SERGIO ANDRES ROMERO SEGUROMEDICINE STUDENT: III SEMESTER

Modifying DNA May Wipe Away Old Memories and Physical reason for chromosome's cylindrical shape

discovered

FOLDING

FOLDING

MODIFYING DNA MAY WIPE AWAY OLD MEMORIES

AND

PHYSICAL REASON FOR CHROMOSOME'S CYLINDRICAL

SHAPE DISCOVERED

INTRODUCTION

NEW STUDY IN MICE SHOWS THAT MODIFYING THE MOLECULES THAT ATTACH TO OUR DNA MAY OFFER A ROUTE TO QUASHING PAINFUL MEMORIES.

NEUROBIOLOGIST LI -HUEI TSAI , HAVE NOW UNCOVERED A CHEMICAL MODIFICATION OF DNA THAT REGULATES GENE ACTIVITY AND DICTATES WHETHER A MEMORY IS TOO OLD FOR RECONSOLIDATION IN MICE.

Modifying DNA May Wipe Away Old Memories

Adapted from Johannes Gräff, et al., Cell (2014)

THE NEUROPLASTICITY IS THE AREA THAT THE TEAM WORK USE TO DEVELOPED THIS TECHNIQUE, IN WHICH THEY ATTENUATE AN OLD TRAUMATIC MEMORY BY THE EPIGENETIC MODIFICATIONS.

Modifying DNA May Wipe Away Old Memories

Adapted from Johannes Gräff, et al., Cell (2014)

THEY DISCOVERED THAT HDAC2 WAS THE ENZYME THAT NEED TO NITROSYLATED TO MAKE A CHANGE IN STRUCTURE OF THE DNA HIPOCAMPUS AND BE ABLE TO ATTENUATE THE TRAUMATIC MEMORY.

Modifying DNA May Wipe Away Old Memories

Adapted from Johannes Gräff, et al., Cell (2014)

THEY NITROSYLATED THE HDAC2 AND IN FACT THEY GET EXCELENT RESULTS SHOWING IS THE FIRST STUDY TO ATTENUATE REMOTE—OLDER—FEAR MEMORIES IN AN ANIMAL MODEL.

Modifying DNA May Wipe Away Old Memories

Adapted from Johannes Gräff, et al., Cell (2014)

OBSERVATIONI THINK THAT THIS

INVESTIGATION IS JUST AMAZING, IS LIKE A ALL

WORLD OF NEW POSIBILITIES THAT CAN MAKE THE DIFERENCE

FOR THE NEXT GENERATION OF

EPIGENETICS RESEARCH WORKS.

NO MATTER WHAT CELL WE ARE TALKING ABOUT THE CHROMOSOME ARE ELONGATED CYLINDERS THAT HAVE RELATIVELY SIMILAR SHAPE PROPORTIONS.

Physical reason for chromosome's cylindrical shape

discoveredJournal of The Royal Society Interface, 2014

CHROMOSOMES ARE SMOOTH CYLINDERS BECAUSE THIS MORPHOLOGY HAS A LOWER SURFACE ENERGY THAN STRUCTURES HAVING IRREGULAR SURFACES.

THIS APPROACH GOES BEYOND THE CAPABILITIES OF CURRENT STRUCTURAL BIOLOGY BASED ON X-RAY CRYSTALLOGRAPHY, BECAUSE IT ALLOWS THE STUDY OF AN ENORMOUS SUPRAMOLECULAR ASSEMBLY THAT CANNOT BE CRYSTALLIZED.

Physical reason for chromosome's cylindrical shape

discoveredJournal of The Royal Society Interface, 2014

. IT IS DEMONSTRATED QUANTITATIVELY THAT INTERNUCLEOSOME INTERACTIONS BETWEEN CHROMATIN LAYERS CAN JUSTIFY THE WORK REQUIRED FOR ELASTIC CHROMOSOME STRETCHING.

