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MF-11 Eleventh Microfluidics Consortium

MF11.4 Video Meeting

London England July 2nd

Draft Agenda V11

Delegate List

Zoom Sign in Arrangements

During the Covid19 Pandemic we are re-inventing MF11 as a virtual

service – delivering consortium meetings over Zoom

These video meetings are designed to replace most of the content /

processes of MF11.4. Some sessions are Members only, others are

open to registered non-members. We are experimenting with ‘Virtual

Booths’ and ‘Pods’ for private conversations/demos – these are open to

members and non-members. See Navigation Instructions at the end of

this document

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The Eleventh Microfluidics Consortium brings together current and future stakeholders from across a wide range of backgrounds with a shared interest in facilitating the growth of the microfluidics industry through better understanding of the challenges, opportunities and choices which it faces.

Our current membership includes: Adhesives Research (Eire), AMF (CH), BD Biosciences (USA), IPGG (F) ;EV Group (A) Philips (NL); Micronit (NL); Danaher (USA); Dolomite (UK) ; Fluigent (F); MicroCAPS (CH), National Research Council of Canada (CAN), Labcyte (USA) ; Lonza (CH) ; IMT (CH), Posalux (CH); Sartorius (USA), Susos (CH), Web Industries (USA); Cryopak (USA), z-microsystems (A), Zeon Speciality Materials (USA) and University of Cambridge (UK).

We organize closed meetings for our members on both sides of the Atlantic where we seek to promote our mission “to grow the market for microfluidics enabled products and services” by

- Finding shared interest across the landscape of applications - Championing modularity and standards where appropriate - Engaging with key industry influencers

While helping our members to do deals along the way.

On this occasion we are delighted to be hosted by Jesus Rodriguez Manzano of the Department of Infectious Diseases at Imperial College

The new Department of Infectious Disease mission is to:

build a diverse and inclusive research community apply excellent science and develop new approaches to address the unmet

clinical needs for the control of infectious disease, both here in the UK and internationally

We host investigators studying all aspects of infectious disease ranging from the fundamental science of microbial pathogens to the clinical outcomes of the infections they cause.

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Our goal is to understand the role of microbes in health and disease and to describe host responses to pathogens, both natural and those induced by vaccines, at molecular, structural and systems levels.

We engage in cross-collaborative working across Imperial College, and partner with industry and government agencies, to translate our discoveries for the prevention, diagnosis and treatment of infectious diseases and to communicate our advances to the wider public.

We aim to inspire the next generation of infectious disease scientists by training undergraduates and postgraduates and developing the careers of our postdoctoral fellows.

We will adhere to principles of equality, fairness and transparency and strive to create a collegiate working environment where all can flourish and be happy

Zoom meeting arrangements:

We will have several virtual rooms delegates can visit:

- Main Auditorium open to: o Members – who will have full audio/video/screen-share/chat/see other

participants rights o Non-Members - who will be able to see/hear the proceedings and

have chat rights to pose questions thro the meeting host - but will be on mute.

- Members Executive Lounge Open to members only and with full A/V meeting facilities for confidential consortium sessions.

- Members’ Private Booths. Hosted by individual members who can invite any delegates to join them at any time for discussions and shared presentation materials. We are expecting booths hosted by:

-

- - - - -

See logistics section at the end of this document for details of how to join this Zoom meeting and visit the private booths.

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July 2 All times are UK Time (=East Coast Time +5, = West Coast Time

+8)

12:00 Zoom login, and Audio-Visual Check . It’s the new coffee and biscuits!

Members and non-members free to chat within Zoom the main auditorium and visit

the member booths for video chats. If you want to be allocated to a particular

member booth or have a one-2-one with another delegate chat with ‘Alice’ who can

set this up..

