Magnetic applications of nanocellulose

Nikorn Laocharoen (465454)26 Feb 2015

Nanotechnology in Forest Biomaterials

What is magnet?

What is the magnetic of nanocellulose?• Combination of magnetic nanoparticle and nanocellulose• Resulting in improved properties; mechanical strength, more flexible, and Magnetic, Thermal property

• Material or object that produces a magnetic field by itself• Magnetic field is invisible • Element: Fe, Co, Ni

Nano cellulose Magnetic particle

Emulsion, ImpregnationGrafting, Composite etc.

Application Fields

Medical/ Biotechnology• Tumor/ Cancer• Drug Delivery

Nano emulsion• Magnetic hybrid cellulose aerogels• Magnetic nanopaper

Nano composites• Films for packaging• Rubber• Nanofiber

Inhibit growth of tumor cell

Application in medical treatment

Magnetic Fluid Hyperthermia (MFH):• Magnetic nanoparticles are injected into the tumor • Apply the external magnetic field• Magnetic thermal induction by nanoparticles • Tumor regression is observed• Superior to conventional anticancer drug

1. Hard core (inner) CoFe2O4

2. Soft shell (outer) MnFe2O4Magnetic nanoparticles

Magnetically triggered release of drugs and biomolecules

Drug and Biomolecules delivery:• Engineered nanoparticles• Commercialized level

How to obtain?• Iron oxide Size < 100 nm• Surface functionalization to magneticnanoparticles• Directly adsorption of drug onto the surface• Surface coating (Inorganic; silica, gold) for biocompatibility• Functionalized with DNA carrier

Application in medical/ biotechnology

Application in Colloid and Interface

Features:• Tunable and strong mechanical property• Used as templates for making lightweight porous magnetic aerogels• Then, compact such aerogels to form magnetic nanopaper

Advantages:• Lightweight• Porous (98%) with high surface area• Flexible• Absorb large amount of water• Apply in microfluidic devices and electronic actuators

compaction

Application in Nano composites

Composite material in natural rubber

Magnetic self standing films

Ferrite powder Ferrite Rubber Composite (FRC)

Advantages:• Low weight (than ceramic)• Resistance to corrosion• Highly flexible• Ease of machining and forming

Advantages:• Anti-counterfeit in security documents• Magnetic ink• Coating• Micro-patterning

• CNC–inorganic (Barium Ferrite) dispersion and then removal of water via filtration (light brown color)• Put in magnet and use magneticfield viewer to distinguish

Composite material in nanofiberAdvantages:• Improved mechanical strength• Strong interaction with water (owing toThe presence of CNC)• Biocompatible (may apply as fluidHyperthermia)

• Electrospinned PVA fiber composite with magnetic CNC-inorganic

Conclusion

• Magnetic application illustrates broad range of utilization• High impact on well-being life of humankind in the future

(tumor/cancer therapy)• Many of the magnetic application are still in research and

development phase

Personal perspective on this topic

• Long term investigation from utilizing magnetic nanocellulose in human

• Recycling aspects of some composite materials (is it easily recycled

or reused)• Take the advantages of magnetic feature for heavy metal

seperation (i.e. water treatment)• Possibility for scale up production (cost of large scale production,

market demand)

References:• Bonini M., Berti D., Baglioni P., 2013. Nanostructures for magnetically triggered release of drugs

and biomolecules. Current Opinion in Colloid & Interface Science. 18, p.459–467.• Jordan A., Scholz R., Wust P., FaK hling H., Felix R., 1998. Magnetic fuid hyperthermia (MFH):

Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. Journal of Magnetism and Magnetic Materials. 201, p.413-419.

• Lee J., Jang J., Choi J., Ho Moon S., Noh S., Kim J., Kim J., Kim I., In Park K., Cheon J., 2011. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nature Nanotechnology. 6, p.418-422.

• Makleda, M.H., Matsuib T., Tsudab H., Mabuchib H., El-Mansya M.K., Moriib K., 2004. Magnetic and dynamic mechanical properties of barium ferrite–natural rubber composites. Journal of Materials Processing Technology. 160, p.229–233.

• Olsson R.T., Azizi Samir M.A.S., Salazar-Alvarez G., Belova L., Ström V., Berglund L.A., Ikkala O., Nogue J.and Gedd U.W., 2010. Making flexible magnetic aerogels and stiff magnetic nanopaper using cellulose nanofibrils as templates. Nature nanotechnology. 5, p.584-588.

• Ridi F., Bonini M., Baglioni P., 2013. Magneto-responsive nanocomposites: Preparation and integration of magnetic nanoparticles into films, capsules, and gels. Advances in Colloid and Interface Science. 207, p.3-13.