti: '*U tt. i:' < *:'1}, i!g ,,**lc{&;;* i'L , C t:
,b* fLi;:. 2411t1i5i;!P, 1. !6.;b' , i;Ft *'L, :, @)ltj:F -
@>46%t ji. , 7b*:ji6E{b@>MBOCA1*0.25%'C'3s o i;:. ;;
ij j @)MBOCA
MBOCA
Cl
-24Bf;j! j 1= *s v*t {, 1 . . 1. !*32%, El'fiik . !C lt3. 1%
b*;; :jf: Ltly. t=. -j ', pcjj! ;- :! ti*, 24, & ftij !=*s
v. t {i90%:btt*:&i 1=;iq0 'C*s O , ;.*. !, ijFtl!! *'L. , @)
ld;1.3%1=i ti:'*. o i;:. i::7: L, t :&i &it:T@>" 1;b , i
l#;ll, ,i=MBOCA:b*jf:lB tLt v. , C !: b. 1;,, !!:!&.!D!@)
; , . j*, :E !jB1!5!. bi:: o tlco o < 1) !: !&11X fL , C 2::b',
;i< t'Li;: .!6!. . i'Li 4 7 @)!6. . ft;!t!1 @>75%7b*5-hydroxy-
MBOCA-5-sulfateZ:' , * fc". C t'L !' .;,:7t<tiU. 'C',
DNA , i 2: {, *j ~ . , g!t. 1 :. 1tE {, t:, v. :b<, i a
*;! . "tio t:!;q, . ld; i:j !: * . ~.:, . 2: *. !,, . j {qat
% jjt5:. jj;'1 :b*j V* !:**; *Lt:. 4 >?"F ? Q/-A '
v*i=i" t, itro: :!;tt', N-hydroxy-MBOCA, 5-hydroxy
-MBOCA@) Ei6ibtiF:tB; *Ltv* ,"i.
l= } @)* ., MBOCA!=ft , 3g: tLtzfj= : '@) . q"*. ,
ld:, * :{b@)MBOCA, 7Lz4. /, t*(N-acetyl-MBOCA,
N, N'-diacetyl-MBOCA) ,5,16:tB *Ltly*. 'z5, , 7-1z+
/v, j*@);jt:!{} it{ < , b. 0 @)i!&j ;:{, MBOCA@)i/ioi;!
Tt', j, .g, '." i. .;typ;j<: . L t4 , ,,, L , MBOCAj**; :
{b@>MBOCA@) 2 ~ 5 { 1!: $&, i """ t'Lt *s O , N- ?", L- ?
o >'U;:*j!, .{*;;5' ' '4'&3!t4U1}: *& ""; *Lt V* ,. i= } @)
:?' 0 /-A !Fllv*iei" "it?0 :g;:t'!,:, MBOCA@)N-2kB&{b::; J: U'/ + V >' @>2k, jt{b**;!j F j'LtV. . " '.
l= } t!*MBOCA@)*5:jj:ilU. JIX*ti ,, 5. t > . , !: *R: '; *, ct ly* . ,"). t!j, E. !1t@)&!, j;: (*i .*i . 1* L i= , @)) j=
!;:lliq l on' i;: 0 2 .24/, g@> ["4C] MBOCA !. if:fit 2!:. i * ', l ft&'1 i: 1. it .@)50%7b*51i :{1:@> !U:iiS*E;t*1=
, '- !, t'L, 4 11! 11Ut 1= 1;*26%;b*j6. jj: ;i ; L. t;t3 0 , fF!;&
! , b*!&li!.@>1! !: *: , C !:lt: i'L, ,:b. 0 /=. * i:=, *!
11.4 2 @)MBOCA, b*! "b ;!jt! L 7:: j!&:tLE;sJ .!=MBOCA
!. it U:i=fi= !: '@) . . MBOCAt ! . 1 *.)& ft6 1; L
i=*& 't'1*, :t 4 11& 11 1.1 :i ;j{ 2. 100pg/g Cr .:;
L *:t , -*t. 1=:;U,!* L, 2j*jit;!B1*23116R !: $ ! ;t.f, 15).