12:30 Location: Main Auditorium

Introduction and Welcome :

- Introduction from the Department of Infectious Diseases Jesus Rodrigues Manzano Imperial College Host

- House Rules and How to get the best out of the meeting

- Guide to Navigation between Rooms on Zoom

- Support and how to get it

Peter Hewkin and Alice Hewkin virtual meeting hosts - CfBI

13:00 Location: Main Auditorium

Session 1 “Research”

We will hear from leading microfluidics researchers in the London / UK Cluster.

Each talk will be followed by Q&A moderated by Peter. Please ‘raise your hand’ if

you want to speak – the host will unmute your microphone

Jesus Rodrigues Manzano – Assistant Professor Imperial College London

I received a BSc in Biological Sciences, an MSc in Advanced Microbiology and a PhD in Biotechnology and Environmental Microbiology from the University of Barcelona. In 2013 I moved to the California Institute of Technology for a three-year postdoctoral position in the Division of Chemistry and Chemical Engineering and in 2016 I moved to Imperial College London in Department of Electrical and Electronic Engineering as a Research Fellow. Currently I am a Lecturer in Antimicrobial Resistance and Infectious Diseases at Imperial College London within the Department of Infectious Disease, Faculty of Medicine.

I have a strong interdisciplinary background in microbiology, molecular biology and bioengineering, and my research interest includes the development of point-of-care technologies and novel molecular

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methods for diagnosis of infectious diseases and antimicrobial resistance in low- and middle-income countries. I am the author of over 40 scientific publications and 9 international patent applications with more than 1,600 citations (H-index: 20; i10-index: 25). Since 2016 I have raised >£3M in research funding and I have been invited to talk at international conferences and meetings on 16 occasions.

Pantelis Georgiou – Reader in Biomedical Electronics Imperial College London. “

We are a team of researchers from Imperial College London excited about bringing our research to the world and help with global health challenges.

We combine state-of-the-art electronics, molecular biology and machine learning to develop new diagnostic technology. We believe that integrating these techniques with portable devces and smartphones will allow the diagnostics of the future to be brought to people in need of testing.

We are now ready to bring our technology to hospitals to validate it for diagnosis of SAR-CoV-2, the virus causing COVID-19 and are excited to share progress as we go along.

Dr. Andrew Gibbons, JSPS Fellow in the Pureosity

Laboratory at iCeMS in Kyoto University, Japan

(www.pureosity.org).

Organized Microfibrillation (OM) is a new method that we have developed for creating microporous structures within polymer films (Nature 2019). OM structures have the dual features of structural color and long range connected porosity making them a suitable candidate for specialty printing and microfluidic devices.

We have demonstrated the capability of the OM process for ultra-high-resolution printing (up to 14,000 DPI) using photolithographic techniques, and recently we have made promising progress for its application in microfluidics. OM is a general process that has been demonstrated in a range of common polymers and with various substrate conditions, such as transparent and flexible substrates. Now we are pushing the OM process towards commercial printing applications and are exploring its application in the world of microfluidics.

In this presentation, I will show how we have used material properties and light to harness the nanoscale deformation process to create OM, a new paradigm in structure transformation.

14:15 close

Members and non-members free to chat within Zoom the main auditorium and visit

the member booths for video chats. If you want to be allocated to a particular

member booth or have a one-2-one with another delegate chat with ‘Alice’ who can

set this up..

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14:30 Session 2: “What’s Up?” - Members presentations.

Location Main Auditorium

This session is an opportunity for members to present on their recent work and

achievements. Each talk will be followed by Q&A.

Pavel Abdulkin – Microcaps

Pavel is Chief Commercial Officer at MicroCAPS.

Microcaps enables precision microencapsulation at

industrial scale. We develop formulations, supply

equipment and provide consumables necessary to take

complex microencapsulation projects from proof of

principle to industrial implementation. We work with

pharmaceutical, biomedical and cosmetics companies on

projects such as active ingredient protection, controlled

release and targeted delivery.

