percutaneous interventions in obstructive chd dr.tahsin.n jan 2012
TRANSCRIPT
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PERCUTANEOUS INTERVENTIONS IN OBSTRUCTIVE CHD
Dr.Tahsin.NJan 2012
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Overview
1. Endovascular Stents
2. Balloon Aortic Valvuloplasty
3. Balloon Pulmonary Valvuloplasty
4. Perforation of the Atretic Pulmonary Valve
5. Mitral Valve Dilation
6. Tricuspid Valve Dilation
7. Coarctation, Recoarctation and Aortic Arch
Obstructions
8. Branch Pulmonary Artery Stenoses
9. Pulmonary Vein Stenoses
10. Systemic Vein Stenoses
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Endovascular Stents
Low profile that allows introduction through small delivery
sheaths
Easy crimp ability or availability as premounted stents
Possibility for re-expansion to adult size
High degree of flexibility for placement around curved
structures
Allowance for rehabilitation of vessels that are overlapped
by the placed stent through the stent meshwork/cells
(e.g., open-cell design)
High radial force to accommodate very tight and scarred
lesions
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Rounded atraumatic edges that avoid damage to the
vessel and the balloon
Nonexisting or low degree of stent-shortening during
expansion
Stent material - MRI compliant, noncorrosive, and
does not lead to increased blood levels of metal
Low risk of neointimal proliferation, possibly through
internal coating
Possibility of biodegradable material with a platform
to sustain drug coating to minimize tissue reaction
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Balloon Aortic Valvuloplasty
Indications
Peak-to-peak gradient >60 mm Hg
Asymptomatic patients
Peak-to-peak gradient > 50 mm Hg
Symptomatic patient or
ECG changes - ischemic
AS in the critically ill neonate
Dilated left ventricle and poor left ventricular
function
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Retrograde - Less traumatic
Antegrade - Better balloon position, No arterial injury
Single balloon - Antegrade
Double balloon - More dilation older patients
Cross aortic valve ; most difficult step
JR / JL /Multipurpose Catheter
Balloon across valve;
Rapid inflation & deflation
Longer balloons
Adenosine – Cardiac standstill
Rapid RV pacing
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Balloon size
Single-balloon technique - 80% of the measured aortic
annulus diameter
Double-balloon technique - combined diameters 1.2
times the measured diameter of the aortic annulus
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Complications
Femoral artery complications –
Avoided by
Antegrade approach
Carotid approach
Double balloon
Aortic regurgitation with AVR
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Outcome
Gradient by 60% to 70% or to a gradient of 30 to 40
mm of Hg
Long-term results surgical valvotomy – palliative
without a sternotomy or cardiopulmonary bypass
In pediatric patients and young adults is now the
standard initial procedure in most centers
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Balloon Pulmonary Valvuloplasty
First introduced by Kan et al. in 1982
December 1986 - 28 centers - reporting to VACA
- successful and safe technique in >680 cases
Standard therapeutic procedure for pulmonary valvar
stenosis in all ages from the newborn period throughout
adult life
Maximum instantaneous systolic echo gradients of 35
mm Hg with evidence of right ventricular hypertrophy
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Long exchange wire to LPA or Duct – Desc. aorta
Optimum balloon diameter - between 1.2 and 1.3 times the
size of the pulmonary valve annulus for a single-balloon
dilation
Low pressure balloons Tyshak II (NuMED, Hopkinton, NY)
with a lower profile
Smaller size
High-pressure balloons ZMed II (NuMED, Hopkinton, NY)
or the double-balloon technique
Larger size – older pts
Dysplastic, thickened pulmonary valves
Associated supravalvar narrowing
Smaller coronary balloons can facilitate predilating the
valve
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Gradient across the nondysplastic pulmonary valve to <10 mm
Hg Reduction in the RV-to-systemic pressure ratio
Relief of the valvar stenosis may unmask infundibular obstruction
Infundibular obstruction - dynamic - regress with time
Dysplastic valves
higher-pressure
gradient reduction less
Immediate results
Good immediate results >95% pts
Very Low mortality rates
Improved Rv fn
Decrease in TR
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Complications
Arrhythmia
Hypotension / collapse
Blood loss
RV / Tricuspid valve injury
Pulm valve / annulus disruption
VACA registry
Death 0.24%
Major complications 0.35%
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Long term results
Restenosis - 5% to 11% within 10 years
Risk factors
Infancy
Very dysplastic pulmonary valves
Undersized balloon
No evidence of increased PV replacement
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Perforation of the Atretic Pulmonary Valve
Pulmonary atresia with intact ventricular septum
(PA/IVS)
Palliative
Acutely decompresses the right ventricle
Facilitate growth of an initially hypoplastic right
ventricle
Suitability by 2D echocardiography
Minimal criteria
Tripartite right ventricle
Membranous atretic pulmonary valve
Well formed infundibulum
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Measure right ventricular and systemic arterial pressures
RV angiography with 20-degree cranial angulation & lateral
projection Measure pulmonary valve plate diameter
Exclude of RV-dependent coronary circulation
LV angiography - same projection – Assess Valve plate
Nykanen RF perforation wire and the Baylis radiofrequency
puncture generator
Power setting of 5 W/s
Balloon dilation performed
Low-profile balloon valvuloplasty catheter- Mini-
Tyshak
Diameter of about 130% of the valve plate annulus
Ductal stenting / surgical shunt – 50%
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Outcome
Most series are very small - include fewer than five
patients
Overall procedural mortality - 8%
Incidence of procedural complications -15%
75% - biventricular or one-and-a-half ventricle
circulation
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Mitral Valve Dilation
Anatomy of congenital MS
Variable
Less favorable for balloon dilation than rheumatic
Femoral veins - transseptal approach – LA - LV
Single or double balloon
Inoue