Physical reason for chromosome's cylindrical shape

discoveredJournal of The Royal Society Interface, 2014

THIS DISCOVERY LED TO THE THIN-PLATE MODEL IN WHICH IT WAS PROPOSED THAT CONDENSED CHROMOSOMES ARE FORMED BY MANY STACKED LAYERS OF CHROMATIN ORIENTED PERPENDICULAR TO THE CHROMOSOME AXIS.

IN THE CELL, THIS MAY BE USEFUL FOR THE MAINTENANCE OF CHROMOSOME INTEGRITY DURING MITOSIS.

Physical reason for chromosome's cylindrical shape

discoveredJournal of The Royal Society Interface, 2014

OBSERVATION

JUST THE REASON THAT EACH DAY ARE LEARNING MORE ABOUT OUR DNA STRUCTURE IS JUST A BIG STEP TO THE PREVENTION OF THE DNA DISORDERS AND EVEN MORE IMPORTANT, UNDERSTAND THE WHY OF THE CELL AS FUNCTIONAL AND STRUCTURAL UNIT.

MEDICAL UTILITY

THE NEUROPLASTICITY PLUS THE EPIGENETICS MODIFICATION ARE THE DYNAMIC DUO THAT IN A COUPLE OF YEARS ARE GOING TO SHOW A NEW VIEW OF BENEFITS THAT THE PEOPLE CAN ABOUT THE PREVENTION AND REHABILITATION OF NEUROLOGICAL DISORDER

MEDICAL UTILITY

THE WHY OF THE THINGS IS JUST THE BASIC REASON FOR WHAT WE LIVE, AND CREATE STABLE CELLS FOR THE NEXT RESEARCHERS IS JUST SO AMAZING THAT WE CAN APPLY TO A NEW WORLD OF INVESTIGATION WITH MORE OPORTUNITIES

MEDICAL UTILITY

NO MATTER HOW MUCH WE DEBATE ABOUT THE MOLECULAR SCIENCE, IN THERE BASES ARE THE ANSWERS THAT WE NEED, AND FOR THAT AND MUCH MORE CHARACTERISTICS WE NEED TO WACH WITH GOOD EYES THE ETICS STUDYS ABOUT DNA AND THE CHANGES THAT WE ARE GOING TO MAKE.

MEDICAL UTILITY

M O D I F Y I N G D N A M AY W I P E AWAY O L D M E M O R I E S , H T T P : / / N E W S . S C I E N C E M A G . O R G / B I O L O G Y / 2 0 1 4 / 0 1 / M O D I F Y I N G -D N A - M AY-W I P E - AWAY- O L D - M E M O R I E S , A D A P T E D F R O M J O H A N N E S G R Ä F F, E T A L . , C E L L ( 2 0 1 4 ) , 2 0 1 4 - 0 1 - 1 7 1 2 : 1 5

P H Y S I C A L R E A S O N F O R C H R O M O S O M E ' S C Y L I N D R I C A L S H A P E D I S C O V E R E DD AT E : J A N U A R Y 1 4 , 2 0 1 4S O U R C E : U N I V E R S I TAT A U T Ò N O M A D E B A R C E L O N A J. - R . D A B A N. T H E E N E R G Y C O M P O N E N T S O F S TA C K E D C H R O M AT I N L AY E R S E X P L A I N T H E M O R P H O L O G Y, D I M E N S I O N S A N D M E C H A N I C A L P R O P E R T I E S O F M E TA P H A S E C H R O M O S O M E S . J O U R N A L O F T H E R O YA L S O C I E T Y I N T E R FA C E , 2 0 1 4 ; 1 1 ( 9 2 ) : 2 0 1 3 1 0 4 3 D O I : 1 0 . 1 0 9 8 / R S I F. 2 0 1 3 . 1 0 4 3

M A R T I N E Z S A N C H E Z , L I N A M A R I A . B I O L O G I A M O L E C U L A R . 7 . E D . M E D E L L I N : U P B . FA C . D E M E D I C I N A , 2 0 1 2 . P 7

 

 

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