in vivo biological response to vitamin e and vitamin-e- doped polyethylene by bryan t. jarrett,...

In Vivo Biological Response to Vitamin E and Vitamin-E-Doped Polyethylene

by Bryan T. Jarrett, Jennifer Cofske, Andrew E. Rosenberg, Ebru Oral, Orhun Muratoglu, and Henrik Malchau

J Bone Joint Surg AmVolume 92(16):2672-2681

November 17, 2010

©2010 by The Journal of Bone and Joint Surgery, Inc.

Representative histological section of a knee capsule from a New Zealand White rabbit two weeks after injection of pure synthetic vitamin E (10 μL), showing signs of acute and chronic

inflammation with surface fibrin deposition and cellular debris (hematoxy...

Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672-2681


Representative histological section of a knee capsule from a New Zealand White rabbit twelve weeks after injection of vitamin-E solution (2 mL of 5 mg/mL), showing no synovial abnormalities

(hematoxylin and eosin).



Subcutaneous pouch surrounding a vitamin-E-doped ultra-high molecular weight polyethylene plug after two weeks in vivo, showing evidence of acute inflammation and tissue repair

(hematoxylin and eosin).



Subcutaneous pouch surrounding vitamin-E-doped ultra-high molecular weight polyethylene plug after twelve weeks in vivo, showing evidence of stable fibrous encapsulation (hematoxylin

and eosin).



Representative example of pseudocapsule formed around the implant from the vitamin-E group with a gross papillary structure and changes in architecture (the black suture indicates the

superior direction).



Representative histological image of a smooth surface pseudocapsule formed around the implant with synovial-like cells at the surface with underlying fibrosis (hematoxylin and eosin).



in vivo biological response to vitamin e and vitamin-e- doped polyethylene by bryan t. jarrett,...

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