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PaperRobot: Incremental Draft Generation of Scientific Ideas
Qingyun Wang1, Lifu Huang1, Zhiying Jiang1,Kevin Knight2, Heng Ji1,3, Mohit Bansal4, Yi Luan5
1 Rensselaer Polytechnic Institute 2 DiDi Labs 3 University of Illinois at Urbana-Champaign4 University of North Carolina at Chapel Hill 5 University of [email protected], [email protected]
Abstract
We present a PaperRobot who performs as anautomatic research assistant by (1) conduct-ing deep understanding of a large collectionof human-written papers in a target domainand constructing comprehensive backgroundknowledge graphs (KGs); (2) creating newideas by predicting links from the backgroundKGs, by combining graph attention and con-textual text attention; (3) incrementally writ-ing some key elements of a new paper basedon memory-attention networks: from the in-put title along with predicted related entitiesto generate a paper abstract, from the abstractto generate conclusion and future work, andfinally from future work to generate a titlefor a follow-on paper. Turing Tests, wherea biomedical domain expert is asked to com-pare a system output and a human-authoredstring, show PaperRobot generated abstracts,conclusion and future work sections, and newtitles are chosen over human-written ones upto 30%, 24% and 12% of the time, respec-tively.1
1 Introduction
Our ambitious goal is to speed up scientific dis-covery and production by building a PaperRobot,who addresses three main tasks as follows.
Read Existing Papers. Scientists now find itdifficult to keep up with the overwhelming amountof papers. For example, in the biomedical domain,on average more than 500K papers are publishedevery year2, and more than 1.2 million new pa-pers are published in 2016 alone, bringing the to-tal number of papers to over 26 million (Van No-orden, 2014). However, human’s reading ability
1The programs, data and resources are publicly avail-able for research purpose at: https://github.com/EagleW/PaperRobot
2http://dan.corlan.net/medline-trend/language/absolute.html
keeps almost the same across years. In 2012,US scientists estimated that they read, on aver-age, only 264 papers per year (1 out of 5000available papers), which is, statistically, not dif-ferent from what they reported in an identical sur-vey last conducted in 2005. PaperRobot automat-ically reads existing papers to build backgroundknowledge graphs (KGs), in which nodes are enti-ties/concepts and edges are the relations betweenthese entities (Section 2.2).
Abstract
Conclusion and Future Work
Human Written Title
Old Human Written Papers
Enriched Knowledge Graphs
New Title
Abstract
...1st Paper
2nd Paper
Conclusion and Future Work
Figure 1: PaperRobot Incremental Writing
Create New Ideas. Scientific discovery canbe considered as creating new nodes or links inthe knowledge graphs. Creating new nodes usu-ally means discovering new entities (e.g., new pro-teins) through a series of real laboratory experi-ments, which is probably too difficult for Paper-Robot. In contrast, creating new edges is eas-ier to automate using the background knowledgegraph as the starting point. Foster et al. (2015)shows that more than 60% of 6.4 million papersin biomedicine and chemistry are about incremen-tal work. This inspires us to automate the in-cremental creation of new ideas and hypothesesby predicting new links in background KGs. Infact, when there is more data available, we canconstruct larger and richer background KGs formore reliable link prediction. Recent work (Jiet al., 2015b) successfully mines strong relevancebetween drugs and diseases from biomedical pa-
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transcription
Knowledge Extraction Graph Attention
Link Prediction
Text Attention
Knowledge Extraction Entity Retrieval
Background Knowledge Graphs
Contextual Sentences
Salient Entities
Old Papers
Existing Paper Reading
Enriched Knowledge Graphs
New Paper WritingReference Embedding
cells Snail ... ...
Related Entity Embedding
nasopharyngeal carcinoma Maspin Snail ... ...
Diallyl Disulfide
Bidirectional GRU
Memory Attention qk
weighted sum sum
Memory Initialization Hop =1,2,...,k φ
...
...Reference Attention
Memory Network ...
...
...Final Distribution
Reference Distribution
Memory Distribution
Language Distribution
<SOS> is
qk−1
Figure 2: PaperRobot Architecture Overview
pers based on KGs constructed from weighted co-occurrence. We propose a new entity representa-tion that combines KG structure and unstructuredcontextual text for link prediction (Section 2.3).
Write a New Paper about New Ideas. The fi-nal step is to communicate the new ideas to thereader clearly, which is a very difficult thing to do;many scientists are, in fact, bad writers (Pinker,2014). Using a novel memory-attention networkarchitecture, PaperRobot automatically writes anew paper abstract about an input title along withpredicted related entities, then further writes con-clusion and future work based on the abstract, andfinally predicts a new title for a future follow-onpaper, as shown in Figure 1 (Section 2.4).
We choose biomedical science as our target do-main due to the sheer volume of available pa-pers. Turing tests show that PaperRobot-generatedoutput strings are sometimes chosen over human-written ones; and most paper abstracts only re-quire minimal edits from domain experts to be-come highly informative and coherent.
2 Approach
2.1 Overview
The overall framework of PaperRobot is illus-trated in Figure 2. A walk-through example pro-duced from this whole process is shown in Table 1.In the following subsections, we will elaborate onthe algorithms for each step.