!;!_L@)*&* '75. ,, MBOCAl*i; : ti @), 3'. ti: , ', * !t., 1= {;1!&10! tL, L*. {j .@)jg. 2: A. , 2:':b*tl: '
: *Lt . :
?:: 1*$j:. k O ;HFtt!! tt . , !: ' . !, t'L . ,.
4 . !Ul!1 !c$s1} .6' , 1 , 1 *&
"1) ;;:., j *!!'1 ""
LD, " ':> v } . 2,100"g/kg, ?.?7. i . 880"g/kg,
litl4:P 64mg/kg
(2) ; .. 1tE$sJ: U"1!!' : 'EE
;;', y F 1.200"g/kg ! lO B 115j; 1:1;1j!F - L f= !: " ', .?. 7
' ~' , ! :#P 11, Jit :*3 J: U2 .@): '*'3a&> , tL,
l. OOOmg/kg@)!:!: i. t1t:, +7 /-.,', i$E55, . Ej:., 5*;g&:, , tLt V, .;,. ' L t C i'LF, @)ml. ;!tj : * :5' !,: ; *'EE .
* tl* / } '\. ?'o l=' >. nn. ,j::bt C , !: j'LtV. . '" '.
'1!&. 1!Ej; . t. jt, 5> .y } , ?fy ;t. , 4 x !=tsv. t, j!@,!g
@)jj jjF;b' !, ?, *Lt v* .6 .
(3) 36;btK, '
!@j!j*iF! !$ ti. it, ;>. y }, ?*;<, { 7 t'MBOCA!c J:
. , gU;b*A. ,7bt. ; , , *Lt V. 6 '"'.
1993(H. 5)LF. :
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'5' v } !=250, 500 :i;:ld;1.000ppm@>MBOCA ':i $d
;F}*:. i8:b. )3 ;!3 . L i:z ! " ;ti*, lih@>1 1 2: 1 ; , '?LM!
;jg, $?>',<)Ujj!;;g, fiT *1 1a;6 @)3t! t :fyUzbt , , fLit. lji
l!t4;F, s J: ue$L1;!; @)3*, E!c l* -it. j ggj *e > 0 , "ih7b,
:! i!d;! :1 **3 ty. ; ti'i*i o t:. {!;i*" l j: 1. L 7;: !:
ld;, m'*M1a; @>3tEE 1, :tiillULi:=, 5* @){tL@>j j 93 E
;* 'iiE:Ec \J: D i{t37b*o i .
;7' v } 1.1,000ppmMBOCA ';*'$q*} :. 2 fFl !i*:g;. L
i: t! " 'tl*, Mi@>1;!1 !:i ; , *3 J: U'm'i ;@)3t! * ilD
:5'; . , t'Lt. V. 6 . ,ihil!ft$;;@)3gt1 ;! :bUl* , > F o -/Vl:: Jb
,<:;jg :f::.? t=. tn: !{ i 1ti= Li. !: , 3rti
1!@4;g@>s6 . 1*ie:i;S:Et2:! ! 1 btjo t::b* t j=tsv. tj*1+@>j M
!:;i!;, il"!=*sv. ti* L; @>36 E , b*L. !. L = > } 0-/,
!=Jl: ;jg: :j=j j < ** t v. Z, .
,y } 1= 1,000:E f= ;*500ppm, ? ,? ;:. 1.2, 000ppm : i:=
!,:1,000ppm@)MBOCA .:!*fii{;F} ! i8;b* H i!}43- L t= 6 .
!6:",'tlt, m**M, j!; @)3*tE ;b*V***t'L@>!im! 'C{,; . ft
@>t6llU!.{\o t*6llU L i::. : f:, ? 7X2.000ppmt;*nn. 11 :5 $: U:im. '1,3j @) . 7bf ,,,*L, ' v } ';*Mi@)!
