lost in the twentieth century

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   A   n   n   u  .    R   e   v  .    B    i   o   c    h   e   m  .    1    9    6    3  .    3    2   :    1      1    5  .    D   o   w   n    l   o   a    d   e    d    f   r   o   m    w   w   w  .   a   n   n   u   a    l   r   e   v    i   e   w   s  .   o   r   g    b   y    1    2    5  .    1    6    3  .    1    1    3  .    2    2    0   o   n    0    6    /    0    9    /    1    4  .    F   o   r   p   e   r   s   o   n   a    l   u   s   e   o   n    l   y  .

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Page 1: Lost in the Twentieth Century

8/11/2019 Lost in the Twentieth Century

http://slidepdf.com/reader/full/lost-in-the-twentieth-century 1/15

   A  n  n  u .   R  e  v .

   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w

  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1

   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

Page 2: Lost in the Twentieth Century

8/11/2019 Lost in the Twentieth Century

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LOT THE TWENTIETH CENTURY

B A borory of he sue for Musle eserh he Mre

Bologl orory os ole Msshusest ud to b aid in my hom town, that h chapt funral you could

gt conitd of taking a candl in your hand and going ou yourlf, o thchurchyard. A udgd by h priou inroducory articl, thi on houldb omthing lik it: an obituary writn by th fllow himlf Lt it b that ha no uarrl with th ida of complting my cycl of lif. What goagaint th grain i writing about mylf inc am ar to all form ofxhibitionim. Moror, lik to look forward, no back

rlooking my ca hitory, nd a complt dichotomy. n h on

hand, my innr tory i xcdingly impl, if no indd dull my lif habn dotd to cinc and my only ral ambition ha bn to contribut oit and li up o i tandard. n complt conradicion o thi, th xrnacour ha bn rathr bumpy. nihd chool in fudal Hungary a th onof a walthy landownr and had no worri about my futur A fw yarlatr nd mylf working in Hamburg, rmany, with a light hungrdma. n 1942 nd mylf in tanbul, inold in crt diplomatic actiity with a ting t for a chap and xciting py tory hortly aftr ga warning that Hitlr had ordrd h ornor of Hungary o appar bforhim, craming my nam a th op of hi oic and dmanding my dliry

Arrt warrant wr pad out n againt mmbr of my family n mypockt nd a wdih paport, haing bn mad a full wdih citin onth ordr of h Kng of wdn am Mr. wnon, my wif, Mrwnon. omtim lar nd mylf in Mocow, tratd in th mooyal fahion by th ornmn (with caiar thr tim a day, but it donot tak long bfor am dclard a traitor of h popl and play throl of th illain on th tag of Budapt. At th am tim, am rfudnranc to h UA for my oit ympathi. Entually, nd pac aWood Ho, Maachu, workng in a oia con of h Man

Biological Laboratory Aftr om nrracking complicaion, du oMcCarhy, thing traightnd ou, but h intrnal ruggl i not compltly or. am troubld by gra doubt about th ufuln of cinticndaor and ha a whol drawr ld with rati on poliic and thirrlaion to cinc, writtn for mylf with th ol purpo of clarifying mymind, and nding an anwr to th ution: will cinc lad to th lationor dtruction of man, and ha my cintic ndaor any n?

All thi, in ilf, would ha no inrt. Thr ar many who did morfor cinc, wr brar, urd mor agony and n paid th pnalty ofdath What may lnd intrt to my tory i that it rct th turbulnc

o our da. o o gi n o my ry wi ha o a by akng whyall thi roubl and what i it rlation to cnc?

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

Page 3: Lost in the Twentieth Century

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ZY{Y

Eamu of Rottdam, that ag of th Ealy Raiac, ditiguihdbtw calm ad tubult priod of huma hitoy which how though-

out th am ptiti toy Ma dlop a ctai philoophy ad catth copodig itituio ad th i pac Th hi thought chagad th w outlook ha to ght th outgow tuctu ad thikig, withall it pjudic ad td itt; th i toubl till th w iw pdomiat ad th copodig w od i tablihd

Th wold ha kow a mo tumultuou piod tha ou ad o, ifEamu i coct, th ha o b a copodigly dp chag i ouida, a chag mo pofoud tha ay ali o t i cla to m whatthi chag i: a taitio fom th pcitic to th citic Not oly ithi chag pofoud, but it ha com upo u too uddly, laig o timto adjut