Two balloon diameters = the measured or estimated maximal normal mitral valve diameter for the patient
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Transseptal Puncture
Transseptal needleBrockenbrough needle with a transseptal Mullins introducer set (Cook)
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Radiofrequency energy
Minimal force and a much lower risk of injuring adjacent
structures
Toronto transseptal catheter with the 8 Fr TorFlex
transseptal sheath and dilator
Curved at the end by about 210 degrees - avoid
continued perforation of adjacent structures
Increased stiffness
Larger patients
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In small infants
4 or 5 French Judkins right (JR) catheter
A 180-cm 0.035-inch outer diameter coaxial injectable
catheter (Baylis) is loaded over a 260-cm 0.024-inch
Nykanen RF perforation wire
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McElhinney et al. 108 patients with congenital MS
Median age - 18 months
BMV - reduction of the mean gradient by - 38%
Significant MR - 28%
Overall 5-year survival - 69%
Later stages of the institutional experience - 87%
The early mortality BMV = surgical mitral valvuloplasty
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Initial procedure - typical congenital MS or double-orifice
mitral valve
Surgical approach - supra valve mitral ring and
parachute mitral valve
Parachute MV
Not a contraindication to BMV
Less effective - single papillary muscle or severe
shortening or virtual absence of the chordal apparatus
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Tricuspid Valve Dilation
Congenital TS
Associated with other cardiac lesions
Less amenable to balloon valvuloplasty than rheumatic
Similar to BMV
Balloon size equal to estimated TV diameter
A successful dilation should eliminate any transvalvar gradient
Limited experience
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Coarctation, Recoarctation and Aortic Arch Obstructions
1979 Sos et al. native coarctation in postmortem specimens
1980 Dr. James Lock et al excised human coarctations as well as experimentally induced coarctations in lambs
Dr. Ronald Grifka and Dr. Charles E. Mullins et al., - Texas Children's Hospital - endovascular stent therapy to treat coarctation
1995, Suarez de Lezo reported the first large series of stent implantation to treat native and recurrent coarctation in humans using the Palmaz stent
1999 Cheatham first reported on a new stent design, the Cheatham-Platinum (CP) stent - also available in a PTFe-covered variety
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Cylindrical fixed maximal-diameter dilating balloons-
high pressures
Goal of the procedure –
Reduction in the gradient to <10 mm Hg or
90% relief of the obstruction angiographically
Zabal et al. - cohort of 54 pts - observational study
Residual gradient of >10 mm Hg was associated with
a significantly higher failure index (heart-related
death, a gradient on follow-up of >20 mm Hg, and
the need for reintervention or complications such as
aneurysm formation)
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Balloon Dilation in CoA
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Stents in CoA
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Bare or Covered Stent
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In smaller patients with an
expected diameter below average
adult size, the Genesis XD or the
Mega LD stents with a maximum
expandable diameter of 18 mm.
If larger maximum diameters are
required, the Max LD, the
Cheatham-Platinum, or older
Palmaz XL (Cordis, Warren, NJ)
stents with maximum expandable
diameters >25 mm
Cheatham-Platinum covered stent
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Balloon angioplasty alone for native coarctation in smaller children and infants - 66% recoarctation rate.
Interventions for native coarctation - greater incidence of aortic aneurysm formation
Catastrophic events as a direct result of aneurysms are rare
Dilation of native coarctation more reasonable for discrete lesions in patients >7 to 12 months of age
In the larger child, primary stent therapy for native coarctation - gradual conservative expansion of stents over two or three procedures to reduce the incidence of dissection or aneurysm formation
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Branch Pulmonary Artery StenosesAccepted standard procedure - not amenable to surgical repair
Reduction in the RV -to-systemic pressure ratio - good indicator for a successful outcome.
Individual pressure gradients to branch pulmonary arteries may be less meaningful
IJV or transhepatic approaches eliminates some of the double-S curves that have to be traversed from a femoral venous approach – better pushability
Balloon should preferably between 2 to 3 times the stenotic area
High pressure balloons & Cutting balloons may be required
Intravascular stents have become the primary mode of therapy for branch pulmonary artery stenoses (except infants)
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Pulmonary Vein Stenoses
Surgical & transcatheter interventions for pulmonary vein stenoses - uniformly bad long-term outcome
Performed as a last resort before considering heart - lung transplantation
Restenosis is observed in most cases
Stents –
No better medium- or long-term results than (cutting) balloon angioplasty alone
Short-term results may be superior than angioplasty
High percentage of complications - systemic stent embolization
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Systemic Vein Stenoses
Successful and carries little risk - even in freshly operated lesions
Surgical alternative for these lesions is poor to nonexistent
Stenosis recurs in most cases
The balloon size between 2 & 3 times the diameter of the stenosed segment
Primary therapy for long-standing venous lesions - intravascular stents
RF energy with covered stents may allow the recanalization of even completely obstructed venous structures
Results of central venous stent implantations - excellent.
No adverse reactions or long-term complications of the stents
Venous restenoses when stents were overdilated
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Conclusion
Treatment of choice in many conditions
Evidence to prove superiority over Sx is lacking
No randomised Trials, only institutional series
More dedicated hardwares are required
Number of centres offering expert Rx increased recently
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