JOURNAL OF VIROLOGYVOLUME 56 * DECEMBER 1985 * NUMBER 3

Arnold J. Levine, Editor in Chief(1989)

Princeton UniversityPrinceton, N.J.David T. Denhardt, Editor (1987)University of Western OntarioLondon, Ontario, CanadaBernard N. Fields, Editor (1988)Harvard Medical SchoolBoston, Mass.Robert M. Krug, Editor (1987)Sloan-Kettering InstituteNew York, N.Y.

Michael B. A. Oldstone, Editor (1988)Scripps Clinic & Research FoundationLa Jolla, Calif.Thomas E. Shenk, Editor (1989)Princeton UniversityPrinceton, N.J.Anna Marie Skalka, Editor (1989)Hoffmann-La Roche Inc.Nutley, N.J.Robert A. Weisberg, Editor (1988)National Institute of Child Healthand Human Development

Bethesda, Md.

David Baltimore (1987)Amiya K. Banerjee (1985)Andrew Becker (1985)Tamar Ben-Porat (1987)Kenneth I. Berns (1985)Michael Botchan (1986)David Botstein (1985)Barrie J. Carter (1987)John M. Coffin (1986)Geoffrey M. Cooper (1987)Donald Court (1987)Richard Courtney (1986)Walter Doerfler (1986)Peter Doherty (1986)Elvera Ehrenfeld (1986)Robert N. Eisenman (1985)Suzanne U. Emerson (1986)Emanuel Faust (1987)S. Jane Flint (1987)Yasuhiro Furuichi (1985)Costa Georgopolous (1986)Walter Gerhard (1986)Larry M. Gold (1985)Peter Gruss (1985)Hidesaburo Hanafusa (1986)

EDITORIAL BOARDWilliam S. Hayward (1987)Roger Hendrix (1987)Martin Hirsch (1986)John J. Holland (1987)Ian H. Holmes (1986)Robert W. Honess (1986)Nancy Hopkins (1986)Peter M. Howley (1987)Alice S. Huang (1987)Tony Hunter (1986)Masayori Inouye (1985)Robert Kamen (1985)Thomas J. Kelly, Jr. (1985)George Khoury (1987)Elliott Kieff (1987)Daniel Kolakofsky (1986)Robert Lamb (1985)Robert A. Lgzzarini (1987)Myron Levine (1985)Douglas R. Lowy (1986)Robert Martin (1987)Warren Masker (1987)Thomas Merigan (1986)George Miller (1987)Lois K. Miller (1985)

Peter Model (1986)Bernard Moss (1986)Fred Murphy (1986)Nancy G. Nossal (1987)Abner Notkins (1986)J. Thomas Parsons (1986)Ulf G. Pettersson (1986)Lennart Philipson (1987)Lewis I. Pizer (1987)Craig R. Pringle (1986)Carol Prives (1986)Robert Purcell (1986)Fred Rapp (1987)Dan S. Ray (1986)M. E. Reichmann (1985)Gordon M. Ringold (1987)Harriet Robinson (1985)William S. Robinson (1986)Berhard Roizman (1985)Naomi Rosenberg (1986)Roland R. Rueckert (1985)Norman P. Salzman (1987)Joseph Sambrook (1985)*Charles E. Samuel (1986)Priscilla A. Schaffer (1987)

Sondra Schlesinger (1986)June R. Scott (1986)Bart Sefton (1985)Phillip A. Sharp (1985)Charles J. Sherr (1987)Saul J. Silverstein (1985)Patricia G. Spear (1987)Nat Sternberg (1986)Mark F. Stinski (1986)James Strauss (1987)F. William Studier (1987)Lawrence S. Sturman (1985)Jesse Summers (1985)William Summers (1985)John M. Taylor (1987)Howard M. Temin (1985)George F. Vande Woude (1986)Inder Verma (1986)Edward K. Wagner (1986)Eckard Wimmer (1985)Owen Witte (1986)Charles Hamish Young (1986)Julius S. Youngner (1986)

Helen R. Whiteley, Chairman, Publications Board Linda M. Illig, Managing Editor, Journals

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW,Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, andanimals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry,biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors arepublished in the January issue each year; reprints are available from the editors and the Publications Department. The Journalis issued monthly, four volumes per year. The nonmember subscription price is $249 per year; single copies are $21 . Themember subscription price is $37 (foreign, $49 [surface rate]) per year; single copies are $7.00. Correspondence relating tosubscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts,and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006(phone: 202 833-9680).Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months afterpublication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues.Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed.Second-class postage paid at Washington, DC 20006, and at additional mailing offices.POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006.Made in the U.S.A.Copyright ©) 1985, American Society for Microbiology. El* ff I J-t14t1t; ( IIItcAll Rights Reserved.The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the arti-cle may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, thatthe copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, forcopying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to otherkinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collectiveworks, or for resale.