Monica Brivio – Micronit

Micronit is a world leader in developing and manufacturing

microfluidic Lab-on-a-Chip and MEMS products for life

science, medical, and industrial applications. Micronit has

extensive know-how and intellectual property in the field of

microfabrication and microfluidics, combining a start-of-

the-art cleanroom with an experienced product

development and R&D team.

Micronit's company strategy is to keep expanding its

knowledge and strengthening its position on various

market segments, among which In-vitro Diagnostics, including Point-of-Care testing,

Pharma, Life Science Research, Organ-on-Chip and bioMEMS. This strategy is

underscored by Micronit's continued R&D activities in defining new manufacturing

processes, novel fabrication materials and next generation microfluidics components as

well as functional integration strategies to provide novel, microfluidic formats that enable

automation of laboratory workflows

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Maximilien Geurin - Advanced Microfluidics (AMF)

All this began when someone needed a solution that didn't exist.

Our first partners were developing a complex lab automation project and could not find suitable components on the market. Knowing our passion for microfluidics, they approached us. Together, we developed a solution that specifically corresponded to their needs. Our first product was born, the automated sample preparator.

The know-how that resulted in this partnership enabled us to identify several additional market needs and develop more products. Thus Advanced Microfluidics was created.

Based in the heart of the Swiss watch and med-tech valley, in the EPFL innovation park, our team is committed to designing high-end, user-friendly fluidic solutions.

Remi Wache – IPGG Covid Dx programme looking for an industry partner!

A team from ESPCI Paris- PSL supported by the City of Paris,

has developed a field test, both fast and reliable, for Covid-19.

The so-called COVIDISC is based on a microfluidics device

developed by the Tabeling’s research group at ESPCI, that has

already proven its effectiveness on several diseases such as

Zika or dengue fever. The test has been adapted for Covid-19,

and has both a high sensitivity and specificity.

This new test relies on the most recent molecular technologies

compared to the existing PCR technology, which is 37 years

old. The key device is simple to use, cheap, portable and can

be kept at room temperature. It produces reliable results in less than an hour and could be

produced on a large scale. If you are interested we can set up a chat pod slot with Remi/team!!

Close 16:00

Members and non-members free to chat by text in the main auditorium and visit the

member booths. If you want to be allocated to a particular member booth chat with

Alice.

Members will transfer to the Executive Lounge. Non-Members can visit

Member Virtual Booths and chat pods in a Parallel Session 3b – see

below

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16:30 Session 3a: Location: Members Executive Lounge. MF 11 Members will

automatically be invited to the Executive Lounge. They need to press the ‘Breakout Room’ button in

the Zoom toolbar to make the transfer. They can

return to the main auditorium when they wish by

pressing the ‘leave breakout room button’ in the

zoom tool bar.

“Microfluidics Hotseat”. Pitches from early

stage microfluidics enabled companies seeking to

engage with the MF11 Consortium

Ufraction8 - Brian Miller

uFraction8 is a young biotech startup based in Falkirk,

Scotland.

At uFraction8, we are focused on sustainable solutions for

bioreactor downstream processing.

We aim to propagate our innovative solution, replacing filters,

membranes, flocculants, centrifuges and other technologies.

We target a wide range of microbes like micro algae, yeast

and bacteria, sorting biomass from culture medium with no

harmful high shear processes

Microfluidx – Antoine Espinet

MICROFLUIDX CELL MANUFACTURING SYSTEMS: THE

POWER OF MICROFLUIDICS AT SCALE

Microfluidics cell culture has been well documented to enable

several advantages compared to conventional single-use

technologies (SUTs):

10-20x lower reactant consumption

Increased process efficiency e.g., transduction can be

up to 5x times faster.

5-50x more cells per unit volume/surface area compared to conventional SUT,

reducing downstream processing need.

High level of precision and control over all process parameters, minimizing product

heterogeneity and improving quality.