M@>36a i ;brr;b' , {, fLi= .
4 .5Z !clOO"g@>MBOCA*:'i; :El;i!3 - L t=:i3!*: ( 5 ~ 8
mg/kg/d)'"'t;,:, j:; -;;., i: 8.3~ 9 @1=t, , 5 1!Eq" 4 !!91=,; ,*;
@) !L; i:U:;1 t 'L. B:; ;b* , , *Li;:. = > } 0 -/, 6 1 !. it
*'A. , ;,'g {bl;*;g $, *L *, i E ;li=; :*: :{bt;6 0 i=
(p <0 .025, Fisher's exact test. one tail). = @>"!@,;;i*
'36'1:Et:'litr !iRl !Ci {' . < , , t'Ll ; 1 '\it il!l L'C
v*?;:, b*j$5i@!= jd: *j1!l LtV*ti:*. o iE. i=, {1 "i** ,\@)
4i -1*jt ', f'Lt v. :. ly*. ifu. j ', j:{!,! j !Et'jd:, MBOCA
ii!{ . t;t@)nn. i iGPT{i :75* . > } 0 -Ji, 1!t1=tb'.:: ': :1=i i
*, o i=.
' '. y } 1. *j ~. ggib*A. ,7j l* > :? :, :., @) ' tL@)* 1/
l, 500 !: ' ~ , *Rf;;.'"i:b', it> . , -75', 4 x !c* " , g ;@, K, ;b j*
/<> :., S. , > J: 0 !d:; ily. 7bt2-+ 7 ,f. )L-7 S. > J: O i3: $v* !:
*:.;j L t ,* :. v. 4!:{ Bt11= 7 .1a 'f" /1, {b;6'i
V*4**!j@> l= } j=tsv*'Cl*gt7btA. .@>j ;1 , 7b*?< V. C !: ' .
:6:, ~. ," '. :* i;:, :6' ;* 7 > 'C'1*N-7kg*{b:b*g*:b*x,
@>3: -X 5" v 7'C'*,; , !: V. b*Lt. i5 D " ', 4 , 1. t, ; J: U'
t; } @>fiT ? n /-A :. FBv. i;: i, ? tii!ro 6 ! . C. N-;!< 8
{bMBOCA@>tE! ;7b<3g&!> 3, *Lt v. . , &isi.
(4) 'q 1 :'1!E, '@>f
'1!'Ju :* @)TA98, s J: U:TAIOO, :!<1!;j , *s J: t}*i3
::{:itii= ,s V. t *E; '!ti;, *t, t'. $, tLt v* . ,. 7= i:, L , S9
(-) t:'ld: 1*;',1*;: , t>t'L ', S9 (+) @)1i @) . E9 ;i
' *' R. *>i'Lt v* . ,, e).
HeLa*m1 *3 J: tFl'1'*B, a ('i> v } , ?,> x, AA ;:. .-, ,>>j. e ) !rjjv. i::DNA{t j;t; ! **1 , !: 0 t v.
. , ,,.,")
? 7 X 1=6.4mg/kg@)MBOCA !1!::i P, ;i!" . U t: !: ,
*3'ffi!@>, 1**; ;i: :** 'ltE !: : o t V* ," .'"1.
MBOCA@){!:;$j!j;bl*DNA !: * i . ~. , c !:7bt, i" "itro
*5 J: U'i" "i"09t! :' C$&f ' tLt V* . ," ~",'. 4 .;t !: L } @)
t!2;i t'ct ly. .Z, " '. 7 -1z ;f. )i, ij 1 . E
7 !=1 ftit! b'3 ,!:. U i:: = E: 1, :, i
\g
C"
li%!btL! .$""al. tsl+ , DNA{*:bn!i @)tEii%:b, *R ; tLt
v* . ,*, i. L*. {, .@)! . jj* 3!*{1aj*;3 , b*: < , 4 >Z ,: 0 {j
l= } @) 13: 5 7b{j6j** o i;: c. !: ,b. ;,, MBOCA11 , 3Sl:: J: - , il
"t; @> ;1 'KE7b'* ti ; tLtV. .6" ).