Author IndexAkusjarvi, Goran, 879Anderson, Kevin P., 814Anderson, Robert W., 757Asselin, Claude, 958

Babiuk, Lorne A., 1037Barrell, Bart, 807Barrington, Alan, 1037Bastin, Marcel, 958Behnke, James N., 912Bestwick, Richard K., 660Bhat, Ramesh A., 750Biggin, Mark D., 807Bornkamm, Georg W., 987Brown, Ronald E., 1041

Cerini, Costantino P., 1014Chambers, Thomas M., 1049Cheng, Yung-Chi, 846Chiou, Jwo-Farn, 846Cho, Myung-Sam, 852, 860Cohen, Gary H., 1014

Deppert, Wolfgang, 821Dietzschold, Bernard, 1014

Eckhart, Walter, 1023Eisenberg, Roselyn J., 1014Enrietto, Paula J., 943, 969Ensinger, Marcia J., 1027Eriksson, B., 996Everitt, Einar, 896

Forss, Sonja, 921Frana, Mark F., 912Freese, U. Karl, 987

Gadler, H., 996Garber, Ellen A., 790Gawlik, Mary E., 839Glorioso, Joseph C., 930Golub, Ellis, 1014Gopalakrishna, Y., 655

Hackett, Perry B., 683

Hanafusa, Hidesaburo, 743,790

Hanafusa, Teruko, 790Hand, Roger, 711Hankins, W. David, 660Hayman, Michael J., 943, 969Hayward, Gary S., 723, 867Hayward, S. Diane, 852, 860Heilman, Conrad J., 1014Hilliker, Sandra, 1030, 1034Holmes, Kathryn V., 904, 912Horowitz, Jonathan M., 798Huang, Eng-Shang, 846

Jeang, Kuan-Teh, 852Jennings, Stephen R., 757Jolicoeur, Paul, 1045Joseph, Anne D., 1014

Kabat, David, 660Kaerner, Hans Christian, 930Kaplan, Paul L., 1023Kawai, Sadaaki, 743Kerr, Ian M., 1041Kerr, Shona M., 1041Kimura, Genki, 951King, Andrew M. Q., 921Klessig, Daniel F., 767, 814,

821Klockmann, Ulrich, 821Kloszewski, Edmond D., 757Kodama, Kazuya, 978Kozak, Christine, 1045Kumel, Gunther, 930

Landolph, Joseph R., 701Laux, Gerhard, 987Lenard, J., 655Lerner, Richard A., 691Levan, Goran, 938Levine, Myron, 930Levy, David E., 691Lohse, Megan A., 938Long, Deborah, 1014

Manor, Haim, 734

Mar, Eng-Chun, 846Maroney, Patricia A., 1049Mayer, Bruce J., 743McAtee, Frank J., 1018McCahon, David, 921Mertz, Janet E., 1002Milman, Gregory, 860Mitsudomi, Tetsuya, 951Mosca, Joseph D., 867Moss, Bernard, 830, 1027Murakami, Seishi, 978

Nayak, Debi P., 1049Newman, John W. I., 921Nilsen, Timothy W., 1049Nishizawa, Makoto, 743Nitayaphan, Sorachai, 887

Oberg, B., 996Ogasawara, Naotake, 978O'Hare, Peter, 723Olsen, John C., 779

Pellett, Philip E., 807Petersen, Robert B., 683Pitha, Paula M., 867Ponce de Leon, Manuel, 1014Portis, John L., 1018Powell, Bernadette B., 839

Ransohoff, Richard M., 1049Rassart, Eric, 1045Reyes, Gregory R., 867Ricard, Cynthia S., 904Rice, Andrew P., 1041Rice, Patricia L., 757Rice, Stephen A., 767Risser, Rex, 798Roberts, Walden K., 1041Roizman, Bernard, 807Roos, Raymond P., 887Rosel, Johannes, 830Roy-Burman, Pradip, 701Ruden, U., 996Ruscetti, Sandra, 717

Sabara, Marta, 1037Saunders, Keith, 921Schroder, Claus H., 930Shaw, Jane, 943Shimizu, Robert W., 701Silverman, Lauren, 814Simon, Suzanne, 1023Slade, William R., 921Smith, Douglas R., 969Soe, Lisa Hokama, 701Somasekhar, Madhu B., 1002Stedman, Deborah, 711Stenberg, Richard M., 665,

676Stinski, Mark F., 665, 676Sturman, Lawrence S., 904,912

Svensson, Ulla K., 896Swanstrom, Ronald, 779Szpirer, Claude, 938Szpirer, Josiane, 938

Takeya, Tatsuo, 743Tevethia, Satvir S., 757Thimmappaya, Bayar, 750Thompson, David L., 757Toth, Marcia M., 887Toyoshima, Kumao, 743Trentin, John J., 839Tsichlis, Philip N., 938Tumilowicz, Joseph J., 839

Vennstrom, Bjorn, 969Villeneuve, Luc, 1045

Wahren, B., 996Weir, Jerry P., 1027Whittaker, Lori, 711Wiggins, Bruce A., 1030, 1034Wilson, Michael C., 691Witte, Pamela R., 665Wohlfart, Claes E. G., 896Wolff, Linda, 717

