liver scoring tab

21
Parameter Negative Positive Tumor size <50% of liver (Radio Button) > 50% of liver (Radio Button) Ascites Absent (Radio Button) Present (Radio Button) Serum albumin >3 g/dl (Radio Button) < 3 g/dl (Radio Button) Bilirubin <3 mg/dl (Radio Button) >3 mg/dl (Radio Button) Okuda Text Box Score will Calculate Automatically on the Basis of Below Parameters and Should Be Displayed in the Text box Okuda I Okuda II Okuda III Okuda if No Postive Factor is Selected if 1 OR 2 Postive Factor is Selected if 3 OR 4 Postive Factor is Selected

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Page 1: Liver Scoring Tab

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Parameter Negative PositiveTumor size <50% of liver (Radio Button) > 50% of liver (Radio Button)

Ascites Absent (Radio Button) Present (Radio Button)

Serum albumin >3 g/dl (Radio Button) < 3 g/dl (Radio Button)

Bilirubin <3 mg/dl (Radio Button) >3 mg/dl (Radio Button)

Okuda Text Box

Score will Calculate Automatically on

the Basis of Below Parameters and

Should Be Displayed in the Text box

Okuda I

Okuda II

Okuda III

Okuda

if No Postive Factor is Selected

if 1 OR 2 Postive Factor is Selected

if 3 OR 4 Postive Factor is Selected

Page 2: Liver Scoring Tab

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Parameter Score 0 Score 1

Child- Pugh stage A (RB) B (RB)

Tumour morphlogyUninodular

and extension

<=50%(RB)

Multinodular andextension

<=50%(RB)

AFP (ng/ml) <400 (RB) >400(RB)

Portal vein thrombosis no(RB) Yes(RB)

Clip Stage Text Box

Early Stage if Score is ZERO

Intermediate Stage if score is 1-3 points

Advanced stage if score is 4 - 6 points

CLIP

Score will Calculate Automati

Parameters and Should Be

Page 3: Liver Scoring Tab

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Score 2

C (RB)

Massive orextension

>50%(RB)

(RB) Radio Button

only one Radio button will be sel

cally on the Basis of Below

isplayed in the Text box

and final score will be the additionwill be selected

Page 4: Liver Scoring Tab

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cted from each row

f corresponding radio button whichn particular row

Page 5: Liver Scoring Tab

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BCLC stage PST Tumour stage Okuda stage Liver function staus

Stage A: early HCC 0

A1 0 Single,<5 cm INo portal hypertensionand nomal bilirubin

A2 0 Single,<5 cm I

portal hypertension and

nomal bilirubin

A3 0 Single,<5 cm I

portal hypertension and

abnomal bilirubin

A4 0 3 tumours <3 cm I-II Child - pugh A-B

Stage B: intermediate HCC 0 Large multinodular I-II Child - pugh A-B

Stage C: advanced HCC 1-2*

Vascular invasion or

extrahepatic spread* I-II Child - pugh A-BStage D: end stage HCC 3-Apr Any III Child-Pugh C

BCLCA

B

C

D

BCLC

Drop Down list

Tumour status

Stage A and B: all criteria should be fulfilled.

Stage C: at least one criterion ; *PST 1-2 or vascular invasion /extrahepatic spread.

Stage D: at least one criterion;PST 3-4 or Okuda stage III/ Child -Pugh C.

Page 6: Liver Scoring Tab

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this is for Display purpose only

and in the Last Provide a Drop Down.

Page 7: Liver Scoring Tab

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Grade

0(RB)

1(RB)

2(RB)

3(RB)4(RB)

5(RB)

ECOG Text Box

RB Radio Button

Dead

Selected Grade will Automatically

E

Fully active, Able to carry on all pre-disease performance without restriction

Restricted in physicallly strenuous activity but ambulatory and able to carry out work o

Ambulatory and capable of all selfcare but unable to carry out any work activities.Up a

Capable of only limited selfcare, confined to bed or chair more then 50% of waking houCompletely disablesd. Cannot carry on any selfcare.Totally confined to bed or chair

Page 8: Liver Scoring Tab

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and only one Radio Button will be Selected from the above Categoryisplay in the Text box.