Th dic btw th two wold i bt illutatd by th toy ofth two to ad of Aitotl, o of th gatt pcitic thik,ad Galilo, o of th t mod citit. Aitotl aid that a big tofall fat tha a mall o Th ittig poit about thi tatmt i otthat it wa wog, but that it occud to Aitotl that h could ty axpimt, to tt hi ida H would ha coidd uch a popoal aiult Ma had oly to thik to d th tuth, hi md g upo tocud xpic. Th mid igd upm Th wa o ao to doubt,

ith, that what th coyd wa th lat ality. f w touch thig,thy fl had o oft, wt o dy o, accodig to Aitotl, th had to bth ultimat lmt out of which th wold wa built Th could ot bth lat doubt that it wa th i which otatd aoud u. t wa oya mall additioal tp to uppo that ou flig w tutwothyguid ad that ou yday xpic could b xtdd to poblmbyod ou ach o if ma td dath th could b o dath, olyHad, Hll, o Ha. f ma wat a hou, h ha to build it, o if thi a i, ombody mut ha built it ad b uig it, ombody mopowful tha oul o ma populatd hi wold with god, o o may,hapd i hi ow imag. ut if th w big mo powful thaoul, w had to b thi mai coc, ad maid th ct.

o gadually, ma built himlf a imagiay wold bad o "faith,that i, accptig thig without idc Thi faith wa codid at ditag a ligio i th am of which m totud, ubugatd, ad killdo aoth What udlay thi pcitic thikig wa ma' td foautitic thikig ad hi boudl lfcodc Whil thikig himlfth ct, upm mat ad judg, ma had to mai th toy of Natu.

Two thouad ya aft Aitotl, omthig mut ha happd to

ma' mid fo h ad th popl appad, lik Copicu o Kpl,who modtly tid to put two ad two togth, whil a boitou ougma wt up a laig tow to dop two to, a big o ad a mall o,biddig hi compaio to o which o hit th pamt t. What itial about thi impl act wa a humbl attitud if w wat to d out

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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T N TH TNTTH NT 3

methg abut the wld aud u we hae t ak uet mdetlythat d expemet

The ame yug ma dd t tut the pefect f h ee ethe adlate bult the telecpe t mpe h ght Wth h mped ght heculd ee the atelle f Jupte ad the g f Satu ee ee by mabefe clealy dcatg that the Uee culd t hae bee ceatedlely f ma' pleaue temptat Tday thee ad a half cetuelate we ee expemetal cece ad expa chagg all paametef huma extece ceatg a etely ew wl whch ma ha becmethe htled habtat f e f the mall atellte f e f the mllf ta f e f the mll f galaxe a Uee expadg at cea-

g peed dmated by uatum law. What udee th chage ewcetc thkg. The eeta featue f th thkg humty theealzat f u mpefect The t cmmad f th thkg taccept thg wthut edece face pblem a uch wth a cl hedwthut fea peudc wth ucmpmg hty f thughtubaed by fea hpe teet

We ae lg the mddle f the tat fm the pecetc t thecetc thkg hece the "tumult We tl hae d u lp ad uc but me u heat. f we ae take ll we may tll pay but wetake pecll algde. We pay f eace but heap up bmb f afetyWe peach Cht ad talk "ekll Th wld ymblzed f me by theclal tatue f Cht tadg a hll Spa tetchg ut Amt makd ad weag ead a emu lghtg cduct tptect m huld the Almghty Fathe ty t mte m by lghtg Wed the ew expadg Uee a athe cld place ad d t dae tabad the ld e The tuble that the tw wld cat be mxed adthe fathe ut wa ght whe he ad t alle that yu teachgad the teachg f the chuch cat ext de by de We cat buldupuhed bmb by cece ethe ad the u the wth the XV

Cetuy egttc aw etmetal ad decetful pltcal thkg tmake ee t ht ataut ut t pace t each the ta adeect teft ccete wall t epaate ma fm ma t w tme pe-cetc thkg dd buld table wld but cece ha eteablyudemed the acuecece mey a the attbute f hum extecead ha udemed the ld heache f gd pce ba hae adhaet wellfed ad hugy deelped ad udedeelped

Thee way back ad we hae t face uaely the fee chce betwee udeamed f wealth ad dgty ad elfdetuct whch ceceha eed y pbe t what cece eadg ad whethe cece

ca buld a wld whch ma ca feel ce me at hme? wll attempt awe thee uet at the e fte hag ge my cae hty

'

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e

  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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ZYY

O my Mthers sde, am the rth geerat scetsts. My Fatheras terested ly armg ad my Mthers ece prevaed

