j exp med 2002 dec 196(12) 1627-38, figures
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ToleranceTRANSCRIPT
![Page 1: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/1.jpg)
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen
Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
by Laura Bonifaz, David Bonnyay, Karsten Mahnke, Miguel Rivera, Michel C. Nussenzweig, and Ralph M. Steinman
JEMVolume 196(12):1627-1638
December 16, 2002
© 2002 Rockefeller University Press
![Page 2: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/2.jpg)
Conjugation and delivery of OVA via monoclonal antibodies.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 3: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/3.jpg)
Targeting of αDEC-205:OVA to CD11c+ lymph node DCs in vitro.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 4: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/4.jpg)
Targeting of αDEC-205:OVA to lymph node CD11c+ DCs in vivo.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 5: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/5.jpg)
Maturation of DCs in vivo by agonistic αCD40 but not by αDEC-205:OVA.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 6: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/6.jpg)
Contrasting responses of OT-I T cells to αDEC-205:OVA in the presence or absence of αCD40-induced DC maturation.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 7: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/7.jpg)
Deletion of OT-I T cells in response to αDEC-205:OVA in steady state.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
![Page 8: J Exp Med 2002 Dec 196(12) 1627-38, Figures](https://reader036.vdocuments.net/reader036/viewer/2022062323/55cf9af7550346d033a43598/html5/thumbnails/8.jpg)
αDEC-205:OVA induces peripheral tolerance to OVA in the steady state.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press