Nanomachinery

ภาควชิาฟิสิกส์ คณะวทิยาศาสตร์ มหาวทิยาลยัมหิดล

ธีรเกียรติ เกิดเจริญ, เติมศักดิ ศรีคิรินทร์, ธนากร โอสถจันทร์

Feynman’s Vision

“It would be, in principle, possible (I

think) for a physicist to synthesize any

chemical substance that the chemist

writes down. . . . Put the atoms down

where the chemist says, and so you

make the substance.

“There’s plenty of room at the bottom”

Richard Feynman Nobel Prize in Physics 1965

Drexler’s Nanomachine

Nanomachinery Mahidol Center of Nanoscience http://nanotech.sc.mahidol.ac.th/

Building

Block

Physics Chemistry Biology

Machine

Carbon Nanotube Supramolecule DNA/Protein

How to construct Mahidol Center of Nanoscience http://nanotech.sc.mahidol.ac.th/

Nanoarchitectonics

Nanomaterials

Nanodevices

Nanoplatform

Nanomachine

Modeling

&

Design

Synthesis

Fabrication

Integration

Mathematics, Physics,

Computational Science, Bioinformatics

Organic Chemistry,

Materials Science,

Chemical Engineering, Biochemistry

Surface Science,

Electrical Engineering,

Physical Chemistry, Cell Biology

Mechanical Engineering,

Systems Engineering, Systems Biology

Platform Example: Drug Delivery Nanobot

Nanoarchitectonics

Nanomaterials

Nanodevices

Nanoplatform

Nanomachine

Platform Exam.: Swarm Sensors, Self-feeding Bot

Nanoarchitectonics

Nanomaterials

Nanodevices

Nanoplatform

Nanomachine

Nanoarchitectonics Mathematics, Physics,

Computational Science, Bioinformatics

Self Assembly

Self Organization

Self Similarity

Self Replication

Self Repair

Self Healing

Self Feeding

Process Technology

Nanomaterials

PCR CVD

Organic Synthesis

Building Block Synthesis

Organic Chemistry,

Materials Science, Chemical Engineering, Biochemistry

Carbon Nanostructure

Conductive Polymer Zeolite

Geopolymer Nanocomposite Quantum Dot

DNA/RNA Nanostructure Peptide/Protein

Spray-Pyrolysis

Sol-Gel Arc-Plasma

Laser Synthesis

Polymerization etc

Devices & Integration

Template Fabrication

Langmuir-Blodgett

Machine Parts Fabrication Tools

Axle, Stator Rotor, Motor Actuator, Clamp Vesicle/Capsule Pump Sensor Wire, Switch Memory

Molecular Beam Epitaxy

Dip-pen Lithography

Surface Science, Electrical Engineering,

Mechanical Engineering, Physical Chemistry, Cell Biology

Photolithography

Etc E-Beam Writing ……

Classical Mechanics

Continuum Mechanics

Statistical Mechanics

Quantum Mechanics

10-10 m

10-8 m

10-6 m

> 10-4 m

• Chemistry

• Molecular Biology • Molecular Physics

• Solid-State Physics

• Biochemistry, Cell Biology • Supramolecular Chemistry

• Materials Science

• Electrical Engineering • Microbiology

• Civil Engineering

• Materials Engineering

• Mechanical Engineering

• Agriculture, Industrial Engineering

Mesoscale

Microscale

Nanoscale

Atomic Scale

Small molecules, drugSmall molecules, drugSmall molecules, drugSmall molecules, drug

Protein, membraneProtein, membraneProtein, membraneProtein, membrane

CellCellCellCell

T issueTissueTissueTissue

Bridging the Scales

Macroscale

OrganismOrganismOrganismOrganism

Mahidol Center of Nanoscience http://nanotech.sc.mahidol.ac.th/

Nano-Platform

MEM, NEMS Pervasive Computers Sensor Mesh, RFID Smart Dust Medical Nanodevices Artificial Life Autonomous Millibot/Microbot Lab-on-Chip Desktop Manufacturing

Converging Technologies

Future lies on …..

Integration of expertise of people in

architecture – materials – devices -

system/machine

Bridging different scales (molecular – nano –

micro –meso – macro)

Converging disciplines from basic science to

applied science to technology management

Mahidol Center of Nanoscience http://nanotech.sc.mahidol.ac.th/