Yamamoto, Tadashi, 743Yoshikawa, Hiroshi, 978

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AUTHOR INDEX

VOLUME 56

Ackermann, Mathias, 207Akusjarvi, Goran, 879Albrecht, Michael, 466Anderson, Kevin P., 378, 814Anderson, Robert W., 757Arthur, Larry O., 571Ashley, Rhoda, 475Askonas, Brigitte A., 55Asselin, Claude, 958

Babiuk, Lorne A., 1037Baluda, Marcel A., 240Bangham, Charles R. M., 55Baric, Ralph S., 449Barker, Christopher S., 571Barrell, Bart, 807Barrington, Alan, 1037Bastin, Marcel, 958Baxt, Barry, 120Behnke, James N., 912Bendinelli, Mauro, 651Berlingieri, Maria Teresa, 284Berns, Kenneth I., 457Bestwick, Richard K., 660Betz, Joan L., 312Bhat, Ramesh A., 750Biggin, Mark D., 807Blomberg, Jonas, 489Bonhomme, Francois, 216Bornkamm, Georg W., 987Bossert, Annemarie, 325Botchan, Michael R., 625Branton, Philip E., 633Broni, Barbara, 201Brown, Ronald E., 1041Bryant, Martin L., 571Brzosko, Witold J., 337Burnett, Roger M., 439

Calos, Michele P., 625Campadelli-Fiume, Gabriella,

127Cannon, Martin J., 55Capobianchi, Maria R., 651Carbonell, Luis F., 153Casey, Thomas A., 194Celis, Esteban, 426Cepko, Constance L., 404Cerini, Costantino P., 1014Chambers, Thomas M., 1049Chanock, Stephen J., 613Chatterjee, Subhendra, 419Chen, Zhang-qun, 607Cheng, Yung-Chi, 846Chiou, Jwo-Farn, 846Cho, Myung-Sam, 852, 860Clark, Harold, 475Cobrinik, D., 589Cohen, Gary H., 1014Colonno, Richard J., 628Condit, Richard C., 395Consigli, Richard A., 365Cooper, Susan J., 110Copeland, Neal G., 172Corey, Lawrence, 475Costa, Robert H., 19Coulson, B. S., 317Creager, Richard S., 221Cutt, John R., 250

Dales, S., 434Dall'Olio, Fabio, 127Dandoy, Francoise, 216Darai, Gholamreza, 466Davis, Michelle Gall, 7Day, Loren A., 268Degener, A. M., 579deHaseth, P., 589del Grosso, N., 579DeLuca, Neal A., 558De Maeyer, Edwaid, 216De Maeyer-Guignard,

Jacqueline, 216Deppert, Wolfgang, 541, 821DesGroseillers, Luc, 639Desselberger, Ulrich, 221De Stasio, P. R., 579Devi-Rao, Gayathri, 19Dianzani, Ferdinando, 651Dietzschold. Bernard, 1014Dietzschold, Bernhard, 12,426

Di Fiore, Pier Paolo, 284Di Lauro, Roberto, 284Di Russo, C., 579Dodson, Lori A., 644Doerfler, Walter, 320Draper, Kenneth G., 19DuBois, Garrett, 607DuBridge, Robert B., 625Duyk, G., 589Dyall-Smith, M. L., 317

Eckhart, Walter, 1023Edson, Clark M., 333Egbert, James, 449Eisenberg, Roselyn J., 1014Elango, Narayanasamy, 298Enrietto. Paula J., 943, 969Ensinger, Marcia J., 1027Eriksson, B., 996Esteban, Mariano, 75, 482Everitt, Einar, 896

Fan, Chieh-Min, 600Fields, Bernard N., 613Flomenberg, Phyllis, 647Flugel, Rolf M., 466Forss, Sonja, 921Frana, Mark F., 912Franke, Christine A., 227Freese, U. Karl, 987Fujimura. Robert K., 245Furuichi, Yasuhiro, 527Fusco, Alfredo, 284

Gadler, H., 996Garber, Ellen A., 790Gardner, Murray B.. 571Gawlik. Mary E., 839Gentsch, Jon R., 356Giangregorio, Anna M.. 651Gibson, Wade, 277Gilden, Raymond V.. 571Glenn, Gary M., 66Glorioso, Joseph C., 930Golub, Ellis. 1014Gopalakrishna, Y., 655Granoff, Allan, 495Graves, Peter N.. 221

Green, Maurice, 183Griffin, Beverly E., 328Griffin, Diane E., 110Grinnell, Brian W., 386Groff, Dennis E., 85Grossman, Zehava, 457Grubman, Marvin J., 120Guenet, Jean-Louis, 216

Haarr, L., 512Hackett, Perry B., 683Haines, Lora L., 293Halbert, Donald N., 250Haller. Otto, 201Hamagishi, Yasutaro, 176Hanafusa, Hidesaburo, 743,