2.2 Background Knowledge Extraction
From a massive collection of existing biomedi-cal papers, we extract entities and their relations
to construct background knowledge graphs (KGs).We apply an entity mention extraction and linkingsystem (Wei et al., 2013) to extract mentions ofthree entity types (Disease, Chemical and Gene)which are the core data categories in the Com-parative Toxicogenomics Database (CTD) (Daviset al., 2016), and obtain a Medical Subject Head-ings (MeSH) Unique ID for each mention. Basedon the MeSH Unique IDs, we further link all enti-ties to the CTD and extract 133 subtypes of rela-tions such as Marker/Mechanism, Therapeutic,and Increase Expression. Figure 3 shows an ex-ample.
2.3 Link Prediction
After constructing the initial KGs from existingpapers, we perform link prediction to enrich them.Both contextual text information and graph struc-ture are important to represent an entity, thus wecombine them to generate a rich representation foreach entity. Based on the entity representations,we determine whether any two entities are seman-tically similar, and if so, we propagate the neigh-bors of one entity to the other. For example, inFigure 3, because Calcium and Zinc are similarin terms of contextual text information and graphstructure, we predict two new neighbors for Cal-cium: CD14 molecule and neuropilin 2 which areneighbors of Zinc in the initial KGs.
We formulate the initial KGs as a list of tuplesnumbered from 0 to κ. Each tuple (ehi , ri, e
ti) is
composed of a head entity ehi , a tail entity eti, andtheir relation ri. Each entity ei may be involved inmultiple tuples and its one-hop connected neigh-bors are denoted as Nei = [ni1, ni2, ...]. ei is
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Calcium Zinc
caspase 3
cyclin D1
affect reaction
affect cotreatment
increase cleavage
affect cotreatment
decrease expressionincrease expression
AKTserine/threonine
kinase 1
increases phosphorylation decrease phosphorylation
decrease reaction increase reaction
CD14 molecule
neuropilin 2
paraoxonase 1
prepronociceptin
decrease reaction
decrease abundance
increase reaction
increase expression
Knowledge Graph
Gene ChemicalContextual Sentence: So, Ca2+possibly promoted caspases activation upstream of cytochrome c release, but inactivatedcaspase activity by calpain and/or fast depletion of ATP; whereas Zn2+ blocked the activation ofprocaspase‐3 with no visiblechange in the level of cytochrome c, and the block possibly resulted from its direct inhibition on caspase‐3 enzyme.
affect transport
affect binding
Figure 3: Biomedical Knowledge Extraction and Link Prediction Example (dash lines are predicted links)
also associated with a context description si whichis randomly selected from the sentences where eioccurs. We randomly initialize vector representa-tions ei and ri for ei and ri respectively.Graph Structure Encoder To capture the impor-tance of each neighbor’s feature to ei, we performself-attention (Velickovic et al., 2018) and com-pute a weight distribution over Nei :
e′i = Weei, n
′ij = Wenij
cij = LeakyReLU(Wf (e′i ⊕ n
′ij))
c′i = Softmax(ci)
where We is a linear transformation matrix ap-plied to each entity. Wf is the parameter for a sin-gle layer feedforward network. ⊕ denotes the con-catenation operation between two matrices. Thenwe use c
′i and Nei to compute a structure based
context representation of εi = σ(∑
c′ijn
′ij
),
where nij ∈ Nei and σ is Sigmoid function.In order to capture various types of relations
between ei and its neighbors, we further performmulti-head attention on each entity, based on mul-tiple linear transformation matrices. Finally, weget a structure based context representation ei =[ε0i ⊕ ... ⊕ εMi ], where εmi refers to the context
representation obtained with the m-th head, andei is the concatenated representation based on theattention of all M heads. Contextual Text En-coder Each entity e is also associated with a con-text sentence [w1, ..., wl]. To incorporate the localcontext information, we first apply a bi-directionallong short-term memory (LSTM) (Graves andSchmidhuber, 2005) network to get the encoder
hidden states Hs = [h1, ...,hl], where hi rep-resents the hidden state of wi. Then we com-pute a bilinear attention weight for each word wi:µi = e>Wshi,µ
′= Softmax(µ), where Ws is
a bilinear term. We finally get the context repre-sentation e = µ
′>hi. Gated Combination Tocombine the graph-based representation e and lo-cal context based representations e, we design agate function to balance these two types of infor-mation:
ge = σ(ge), e = ge � e+ (1− ge)� e
where ge is an entity-dependent gate function ofwhich each element is in [0, 1], ge is a learnableparameter for each entity e, σ is a Sigmoid func-tion, and � is an element-wise multiplication.Training and Prediction To optimize bothentity and relation representations, followingTransE (Bordes et al., 2013), we assume the re-lation between two entities can be interpreted astranslations operated on the entity representations,namely h+ r ≈ t if (h, r, t) holds. Therefore, foreach tuple (ehi , ri, e
ti), we can compute their dis-
tance score: F (ehi , ri, eti) =‖ ehi + ri − eti ‖22. We
use marginal loss to train the model:
Loss =∑
(ehi ,ri,eti)∈K
∑(ehi ,ri,e
ti)∈K
max(0,
γ + F (ehi , ri, eti)− F (ehi , ri, e
ti))
where (eh, r, th) is a positive tuple and (eh, rh, th)is a negative tuple, and γ is a margin. The negativetuples are generated by either replacing the heador the tail entity of positive tuples with a randomlychosen different entity.