7*=+),{b7b*i t, 1=0tLtMBOCA1, :'g 56J;:. **55
< ,*: o t v. , C !:'"'*s J: 0:DNA{*'jiq!jriltfi!, 7 -1z +/, ;
t'Ltv* f: C !: " ', b. ,,, MBOCA@)7*='f. }L{b;*fi\';i !=,:i '
" " *'L ;5 .
5 . 1=. } 1=*s1+ .3, 3 '1 \*R.(i) ; ., i!E !r-j
MBOCAl= ; , it. 7;: 6 A g. 2 .Al= !6ii6. 2: im. ! . . Sg
,!>i:::b* , '0)a *!tl*i 1 t', 1 i 1 !P, 1=t ; Ui=*"i. fc
i:, L, = @)fl=g!;: 'i;:t i*, MBOCA : {i!. } )L. =. >. :?
4 Y $,, 7*- } , ;ie U :r. .::. ' ivjjjj , ;t! U =.-. ')Ll*:i
,1 , 4 \,' >, 7*- F ! 't?tt:'11 !. {, 1 , 3t: - tctts D , iitr
@> :jj:bi*MBOCAl= J: .6, {' @) !: !* *r:ii t , . v. !:
t'Lt v* ; ,.
MBOCA@)51"i*bt iji=b*;b* o i::{j= ::j}. i= ,s ly* e, j:i
ig-, F!*
@) lt!,:ER. rt. MBOCAt!$1t:@)1R:i jj li*1,400/, g/g
creatininet' i o j::30i.
* 11 .4 @ @>i; i, ;MBOCA :._L, jEJ$, i=;t;'u?i= l'c. ia:, !;3
j;b*gt:t; . . L t:, b* ll'j !;, \ $ gt {, 5 '1*F6 tt
, / } ,\, E ?"D l=' >m. 3 ' t1 1 !. {,11}:91, L ,*:b' o i= " '.
(2) '1!6' :; '1!E
!;R. *. MBOCAi&i;E*, 25.000j, g/ 4 . L i::i9ii&1 i! 6
: '1. ;!5 V. t :' A, . 3, nn. tj= g jL** !' V. 2: $& ' *L t V.
.6, 17).
(3) 3*:b*/.,,,
Linch ," 'lt, {BIAll :i!!31;Eb*0,02mg/m. i;!Tt, *, ,.
!j tttiv. t v. .:){j= : '31 5, ,s J: U*1954~1969, F@)1 1=
l . 38;*i!i; i*: U tv. . , fF : '178 i@) +209 1.0v. 'C,
tj, j"j*:. j;t v. jz, *,*.= , tt:!. J: , *"! !;t. . i' ,:: v. , {,,
!C;* ;j , *< J, ;j !1 1.01y. t@>*Lpt $1 j' jaA:/;:, b*, ,
!. MBOCAi;Ei5k' 2::;9' . 4, t'L ; , g . 'itj3,;1! L t v* :. ly* 2:
1971, F!.*R. f!;'L 'C v* 6. c t'L{,{j=: : @>ii{q. MBOCAtE!
j j*qZi j, b*620/tg/ 4 , 1!:i9;{16:1*4. 150/, g/ Q t';*, 0 /::. t!*
, @> 'j *5 t5jj:L!c !dii : L t v* . , {'j= 'j= oly. t !* . @)j
1981, i= t! 1 ; *sJ: U, . :i @)*M"t! ' . - 5 t L7=
7b*, 1 1jt;j j*ggj;!, tLt V*tj:V**". j ? '1= F @)1 bt; ;@)i
{}tjgjj15 jt 51ZJ; j20, j=i;!L !: b j'Lt ,s 1) " ', 7 / U *
osHAja: *75'5' 4 7'5"- @> . {4. !: Lt r4* j:- < !:
i20, Fi;lLd>" :! 1 , b*,> 0 , 4 . < !: {}ttg Bj , 5*!
i71 @) ";!, 3R:7b. , 30, i: i;!L *> 6, c !: . :.; $ lf 'c v. ," i.
