interpenetrating networks for delivery systems client: professor w. john kao, school of pharmacy...
TRANSCRIPT
Interpenetrating Networks for Delivery Systems
Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering
Advisor: Professor Naomi Chesler, Department of Biomedical Engineering
Ashley HuthClaire FlanaganAdam Rieves
Jon Sass
Overview• Background Information
• Interpenetrating Networks (IPNs)• Competing Products• Past Semester
• Problem Statement• Design Requirements• Proposed Designs• Future Work• Questions
Problem Statement• To design a novel delivery mechanism
to reconstitute the components of an interpenetrating network (IPN).
Background: IPNs
*Kao, W.J.
What is an IPN?A bioactive wound dressing for
large surface area wounds
IPNConventional Dressings
Irregular Wound
Background: IPNs
• Kao, W.J.
Solution(drugs + matrix component)
Covalently Linked Therapeutic(s) and/orCell Adhesion Ligands
Soluble Therapeutic(s)
Biodegradable Gelatin Backbone
PEG-diacrylate(2-3.4 kDa )
in situ UV curing
IPNs are composed of multiple components
Clinical Application• Benefits
– Biocompatible– Moist healing environment– Conforms to irregular wounds– Covers large surface area wounds– Delivers drug cocktails
• Issues– Heat– Uneven administration– Lengthy application process
Current Administration Technique
Ingredients/drug(s) in singlecontainer
Mix11
Cover55
Heat22
33 Inject Syringe is use to administer solution
44 Curein 30 sec to obtain a rubbery film
66 Sustained Releasewhile the IPN biodegrades
Day7
Day3Day
1
77 Clean
*Kao, W.J
Components•pegDA•Gelatin•Photoinitator•Water
Last Semester• Focused on optimizing IPN solution
composition– Gelatin dissolution impacts efficacy & administration of IPNs
– Integrated laboratory & design-based research
• Developed IPN recipe
• Modified IPN administration
This Semester• Administration technique
• Product packaging
• Further laboratory research
Design Requirements• Minimal preparation and effort required to
administer the IPN• Compartmentalization • Even spray pattern• Uniform solution• Straightforward mixing procedure• Disposable • Can be sterilized • Low-cost• Few parts
Competing Products
• Duoject Medical Systems Inc. – Inter-Vial
• Debiotech – Clip’n’ject
• U-Mix – Travel Bottle
• Hansplast – Spray Bandage
Design 1: Syringe
• Liquid in plunger• Powder stored in
barrel• Mechanism to release
liquid into powder• Hand mixing• Hand powered
delivery• Luer-Lock spray tip
Design 1: Syringe• Pros
– All in one packaging– Easy application– Controllable spray rate
• Cons– Custom manufacturing required– Moving parts
Design 2: Pressurized Bottle
• Manual pressure vacuum
• Unique cap design– Facilitates stirring
mechanism
• Perforated seal
Design 3: Pressurized Bottle• Pros
– Incorporates mixing mechanism– Provides slow release of photo-initiator
• Cons– Laborious application technique– Non-standard parts
Design 1: Spray Bottle
• Threaded straw • Blades puncture inner
container• Single pump, single
spray• Includes mixing
mechanism
Design 3: Spray Bottle• Pros
– Incorporates mixing mechanism– Provides slow release of photo-initiator
• Cons– Laborious application technique– Non-standard parts
Design Matrix
Criteria WeightDesign 1 Syringe
Design 2 Pressurize
Design 3 Spray
Mixing Procedure 15 10 9 12Uniform Solution 10 6 7 7Compartmentalization 10 9 5 8Parts Availability 10 7 9 6Application Ergonomics 10 8 6 4Safety 10 8 6 8Cost 10 5 3 7Sterility 5 5 3 4Scalability 5 5 2 4Spray Pattern 5 4 5 2Client Preference 5 5 5 3Photo-initiator Protection 5 3 5 4TOTAL 100 75 65 69