790Hanafusa, Teruko, 790Hand, Roger, 711Hankins, W. David, 660Hansen, Ulla M., 293Harris, Ann, 328Hay, John, 194, 600Hayman, Michael J., 943, 969Hayward, Gary S., 723, 867Hayward, S. Diane, 852, 860Heidecker, Gisela, 571Heilman, Conrad J., 1014Hell, Wolfgang, 414Henning, Roland, 520Henrickson, Roy V., 571Hill, Thomas M., 312Hilliker, Sandra, 1030, 1034Hinze, Harry C., 60Holmes, 1. H., 317Holmes, Kathryn V., 904, 912Horohov, David W., 1Horowitz, Jonathan M., 798Horwitz, Marshall S., 647Hosler, Betsy A., 333Hruby, Dennis E., 227Huang, Eng-Shang, 7, 846Hunter, Eric, 419, 571Hyman, Richard W., 92

Irmiere, Alice, 277Ishioka, Glenn Y., 49

Jambou, Robert C., 298Janeczko, Richard, 482Jeang, Kuan-Teh, 852Jenkins, Nancy A., 172Jennings, Stephen R., 757Johansson, P. J. Hugo, 489Johnston, Jeffrey M., 378Jolicoeur, Paul, 639, 1045Joseph, Anne D., 1014

Kabat, David, 660Kaerner, Hans Christian, 930Kaplan, Paul L., 1023Kapsenberg, Jacoba G., 337Karjalainen, Henry E., 373Karzon, David T., 55Kawai, Sadaaki, 743Keck, James G., 449Kendall, Joe, 120Kerr, Ian M., 1041Kerr, Shona M., 1041Kimelman, David, 404

Kimura, Genki, 951Kinchington, Paul R., 194King, Andrew M. Q., 921Klessig, Daniel F., 378, 767,

814, 821Klockmann, Ulrich, 541, 821Kloszewski, Edmond D., 757Klowden, Marc J., 153Kluge, John D., 571Kodama, Kazuya, 978Konings, Ruud N. H., 268Koprowski, Hilary, 12, 426Kowal, R., 589Kozak, Christine, 1045Kramp, William J., 60Krata, Lewis, 613Kristensson, Krister, 337Krochmalnic, Gabriella, 549Krug, Robert M., 201Krystal, Mark, 221Kumel, Gunther, 930

Lai, Michael M. C., 449Lamb, Robert A., 502Lancaster, Wayne D., 85Landolph, Joseph R., 701Laux, Gerhard, 987Lazdins, I., 317Leibowitz, Julian L., 449Leis, J., 589Lemischka, ihor R., 404Lenard, J., 655Lerche, Nicholas W., 571Lerner, Richard A., 691Levan, Goran, 938Levine, Myron, 930Levy, David E., 691Lipsick, Joseph S., 240Livingston, David M., 293Loewenstein, Paul M., 183Lohse, Megan A., 258, 938Long, Deborah, 1014Longiaru, M., 589Lowenstine, Linda J., 571Lucas-Lenard, Jean M., 161Lucher, Lynne A., 183Luiten, Ruud G. M., 268Lukacs, Noemi, 307Lusky, Monika, 625

Macfarlan, Roderick I., 12Makino, Shinji, 449Malagolini, Nadia, 127Malley, Arthur, 571Manor, Haim, 734Mar, Eng-Chun, 846Maroney, Patricia A., 1049Marriott, Susan J., 365Marsden, H. S., 512Martin, Malcolm A., 176Martin, Robert G., 293Martiniello, M. G., 579Marx, Preston A., 571Masker, Warren E., 644Matteucci, Donatella, 651Maul, Donald H., 571Maupin, Marilyn, 644Mayer, Bruce J., 743McAtee, Frank J., 1018McCahon, David, 921

ii AUTHOR INDEX

McCarthy, Alice M., 558McGinnes, L. W., 341McNulty, Wilbur P., 571Medveczky, Peter, 60Mertz, Gregory, 475Mertz, Janet E., 1002Mettenleiter, Thomas C., 307Midulla, M., 579Miller, Jacqueline S., 404Miller, Lois K., 153Milman, Gregory, 860Mitsudomi, Tetsuya, 951Mizutani, Satoshi, 628Mocarski, Edward S., 135Modrow, Susanne, 414Moore, Robert N., 1Moorhead, John W., 49Morgan, Donald O., 120Morrison, T., 341Mosca, Joseph D., 867Moss, Bernard, 349, 534, 830,

1027Mulder, Carel, 60Mulgaonkar, Pratima, 325Mulligan, Richard C., 404Munn, Robert J., 571Murakami, Seishi, 978Myhre, Erling B., 489

Nakada, Susumu, 221Nash, William G., 303Nayak, Debi P., 1049Newman, John W. I., 921Nilsen, Timothy W., 1049Nishizawa, Makoto, 743Nitayaphan, Sorachai, 887Norrby, Erling, 337Nuss, Donald L., 620

Oberg, B., 996O'Brien, Stephen J., 303Ogasawara, Naotake, 978O'Hare, Peter, 723Olsen, John C., 779Olson, Leonard C., 571Osborn, Kent G., 571Ostrove, Jeffrey M., 600

