onyx 34 liquid embolic system for treatment of type 1 ... · 4 endoleaks type 1a after chimney...

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Onyx 34 liquid embolic system for treatment of type 1 endoleaks after chimney stentgrafts Christoph A. Binkert, MD, MBA

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Page 1: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

Onyx 34 liquid embolic system for

treatment of type 1 endoleaks after

chimney stentgrafts

Christoph A. Binkert, MD, MBA

Page 2: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Chimney stentgraft technique

Chimney / snorkel / periscope used for

juxtarenal AAA

short proximal necks

Alternative to fenestrated grafts

Page 3: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Problem of Chimney stentgrafts

Flow through „gutter“

= endoleak type 1a

Page 4: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73

41 patients (2008-2012) with chimney stentgrafts

Type 1a endoleaks:

1/41 (2.5%) at procedure

3/41 (7.5%) during follow-up (median f-up 18.2 months)

→ total type 1a endoleak 4/41 (10%)

Page 5: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Endoleaks type 1a after chimney Moulakakis et al. J Vasc Surg. 2012;55:1497-1503

Review of 15 published reports on chimney stentgrafts

93 patients

Type 1a endoleaks:

3/93 (3%) at procedure

10/93 (11%) during follow-up (mean f-up 9 months)

→ total type 1a endoleak 13/93 (14%)

Page 6: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Treatment options: block the gutter

Coils

(likely incomplete)

Liquids

(complete filling)

Page 7: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Ethylene vinyl alcohol copolymer

„ONYX“ (Covidien)

Liquid embolic

Slow hardening

starting at surface

Controlled application

Good visibility

(artefacts on CT!)

Page 8: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX to treat type 1a endoleaks Henrikson et al. Vascular. 2011;19(2):77-81

Successful sealing of a type 1a endoleak

after chimney stentgraft in 4 patients

Page 9: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Case example

74 y/o male with 6.2cm juxtarenal AAA

Chimney stentgraft 2 years ago

Type 1a endoleak 1 year ago

Page 10: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Aortogram pre

Page 11: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Catheter placement into endoleak

Stable catheter position is important

reversed catheter (femoral)

angled catheter (radial)

Coaxial microcatheter into endoleak

Page 12: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Catheter placement into endoleak

Page 13: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

start slow

Page 14: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 15: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

go with the flow

Page 16: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 17: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

origin of IMA

Page 18: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 19: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 20: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 21: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 22: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 23: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 24: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

Page 25: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection

stop!

Page 26: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX injection: different views

Page 27: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Aortogram post

Page 28: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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CT follow-up at 3 months

Page 29: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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ONYX artefacts on CT http://www.cirse.org/index.php?pid=1008

New formula with less tantalum: ONYX 34L

Page 30: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Amount of ONYX needed Eberhardt et al. J Endovasc Ther. 2014 ;21(1):162-71

Transcatheter embolization 6 patients with type 1 endoleak

after abdominal EVAR

ONYX 34 (because of high viscosity)

Mean amount of ONYX: 11.8 ml (range 3.0- 25.5ml)

Page 31: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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New ONYX 34L for peripheral use

6ml vial

(less vials necessary)

Shake for >10min.

Page 32: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

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Take home points

Type 1a endoleaks not uncommon after chimney stentgrafts

ONYX is well suited to treat type 1 endoleaks

Technical tips

stable catheter position

take enough images (different views)

start slow, go with the flow and stop on time

Page 33: Onyx 34 liquid embolic system for treatment of type 1 ... · 4 Endoleaks type 1a after chimney Scali et al. J Vasc Surg. 2014;60(4):865-73 41 patients (2008-2012) with chimney stentgrafts

Onyx 34 liquid embolic system for

treatment of type 1 endoleaks after

chimney stentgrafts

Christoph A. Binkert, MD, MBA