Msc lled the hse ad the cversat at the table ramed abt thetellectal achevemets the etre rld. Pltcs ad ace had place r thghts am a scetst, msel, becase at a early age leared that l tellectal vales ere rth strvg r, artstc rscetc creat beg the hghest am. strgly beleve that e establshthe crdates r evalat at a ver early age. What e d laterdepeds ths scale vales hch mstly cat be chaged later Weare smehat lke Dr Lrez gse hch has hatched at the t a charad recgzed the char as ts mther all ts later le hs s mprtat redcat, case e are t tedg t prdce ly crprat me

th ther tellectal cre cts. mst have bee a very dll chld Nthg happeed t me read

bks ad eeded prvate ttrg t pass my exams Ard pbert, smethg chaged ad became a vracs reader ad decded becme ascetst My cle, a ted hstlgst (M Lehssek, h dmated ramly ad as a preccs chld hmsel, vletly prtested, seeg tre r sch a dll ygster scece Whe hs p gradall med he csened my gng n csmecs er he een cnsderedmy becmg a detst Whe shed hgh schl th tp marks, he

admtted he ssiiliy my becmg a prctlgst (specalst as adrectm he had haemrrhds) S my rst scetc paper, rtte therst ear my medcal stdes, dealt th the epthelm the as started scece the rg ed bt s shted t the vtres bdy, thebrllar e strctre explred th e methds

have meted ths early hstry me becase t sggests that al dgmet shld be made chldre at t early a age

mst have acheved sme reptat as a hstlgst he, as a thrdear medcal stdet, became creasgl dsctet th mrphlgyhch tld me lttle abt le S, shted t physlgy bt had t break

m stdes r cmplsry mltary servce Wrld War d me rm

Cetresld tradt tld s Hgaras t ask qest he eere called p t ght dd accrdgly, bt drg the rst three years the ar as gradally vercme by a brg desre t retr t sceceAt the same tme became creasgl dsgsted th the mral trptde mltary servce. cld see clearly that e had lst the ar ad that eere beg sacrced seselessl by a rlg clqe the best servce cld dr my ctry as t stay alve S, e day, he the eld, tk my

g ad sht mysel thrgh the be my arm Wth all the deeply graed tradt ths as te dclt t d ad t as als the mredagers rad Aya, t tk me back t the captal here gt myMD., ater hch cted my servce a bacterlgcal labratry the army Here, gt t trble bt ce, he bected t expermets,

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e

  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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T N TH TTTH CNTRY 5

dages t le, de tala ses a Se the ma essble these eemets had t stas me tha I had, as shed, ad

set t the th Itala sams hee tal malaa made le exe-tay vey sht. A e eeks late the a llased ad s lled talve ad eted t the labaty

ated t destad le bt d the mlety hyslgy vehelmg S shted t hamalgy hee, at least, e the ates,the dg, as smle. Ths, I d, dd t eleve the dlty S, ett batelgy, bt d batea t mle, t I shted , thyshemsty ad the t hemsty, that s, t mleles, the smallestts thse days Te yeas ag I d meles t mle ad shtedt elets, hg t have eahed bttm Bt ate has bttm tsmst bas le s "gaat I ate ts t thgs tgetheshe des smethg e th e qaltes, hh at be eessed tems qaltes the mets Whe gg m elets adts t atms, m hee t mleles mlela aggegates, et, tthe ell the hle amal, at evey level e d smethg e, a ebeathtakg vsta Wheeve e seaate t thgs, e lse smethg,smethg hh may have bee the st essetal eate S , at , Iam t k my ay aga llg elets the mt thghme etesve systems, hg t ave, smeday, at a destadg

the ellla level gaat S the teal se my le made asmth ssd ve t s the eteal seAte the Wa, beame assstat at the hamalgal labaty

the ely ded vesty Psy, a ld Hgaa t A emths late Psy as gve, by the Vesalles Teaty, t Cehslvaka(t s alled Batslava ad e hd t lea t. We saved seteqmet t tht dage, gettg t e ght, dessed as kme,thgh the lsely gaded gates the ams Meahle, Hgay, themmsts tk ve, hh meat a mlete lss all my belggs Atthe vey last mmet, esed e thsad Eglsh ds These I

shaed th my Mthe, hm I vsted at Bdaest. F sh a vst thety Dabe had t be ssed a small veaded bat at ght, at at hee thee ee Ceh atls, h sht at sght. I my mayas a , Sste Agela, h as deadly ghteed ad lg t medeseately O my et had t sed a ght the s ad aved Psy th a gave ema. I bably e my le t the devtedsg Sste Agela Ate ths, I tk my e ad hld ad steeedest. The Eglsh ds alled me t lve, vey mdestly, a lttlehle, dg hh tme ated t gaty my dese t d eseah Fst,

et t Page t lea sme elethyslgy m Am v Tshemak, m thee t Bel t lea abt H m Mhaels, (h lateset hs last smme my gest he at Wds Hle) m Bel ett Hambg t the Isttte Tal Hygee. My allat as thathle I dd eseah hyhmal les, I ld lea h at