Linch3, @>;la3!E" '.!s J: U: . @>j @>8a: " )lttt jj @>;
i i:b*20<F-51Lii t' > , 5 ., *m1 3 !. J: - 4'1; i 1* , @>'C
g6, b*A. . :. g;'j t"!;' - 5"- . ' 2: 1* ,. . . tC V.
1983, F@>Cartwright@)*&{ , tl*, r{ \U ;:.@)MBOCA
!; i; @)ttE! Et (A : <QB) i=, ! i : -1 t13 i@)
fi;;"t;1 @> i!t!. bt36 . - *ttc. lABOCA: 7 1*MBOCAg!
it ;!t l= } !C ;b*, 4. , *:';!; C L 5 - , J !: t!;t: f'Lt V* , " '. 1, zb*
L :. *, 4, , e. @)*R . 1*MBOCA@>1 , ggi!{j6: {> 7j<g .,
i
.:Ut, 5*~; ' i:: t*>tL7= j** .
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MBOCA2;a3t!1! . gg:!:"it?idt :.** L. , *rx, ; !i=?u*t
@) i! {i-ti: < 33*tA. ,@);iEtLZ:.*'. , ic !,:7t<+ . .*& !:
*'Lt V. .g, " '.
Ward ,'*." '1*MBOCAR;$33::3'@> . ;t: - E ;la; 1= J: o
t 3 1@>1t, it; . 3E. ;$, L 'Cly, ;,,. - . t'Li= J:; 2:, 1968~
1979,1=-!. b. i* tMBOCA . 9 :!5 L. t v. i L4;E, @>ttE3 &.;4
552E; (532 j;*:1968~1979, F!=, av*'cll , :j :!3:i*> 0 , 20
1*1980~1981, F-1. t 1:L* != !tba;$, 89.5% :b'S9; ,1 ,
82.7%:b*:! *i, @)li 3S:BS:1=30i;,*i , 5Fi t*Sk Bl !*U .5
,1=, !!fy ifF :@) . :. ji6:1*3.2b. ig ) a) *;, 452 il=a38ii!=
J: - , aa :f:ti', 9:v. , ;E. @)385 il=ov*t . i nn. .! *3 J: U'
*ml ; .:9tts Li:. *"1 , t '@>Fti *Lt: t,
@), i 'nn. 1;t'1!E : t: ld:nn. > <;b* 1 * !;f1= 1 ~ 2 i L! , 1, *:
) @> r77 i, ts J: u, i S3EEaa ;b. ?,{ i&i 1 *9i=i4
,F!;!_L, :i 1*i i ! 1 *B1= 8 7b*H !J=@> '8235@)
'k1593;i : A4 U x ? ?'iL-7!: L ti39U2, @>F9653!iib',
l; !, f$. i:1 ; ! !,'i=. @)*;, , tg . 3 51ci Dt; ( F
:i !; ?LEii t; t L! ; 1 ~11! , '?L9t ti 4 LE:; l
li5, F3*i :;! LE;t :: 4 J= :; ll ) ,b*3E;3 tLi=. 3
S: "C, b**lllt!3>1*:E:i%'ti*, o i:** 1 ;1* 1*!ttf1. 741a
@)ai;im. ig , b*4*:tB tL/:= . !: 1= J: 0 , 2 1*i*iiRi :1 . E* !