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Title Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cellsEntities Related: nasopharyngeal carcinoma; diallyl disulfideOutput Human (Neal et al., 2012) System Post-edited by HumanAbstract Background: Maspin, a putative tu-
mor suppressor that is down-regulatedin breast and prostate cancer, has beenassociated with decreased cell motility.Snail transcription factor is a zinc fin-ger protein that is increased in breastcancer and is associated with increasedtumor motility and invasion by induc-tion of epithelial-mesenchymal transi-tion (EMT). We investigated the molec-ular mechanisms by which Snail in-creases tumor motility and invasionutilizing prostate cancer cells. Meth-ods: Expression levels were analyzedby RT-PCR and western blot analyses.Cell motility and invasion assays wereperformed , while Snail regulation andbinding to maspin promoter was ana-lyzed by luciferase reporter and chro-matin immunoprecipitation (ChIP) as-says. Results: Snail protein expressionwas higher in different prostate can-cer cells lines as compared to normalprostate epithelial cells.
Background: Snail is a multi-functional protein that plays animportant role in the pathogene-sis of prostate cancer. However,it has been shown to be associ-ated with poor prognosis. Thepurpose of this study was to in-vestigate the effect of negativelyon the expression of maspin inhuman nasopharyngeal carci-noma cell lines. Methods: Quan-titative real-time PCR and west-ern blot analysis were used todetermine whether the demethy-lating agent was investigated byquantitative RT-PCR (qRT-PCR)and Western blotting. Resultsshowed that the binding proteinplays a significant role in the reg-ulation of tumor growth and pro-gression.
Background: Snail is amultifunctional protein thatplays an important role inthe pathogenesis of prostatecancer. It has been shownassociated with poor prog-nosis. The purpose of thisstudy is to investigate thenegative effect of on the ex-pression of Maspin in hu-man nasopharyngeal car-cinoma cell lines. Meth-ods: Quantitative RT-PCR(qRT-PCR) and western blotanalyses were used to deter-mine correlation of the twoproteins expressions. Re-sults showed that the bind-ing protein plays a signifi-cant role in the regulation oftumor growth and progres-sion.
Conclusionand Future
work
Collectively, our results indicate for thefirst time that Snail can negatively reg-ulate maspin through direct promoterrepression resulting in increased migra-tion and invasion in prostate cancercells. This study reveals a novel mech-anism of how Snail may function andshow the importance of therapeutic tar-geting of Snail signaling in future.
In summary, our study demon-strates that Snail negatively in-hibited the expression of Maspinin human nasopharyngeal car-cinoma cell lines and in vitro.Our results indicate that the com-bination of the demethylatingagent might be a potential ther-apeutic target for the treatment ofprostate cancer.
In summary, our study invitro demonstrates that Snailnegatively inhibits the ex-pression of Maspin in hu-man nasopharyngeal carci-noma cell lines. Our resultsfurther indicate that Maspinmight be a potential thera-peutic target for the treat-ment of prostate cancer.
New Title Role of maspin in cancer (Berardiet al., 2013)
The role of nasopharyngeal car-cinoma in the rat model ofprostate cancer cells
The role of Maspin in therat model of nasopharyn-geal carcinoma cells
Table 1: Comparison of Human and System Written Paper Elements (bold words are topically related entities;italic words show human edits)
After training, for each pair of indirectly con-nected entities ei, ej and a relation type r, wecompute a score y to indicate the probability that(ei, r, ej) holds, and obtain an enriched knowledgegraph K = [(ehκ+1, rκ+1, e
tκ+1, yκ+1)...].
2.4 New Paper Writing
In this section, we use title-to-abstract generationas a case study to describe the details of our pa-per writing approach. Other tasks (abstract-to-conclusion and future work, and conclusion andfuture work-to-title) follow the same architecture.
Given a reference title τ = [w1, ..., wl], we ap-ply the knowledge extractor (Section 2.2) to ex-tract entities from τ . For each entity, we retrieve aset of related entities from the enriched knowledgegraph K after link prediction. We rank all the re-lated entities by confidence scores and select up to
10 most related entities Eτ = [eτ1 , ..., eτv ]. Then
we feed τ and Eτ together into the paper genera-tion framework as shown in Figure 2. The frame-work is based on a hybrid approach of a Mem2seqmodel (Madotto et al., 2018) and a pointer gener-ator (Gu et al., 2016; See et al., 2017). It allowsus to balance three types of sources for each timestep during decoding: the probability of generat-ing a token from the entire word vocabulary basedon language model, the probability of copying aword from the reference title, such as regulates inTable 1, and the probability of incorporating a re-lated entity, such as Snail in Table 1. The output isa paragraph Y = [y1, ..., yo].
3
Reference Encoder For each word in the refer-
3During training, we truncate both of the input and theoutput to around 120 tokens to expedite training. We labelthe words with frequency < 5 as Out-of-vocabulary.