MicrofluidX leverages the power of microfluidics thanks to its highly parallelisable microfluidic

bioprocessing system that:

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Combines multiple cell culture capabilities (seeding, expansion, differentiation,

transduction, washing, sorting, concentration, sampling, harvest) in one closed system

Is fully scalable from thousands to several hundred million cells without the need to re-

engineer your process: same yield, same quality, same results

OOYOO Prof. Easan Sivaniah, is founder of OOYOO, and head of the Pureosity Laboratory in

Kyoto University, Japan (www.pureosity.org). He is an alumni of

Imperial College (Chemical Engineering), and the Cavendish

Laboratory, Cambridge University.

OOYOO is a Kyoto University spin-out with mature technologies

in the air and gas industry (www.ooyoo.co.jp).

As a vehicle to generate exciting spin-outs of the future,

OOYOO is incubating a future printing platform for microfluidic

device manufacture that is:

Multi-dimensional

Multi-material

Few step processing

Flexible and transparent

Ultra-high resolution (14,000 DPI)

Scaleable and Portable

The fundamentals of the work has been patented, and published in Nature (2019). We see

a number of exciting applications for our platform technology, from anti-counterfeit security

printing to fabrication of small scale biomedical devices. Though early stage, the technology

holds remarkable promise to reshape the world of microfluidics, and we invite feedback from

the many stake-holders in the microfluidic community, in order to develop the technology to

venture-phase with market needs in sharp focus.

Stuart Lowe (of TTP) presenting for DNA – Nudge – DNA

Nudge originally focused on diet advice arising from their retail

DNA nudge product. Their scientists have recently developed a

bespoke Nudge Cartridge for rapid lab-free Covid-19 testing and

are currently deploying it in the NHS.

Each talk followed by Q & A hosted by Peter Hewkin.

Free Format Members Discussion – Opportunities arising from Covid 19

17:30 Close and Return to the main auditorium where delegates are free to continue the

conversation and join the parallel sessions.

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16:30 Parallel Session 3B. Structured Partner Finding session open to members

and non-members where delegates can select 15 minute slots for 1-2-1 meetings

with MF11 members in their booth or in chat pods. Anyone can ‘Ask Alice’ Members

can ‘Claim Host’ if they would like to set up a meeting in one of these slots.

Slot Start Time Member Booth Chat Pod A Chat Pod B Chat Pod B

Chat Pod C

Chat Pod D

Chat Pod E

Talks / Demos Slot 1 16:30 UK 17:30 Europe ZeonSMI 1A 1B 1C 1D 1E 1F 11:30 Eastern 8:30 Pacific

Slot 2 16:45 UK Susos 2A 2B 2C 2D 2E 2f 17:45 Europe 11:45 Eastern 8:45 Pacific

Slot 3 17:00 UK Micronit 3A 3B 3C 3D 3E 3F 18:00 Europe 12:00 Eastern 9:00 Pacific

Slot 4 17:15 UK Fluigent 4A 4B 4C 4D 4E 4F 18:15 Europe 11:15 Eastern 9:15 Pacific

Booth Holders Promotion to Delegates

Micronit Showing webinars on microfluidics used in IVD, single-cell analysis & DNA sequencing - Please ‘drop in for a chat’ as well!

ZeonSMI Showing presentation on COP materials and milling for microfluidics applications – Please ‘drop in for a chat’ as well!

AMF Please ‘drop in for a chat’ Fluigent Fluigent has launched during the first part of 2020, a number of various

new product to push the boundaries of microfluidics. From Push pull, to P-Switch through our new RX pressure source, join us in our booth to discover what is behind those names and how these novelties can help you to take advantage of microfluidics on a daily basis.

Susos We solve surface-related problems, from unspecific protein-attachment

in Microfluidics to biofunctional coatings for diagnostics. Drop by our booth to get a presentation on our proprietary surface chemistry that enable best-in-class medical devices and diagnostic applications

MicroCAPS Please ‘drop in for a chat’

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18:30 close (Zoom will be kept open after this for delegates who want to linger ?over a glass

of wine?