!S;:li'tV. iE C !:1= J: 0 ;t. ? li -=. > 7 *Li:.. ,t'@)T*1$
@> :S. MBOCAi!9:1 i*iRl::ik *Lt v. *:v*;b*, gy!j S, JLj
:b. !3 *t* ie !: @)fj=: $:K'@>1 q. MBOCAj&j , 0*j j
50, 000j, g/ !: ? ,1=jgjv*{ ! >j L t: C t: ,s J: U:i!t!!iEt;:
'! @> E: :L @)MBOCAi!! 1 75*55ppm}: L*B{*i!t @>
MBOCAi ;$75, 1jEt!: :.-, i;: C !: " 'b. ,, i il;;:i=t!$:;$
*Li;=11**3i;: !: :3. . , tL; . j ,, b* $ :L i=@)!tMBOCA
@> !;i mi:;Flt;'k:,;2, 0- ?' n iP7. = U >,, *<Jl-,? li > *5 J:
U, t!6 @)MBOCA@)1 :b. 4-?' 0 JL--0- } iL-,' :$ >, o
- F iL. 4 :, y, s J: u2/ ,f. u > :? 7=. U y tz. !:'17@)3t:!i, K. .
'1' '19:"?E> . , *fy:E !: tLt ,, " '. . tL f, #?Etl at@) 5 ,,
;tl t:'1: 1it;;57bt33tE. L t V* . , @) j* 0- } Ju. { :, :,,"i
!:MBOCA" 't*) ,. f:MBOCA9! ii :T*! 4F : .@)o
- } )!, 4 $3 :, 11 , 33ft!= 1;5 ~ - i 5"- '1*; . tLt .*3 ,
*" "" '"", 0- } iL-4 :, >*t!:'@>t!$jE:fi; "t; @>3t{El= i:- ;-
L i::;b. 1t7= Ut, ;t, ,, 1 ft!*;$, 3 j@>MBOCAlg5i ! i, : i
,F, 9 **H : i::!*1.5;b*)t 2:j,iV. :6*jtj@gj 1 j g* lc V. i;:
c 2:, 2 ;1.0v*'Cl*{t 1={b, j*T*!f'C, Umv. t: c !:, 5*tj: v*
. }:, ,F*g:b*28i!t, 29i ;, 44i E:; '< ,b*0!9g: ;! ** ,
v. b. : /:: i, :JLei>'C V. , C !: ,,, !:'** ,, C t'L k, 3 :j, 1:: f$. ,
*Li::fi; 1, t; ;*MBOCA11 3S:!= J: . , {, @> !: tK; tLt v*
.,, 32,3Bj
6 . t$31-1 11. ,s!,' 6, *k, fill{ : t: 1* i '
?Kl jOSHAi* ':5 -y } !: ? * ;!.!c ts v. t3EhtA, ,1 :b, ,3 ,
,, tLi: C !: *. k,, L974, i,1=MBOCAF:. 33;b',,{,!1*i at !: L t
*!lMl3~"). k 5 U x } lcili% :'t:. L*. L, : !. jR!@)jj 1 j=
.k O 3!t ! !: ti: o i:=" '. ,t'@) *;iK!:, *!lfb11 ' iEi t'. != 1= *
O , 1976, F, b* , MBOCA !3t, b*A, !1*i*j@) li x } b. ,#'F L
TWA, L. t0,02ppm (0.22mg/m. ) !;;i:&>t, * ," ,,, 1.
NIOSH1*1973ti= t:1978fi=1=MBOCA@>3tbf, 4, , . L,
E:'5. - L, ' . y } , ?,>' >!., t3 J: U, 4 >: @> ! : i!E,*'
9;. :t @)
*
&>, Potentialhuman carcinogen!:,:;,;*:. L, t* *" D
{ v*j!glf,j= , >, F o -iL, ';',*: ti'*> 6, C !: *. ,,, { :it
)i :!1, F1{9 -t ,6, 0,003"g/m' ( R5; 5p! j j )
"" ' " "' "' ti: v* , ;jj . L ' ly' "" " "'
IARCi* 1974, i= !: 1987&t=!= v e' =. - ; L , !mi!1FiKk! * i !its"k U, Cartwright@> t . . 2:!=, MBOCA .?'iP-
72Ai=i ..Eit L t v. ;:,,, i.