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ence title, we randomly embed it into a vectorand obtain τ = [w1, ...,wl]. Then, we applya bi-directional Gated Recurrent Unit (GRU) en-coder (Cho et al., 2014) on τ to produce the en-coder hidden statesH = [h1, ...,hl].Decoder Hidden State Initialization Not all pre-dicted entities are equally relevant to the title.For example, for the title in Table 2, we pre-dict multiple related entities including nasopha-ryngeal carcinoma and diallyl disulfide, but na-sopharyngeal carcinoma is more related becausenasopharyngeal carcinoma is also a cancer relatedto snail transcription factor, while diallyl disul-fide is less related because diallyl disulfide’s anti-cancer mechanism is not closely related to maspintumor suppressor. We propose to apply memory-attention networks to further filter the irrelevantones. Recent approaches (Sukhbaatar et al., 2015;Madotto et al., 2018) show that compared withsoft-attention, memory-based multihop attentionis able to refine the attention weight of each mem-ory cell to the query multiple times, drawing bettercorrelations. Therefore, we apply a multihop at-tention mechanism to generate the initial decoderhidden state.
Given the set of related entities E = [e1, ..., ev],we randomly initialize their vector representationE = [e1, ..., ev] and store them in memories.Then we use the last hidden state of reference en-coderhl as the first query vector q0, and iterativelycompute the attention distribution over all memo-ries and update the query vector:
pki = ν>k tanh(W k
q qk−1 +Uke ei + bk
)qk = p>k e+ qk−1
where k denotes the k-th hop among ϕ hops intotal.4 After ϕ hops, we obtain qϕ and take it asthe initial hidden state of the GRU decoder.Memory Network To better capture the contri-bution of each entity ej to each decoding output,at each decoding step i, we compute an attentionweight for each entity and apply a memory net-work to refine the weights multiple times. We takethe hidden state hi as the initial query q0 = hi anditeratively update it:
pkj = ν>k tanh(W k
q qk−1 + Uke ej +Wccij + bk
)uik = p
′>k ej , qk = uik + qk−1
4We set ϕ = 3 since it performs the best on the develop-ment set.
where cij =∑i−1
m=0 βmj is an entity coverage vec-tor and βi is the attention distribution of last hopβi = p
′ψ, and ψ is the total number of hops. We
then obtain a final memory based context vectorfor the set of related entities χi = uiψ.Reference Attention Our reference attention issimilar to (Bahdanau et al., 2015; See et al., 2017),which aims to capture the contribution of eachword in the reference title to the decoding output.At each time step i, the decoder receives the pre-vious word embedding and generate decoder statehi, the attention weight of each reference token iscomputed as:
αij = ς> tanh(Whhi +Wτhj +Wccij + bτ
)α
′i = Softmax (αi) ; φi = α
′>i hj
cij =∑i−1
m=0 αmj is a reference coverage vector,which is the sum of attention distributions overall previous decoder time steps to reduce repeti-tion (See et al., 2017). φi is the reference contextvector.Generator For a particular word w, it may occurmultiple times in the reference title or in multi-ple related entities. Therefore, at each decodingstep i, for each word w, we aggregate its attentionweights from the reference attention and memoryattention distributions: P iτ =
∑m|wm=w α
′im and
P ie =∑
m|w∈em βim respectively. In addition, ateach decoding step i, each word in the vocabu-lary may also be generated with a probability ac-cording to the language model. The probability iscomputed from the decoder state hi, the referencecontext vector φi, and the memory context vectorχi: Pgen = Softmax(Wgen[hi;φi;χi] + bgen),where Wgen and bgen are learnable parameters.To combine Pτ , Pe and Pgen, we compute a gategτ as a soft switch between generating a wordfrom the vocabulary and copying words from thereference title τ or the related entities E: gp =σ(W>
p hi + W>z zi−1 + bp), where zi−1 is the
embedding of the previous generated token at stepi − 1. Wp, Wz , and bp are learnable parame-ters, and σ is a Sigmoid function. We also com-pute a gate gp as a soft switch between copyingwords from reference text and the related entities:gp = σ(W>
φ φi +W>χ χi + bp), whereWφ,Wχ,
and bp are learnable parameters.The final probability of generating a token z at
decoding step i can be computed by:
P (zi) = gpPgen + (1− gp) (gpPτ + (1− gp)Pe)
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Dataset # papers # avg entitiesin Title /
paper
# avg predictedrelated entities /
paperTitle-to-Abstract
Abstract-to-Conclusionand Future work
Conclusion andFuture work-to-Title
Training 22,811 22,811 15,902 4.8 -Development 2,095 2,095 2,095 5.6 6.1Test 2,095 2,095 2,095 5.7 8.5
Table 2: Paper Writing Statistics
Model Title-to-Abstract Abstract-to-Conclusionand Future Work
Conclusion andFuture Work-to-Title
Perplexity METEOR Perplexity METEOR Perplexity METEORSeq2seq (Bahdanau et al., 2015) 19.6 9.1 44.4 8.6 49.7 6.0Editing Network (Wang et al., 2018b) 18.8 9.2 30.5 8.7 55.7 5.5Pointer Network (See et al., 2017) 146.7 8.5 74.0 8.1 47.1 6.6Our Approach (-Repetition Removal) 13.4 12.4 24.9 12.3 31.8 7.4Our Approach 11.5 13.0 18.3 11.2 14.8 8.9
Table 3: Automatic Evaluation on Paper Writing for Diagnostic Tasks (%). The Pointer Network can be viewed asremoving memory network part from our approach without repetition removal.