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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6 NTGYORGYI

tpica medicie t be ired by sme cia gvermet ce my mey

gave t Tis time avig arrived I bgt my trpical eqipmet readyt g bt fate ld ave it tat te Dtc Pysigical Sciety eld itsmeetig i ambrg ad e f te participas as W Strm va eee prfessr f parmaclgy i Leide e ad it im Prfessr FritzVerzar servig as is assciate prfessr Verzar as abt t retr tgary s e itrdced me t Strm va eee ivited me t takeVerzar's pst ic I tk After t years at Leide ere I devted myfree time t earig cemistry I jied ambrger's Labratry at Grige ere I rked fr ater fr years. Salaries ere very btalled fr a very mdest life ic as appy ad qiet

N I tgt myself capable f tacklig a bicemical prbem Iembarked bilgical xidatis. At tat time a viet ctrversy ragedbetee O Warbrg ad Wielad ad teir flers Te frmer tgttat xyge activati as te mst essetia featre f respirati ileWielad pt activati i te fre I cld s tat bt prcesses ereivved I simply kcked t O activati (ad it it respirati bycyaide ad te added metyee ble t te miced tisse Te dyerestred respirati repacig O activati It as redced by activated ad te rexidized staesly. Dri tese exeimets I becamefasciated by te scci ad citrcdeydrgease Tese deydrgeasesdiered frm ter deydrgeases by beig bd t strctre ad "strctre ad t mea smethig very imprtat Tey cd t pssby bejst rdiary metablic ezymes tey ad t ave sme geeral catalyticrle If tis as s te te le f respirati ad t be iibited ce tesccideydrgease as iactivated ic cld be de by malicacid as s earier by Qastel S I added maic acid t te micedtisse ad respirati stpped Tis prved tat scciic acid ad citcacd ad t ave sme geeral catalytic activity ad cld t be simplymetablites as tgt befre. Tese ideas ere ater cmpleted by Krebs

ad are te fdati f te scalled "Krebs cycle It as partly tisdiscvery f te C dicarbxylic acid catalysis ic as red ater byte Nbe pze

I als became iterested i vegetabe respirati beig cviced tattere is basic dierece betee ma ad te grass e ms Plats attat time ere divided it t grps te "catec xidase ad "perxidase plats I started it te catecl xidase pats ic ctai cate-c ad a strg catec xidase I simpied te accepted rater cmplexideas abt tis xidati system Te I sifted t "perxidase patsic are caed s becase tey ctai perxdase i ig ccetratiIf perxide is added t a mixtre f perxidase ad bezidie immediatelya itese ble cr appears de t te xidati f bezidie I f tati te reacti as perfrmed it te pat jice istead f pried perxi-ase tere as a very srt delay f a secd r s i te bezidie reactis fasciated me Tere ad t be preset a redcig aget ic redce

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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LT N TH TTTH CNTRY 7

te oded bede te dela corespodg to te tme ecessar toode awa ts kow redcg aget late to be kow as ascobc

acdI meto ts sto sc detal becase t llstates te basc tat o

m wa o wokg I make te wldest teoes coectg p te test tbereacto wt broadest plosopcal deas bt sped most o m tme telaboato plag wt lvg matte keepg m ees ope observg adpsg te smallest detal Te cet aso s to avod makg teoes(te ma be wrog) ad lmt oe's obsevatos to readg poters Itk tat a tmate getp redsp wt lvg matter s stll m-portat o te bologst. B wokg ts wa sall sometg cops

p some small dscrepac wc ollowed p ma lead to basc ds-coveres Te teoes seve to sats te md prepae t or a "accdetad keep oe gog I mst admt tat most o te ew observatos I madewere based o wog teoes. M teres collapsed bt somet was letaterwards

I also made teoes abot te adreal glad w led me to assm tatte redcg aget o peodase plats sold also be preset te adrealcorte g cocetrato. od t was preset (tog te derlgteo tred ot to be wrog later)