>j 1 1ACGIHi*, NIOSH@>;;Ei&::ii8 !cJ: 0 !i%B ; , b**&
' f'Li:: C !::b. ,,, 1991~i992Ei=1;E*t&!;'tMBOCA !. Al
(Human carcinogen) lC:5i. Eii L, 6i' iU!1;, :. !!:5i{ L :*:' V,
C !: !;t * Lf=""." '7bt c } @>:33:b*A. ,tit l;btMBOCAg!
i :E*gj;Eg$Rti*d> ",:b*{g!= {i1%mt; f:3t; L ' ,
;! t7 >, 1= {)11 , 38: *Ltts O MBOCA1 . 3g:1= J: . , !: 1*
v. v. tLi*!v* !: v* 5 13Z;ii ""." ' !ii!. 0 7. *Lt, 1992~93, F
t!tit 't'i*A2(Suspected Carcinogen) != L, , TWAf:. C
t'L : 7:'@)0,02ppm (0.22mg/m, ) *. , 0.01ppm(0. 11mg/
m. )!CTlft * K:;LtV. 6" i.
X*=.- "yl*, C2 (probable human carcinogen)
!=i 'EijL. , i ; v. !c j, : . m 3ggd, ;@) ! , S2:
L, 3 ' tg!j3:' :. t :;i< L t ,*t:v. " ). >*-;t. } ;> U 7, ,:/L.
*-, 7 4 > ;j> > 1*, 7 ;5' >' X@> . 1*1 , C21=i5i'tliL 'Cly.
, 7bt, TWA !: L t0 .02ppm . !$3; Ltv. . ," ). F 4 ,y j*
A2(animalcarcinogen) 1=; .*iil, MAKF:. 8*tt:. it ', ;
j1 ,F11 ESt!&i ,(TechnicalExposure Limits, TRK) !: L
'C0.02"g/m. (total dust) F:.:ij:&btV* 6," '. ;fFj3ll*g375*A,
cancer) 1= .3iiL. , : =1 39i&!
(MaximumExposure Limit, MEL) !: L*C0*005"g/m,
(8h-TWA) . jit&b'C v. ," }, v*f*L@>1 1 {}jj K:.!!!lD!@>3>
. i = !: '&:{* i L 'C V. ;,,.
7 i:
MBOCA@): ;, li;E@> .> *>:!a : {iltB !: *: , @) 1*3t;b', A, ,1 Zi'
E> .!&tr*bt:'d)33;6'K. ,{ i*, v } , ?*' X .*3 J: U'4 >: !=
*sv*ttQi;;k itt, s O ,lARC, s .k U: -1 1!: {}MBOCA
*, animal CaTCinOgent'*;.6i . !: f:'3g, !>t v".,,, 0. ,a~, 6j.
IARCld:Linch" '. ts J: U:Cartwright" ' &, @)*&ff; ti'i* l=
} @> 5"'- :bt:4<+t ."C. i*i , != L tMBOCA f:. 2A!=i5 .; ii
L t V. . ",';bt '@>t , Wardi;," ." '@>?;2: !:316 fc * O
552 5 @)11 E8:fi.; 'd, 3 i@)1%Dt; @)3E! ., 6**& . tLt
,. ,.
l;!J:.@> = 2: b. ,, !&bi*it'j . 1$, tL/=MBOCA@)t"jE1* t;
} 'C'@)gt7b*A. .' ' !+. '!cjjEjR! L 5 ;2, {, @)'C'3;, 0 , , 1.
:*:fj=:i,: '1= *slf ;,,! mf; @>33 .** 2 . ,.
t'LtV. ,. C t'L, , @> 1= } @>3E7b'A, *&. f;;'1= t3V. tl* V. 'j**L
{, jj, -i! jg:bt: :;tE'j' . , 1' 8.1tE ' 'j ;,: ' . v*bf - @)
=1 1itMBOCA !:;ig .: . @):b*:g;- ! t;i5 . ,. L. *. L, '@)
g , 5*A. ,j :1 {tEf:' :tf! ~ , 1= .6, R 3gf *Rl*t k, tLt V*,
4; i aF (may cause
MBOCA9!