The loss function, combined with the coverageloss (See et al., 2017) for both reference attentionand memory distribution, is presented as:
Loss =∑
i− logP (zi) + λ
∑i(min (αij , cij)
+ min (βij , cij))
where P (zi) is the prediction probability of theground truth token zi, and λ is a hyperparameter.Repetition Removal Similar to many other longtext generation tasks (Suzuki and Nagata, 2017),repetition remains a major challenge (Foster andWhite, 2007; Xie, 2017). In fact, 11% sentencesin human written abstracts include repeated enti-ties, which may mislead the language model. Fol-lowing the coverage mechanism proposed by (Tuet al., 2016; See et al., 2017), we use a cover-age loss to avoid any entity in reference inputtext or related entity receiving attention multipletimes. We further design a new and simple mask-ing method to remove repetition during the testtime. We apply beam search with beam size 4 togenerate each output, if a word is not a stop wordor punctuation and it is already generated in theprevious context, we will not choose it again inthe same output.
3 Experiment
3.1 DataWe collect biomedical papers from the PMC OpenAccess Subset.5 To construct ground truth fornew title prediction, if a human written paper A
5ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/
cites a paper B, we assume the title of A is gen-erated from B’s conclusion and future work ses-sion. We construct background knowledge graphsfrom 1,687,060 papers which include 30,483 enti-ties and 875,698 relations. Tables 2 shows the de-tailed data statistics. The hyperparameters of ourmodel are presented in the Appendix.
3.2 Automatic Evaluation
Previous work (Liu et al., 2016; Li et al., 2016;Lowe et al., 2015) has proven it to be a majorchallenge to automatically evaluate long text gen-eration. Following the story generation work (Fanet al., 2018), we use METEOR (Denkowski andLavie, 2014) to measure the topic relevance to-wards given titles and use perplexity to furtherevaluate the quality of the language model. Theperplexity scores of our model are based on thelanguage model6 learned on other PubMed pa-pers (500,000 titles, 50,000 abstracts, 50,000 con-clusions and future work) which are not used fortraining or testing in our experiment.7 The resultsare shown in Table 3. We can see that our frame-work outperforms all previous approaches.
3.3 Turing Test
Similar to (Wang et al., 2018b), we conduct Turingtests by a biomedical expert (non-native speaker)and a non-expert (native speaker). Each humanjudge is asked to compare a system output and ahuman-authored string, and select the better one.
6https://github.com/pytorch/examples/tree/master/word_language_model
7The perplexity scores of the language model are in theAppendix.
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Task Input Output Domain Expert Non-expert
End-to-End
Human Title Different Abstract (1st) 10 30Same 30 16
System Abstract Different Conclusion andFuture work
12 0Same 8 8
System Conclusion andFuture work
DifferentTitle
12 2Same 12 25
System Title Different Abstract (2nd) 14 4
DiagnosticHuman Abstract Different Conclusion and
Future work12 14
Same 24 20Human Conclusion and
Future workDifferent Title 8 12
Same 2 10
Table 4: Turing Test Human Subject Passing Rates (%). Percentages show how often a human judge chooses oursystem’s output over human’s when it is mixed with a human-authored string. If the output strings (e.g., abstracts)are based on the same input string (e.g., title), the Input condition is marked “Same”, otherwise “Different”.
BLEU1 BLEU2 BLEU3 BLEU4 ROUGE TER59.6 58.1 56.7 55.4 73.3 35.2
Table 5: Evaluation on Human Post-Editing(%)
Table 4 shows the results on 50 pairs in eachsetting. We can see that PaperRobot generatedabstracts are chosen over human-written ones bythe expert up to 30% times, conclusion and fu-ture work up to 24% times, and new titles up to12% times. We don’t observe the domain expertperforms significantly better than the non-expert,because they tend to focus on different aspects -the expert focuses on content (entities, topics, etc.)while the non-expert focuses on the language.
3.4 Human Post-Editing
In order to measure the effectiveness of Paper-Robot acting as a wring assistant, we randomlyselect 50 paper abstracts generated by the systemduring the first iteration and ask the domain expertto edit them until he thinks they are informativeand coherent. The BLEU (Papineni et al., 2002),ROUGE (Lin, 2004) and TER (Snover et al., 2006)scores by comparing the abstracts before and af-ter human editing are presented in Table 5. It tookabout 40 minutes for the expert to finish editing 50abstracts. Table 1 includes the post-edited exam-ple. We can see that most edits are stylist changes.
3.5 Analysis and Discussions
To better justify the function of each component,we conduct ablation studies by removing mem-ory networks, link prediction, and repetition re-moval respectively. The results are shown in Ta-ble 6. We can see that the approach withoutmemory networks tends to diverge from the maintopic, especially for generating long texts such as
abstracts (the detailed length statistics are shownin Table 8). From Table 6 we can see the laterparts of the abstract (Methods and Results) includetopically irrelevant entities such as “imipramine”which is used to treat depression instead of humanprostate cancer.
Link prediction successfully introduces newand topically related ideas, such as “RT-PCR” and“western blot” which are two methods for ana-lyzing the expression level of Snail protein, asalso mentioned in the human written abstract inTable 1. Table 7 shows more examples of enti-ties which are related to the entities in input titlesbased on link prediction. We can see that the pre-dicted entities are often genes or proteins whichcause the disease mentioned in a given title, orother diseases from the same family.
