kate li chemical engineering & biochemistry. figure 1: diagram of different ways to...
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Characterization of Diffusion from Mesoporous Silica Nanoparticles for Potential Drug-Delivery Applications
Kate LiChemical Engineering & Biochemistry
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Mesoporous Silica Nanoparticles
Figure 1: Diagram of different ways to functionalize a mesoporous silica nanoparticle – external and pore surface functionalization (Colila et. al 2013).
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Why MSNPs?
Tunable drug delivery Antibodies for site
specificity Within threshold size for
cellular uptake (D ~100 nm)
Controlled and sustained release
Applications: chemo toxic drugs, nonpolar with low bioactivity in the body due to poor solubility
Silica is bioinertGlass cardiovascular system sculpture by Gary Farlow
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Modified Stӧber Process
Reagents: Cetyltetra-ammoniumbutylate
(CTAB) Tetraethyl orthosilicate (TEOS) NaOH EtOH Water
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Forming a Liquid Crystal
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Experimental ProcedureMaterials: - TEOS (tetra ethyl orthosilicate) - EtOH (ethanol) - CTAB (cetyl trimethylammonium bromide) - NaOH (sodium hydroxide) - dI H2O(deionized water)
Characterization: - N2 absorption - SEM, TEM, SAXRD
Procedure:1. Add .375 g of CTAB, .4375 mL 2.0 M NaOH and 30 mL dI H2O to roundbottom flask with magnetic stir bar and heat to 80⁰C for 30 minutes.2. To clear solution, add 2.48 mL TEOS via rapid injection. 3. White precipitate will be observed after 1-2 minutes of stirring. 4. Maintain reaction temperature at 80⁰C for 2 hrs.5. Isolate product via ethanol wash and centrifugation/sonication cycles of 10 minutes each, four times. Dilute and suspend in ethanol.
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Experimental Observations
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Results
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Results
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Theoretical Modeling
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Further research
Further research on the parameters of the Modified Stӧber Process
Attempting functionalization of surface and pores
Generate diffusion data
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Questions?
Thank youNASA Space GrantUA Honors College – Alumni Travel GrantsDr. Anthony Muscat
NASA Space Grant Consortium