Company Presentation 2014

• Over 40 years of experience in Fluorination

• Public traded company

• Manufacturing capabilities of developing fluorinating reagents at all scales

• Expertise in site selective fluorination & perfluorination techniques

• Innovator of novel fluorinated building blocks

• Portfolio of over 25,000 compounds

About Us – NFIL & MOL

Global Presence

Global Presence

Over 580 professionally qualified employees across the globe...

• 185 scientists in India and UK - Most at PhD or BSc (or equivalent)

• 70 commercial staff - with strong scientific background

throughout the organisation

• 285 production engineers and technicians

• 35 support staff

• 5 full time HSE personnel

Importance of Fluorine

Fluorination Strategy

O CF 3 O CHF 2 O CF 2 ClS CF 3 S CHF 2 S CF 2 Cl

O

Br

CF 3

Novelty increases

• Known compounds • Inexpensive • Commercially available

S

Br

CF 3S

Br

CHF 2S

Br

CF 2 ClO

Br

CF 2 ClO

Br

CHF 2

• Not commercially available • Unknown or few lit reports • Novel

Novel functional groups

O CF 3

O

Br

CF 3

• Known compound • Inexpensive • Commercially available

• Not commercially available • No literature reports • Novel

N Br

OCF 3 N

N Br

OCF 3

• Known compound • Expensive • Only recently available

Novelty increases

Novel molecules

Custom Synthesis

• Over 3000 IP protected compounds produced over past ten years

• Complex multi-stage chemistry undertaken by team of experienced PhD chemists

• Strong track record of on-time delivery to agreed specifications with accurate updates as per client requirements

• Fast turn-around time, typically less than six weeks for most projects

• All IP related to custom projects stored on secure, limited access, database

• Rapid access to cost-effective raw material sources from our own catalogue of over 25,000 building blocks

• Route development and optimisation if required, including further scale up

Custom Synthesis - Examples

CCHH22

OO

OO––

NN++

HHOO

OO

RROO

RR

250g prepared, 4 stages

ClClHH

OONN

RR

OO

NN

NN OO

OORR

1g prepared, 7 stages

RR

OO

NNNN

OORR

OORR

NNHH

RR

NN

OO RR

5 g prepared, 7 stages

OORR

NN

OO

OO

OOHH

RR

100g prepared, 3 stages

RR

OO

OO

RR

SS NN

OO

100g prepared, 8 stages

ClClHH

NN

NNHH

NN

OORR

RR

15g prepared, 14 stages

Chemistry Processes

• Acylation

• Alkylation-liquid & vapor phase

• Bromination & chlorination

• Side chain chlorination

• Fluorination - both liquid & vapour phase

• Nitration

• Reduction

• Catalytic Hydrogenation

• Hydro-dehalogenation

• Fries Rearrangement

• Esterification

• Claisen’s Condensation

• Diazotization

• Hydrolysis

• Oxidation

• Ammonolysis

• Deamination

• Grignard’s Reactions

• Cyanation

• Halex Reactions

Online catalogue

• Extensive range of over 25,000 novel

organic building blocks and intermediates

• Secure on-line ordering & account setup

• Structure searchable

• Credit cards accepted

• New products added weekly

• Large stock for prompt despatch

• MSDS’s downloaded from site

UK Operations, Runcorn

• 55 fume hoods across 6 laboratories

• High pressure chemistry facilities including:

- Fluorination

- Carbonylation

- Hydrogenation

• Radley’s Carousel’s & Biotage Isolera automated

chromatography systems for rapid screening

• Vessel sizes up to 20 L (Glass & stainless steel)

• MLS microwave reactor

R&D Operations, India

• 27,000 ft2 of laboratories

• Two Aliphatic & Aromatic Synthetic Labs

• Special laboratories include:

- Continuous Vapor Phase Fluorination Lab

- High Pressure Lab

- Inorganic Synthetic Lab

• Operational temperature ranges from -78 C to 400 C

• Online literature search facilities including Reaxsys, STN & Sci-Finder

cGMP pilot plant: Dewas, India

• Flexible reactors systems: 50L to 1500L

• GL, SS, Alloy 20, Hastelloy, Nickel & Inconel reactors

• Multiple solids isolation and drying capabilities

• 2-stage cGMP distillation column and a separate liquids packaging

• cGMP hydrogenation unit for corrosive reaction conditions - pressures up to 40 psi

• cGMP fluorination suite opened July 2012

• Full on-site analytical support and equipment

• Approval for significant expansion of current cGMP facility in Dewas given September 2013

• Multi-ton, multi-purpose plant scheduled for completion Q1-2015

• Expansion of R&D and analytical laboratories at Dewas site also approved

• Expansion required due to number of projects moving into Phase III and commercial

Dewas Site - Expansion Plans

Dewas Site - Expansion Plans • New cGMP plant will have Intermediate, High pressure

Hydrogenation & Distillation area

• Mfg. plant will have working capaciy of 28KL

• Various type of MOC such as SS316L,Glass Lined,Halar lined & Inconel.

• Min reactor capacity 500Ltr & max capacity of 3000Ltr

• Max operating pressure will be 100 Bar

• GMP Plant will have 10 reactors in Intermediate Area and 6 reactors in High Pressure Area.

• Additional space for minimum of 4 reactors in Intermediate area and 2 reactors in High Pressure area shall be provided

• Two Distillation systems will be provided in GMP plant.

• New Kilo Lab, process development labs and analytical and in-

process labs to be added

• New Admin building (only ground floor) with Area of 310 Sq Mts will be provided.

• A NMR and Reaction calorimeter apart from including additional GCs and HPLCs in QC has also been considered

Dewas Site - Expansion Plans

Quality Control

• NMR (300MHz)

• GC; HPLC; GC-MS; LC-MS

• Titration including KF

• UV spectrophotometer

• Stability chambers inc. photo-stability

• Polarimetry & variety of chiral LC columns

for enantio-pure compounds

• Melting-point apparatus with AVI files

• X-ray Fluorimeter

• Flame Photometers

Health, Safety & Environment

• Site specific safety protocols

• On-site fire station, medical centre & 24 hour security

• Comprehensive staff training programs

• Process safety (project specific)

- HAZOP

- COSHH

- Risk Analysis

• ISO 9001/14001/18001 accredited firm

• Regular external assessments

• Client audits are both welcome & encouraged

Why?

• Reliable • Project management • High quality • On-time deliverables

• Core expertise in fluorination – from R&D to commercial

• Highly experienced team – diverse range of chemistries offered

• Flexibility

• Strong track-record on health & safety and the environment

Company Presentation 2013