Our simple beam search based masking methodsuccessfully removes some repeated words andphrases and thus produces more informative out-put. The plagiarism check in Table 9 shows ourmodel is creative, because it’s not simply copyingfrom the human input.
3.6 Remaining Challenges
Our generation model is still largely dependenton language model and extracted facts, and thusit lacks of knowledge reasoning. It generates afew incorrect abbreviations such as “Organophos-phates(BA)”, “chronic kidney disease(UC)” and“Fibrosis(DC)”) because they appear rarely in thetraining data and thus their contextual representa-tions are not reliable. It also generates some in-correct numbers (e.g., “The patients were dividedinto four groups : Group 1 , Group B...”) and pro-nouns (e.g., “A 63-year-old man was referred toour hospital ... she was treated with the use of thedescending coronary artery” ).
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Output Without Memory Networks Without Link Prediction Without Repetition RemovalAbstract Background: Snail has been reported
to exhibit a variety of biological func-tions. In this study, we investigatedthe effect of negatively on maspindemethylation in human prostatecancer cells. Methods: Quantitativereal-time PCR and western blot analy-sis were used to investigate the effectsof the demethylating agent on the ex-pression of the protein kinase (TF)gene promoter. Results: The resultsshowed that the presence of a singledose of 50 µM in a dose-dependentmanner, whereas the level of the BMPimipramine was significantly higherthan that of the control group.
Background: Snail has beenshown to be associated withpoor prognosis. In this study,we investigated the effect ofnegatively on the expressionof maspin in human prostatecancer cells. Methods: Cellswere treated with a single doseof radiotherapy for 24 h, andwas used to investigate the sig-nificance of a quantitative factorfor the treatment of the disease.Results: The remaining controlsshowed a significant increase inthe G2/M phase of the tumorsuppressor protein (p<0.05).
Background: Snail is a majorhealth problem in human ma-lignancies. However, the roleof Snail on the expression ofmaspin in human prostate can-cer cells is not well understood.The aim of this study was toinvestigate the effect of Snailon the expression of maspin inhuman prostate cancer cells.Methods: The expression of theexpression of Snail and maspinwas investigated using quantita-tive RT-PCR and western blotanalysis. Results: The remainingoverall survival (OS) and overallsurvival (OS) were analyzed.
Conclusionand
Futurework
In summary, our study demonstratedthat negatively inhibited the expres-sion of the BMP imipramine in hu-man prostate cancer cells. Our find-ings suggest that the inhibition ofmaspin may be a promising therapeu-tic strategy for the treatment.
In summary, our results demon-strate that negatively inhibitedthe expression of maspin in hu-man prostate cancer cells. Ourfindings suggest that the combi-nation of radiotherapy may bea potential therapeutic target forthe treatment of disease.
In summary, our results demon-strate that snail inhibited the ex-pression of maspin in humanprostatic cells. The expressionof snail in PC-3 cells by snail,and the expression of maspinwas observed in the presence ofthe expression of maspin.
New Title Protective effects of homolog on hu-man breast cancer cells by inhibitingthe Endoplasmic Reticulum Stress
The role of prostate cancer inhuman breast cancer cells
The role of maspin and maspinin human breast cancer cells
Table 6: Ablation Test Results on the Same Title in Table 1
Titles Predicted Related EntitiesPseudoachondroplasia/COMP translating from the bench to thebedside
osteoarthritis; skeletal dysplasia; thrombospondin-5
Role of ceramide in diabetes mellitus: evidence and mechanisms diabetes insulin ceramide; metabolic diseaseExuberant clinical picture of Buschke-Fischer-Brauer palmo-plantar keratoderma in bedridden patient
neoplasms; retinoids; autosomal dominant disease
Relationship between serum adipokine levels and radiographicprogression in patients with ankylosing spondylitis
leptin; rheumatic diseases; adiponectin; necrosis;DKK-1; IL-6-RFP
Table 7: More Link Prediction Examples (bold words are entities detected from titles)
Abstract Conclusion andFuture Work
Title
System 112.4 88.1 16.5Human 106.5 105.5 13.0
Table 8: The Average Number of Words of System andHuman Output
Output 1 2 3 4 5Abstracts 58.3 20.1 8.03 3.60 1.46
Conclusions 43.8 12.5 5.52 2.58 1.28Titles 20.1 1.31 0.23 0.06 0.00
Table 9: Plagiarism Check: Percentage (%) of n-gramsin human input which appear in system generated out-put for test data.
All of the system generated titles are declar-ative sentences while human generated titles areoften more engaging (e.g., “Does HPV play anyrole in the initiation or prognosis of endometrial
adenocarcinomas?”). Human generated titles of-ten include more concrete and detailed ideas suchas “etumorType , An Algorithm of DiscriminatingCancer Types for Circulating Tumor Cells or Cell-free DNAs in Blood”, and even create new entityabbreviations such as etumorType in this example.