Hambrger's deat made a ed to all ts. Hs sccesso was a ps-

cologst wo dslked cemstr ad dslked me wt t. I togt tat Iad to gve p altogeter beg stll a beger scece wo ad o moremoe ad o oeg dploma So I set m we wt o cld back toHga to e paets ad prepaed o te ed saw o cace let Fora aewell to scece I wet to atted te teatoal Psologcal Cogress at Stockolm (2). Te pesdetal address was delveed b SrFedeck Gowlad Hopks wo to m spse metoed m ame eetmes moe ta aoe elses So ate s lecte pcked p all m co-age ad addressed m "W do't o come to Cambrdge? e asked." w see to t tat o get a ockeelle ellowsp. d so e dd He wasad stll s a mster to me He was te ma wo ad te most ece om scetc developmet tog ever talked to m abot scee adead m speak bt oce or twce. Hs papers were ot especall ascatg et e ad a magc ece o te people aod m. Tat lttleassmg ma wt all s cld vat was a mble seace ott Wat s dvdalt poclamed was tat spte o all te ardwok volved researc s ot a sstematc occpato bt a ttve atstcvocato.

Cambdge I solated te edcg aget od at oge

cstalled t om orages lemos cabbages ad adreal glads. I kew twas related to sgas ol dd ot kow wc. "gosco meag "dotkow ad te edg "ose meag sgar called ts arbodate"Igose Hade te edto o te Bohml Joul dd ot lke okesad epmaded me odose was ot moe sccessl ad so ollowg

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e

  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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8 ZYY

ade popoto, I called the ew ubtace hexuoc acd ce thad C ad wa acdc I ot m PhD fo t

The touble wa that I could make t o be cale fom oe mateal

ol, adeal lad, but thee wee ot avalable Elad ucetquatt So I accepted Kedall vtato to o to the Mao Clc, atochete, Meota, whee ample mateal fom the St Paul lauhtehoue wa avalable. I woked fo oe ea the SA, to etu to Cambde wth 2 am of hexuoc acd m pocket, mot of whch Iave to awoth, the eat cabohdate chemt, who udetook thecottuto aal

ua, at that tme (1932 had a ve outtad Mte (Seceta of Educato e wated to modeze uaa cece ad akedfo m help So I accepted the cha of medcal chemt at the vet,

Szeed, ad left Cambde wth a heav heat, fo the vet of SzeedM laboato wa oo lled wth able ou eeache I wet back tooxdato ad wa oo facated b a ukow ellow detu, ctoave, wth t pledd uoecece ad eveble educblt av opectocope I could ot decbe t popel ow t called boav Ialo became teeted lactocodehdoeae foud t actvt lked toa coeme, a ucleotde whch I lated qua ode to hdolet fo t aal. I had a to huch that pde devatve wee volved a bae I wated to pecptate the hdolate wth platcchlode but whe I came to t I foud, to m dma, the bottle of platcchlode empt. Wth the hotae of chemcal m eot to et hold of omeplat chlode faled, ad o m hdolate ut wtheed awa I followedpactcall the ame oute whch led Wabu to the dcove of the pdeucleotde

Oe da a ce ou Amecabo uaa, . Swbel, came toSzeed to wok wth me Whe I aked hm what he kew he ad he couldd out whethe a ubtace cotaed Vtam C. I tl had a am o o om hexuoc acd I ave t to hm to tet fo vtamc actvt I told hmthat I expected he would d t detcal wth Vtam C I alwa had a

to huch that th wa o but eve had teted t. wa ot acquatedwth amal tet th eld ad the whole poblem wa fo me, too lamouou, ad vtam wee, to m md, theoetcall uteet Vtam mea that oe ha to eat t What oe ha to eat the t coce ofthe chef ot the cett

Awa, Swbel teted hexuoc acd A full tet took two moth butafte oe moth the eult wa evdet hexuoc acd wa Vtam CWe made o ecet of th ad hed the tet whch left o doubt about thedett So, we (awoth ad I) ebaptzed hexuoc acd to acobcacd

Thee we wee Acobc acd eemed medcall mot mpotat but theewa oe of t, ad oe of the avalable veetable ouce allowed bcalepepaato Adeal wee ot avalable, quatt, ua A t

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e

  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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T N THE TNTTH CNTY 9

happene, See the ente the papka (e peppe) nut. Papkaa nt avalale at ame. ne a t n the maket ut the ven

autne me that t a pnu One nht e ha eh e peppe uppe nt ee lke ean t a thuht a a ut. Suenl tue t me that th a patall the nl plant ha neve tete tk t t the laat an aut mnht kne that t a a teauehet vtamn ntann 2 m pe am A e eek late ha klam talne Vamn hh tute all ve the l amneeahe h ante t k n Th n mae mpete anaan nthe ple eeve m el pze patl th k hhal le t anthe unexpete ve When tll ha nl mpue uthhl nentate lutn a a e te m extat n ae enh Pupua. n uv thee a eat aplla alt aunuutaneu een, t eeme a t t m extat n pupua(uutaneu leen) The e When ha talne a we tried it agn, expecing a ll e an t nhn. ventl,m mpue extat ntane an atnal utane epnle theatn. uee that t mht e "avne hh the tk M uepve ht ate the avne m "papka an the ue pupua. alle th up utane Vtamn "P ue the lette P eaue a nt ute ue that t a a vtamn The alphaet a upe nl up