Pacha, Radiya F., 395Pacitti, Anne F., 356Paez, Eduardo, 75Paglianti, Matilde, 651Pagnotti, P., 579Pal, Ranajit, 386Palese, Peter, 221Pana, A., 579Patti, A.-M., 579Pellett, Philip E., 807Penman, Sheldon, 549Pensiero, Michael N., 161

Pepinsky, R. Blake, 31Perbal, Bernard, 240Perez-Bercoff, R., 579Perkus, Marion E., 40Petersen, Robert B., 683Peterson, Andrew J., 620Pitha, Paula M., 867Pizer, Lewis I., 49Polatnick, Jerome, 617Ponce de Leon, Manuel, 1014Portella, Giuseppe, 284Portis, John L., 1018Powell, Bernadette B., 839Preston, C. M., 512Putterman, Debra Gluck, 268

Rabson, Arnold B., 176Ransohoff, Richard M., 1049Rassart, Eric, 1045Reeves, Roger H., 303Reinhold, William, 194, 600Respess, Richard A., 333Reyes, Gregory R., 867Ricard, Cynthia S., 904Ricciardi, Robert P., 66Rice, Andrew P., 1041Rice, Charles M., 227Rice, Patricia L., 757Rice, Stephen A., 767Richardson, Christopher D.,

502Richardson, Michael A., 527Riedle, Gudrun, 520Risser, Rex, 798Roberts, Bryan E., 404Roberts, Walden K., 1041Rodriguez, Jose F., 482Rohrmann, George, 349Roizman, Bernard, 207, 807Roop, Barbara C., 245Roos, Raymond P., 887Rosel, Johannes, 830Rouse, Barry T., 1Rowe, David T., 633Rowe, Lucy, 172Roy-Burman, Pradip, 701Ruden, U., 996Ruggeri, F., 579Rundell, Kathleen, 325Ruscetti, Sandra, 717Ruyechan, William T., 194Rziha, Hanns-Joachim, 307

Sabara, Marta, 1037Sadler, John R., 312Salter, Deborah, 475Sarmiento, Marion, 207Saunders, Keith, 921Schaffer, Priscilla A., 558Schick, Michael, 475

Schneider, Arthur B., 284Schneider, Sandra Sue, 245Schoenmakers, John G. G.,

268Schroder, Claus H., 930Semerjian, A., 341Serafini-Cessi, Franca, 127Seth, Arun, 144Shapiro, Geoffrey, 201Shaw, Jane, 943Shaw, Michael, 201Shenk, Thomas, 250Shih, Thomas Y., 607Shiigi, Stanley M., 571Shimizu, Robert W., 701Shub, David A., 40Silva, Robert F., 240Silverman, Lauren, 814Simon, Suzanne, 1023Skalka, A. M., 589Slade, William R., 921Smiley, J. R., 512Smith, Douglas R., 969Snyder, Ruth M., 386Soe, Lisa Hokama, 701Somasekhar, Madhu B., 1002Sonza, S., 317Sorensen, O., 434Southard, Laurel E., 31Spaete, Richard R., 135Speziali, Valeria, 127Stanley, Jeff, 110Stedman, Deborah, 711Steele, Paul E., 176Stenberg, Richard M., 665,676

Stinski, Mark F., 665, 676Stohlman, Stephen A., 449Straus, Stephen E., 194, 600Strauss, James H., 227Strauss, P. Gunter, 258Sturman, Lawrence S., 904,

912Sullivan, John L., 60Summers, W. C., 512Summers, W. P., 512Svensson, Ulla K., 896Svoboda, Jan, 240Swanstrom, Ronald, 779Szpirer, Claude, 938Szpirer, Josiane, 938

Takeya, Tatsuo, 743Taylor, Benjamin A., 172Tenen, Daniel G., 293Tevethia, Mary J., 373Tevethia, Satvir S., 373, 757Thimmappaya, Bayar, 750Thompson, David L., 757Thompson, Richard L., 19

Thorley-Lawson, David A.,333

Torres-Anjel, M. J., 12Toth, Marcia M., 887Toyoshima, Kumao, 743Trentin, John J., 839Trojanowski, John Q., 12Tsichlis, Philip N., 258, 938Tumilowicz, Joseph J., 839Tykocinski, Mark, 176

Ulsh, Linda S., 607

Valderrama-Leon, Graciela,647

Vande Woude, George F., 144van Oostrum, Jan, 439Vecchio, Giancarlo, 284Venkatesan, Sundararajan,

298Vennstrom, Bjorn, 969Venuti, A., 579Villeneuve, Luc, 1045Vlazny, Donald A., 92Vogt, Volker M., 31

Wachter, Michaela, 520Wagner, Edward K., 19Wagner, Robert R., 386Wahren, B., 996Waters, David J., 333Weed, Harrison G., 549Weir, Jerry P., 534, 1027Wenske, Elizabeth A., 613Whitley, Richard, 419Whittaker, Lori, 711Wienhues, Ulla, 320Wiggins, Bruce A., 1030, 1034Wiktor, Tadeusz J., 12, 426Williams, Ruby L., 102Willis, Dawn B., 495Wilson, Billie J., 571Wilson, Michael C., 691Wilson, Van G., 102Winocour, Ernest, 457Witte, Pamela R., 665Wohlfart, Claes E. G., 896Wolf, Hans, 414Wolff, Linda, 717Wool, Steven H., 617Wunner, William H., 12