Delegate List

Name Surname Organisation Country

Pavel Abdulkin Microcaps CH

Aytan Abraham Lonza US

Samin Akbari Sartorius US

Don Arnold Veristad US

Mark Aruda Fluigent US

Mariam Assadian Heidenhain US

Larry Atupen Zeon SMI US

Maurice Barakat Cryopak US

Karan Bali University of Cambridge UK

Abir-Wissam Boudaoud CETIAT F

Bojan Boskovic CfBI UK

Monica Brivio Micronit NL

Julian Burke Danaher / Leica UK

Eadaoin Carthy Dublin City University Eire

Arnaud Cartier Fluigent F

Jehangir Cama University of Cambridge UK

Olivier Cantada Sage Science Inc US

Pin Chen BD US

Pavankumar Challa University of Cambridge UK

Sammy Datwani Inscripta Inc US

Robin de Bruin Philips NL

Yasaman Daghighi Bio-Rad US

Bernd Dielacher EV Group A

Antoine Espinet MicrofluidX UK

Jacques Fattaccioli IPGG F

Joanna Fielding Pall Corp US

Hirotaro Fujiki Zeon Corp Japan

Aytug Gencoglu Bio-Rad US

Andrew Gibbons University of Kyoto Japan

Cedric Goyer Posalux CH

Richard Gray Blacktrace UK

Maximilien Guerin AMF CH

Eric Hall Bio-Rad US

France Hamber Fluigent F

Yusuke Harada DestinHaus US

Jan Heck University of Cambridge UK

Alice Hewkin CfBI / Zoom Host UK

Peter Hewkin CfBI UK

Doug Goldstein Adhesives Research EI

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Yasuko Horiguchi Zeon Corp Japan

Jeffrey Kelly Launchworks US

Guillaume Laffite IPGG F

Darin Latimer Danaher US

Jas Lee Wolf Greenfield US

Mahesh Lokesh Fluidic Analytics UK

Stuart Lowe TTP UK

Christian Mathis Susos CH

Sean Meaney Adhesives Research US

Lou Medina Adhesives Research US

Brian Miller ufraction8 UK

Yask Mishra University of Cambridge UK

Darren Morofke Danaher UK

Marko Nadalin Posalux CH

Kareem Al Nahas University ofCambridge UK

Birgit Nelsen-Salz Lonza D

Alessandro Ofner MicroCAPS CH

Georgiou Pantelis Imperial Colege UK

Robert Pelletier Fluigent US

Jennifer Ponti Web Industries US

Bryan Presley Posalux US

Yatian Qu Bay Area Microfluidics Network US

Andy Racher Lonza UK

Rahul Ramesh DestinHaus US

Mark Olde Riekerink Micronit NL

Jesus Rodriguez Imperial College UK

Sonia Smith z-microsystems A

Philipp Spuhler BD US

Sebastian Stoeckeler z-microsystems A

Joe Sigler Converting Systems US

Easan Sivaniah ooyoo Japan

Mattias Tidare Danaher / Cytiva S

Samuele Tosatti Susos CH

Alexios Tzannis IMT CH

Joost van Philips NL

Remi Wache IPGG F

Abdul Wasay National Research Council of Canada CAN

Qihua Xu BD US

Mengxue Zhang IPGG F

Tim Zhu BD US

Bold = MF11 Member Organisation (with access to Executive Lounge) Red = Virtual Booth Holder (ask them if you want to visit their booth)

Logistics:

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Following our member survey, we using the Zoom platform. You need Version 5.0

with the latest security features. Delegates have to register in advance of participating.

Follow the links below for detailed instructions.

- MF11 members register here for free. They can participate in all sessions.

- Non-MF11 members register here. There is a charge and they can non participate in the sessions in the Executive Lounge

In the members only session in the Executive Lounge Chatham House Rule applies.

Delegates will know who else is participating in the conversation. Recording is disabled /

forbidden.

We will also make breakout rooms (Chat Pods) available for smaller member meetings.

