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Mario PhilipsLife Sciences Efficiency

Derek Pendlebury

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Marketplace Dynamics

• Semiconductor…or Life Sciences?• Development costs escalating• Margins under pressure• High purity products with high safety profiles• Global customers• Niche products with high associated costs• Multi-product manufacturing sites• Highly complex/regulated manufacturing• Selection of partner = Right technology / Quality

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ATMI…and Life Sciences…

• Semiconductor and Life Sciences/Bio-Pharma share the need for…• High purity• Materials integrity• Reduced fixed costs and capital spending• Shortening production runs• Reliable, repeatable production• More process automation• Higher productivity

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ATMI…and Life Sciences…

• ATMI’s semiconductor materials packaging expertise fits Life Sciences• Life Sciences one-time use/disposable market about a decade

behind semiconductor

• No process is more demanding than semiconductor; pharma is “easier”

• Expertise handling, storing, delivering critical materials reliably

• Understand interactions of materials with packaging

• Know how to sell value of disposables into risk-averse industry

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Biotech Process Flow One-time Use Opportunity

Stainless Steel Process, schematic

ATMI

ATMI

ATMI ATMIATMI Bioreactor

Disposable Process, schematic

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ATMI Disposable Technologies Solve Key Issues

• Disposable alternative to fixed stainless steel manufacturing systems • Faster development and production cycles

• Quicker time to market

• Rapid process changeover

• Ensure materials integrity across “multi-product” manufacturing facilities

• Increase throughput and improved facility utilization

• Reduced capital investment

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• Build on more demanding semiconductor experience of materials and packaging interface/high throughput science expertise

• Process efficiency focus and the strongest technology range in mixing and containment, positioned in all stages of product development

• Benchmark mixing technology to the market

• Immediately available scalable technology for one-time use process vessel applications like mixing, contained storage and bioreactors

• Direct control of own film production = unique in BioPharm

ATMI Advantage

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Case Study Pharmaceutical Manufacturer, NJ• 1000L mixing @ 300 batches per year. Porcine skin rafts suspensions

Disposable

Stainless Steel$0

$1,000

$2,000

$3,000

$4,000

$5,000

$6,000

$7,000

Cost Benefits / BatchCost Efficiencies

Traditional: Stainless Steel (cost per batch)

Consumables - $4000Process Set-up

Time/Labor - $5775

Depreciation - $60

Annual cost: $2.95 million Cost per batch: $9835

New: Disposable (cost per batch

Consumables - $1000

Process Set-up Time/Labor - $1925

Depreciation - $40

Annual cost: $0.89 million Cost per batch: $2965

Efficiency Gain >300%

Max # Runs

Per Shift Max # Runs

Per Week Max # Runs

Per Year

Disposable

Stainless Steel 0

200

400

600

800

1000

1200

1400

Process Efficiency Gains

Process Efficiencies

Traditional: Stainless Steel

per Shift 2

per Year 427

New: Disposable

Per Shift 6

Per Year 1280

Efficiency Gain 300%

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Market Overview

• 25% CAGR biotechnology market for• Sterile fluid storage and containment

• Mixing and blending

• Bioreactor and fermentation

• Growth• Expanding, quality-demanding market

• Disposables heavily adopted in all new facilities, retrofitted into existing ones

• 81% of customers specify single use in new processes

• Technology-driven disposable solutions

• Huge opportunities for focused suppliers

Disposable Market Growth, BioPharm

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Impact on ATMI LifeSciences Revenue

Other opportunities in LifeSciences• Mammalian Cell Culture• Storage• Fermentation• Dispensing

Other markets Traditional Pharma Cosmetic / Dermal

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Q&A

ATMI, the ATMI logo, AccuDose, AutoClean, Better Process. Delivered., Cerulean, EPM, ErgoNOW, GasGauge, IDEAL Clean, LOK cap, NOWPak, NOWTrak, PDMPak, ProAct, the ProAct logo, ProE-Vap, RegenSi, SAGE, The Source of Process Efficiency, TiTaN Kleen, UniChem and VAC are trademarks or registered trademarks of Advanced Technology Materials, Inc. in the United States, other

countries or both.

SDS is a trademark or registered trademark of Advanced Technology Materials, Inc. and Matheson Gas Products, Inc. in the United States, other countries or both.

Other company, product, or service names may be trademarks or service marks of others.