Yamamoto, Tadashi, 743Yoshikawa, Hiroshi, 978Young, Bryan D., 328

Zaiss, Conrad P., 571Zebedee, Suzanne L., 502Zorn, Suzanne, 600

J. VIROL.

SUBJECT INDEXVOLUME 56

Adeno-associated virusrecombinant genomes with SV40

structure, 457Adenovirus 2Ad2 + ND4deI

helper defect, 821Ad2 +ND5

helper defect, 821Ad2+ND5-specified 42K protein

synthesis, 814human

block to transcription in monkeycells, 378

neutralization, 896parental and newly synthesized DNA

lack of evidence for methylation inproductive infections, 320

region Litranscripts, 879

virioninteraction with HeLa cells, 896molecular composition, 439

Adenovirus 5early region IAgene products, 404missense mutants, 66

early region 2A mutantsisolation and analysis, 767

early region 4functions, 250

humanearly region 1 proteins, 633

substitution mutantsconstruction and analysis, 750

Adenovirus 12early transformation region 1AT antigen phosphorylation, 183

Adenovirus 35restriction endonuclease mapping, 647

AKR/J mouse strainmurine leukemia virus proviruseschromosomal assignment, 172

Apathogenic rabies virusspread in vivo and in vitro, 12

Autographa californicanuclear polyhedrosis virus

host range, 153Avian myeloblastosis virus

implications for genesis, 240Avian myelocytomatosis virus MC29

provirus HBIfibroblast transformation, 943gag sequences, 943nucleotide sequence, 969

Avian sarcoma and leukemia virusprimary structure of p19, 31

Avian sarcoma and leukosis virusendonuclease cleavage of long terminal

repeats, 589Avian sarcoma virus U2

transforming protein P68membrane association, 790

Bacillus subtilisphage SPOlmapping of terminal redundancy, 40

Bacterial expression vectoridentification of vaccinia virus gene, 534

Bacteriophage LDNA homology with genomes of phage

P22, 1030

Bacteriophage P22DNA homology with genomes of phage

L, 1030late regulation and lysis genes

genetic and DNA mapping, 1030Bacteriophage Pfgenome

nucleotide sequence, 268Bacteriophage SPOlB. subtilis, 40mapping of terminal redundancy, 40

Bacteriophage T5DNA polymerase gene

transcription, 245Bacteriophage T7DNA

mutagenesis by alkylation damage,644

BaculovirusA. californica nuclear polyhedrosis vi-

rushost range, 153

BALB/c miceendogenous ecotropic provirus, 798

B lymphocyteinfection by herpesvirus sylvilagus in

vivo, 60Bovine papillomaviruschimera amplification, 625

Bovine rotavirusglycoprotein fragment immunogenicity,

1037

Capsid intermediatesfoot-and-mouth disease virus, 120

Cat endogenous retroviral sequencesRD-114

genetic mapping, 303Coliphage X

late regulation and lysis genesgenetic and DNA mapping, 1030

Coronavirusmurine

glycoprotein cleavage and fusion, 904host-dependent glycoprotein cleavage,

912Coxsackievirusgroup B

establishment of persistent infectionsin human lymphoid cell lines, 651

Cytomegalovirusgene regulation, 135genome

activity in presence of PP, analogs,996

humanDNA polymerase induction, 846immediate-early region 1 autoregula-

tion, 676immediate-early region 2 RNAs, 665isolation and characterization of

capsid proteins, 277nucleotide sequence of DNA frag-

ment, 7replication in smooth muscle cell cul-

tures, 839

Deer papillomavirusmolecular cloning, 85nucleotide sequence, 85

Defective retrovirus DNA

generationnew pathway, 779

Endogenous ecotropic provirusBALB/c mice

molecular and biological characteriza-tion, 798

Endogenous retroviral envelope RNAshuman, 176

Endogenous retroviral sequencedomestic cats, 303genetic mapping, 303segments identical to mink cell focus-forming virus, 691

Envelope RNA transcriptscharacterization, 176human endogenous retroviral, 176

Epstein-Barr virusBamHI-M early antigen, 860BamHI-M-S early antigen, 852genomeshomology with HSV-1 glycoprotein

B, 807random association with host cell

metaphase chromosomes inBurkitt's lymphoma-derived celllines, 328

transcription unitsstructure and evolution, 987

Escherichia colireovirus nonstructural protein UNS syn-

thesis, 527

Fc receptorsHSV-1, 489specificity, 489

Feline leukemia virusendogenous elements

molecular analysis, 701Foot-and-mouth disease virus

analysis of capsid intermediates, 120guanidine-resistant mutants

recombination and oligonucleotideanalysis, 921

RNA polymeraseassociation with Golgi apparatus, 617

Frog virus 3immediate-early promoter

trans activation by a virion protein,495

Glycoprotein CHSV-1, 1270-linked chains, 127

Golgi apparatusassociation with foot-and-mouth disease

virus-induced RNA polymerase, 617

HeLa cellsinteraction with adenovirus 2 virions,

896Hepatitis A virushuman

isolation and molecular cloning of acytolytic strain, 579

Herpes simplex virusdelayed-early promoter, 867differential activation of hybrid genes,