t F thee a ample tme t elmnate "P thut aun tule thevtamn natue eame pve. et ha n enuh expeene attakn me me mpex

lal pe, hh u lea me le t the unetann le he mule ntatn. Wth t lent phal, hemal, an men-nal hane, mule an eal mateal t tu ne emak n uha ne el ne uuall e nt kn hee t en. Thee ne thn nean aa an th epeat e k mate. epeate hatW Khne a hune ea eale extate mn th tnptaum hle (K!) an kept m ee pen Wth m aate,

Bana, e eve that the etatn a plne, a me tkextat a tane thut extatn muh me pten e n unhat th hane a ue t he appeaane a ne pten "atn,late n a ve eleant pee k m pupl, F. Stau, hle "talze mn Mn, evetl, a a ntatle pten, ut thetule a that vo t ul nthn A ntatle pten hulntat heeve t S e mae thea the hhl vu ne mplex atn an mn, "atm, an ae e mue ue Ththea ntate T ee them tat the t tme, an t have

epue ne te let n le, mtn, a pehap themt thlln mment e. A lttle ke n he that hatmae t ntat a A an n. M nlun, that mule ntatna eena an ntean atmn an ATP a n tnattake, evelpe (late at W le) the meth lenatn

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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SZENT-GYORGYI

n glycerned (exced wh dlued lyceol low empeure heo mucle of he bb. Th mehod now wdely ued for coneronf bolocl mel uch perm On ddon of ATP, my glycenemucle conced, developn he me enon developed mmlly

vo. Th ed me nd w ure h n few week me he wholeoblem of mucle concon would be clered up, bu en ye le lldd no undend mucle, whch mde me conclude h omehn hd obe mn fom our bc de, omehng h w eenl for he undernn of eney nformon. So lef mucle o n wh h ome-hng Th ook me, dully, no my peen eld, h of elecrondmenon nd mobly

A empoy peden of my unvery Szeed, red o pu nocon he de pcked up n he we ceed n nene culul lfemon uden whch culmned n ou producn Hmle, nd poducn

ell Bu my democc de brouh me more n moe no conc whhe n de of fcm w no who wen no polc olc:cmeno our lve nd when book were buned nd my Jewh frend weeoecued hd o y "ye or no d "no nd when le dunWorld Wr oup of ledn Hunrn cme, ecrely, o me nd kedme o do omehn o ve uny fom Germny p, wen, unecove of n lleed lecue, o nbul o e n ouch wh he Bh ndAmecn dplom o ee wh coud be done Th w rky undeknfor Germnoccuped eoy hd o be coed nd nbul w he pyn eer wh hhly developed echqe nd w ewome n hbune. fel h could be more ueful f dd no o meely prvendvdul o nbul nd ook chnce. wen o our Pme Mne, MrM Klly, nd old hm bou my pln. Ouwdly, Mr Klly w Nz bu upeced h he w ood unn, wn fo h chnce obrn h couny over o he oher de. My ue w h ned of hvn me reed he ked me o epeen hm nd convey cern mee ohe Alle. n nbul ucceeded n en n ouch wh he hed of heBh Sece Sevce, mk wh hm deled pln whch oon hd heblen of London Wh mde hee deln ecn w h, ll he end,

could no know fo cern wheher w deln wh he Brh, or heGemn Sece Servce. Th could only nd ou ler, when cron Gemn eroy No ben eed on my eun, w nlly ure h whe Bh o whom hd lked.

Unfounely, he ece of my mon leked ou, nd coul no eup ece wele on whch w eenl for my pln w plcedunder houe e. ler demnded my delvery Ler, when he occupedHunry, voded nl re by he Gepo only by n nch, own myecpe moe o ood luck hn bly. Are would hve men ery pn-ful deh. Even my duhe hd o o no hdn, n rre wrn hvn

been ued lo n her Wokn n Hle nd lvn underoundw full of colo whch wee no lwy plen epeced o be klled o

   A  n  n  u .