3.7 Requirements to Make PaperRobotWork: Case Study on NLP Domain
When a cool Natural Language Processing (NLP)system like PaperRobot is built, it’s natural to askwhether she can benefit the NLP community it-self. We re-build the system based on 23,594NLP papers from the new ACL Anthology Net-work (Radev et al., 2013). For knowledge ex-traction we apply our previous system trained forthe NLP domain (Luan et al., 2018). But the re-sults are much less satisfactory compared to the
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biomedical domain. Due to the small size of data,the language model is not able to effectively copyout-of-vocabulary words and thus the output is of-ten too generic. For example, given a title “Statis-tics based hybrid approach to Chinese base phraseidentification”, PaperRobot generates a fluent butuninformative abstract “This paper describes anovel approach to the task of Chinese-base-phraseidentification. We first utilize the solid foundationfor the Chinese parser, and we show that our toolcan be easily extended to meet the needs of thesentence structure.”.
Moreover, compared to the biomedical domain,the types of entities and relations in the NLP do-main are rather coarse-grained, which often leadsto inaccurate prediction of related entities. For ex-ample, for an NLP paper title “Extracting molec-ular binding relationships from biomedical text”,PaperRobot mistakenly extracts “prolog” as a re-lated entity and generates an abstract “In this pa-per, we present a novel approach to the problemof extracting relationships among the prolog pro-gram. We present a system that uses a macro-molecular binding relationships to extract the re-lationships between the abstracts of the entry. Theresults show that the system is able to extractthe most important concepts in the prolog pro-gram.”.
4 Related Work
Link Prediction. Translation-based ap-proaches (Nickel et al., 2011; Bordes et al.,2013; Wang et al., 2014; Lin et al., 2015; Jiet al., 2015a) have been widely exploited for linkprediction. Compared with these studies, we arethe first to incorporate multi-head graph atten-tion (Sukhbaatar et al., 2015; Madotto et al., 2018;Velickovic et al., 2018) to encourage the modelto capture multi-aspect relevance among nodes.Similar to (Wang and Li, 2016; Xu et al., 2017),we enrich entity representation by combining thecontextual sentences that include the target entityand its neighbors from the graph structure. This isthe first work to incorporate new idea creation vialink prediction into automatic paper writing.
Knowledge-driven Generation. Deep Neu-ral Networks have been applied to generate nat-ural language to describe structured knowledgebases (Duma and Klein, 2013; Konstas and Lap-ata, 2013; Flanigan et al., 2016; Hardy and Vla-chos, 2018; Pourdamghani et al., 2016; Trisedya
et al., 2018; Xu et al., 2018; Madotto et al.,2018; Nie et al., 2018), biographies based on at-tributes (Lebret et al., 2016; Chisholm et al., 2017;Liu et al., 2018; Sha et al., 2018; Kaffee et al.,2018; Wang et al., 2018a; Wiseman et al., 2018),and image/video captions based on backgroundentities and events (Krishnamoorthy et al., 2013;Wu et al., 2018; Whitehead et al., 2018; Lu et al.,2018). To handle unknown words, we designan architecture similar to pointer-generator net-works (See et al., 2017) and copy mechanism (Guet al., 2016). Some interesting applications in-clude generating abstracts based on titles for thenatural language processing domain (Wang et al.,2018b), generating a poster (Qiang et al., 2016) ora science news blog title (Vadapalli et al., 2018)about a published paper. This is the first work onautomatic writing of key paper elements for thebiomedical domain, especially conclusion and fu-ture work, and follow-on paper titles.
5 Conclusions and Future Work
We build a PaperRobot who can predict related en-tities for an input title and write some key elementsof a new paper (abstract, conclusion and futurework) and predict a new title. Automatic evalua-tions and human Turing tests both demonstrate herpromising performance. PaperRobot is merely anassistant to help scientists speed up scientific dis-covery and production. Conducting experimentsis beyond her scope, and each of her current com-ponents still requires human intervention: con-structed knowledge graphs cannot cover all tech-nical details, predicted new links need to be veri-fied, and paper drafts need further editing. In thefuture, we plan to develop techniques for extract-ing entities of more fine-grained entity types, andextend PaperRobot to write related work, predictauthors, their affiliations and publication venues.
Acknowledgments
The knowledge extraction and prediction com-ponents were supported by the U.S. NSF No.1741634 and Tencent AI Lab Rhino-Bird GiftFund. The views and conclusions contained inthis document are those of the authors and shouldnot be interpreted as representing the official poli-cies, either expressed or implied, of the U.S. Gov-ernment. The U.S. Government is authorized toreproduce and distribute reprints for Governmentpurposes notwithstanding any copyright notation
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here on.
A Hyperparameters
Table 10 shows the hyperparameters of our model.
Models Parameter Value
LinkPrediction
# Multi-head 8Multi-head hidden 8Entity embedding 64LeakyReLU α 0.2Margin loss γ 1
PaperWriting
Decoder hidden 256Coverage loss λ 1
Both
Vocabulary size 32553Text embedding 128Optimization Adam (Hu et al., 2009)Learning rate 0.001
Table 10: Hyperparameters
B Language model details
The perplexity scores of the language model are96.24, 59.69, and 120.31 on titles, abstracts, andconclusions respectively.
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C Good Examples that Passed Turing Test
System Output Human OutputEfficacy and Safety of Artesunate in the Treat-ment of Uncomplicated Malaria: a SystematicReview and Meta-analysis.