OG

f a light or sedentary nature, e.g., light house work, Office Work

d about more than 50% of waking Hours

rs

ECOG

Page 9: Liver Scoring Tab

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Measure 1 point 2 points

Total bilirubin,umol/I(mg/dl) <34(<2)(RB) 34-50(2-3)(RB)

Serum albumin, g/l >35(RB) 28-35(RB)

PT INR <1.7(4)(RB) 1.71-2.20(4-6)(RB)

Ascites None(RB) Mild (RB)

Hepatic encephalopathy None(RB) Grade I-II(RB)

CTP Score Text Box

CTP Score

Score will Calculate Au

Selected Parameters an

Page 10: Liver Scoring Tab

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3 points

>50(3)(RB)

<28(RB)

>2.20(>6)(RB)

Severe(RB)

Grade III-IV (or refractory)(RB)

only one Radio button will be sel

and final score will be the addition

omatically on the Basis of Above

d Should Be Displayed in the Text

box

Page 11: Liver Scoring Tab

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cted from each row

f corresponding radio button which

Page 12: Liver Scoring Tab

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Category Variables Score CategorySex Female (RB) Plus 2 HLA

AP:AST(orALT)ratio >3(RB) Minus2 Immune Disease

<1.5(RB) Plus 2

y globulin or lgG level

above normal >2.0(RB) Plus 3 Other markers

1.5 2.0(RB) Plus 2

<1.0(RB) 0

ANA, SMA, or LKM1 titers >1:80(RB) Plus 3 Histological features

1;80(RB) Plus 2

01:40:00(RB) Plus 1

<1:40(RB) 0

AMA Positve (RB) Minus 4 Treatment response

Viral markers Positive(RB) Minus 3

Negative(RB) Minus 3

Drugs Yes (RB) Minus 4 Pretreatment aggregate score:

No (RB) Plus 1

Alcohol <25 g/day(RB) Plus 2 posttreatment aggregate score:

>60 g/day(RB) Minus 2

Only one will be Selected from

And Please Treat

Plus as + SignAnd Please Treat

Minus as - Sign

RB Radio Button

Probable diagnosis 12 17

ALH SCORE

Definite Diagnosis>15

Probable Diagnosis 10 15

Definite diagnosis >17

Page 13: Liver Scoring Tab

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Variables ScoreDR3 Or DR4(RB) Plus 1

Thyroiditis, colitis, others (RB) Plus2

Anti SLA, anti actin, anti LC1,pANCA(RB) Plus 2

Interface hepatitis (RB) Plus 3

Plasmacytic(RB) Plus 1

Rosettes(RB) Plus1

None of above(RB) Minus5

Billary changes(RB) Minus3

other features(RB) Minus3

Complete(RB) Plus2

Relapse(RB) Plus 3

Text Box

Text Box

a Particular Category

Score wi

Above P

Score wi

Above P

Page 14: Liver Scoring Tab

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ll Calculate Automatically on the Basis of 

rameters and Should Be Displayed in the

Text box

ll Calculate Automatically on the Basis of 

rameters and Should Be Displayed in the

Text box

Page 15: Liver Scoring Tab

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MELD = 3.78[Ln serum bilirubin (mg/dL)] + 11.2[LnINR] +9.57[LnserumCREATINI

is given a value of 1]

Maddrey's (Discriminant Function ) = 4.6* (PT in seconds prolonged ) + Total bilir

Lilley Model score: Text Box

Page 16: Liver Scoring Tab

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E (MG/DL)] +6.43 [Any value less than one

bin

In the Lilley Model Score,

Require

Automatically Take Values

TAB and calculated

Automatically Take Values

TAB and calculated

Page 17: Liver Scoring Tab

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only a text box is

rom Investigation

the Score

rom Investigation

the Score

Page 18: Liver Scoring Tab

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Mrecist for HCC

only Check Box Required

1 CR=Disappearance of any intratumoral arterial enhancement in all target lesions (Check Box)

2 PR =At least a 30% decrease in the sum of diameters of viable ( enhancement in the arterial ph

3 SD= Any cases that do not qualigy for either partial response or progressive disease (Check Bo

4 PD = An increase of at least 20% in the sum of the diameters of viable (enhancing ) target lesio

Page 19: Liver Scoring Tab

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mRECIST

ase)target lesion, taking as reference the baseli

)

ns, taking as reference the smallest sum of the

Page 20: Liver Scoring Tab

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ne sum of the diameters of target lesions (Check Box)

diameters of viable ( enhancing ) target lesions recorded since treatment

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tarted (Check Box)