   R  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0

   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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LT IN THE TWETIETH CENTURY 1

w up my ba muc, whch I dd wa b I hm pubca h Acta Scandinavica my d Hu The

N kw whe I wa, he cbaed accpace y w, cae wdh La, Budap Fae wud hae ha a ha me I waacuay hd a h wdh Lea, ad Th' w ae maway Th Geap mmedaey eachd h uud hu ubaa m h wdh La, whch d a a wa A,a h m a edy Gma dpma made de ha ae wamm. e A, h head h La, mud me u hback h ca h e h. hy ae, h Naz ke he wdhLa, eachd, bbd, ad paccay deyd . Th wed a exc ua had by my w A h d, w had pa,hd he bcm ky Tw my hd pac we deydby bmb hy a I e hem, ad, h d I cud ad a yby hd he cy h e whe h Gap dd da cme

Th pud du we Nam mad u uy a aa pcwhu hk I mad u be ha a H wa hda we had d b h a d a pac wa hw dw wad h I ue a h h cmmu ped Huay, ae Wd Wa I, h Cmmu bhaed ey bady, bu ha

wa a A w wd wa cm Th wa a m ac whaa cuce Fm my hd pace I cacd G Hhy,wh wa h ma h ua. We me ce, ad d myc a a y he Ae pepae Huay' j hm. Hemed accp bu whe h ced my dy dp wad he he dd u h m ad I e aw hm aa I ca pachy my h au I hud hae ak Hhy' meay accu H hd Rua ad ad

eay, I dd expc a bee eam m h ha Ihad expcd m He, ha my hay d Nbe Mda

Fad wh h dcaed wa h, ad h mda ma meha u d I wa upd whe, ae he "bea Budape, a pa wh a Ehpak ma a had cameeach m. I a mye up. T my up h pa dd m a m bu m ay M' pea d I ue a, wa ea my we' b amy h ey dauua he pa h Capa he wh amy wa ake ay, wh my we ad I we ak Mawk' hadua whewe we ed back e wh um cae ad cda Lae, I wa

ed Mcw wh I p w mh ad add h Caba he Acadmy h up wh p AmaI w Mcw wh h hp a Wha mad m wa

e hm wa h a ha h Amy Huay bhad eyady Na my me w Huaa m ad dw m

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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SZENTY{Y

antin to or Hiter Te oe reimen a roded ino a malprion ere it a oon exerminaed by typu ever In Budapet te endo ree ere uddenly oed by Sovie oldier and a te youner menee eded tee Te dumen ee aken aay, i iped ou

teir ideniy. About 0-0000 men ere arreed i ay and ten erdedto eed, a nearby amp ere tere a no ood and poor aniaionDyenery and ypoid bean to deimae em Te ream oud be eardrom on ditane Toe o ere le ere erded ino train, te door oi ere eaed; nobody kne ere tey en We oud no ue, attat ime, tat tee peope ere imply taken to Ruia a lave, te oletranaion realin te darke day o Arian ave trade Wit our iul tinkin e tried to nd exue or te Sovie atroiie. We even triedto nd exue or te ndividual mibeavior o Soviet odier; ar i a

beay buine, and make bea o men So, I en o Moo i eope o bein abe to te Sain a a oin on in Hunary, ta eunarian aned to be riend it e Soviet bu ouldn be i e did notend i rue I aked or an intervie and a taken ino e orein Oebeore Mr Deanoov, o ad o nd out at I aned rom Sain MrDeanoov mu ave been a very i oial beaue e a later exeuedtoeter i eria e aked e a aned. d i Hi eaina unexpeted e bean to ou At ti momen I el tat a Iout to be e over eal o loa ommander a all planned in Moo.oin ome, I ill oninued orkin or an underandin it te Soviet

e ad o ie toeer, e ad bee underand ea oter Te Ruanpeope are a ne peope om one anno ep likin one one kno em

I out, ao, to ave anoter voaion to ep rebuid te devataeduture o Hunary and ave our leadin inelleua rom arvation. Iould ep ony a limied number, o I tared a ne "Sieni Aademy,and eeed i member, 0 o 0 Te Aademy onied, iey, o aroery ore i a kep eoked and rom i member o eAademy oud ake at tey neeed ree o are A riend o mineeped me nane i enerprie He ao eped me o eabi a ne oo

o bioemia reear Ti a no eay, beaue, o nd a poao in toeday a a ullime ob and i I aned my aoiate to ork ad o eedtem My aboratory ooked like a ik embryo i i reat vieine akIt onted o a bi kien, ed by my ie, and a aboratory, ed by yel

Peronay, I ad no omplaint aain te Soviet, o aay ave mee mo dinuied reaent. n oder o ok y Aadem I neededruk and it my riend, te rier, L. iay, e aked or ruk romMarall Voroiov o readily ompied Wi ee truk e eabieda tavel aeny In oe day everybody anted o et aay rom teapia bu tere a no ranporaion So, e oud are i prie or

takin people to te ountry, ere, it e are oleted, e bout oodor te Aademy.