867early shutoff of type 2-induced host pro-

tein synthesis

iii

iv SUBJECT INDEX

interference of type 1 virion compo-nent, 312

glycoprotein Bcross-reactivity with varicella-zoster

virus envelope glycoprotein, 333homology with Epstein-Barr virus

genome, 807immediate-early promotor, 867monoclonal antibodies

protection against encephalitis, 930morphogenesis

effect of cloned human interferons,419

0-linked chains of glycoprotein C, 127promoter VP5

bacterial chloramphenicol acetyltrans-ferase gene expression, 19

protein synthesiseffect of cloned human interferons,

419reduced H-2 expression, 757suppressor cell regulation of lymphopro-

liferative response, 1suppressor T cells

induction requirements, 49synthetic glycoprotein D-related pep-

tidesprotection of mice, 1014

thymidine kinase polypeptides, 512trans-acting regulatory proteins

modulation of immediate-early geneexpression, 723

type 1a22 protein synthesis, 207deletion mutants in the ICP4 gene,

558Fc receptors, 489

type 1 virion componentinterference with early shutoff of type

2-induced host protein synthesis,312

type 2 glycoprotein vaccinehuman antibody response, 475

Herpesvirus saimiriproteinsmapping on viral genome, 414

Herpesvirus sylvilagusB and T lymphocyte infection in vivo,

60Host range mutants

adenovirus 5 early region 1A, 66generation of single amino acid substitu-

tions, 66Human adenovirus 2

late gene transcriptionblock in monkey cells, 378

Human adenovirus 5early region 1 proteins

stabilities and interrelations, 633Human cytomegalovirus

capsid proteinscharacterization of constituents, 277isolation, 277

DNA fragmentnucleotide sequence, 7

DNA polymerase induction, 846immediate-early region 1

autoregulation, 676common initiation site, 665

immediate-early region 2 RNAs, 665Human endogenous retroviral envelopeRNAscharacterization, 176

Human hepatitis A viruscytolytic strain

isolation and molecular cloning, 579Human parainfluenza virus type 3

proteins, 298Human rhinovirus type 14

infectious RNA from cDNA clonesin vitro synthesis, 628

Influenza C virusNS gene sequence, 221

Influenza virusM2 integral membrane protein

characterization, 502expression at the infected-cell surface

from cloned cDNA, 502mRNA synthesis

inhibition in cells expressing Mxgene, 201

replication in MDBK cellseffect of human alpha A interferon,

1049Interferon

effect on HSV protein synthesis andmorphogenesis, 419

human alpha Aeffect on influenza virus replication in

MDBK cells, 1049murine

linkage of a and 3 genes, 216Mx gene product

inhibition of influenza virus mRNAsynthesis, 201

prevention of spontaneous deletions invaccinia virus DNA, 75

vaccinia virus treatment, 1041

JHM virusantigen and RNA

distribution in rat central nervous sys-tem, 434

Large T antigenSV40, 541transmembrane orientation, 541

Lymphoproliferative responseHSV-specific, 1suppressor cell regulation, 1

Mammalian reovirusgenetic reassortment in mice, 613

Matrix proteinregulation of viral transcription, 386vesicular stomatitis virus, 386

Measles virusmatrix protein

detection with monoclonal antibodies,337

Mengovirusinhibition of host translation, 161

Mink cell focus-forming virussegments identical to endogenous retro-

viral RNA, 691Moloney murine leukemia virus

induction of rat thymic lymphomasconcerted DNA rearrangements, 258

Moloney murine sarcoma virusmos gene

nucleotide sequence and biochemicalactivities, 144

Monoclonal antibodiesHSV, 930polyomavirus protein VP1, 365

protection against encephalitis, 930Sindbis virus

discrimination of wild type fromneuroadapted, 110

vaccinia virus, 482Mouse hepatitis virusnonsegmented RNA genome

recombination, 449Murine coronavirusE2 glycoprotein

cleavage and fusion, 904host-dependent cleavage, 912

Murine interferonlinkage of a and f3 genes, 216

Murine leukemia virusAKR/J mouse strainmapping of two proviruses, 172

induction of rat thymic lymphomas, 258integration region Mis-imouse chromosomal mapping, 1045

