organs affected with aids-lymphoid tissue. hiv in the nervous system aids dementia
DESCRIPTION
First reported by Hungarian physician: Moritz Karposi in 1872 Multifocal cancer: dominant type is called spindle cells: endothelial origin Typically in older man in Mediterranian rim In HIV-1: very aggressive: occurs in 20% of infected homosexual man, only 2% in others Evidence that Herpes virus (HHV8) is necessary is strong Karposi SarkomaTRANSCRIPT
Organs affected with AIDS-lymphoid tissue
HIV in the nervous system AIDS dementia
• First reported by Hungarian physician: Moritz Karposi in 1872
• Multifocal cancer: dominant type is called spindle cells: endothelial origin
• Typically in older man in Mediterranian rim• In HIV-1: very aggressive: occurs in 20% of
infected homosexual man, only 2% in others• Evidence that Herpes virus (HHV8) is necessary
is strong
Karposi Sarkoma
Karposi Sarkoma
Karposi Sarkoma
• HAART: highly efficient triple combination therapy: (2x anti-reverse transcriptase, 1xprotease inhib.)
Treatment of AIDS
Viral decay on drug treatment
Resistance of HIV to protease inhibitors
HIV Infection is spreading over all continents
Difficulties:• Rapid mutations in virus• Danger to cause an inappropriate immune
response• Necessity to target privileged sites
(mucosa, brain)• Small animal models not available• Ethical issues of vaccination: people
should adjust behaviour
Immune Therapies/Prophylactic vaccine development
• Prevention!!!!!• Multiple steps in viral replication offer new
targets
Perspectives
“Innate Immunity”Adelheid Cerwenka, PhD, D080
Theodor Boveri-Group since April 2003
PhD studentsNorman NauschKai Zanzinger
Anja Schmidtke
TechnicianSandra Kosten