I pite te peronal avour i eame more and more iult or me

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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S IN E WENEH CENRY 13

o nd xu fo h ov' bhvou, hh dd no undndOn dy I n o znd o o my hlh on my k. Th ov

ommnd ud my bn o d of my p fnd ho nnmy booy nd Admy dnppd Th nx dy h ommun pp bouh ou l bou hm, yn h h o mony nd ny I nomd bou h hppnn nd pu n my nuno hv my fnd d Th uho mud. f I hd bn nuny I oud hv don nohn A l, n zlnd, I ould l hod non o h on on n uny, nd h oud hvbn bd pon n Moo fo ou lo ommun ld My oh Pm Mn nd h ommun Do f no doub bou mydmnon. My fnd d, nd vn ppo o lv houny, hvn "n oo muh To pvn ond kdnppn myf ompnd hm by o zlnd, hopn h h ov oudno k ouhn h. In nd I nd fom my fnd h on on bhd h priso was, hch I could neve d ot at home. Thslld m h uh pofound du I unbl o un To o bknd h ov md no n nd pn fvou mpob o ddd no o un. Evnully, I ound my hvn n ood ol, hI m nbld, no, by Amn noy, o ok unhmpd by nyoh fo hn my on pon mon.

* *

Th o nl n n h oy h hd vvd h on hubuln of ou dy, hon h on bn my n od ndpcnc uoundn hh mmbl ookn bk v m hfn of fuon. n l, budn dm, h hoovn fo y h n on h nd of nn ubnd h o h p of h old I okd fo oddn don olony, nd o mnknd on h bnk of xnon Th d of bnkd fo my d nv fhnd m. A on m vn md nulBu o hv pn o muh f nd ny n vn dpn, nd I hv ok myf, o mny oh n mu do: h h ny n?houd n no b oppd mn h h muy ny o dh h fo hh n , hou h dn of fduon?

In y, h uon h no n, fo n po nno boppd. umn uoy nno b unhd Th uon , hdo n po o y ou? To h uon my n nmph "y.

In h pmbl, I hv ouhd upon o f of n, y of

hnkn nd h oo Th dn of ou dy h po hun y h h oo vn h y of hnkn bhnd Th fod by n n b hndd on by h mnly hh d hmo f h y ou no n uppn, u n pdn n lln hough bom unly on o on od od

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .

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4 SZNGYGYI

ma be beced ha human reans are n dmnaed b hughsbu b mras and scence has n ma cnen Mras are he sme re-scrns whch mae ng geher ssbe. The hae n nrnsc meann wud mae e sense sa a ger Thu sha n rreach a muse Thu sha n sea. Bu a human sce cannes whu such rues

Bu s rue ha scence has n mra cnen? s scence n mre hanus a mehd hnng s r a cecn daa and bs s scencen a ng sce? hn s. T me scence n he rs ace s a sce men whch nws n ms n me and sace am ng n such a cmmun n whch aser and Newn are m da cmanns an ndan

r Chnese scens s cser me han m wn mman. The basc marue hs sce s sme muua resec neecua hnes and gdw S hn scence des hae s mra cde whch ers as s hrdace n whch a new wrd rder can be bu. Scence has rased man rmsench and dr beraed hm rm he masmas whch decmaed hm nearer mes aws he bearng chdren whu ear has areadshwn he ssb a dgned e he eecan whch has greaeended s rue has reduced man a er mdes ace n Creanbu hen why no ry o f ouseves accepg e esponsy o ou

wn ae? Wh u dwn ne anher urher snn ur wn ams-here, shwng hw eas e can be wed u? Scence has ened endessssbes r eansn we wr geher nsead snachng smaadanages rm ne anher Scence has heed us undersand and maser Naure. Mabe w he us undersand and maser ursees, creang an eeaed new rm human e he weah and beau whch cann be cured da b he eenes magnan

   A  n  n  u .   R

  e  v .   B   i  o  c   h  e  m .   1   9   6   3 .   3   2  :   1  -   1   5 .   D  o  w

  n   l  o  a   d  e   d   f  r  o  m   w  w  w .  a  n  n  u  a   l  r  e  v   i  e  w  s .  o  r  g

   b  y   1   2   5 .   1   6   3 .   1   1   3 .   2   2   0  o  n   0   6   /   0   9

   /   1   4 .   F  o  r  p  e  r  s  o  n  a   l  u  s  e  o  n   l  y .