neurotropic Cas-BR-Eleukemogenicity determinants, 639

Murine retrovirusencoding of polyomavirus middle T pro-

tein, 1023Murine sarcoma virus

nucleotide sequence and biochemicalactivities of mos gene, 144

Mx geneinfluenza virus mRNA synthesis, 201

Myeloblastosis-associated virustype 1

proviral clone, 240Myeloproliferative sarcoma virus

transformation of 424 cells, 284

Newcastle disease virusfusion glycoproteins

conformational changes during intra-cellular transport, 341

NS geneinfluenza C virus, 221sequence, 221

Nuclear polyhedrosis virusA. californica, 153host range, 153

Papillomavirusbovine

chimera amplification, 625deer

molecular cloning and nucleotide se-quence, 85

Pathogenic rabies virusspread in vivo and in vitro, 12

Polioviruscytoskeletal framework, 549metabolism, 549

PolyomavirusDNA

patterns of methylation, 734large T gene sequences

immortalization of primary rat em-bryo fibroblasts, 958

protein VP1monoclonal antibodies, 365

retrovirus-encoded middle T proteintransformation of nonestablished

chicken embryo cells, 1023Promoter VP5HSV, 19

JOURNAL OF VIROLOGY

SUBJECT INDEX v

control of chloramphenicol acetyl-transferase gene expression, 19

Protein a22HSV-1, 207synthesis, 207

Protein ICP4HSV-1 deletion mutants

isolation and characterization, 558Protein M2

characterization, 502expression at the infected-cell surfacefrom cloned cDNA, 502

influenza virus, 502Protein p21 ras

posttranslational processing, 607Provirus

integration in rat thymomas, 938Pseudomonas aeruginosa

phage Pf3 genomenucleotide sequence, 268

Pseudorabies virusavirulent strains

inability to express a major glycopro-tein, 307

Rabies viruspathogenic and apathogenic

spread in vivo and in vitro, 12stimulation of human T-cell lines

amplification by antigen-specific anti-bodies, 426

Rat thymic lymphomascellular DNA region involvement, 938

Rauscher erythroleukemiaroles of helper and defective retroviralgenomes, 660

Reovirusmammalian

genetic reassortment in mice, 613Reovirus CrNS

synthesis in E. coli, 527Reovirus type 3

attachment to neuraminidase-treatedcells, 356

Respiratory syncytial viruscytotoxic T-cell response in mice, 55

Retrovirus DNAdefectivenew pathway in generation, 779

Rhinovirus type 14human

in vitro synthesis of infectious RNAfrom cDNA clones, 628

Rotavirusbovine

glycoprotein fragment immunogenic-ity, 1037

Rotavirus SAlantigenic variant analysis

demonstration of immunodominantneutralization site, 317

Rous sarcoma virusRNA

characterization of ribosome bindingin vitro, 683

temperature-sensitive cell transforma-tion, 743

Simian acquired immune deficiency syn-dromeisolation of a new serotype from

Celebes macaques, 571Simian virus 40Ad2 - ND4deI

helper defect, 821Ad2 +ND5

helper defect, 821Ad2- ND5-specified 42K protein

synthesis, 814bacteria-produced small-T antigen

interaction with 56K and 32K pro-teins of animal cells, 325

chimera amplification, 625induction of DNA synthesis, 958inhibition of transformation, 373large T antigen

oligomerization, 520oligomers, 711transmembrane orientation, 541

large T gene sequencesimmortalization of primary rat em-

bryo fibroblasts, 958late RNAs

5' termini, 1002recombinant genomes with adeno-assoc-

iated virusstructure, 457

replication originabolition of T-antigen binding, 293cruciform structure formation, 293

SVT2 cellsDNA binding by super-T antigen, 102

Sindbis virusdiscrimination of wild type from

neuroadapted by monoclonal antibod-ies, 110

structural proteinsexpression via recombinant vaccinia

virus, 227Spleen focus-forming virus

variantsbiological and biochemical

differences, 717Suppressor cells

regulation of HSV-specificlymphoproliferation, 1

Suppressor T cellsHSV, 49

induction requirements, 49SVT2 cells

origin binding by super-T antigen, 102

T cellsresponse to respiratory syncytial virus

in mice, 55Theiler's murine encephalomyelitis virus

neutralization sitelocalization, 886

T lymphocyteinfection by herpesvirus sylvilagus in

vivo, 60Tumor antigen

adenovirus 12 early transformation re-gion 1A, 183

phosphorylation, 183Tupaia herpesvirusDNA

structure of termini, 466

Vaccinia viruscore protein, 534DNA

prevention of spontaneous deletionsby interferon, 75

gene sequence, 830interferon-treated, 1041neutralizing monoclonal antibodies

isolation and characterization, 482recombinant

expression of Sindbis proteins, 227RNA breakdown, 395synthesis of novel 2',5'-oligoadenylates,

1041temperature-sensitive mutations

fine structure marker rescue, 1027transcription of early genes, 349

Varicella-zoster virusaberrant vaccine DNAs, 92envelope glycoprotein

cross-reactivity with HSV glycopro-tein B, 333

genomeinversion and circularization, 194transcription mapping, 600

Vesicular stomatitis virusmatrix protein

regulation of viral transcription, 386temperature-sensitive M-protein mu-

tantssequence alterations, 655

Woodchuck hepatitis viruscloned DNA

nucleotide sequence, 978Wound tumor virus

polypeptide synthesis, 620

VOL. 56, 1985

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