Members should chat with ‘Alice’ if they have a real time request to talk with someone 1-2-1

You will get the best experience if you use a PC/Laptop (make sure that your mic / camera

work by using the Zoom sound-check feature) – but participation by phone/smart phone is

also possible. We recommend that you keep your video on. If the room gets over crowded we

will mute microphones except for the speaker.

There is no charge for using the Zoom platform – but you might have to pay your

phone/internet company for time/data use.

If you have not used Zoom before, we recommend that you practise. Check out features

like ‘Test mic/video’, ‘Gallery View’/’Speaker View’ ‘Chat’ and ‘Breakout Rooms’. The

participant experience (particularly in the discussions) is best if you enable video .. but this

uses more bandwidth and might cost you more

Main Auditorium 1-2-1

Chat

Open to All Pods

from 12:30 Open to

All

from

12:30

Executive Lounge Member Booths Ask

Members Only Open to All Alice

Use Ask Alice to set

to allocate you to Open from 16:30 from 16:30 your

one of the other areas Press Leave Room Press Leave Room 1-2-1

Press Go to Breakout to Go to Main Auditorium to Go to Main Auditorium up!!

Break out Room to go

to another area

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Main Auditorium:

All delegates land here when they join the meeting. They will usually see a screen like this

Or the live presentations. They can move to their allocated breakout room whenever they like.

MF11 Members’ Executive Lounge:

This has been realized using the ‘Breakout Room’ feature in zoom. All MF11 members

have been allocated access to this room by default. They can use the toolbar breakout

room icon to visit the Executive Lounge and the red ‘leave breakout room’ message

to return to the main auditorium.

MF11 members will automatically be invited to transfer to the Executive Lounge when

Members only sessions are starting.

On arrival in the MF11 Members’ Executive Lounge you will see a screen like this:

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You can return to the Main Auditorium by pressing the red ‘Leave Breakout Room’

button to the right of the toolbar.

Non-MF11 members cannot access the MF11 Members Executive Lounge. But they

can access the member booths.

Members Booths:

These have been realized using the ‘Breakout Room’ feature in zoom. The Members

with booths will have a permanent presence in their room – where they can hold video

discussions with visitors, share screens and show presentations at anytime they like.

Non-member guests will have access to the booth of their host member. They can use

the breakout room icon to visit this private member booth and the red ‘leave breakout

room’ message to return to the main auditorium.

At present we expect to have Member Private Booths for:

Micronit Showing webinars on microfluidics used in IVD, single-cell analysis & DNA sequencing - Please ‘drop in for a chat’ as well!

ZeonSMI Showing presentation on COP materials and milling for microfluidics applications – Please ‘drop in for a chat’ as well!

AMF Please ‘drop in for a chat’ Fluigent Fluigent has launched during the first part of 2020, a number of various

new product to push the boundaries of microfluidics. From Push pull, to P-Switch through our new RX pressure source, join us in our booth to discover what is behind those names and how these novelties can help you to take advantage of microfluidics on a daily basis.

Susos We solve surface-related problems, from unspecific protein-attachment

in Microfluidics to biofunctional coatings for diagnostics. Drop by our booth to get a presentation on our proprietary surface chemistry that enable best-in-class medical devices and diagnostic applications

MicroCAPS Please ‘drop in for a chat’

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Where a representative of these companies will welcome you at any time. Companies with

Booths are able to invite delegates to join them at any time.

Delegates and non-delegates wanting to visit a booth other than their assigned

breakout room need to ask the host to change their assigned room.

Send a message by zoom chat to Alice to do this. You will then receive an invitation

to join your new selected Booth.

Booth owners can also ask Alice for host rights and allocate delegates (with their

permission, please!) their booth.

Questions?:

We know that these processes are sub-optimal and expect some rough edges! Please

contact Peter on ceo@cfbi.com or ++44 7951721110 if you have an urgent problem –

or use the chat feature to contact Alice by Zoom chat in the Main Auditorium for less

urgent things.