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. t'Li9> ., : ,:,; : t'@)jH'*RitMBOCAf:. b E j. js!,. ,
gt**A, !9jj j!: Efr$;9,'. E, 1= 1* ti:*3+ 't*, 6 !: 1* '". f, *L
t:. v. ;bti= } t:. 0> ;b*x. ,jt;j :, bfK< v*@)t", gj ;$j $j;
2 *\A*ti j!c- ' iiL, i 0.005mg/m, (! ) ! ': i&1 !
L 'c&!f; :,' "'
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i) %. m' ti! i;, et{i . ii i ! , a' . t! R@:! i;: 4. ,1* '"i!i; ;i! JL1;3 ., 1985 288-289.
2) {b! *T B*R !:. 10889@>{b, !\:il;ifff, !!:i;t {b! e:E a$E:tt, 1989 534-535.3) Farmer PB, Rickard BJ. Robertson S. Themetabolism and distribution of 4,4'-methylenebis (2-chloroaniline) (MBOCA) in rats. J Appl Toxicoli98i 1 31?-322.
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aminobiphenyl and
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C)
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21) Russfield AB, Homburger FF, Boger E, VanDongen CG, Weisburger EK, Weisburger JH. Thecarcinogeic effect of 4,4'-methylene-bis (2-chloroaniline) in mice and rats. Toxicol ApplPhannac011975 31 4?-54.22) Morris CR, Voytek P. Hazard and risk assessmentanalysis of 4,4'-methylene-bis (2-chloroaniline)(MBOCA). i99i.23) Stula EF, Barnes jR, Sherman H, Reinhardt CF,Zapp JA jr. Urinarybladdertumors in dogsfrom 4,4'-methylene-bis(2-chloroaniline) (MOCAO ). EnvironPatholToxic011977 1 31-50.24) Miller EC. Some current perspectives on chemicalcarcinogenesis inhumans and experimentalanimals :Presidentialaddress. CancerRes1978 38 1479-1496.25) Silk NA, Lay JO, Martin CN. Covalent binding of4,4'-methylenebis-(2-chloroaniline) to rat liver DNAi" t, i"o and ofits N-hydroxylated derivative to DNAi" "i!ro. BiochemPharmac011989 38 279-287.26) ml*1!!*+, iii - rs, / .f. v y:?7=. u > : /+v >t:':< (2-? 0 iL-7= U >) li : i. '5. v } ;=,;sli' 60NA{*' n!! @>t tU. i5: :! ! & 1991 33 430-431.27) Shivapurkar HS, Lehman TA, Schut HAJ, StonerGD. DNA biding of 4,4'-methylene-bis(2-chloroanline) (MOCA) in explant culture of humanand dogbladder. Cancer Lett 1987 38 : 41-48.28) Hesbert A, Bottin MC, DeCeaurriz j. Mutagenicityof 4,4'-methylene-bis-(2-chloroaniline) "MOCA" andits N-acetyl derivatives in S. t! , hyim", i"m. lnt ArchOccupEnvironHealth1985 55 169-174.29) Mastromatteo E. Recent occupational healthexperiencesin Ontario. J Occup Med 1965 : 7 ' 502.30) Hosein HB, Van Roosmalen PB. Acute exposuretomethylene bis 2-chloroaniline (MOCA). Am lnd HygAssocJ1978 39 496-497.31) Ward E, Smith AB, Halperin W. 4,4'-Methylenebis(2-chloroaniline) an unregulated carcinogen. Am jlndMedL987 12 537-549.32) Ward E, Halperin W, Thun M, el @1. Screeningworkers exposed t0 4,4'-Methylenebis(2-chloroaniline) for bladder cancer by cystoscopy. jOccupMed1990 32 865-868.
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for biologicalcase
methylene
exposureLondon
limits
( E":j , 35 4 353~358: )
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