Low RBM3 Protein Expression Correlates withClinical Stage, PrognOStic Classification and In-creased Risk of Treatment Failure in TesticularNon-Seminomatous Germ Cell Cancer.
Background The aim of the present study wasto investigate the effect of Cnidium Lactone onthe expression of Mutant and histone deacety-lase (HDAC) inhibitors in human prostate cancer(PC). Material/Methods We evaluated the effectsof Prostate Cancer on cell proliferation and inva-sion in vitro and in vivo. Cells were incubatedwith a single dose of 25 (50 mg/kg), and 10 (100mg/kg/day), respectively. The primary endpointwas the ability of the mRNA and protein levels oftranscription factor (VEGF).
Background Cnidium Lactone is a naturalcoumarin compound that can inhibit a variety ofcancer cell proliferation and induce cancer cellapoptosis. This experiment investigated the effectof cnidium Lactone on molecular marker expres-sion in prostate cancer nude mice to study its ef-fect in inducing apoptosis . Material/Methods Werandomly and equally divided 30 male BALB/Cnude mice inoculated with human prostate can-cer cells PC-3 into a negative control group, a cy-clophosphamide group (500 mg/Kg) , and cnid-ium Lactone groups at 3 doses (280 mg/Kg, 140mg/Kg, and 70 mg/Kg). The mice were weighedat 2 weeks after administration.
Abstract Rationale: Aliskiren is a rare diseasecharacterized by a variety of hypertensive disor-ders . The aim of the present study was to eval-uate the effectiveness of aliskiren , pharmacody-namics , and clinical outcomes in patients withhypertension . Methods We reviewed the medi-cal records of ambulatory blood pressure ( BP ) ,kinetics , and high-sensitivity C-reactive protein( CRP ) levels in the treatment of corneal tissue. We performed a retrospective review of the En-glish literature search of PubMed , EMBASE ,and Cochrane Library databases . The primaryoutcome was established by using a scoring sys-tem.
The use of nanoparticles in medicine is an attrac-tive proposition. In the present study, Zinc oxideand silver nanoparticles were evaluated for theirantidiabetic activity . Fifty male albino rats withweight 120 ± 20 and age 6 months were used .Animals were grouped as follows: control; didnot receive any type of treatment, diabetic; re-ceived a single intraperitoneal dose of streptozo-tocin (100 mg/kg), diabetic + Zinc oxide nanopar-ticles (ZnONPs), received single daily oral doseof 10 mg/kg ZnONPs in suspension, diabetic+ silver nanoparticles (SNPs); received a singledaily oral dose of SNP of 10 mg/kg in suspensionand diabetic + insulin; received a single subcuta-neous dose of 0.6 units/50 g body.
Table 11: Good Examples that Passed Turing Test
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System Output Human OutputIn conclusion , our study demonstrated thatHOTAIR transcript expression in NSCLC cells.These results suggest that the overexpression ofmetastasis may play a role in regulating tumorprogression and invasion. Further studies areneeded to elucidate the molecular mechanisms in-volved in the development of cancer.
VWF is an autocrine/paracrine effector of signaltransduction and gene expression in ECs that reg-ulates EC adhesiveness for MSCs via activationof p38 MAPK in ECs.
In summary, the present study demonstrated thatBBR could suppress tubulointerstitial fibrosis inNRK 52E cells. In addition, the effects of ac-tion on the EMT and HG of DN in the liver celllines, and the inhibition of renal function may bea potential therapeutic agent for the treatment ofdiabetic mice. Further studies are needed to elu-cidate the mechanisms underlying the mechanismof these drugs in the future.
We characterised KGN cells as a malignanttumour model of GCTs. Continuously culti-vated KGN cells acquire an aggressive pheno-type, confirmed by the analysis of cellular ac-tivities and the expression of biomarkers. Morestrikingly, KGN cells injected under the skinwere metastatic with nodule formation occurringmostly in the bowel. Thus, this cell line is agood model for analysing GCT progression andthe mechanisms of metastasis.
In summary, the present study demonstrated thatHydrogen alleviates neuronal apoptosis in SAHrats. These results suggest that the Akt/GSK3 sig-naling pathway may be a novel therapeutic targetfor the treatment of EBI.
In reproductive-age women with ovarian en-dometriosis, the transcriptional factor SOX2 andNANOG are over expression. Future studies isneed to determine their role in pathogenesis ofovarian endometriosis.
In conclusion, the present study demonstratedthat DNA methylation and BMP-2 expressionwas associated with a higher risk of develop-ing Wnt/-catenin pathway in OA chondrocytes.These results suggest that the SOST of Wnt sig-naling pathways may be a potential target for thetreatment of disease.
Our novel data strongly suggest that BMP-2signaling modulates SOST transcription in OAthrough changes in Smad 1/5/8 binding affinityto the CpG region located upstream of the TSS inthe SOST gene, pointing towards the involvementof DNA methylation in SOST expression in OA.
The role of cancer stem cells to trastuzumab-based and breast cancer cell proliferation, migra-tion, and invasion.
Long-term supplementation of decaffeinatedgreen tea extract does not modify body weight orabdominal obesity in a randomized trial of men athigh risk for Prostate cancer.
Table 12: Good Examples that Passed Turing Test
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