pesticides poisning

Quick Reference forTreatment of Pesticides Poisoning

Containing treatment outlines for the most commonly used pesticides.

The information and recommendations given in this booklet are based on ourbest present knowledge. PAPA declines any responsibility or liability arisingfrom the use or misuse of the information contained herein.

Second Edit ionS e p t e m b e r 1 9 9 9

Pakistan Pesticides

909-910, Park Avenue, P.E.C.H.S.,Shahrah-e-Faisal, Karachi-75400Tel: 454 1562 Fax: 454 6131

I M P O R T A N T N O T E S

1 . This booklet is a quick guide for emergency treatment for cases of acutepesticides poisoning meant for use by qualified medical practitioners,doctors and physicians. This is NOT a guide for first aid treatment or acomprehensive medical text.

2. in all cases of reported pesticides poisoning, efforts should be made toobtain the original container to verify the intoxicants.

3. In case of acute poisoning, samples of mesis, gastric lavage or skinwashings shouid be taken for chemical analysis.

Acknowledgments:The Safety, Health and Environment Committee of Pakistan AgriculturalPesticides Association is thankful to its founder member Novartis (Pakistan)Limited who very kindly assisted the Association in developing this referencebooklet on treatment of Pesticides Poisoning. This booklet is meant for use byqualified medical practitioners only.

CONTENTS

Recommended Method for Gastric Lavage1 .2 .3 .4 .5 .6 .7 .8 .9 .1 0 .1 1 .1 2 .1 3 .1 4 .1 5 .1 6 .1 7 .18.1 9 .20.21.22.

Chlorinated Hydrocarbons -----------------Organophosphorous Compounds --------------------------Carbamates ____________; _________-__________---------------------

Pyrethroids --------Aresenicals ________________________________ _______

Phosphine

Coumarin lndandiones -- ---- --

----- ----- --

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

- - - - - - -

---- --

- - - - -

- -

Emergency Response Addiesses -------------------------

Page

124791 1131416171819202 1232526272932333442

RECOMMENDED METHOD FOR GASTRIC LAVAGE

NOTE: UNCONSCIOUS PATIENTS HAVE TO BE TREATED WITHSPECIAL CARE. FOR EXAMPLE AN ENDOTRACHEALTUBE SHOULD BE PLACED PRIOR TO GASTRICINTUBATION

If the patient has a poor cough reflex, protect the lungs and the patency ofthe airway by inserting a cuffed endotracheal tube before passing a stom-ach tube. In conscious patients and even unconscious patients with intactcough and gag reflexes, a large bore stomach tube may be passed atonce. Place the patient so that his mouth is lower than his trachea. Re-move any dentures and keep the mouth open with a gag. Lubricate thetube with glycerine or a suitable jelly, and ease it over the tongue and downthe esophagus to a distance of about 50 cm in adults. Suck out the stom-ach contents using gentle mechanical suction if available. If a source ofcontinuous suction is not available, a large syringe fitted with an adaptorwill help. If little or nothing is obtained, it may be that the tube is not cor-rectly located. Proper positioning of the tube can be checked by forcing alittle air down it and listening with a stethoscope over the stomach-for bub-bling sounds.

After making a reasonable effort to remove any stomach contents and be-ing quite certain that the end of the tube is in the stomach attach a largeevacuator or funnel to the oral end of the tube. Add water or physiologicalsaline heated to about body temperature. (300 ml for adults, or less forchildren). If a funnel is used, elevate the oral end of the tube and allow thewater to enter the stomach by gravity. For this purpose, it may be neces-sary to use an adaptor and add a length of tubing between the funnel andthe stomach tube so to increase the overall length and make it easier toregulate the height of the column of water. Before all the water has passedinto the stomach, lower the tube into a basin or jar and allow the stomachcontents to spihon off, do not use more than 300 ml for each washing,because a large volume would have more tendency to cause emptying ofthe stomach contents into the duodenum. Repeat the lavage the re-turning fluid is clear.

As tube used for evacuating the stomach content must have a rounded,solid end to facilitate passage through the oesophagus. If must have atleast one large opening in the side just behind the tip and is better if it hasseveral large holes placed at intervals back from the tip. The outer wallmust be very smooth. Stomach evacuator tubes commonly sold for use inchildren have an outside diameter of 7.33 mm (No 22 Charriere scale).Those for adults commonly measure 10 mm (No 30 Charrfere scale).

Source: Guidelines for emergency measures in case of pesticidepoisoning GCPF

CHLORINATED HYDROCARBONS

Examples of Commercial Products and Generic Names

BHC

Chlorothalonil (Daconil)

D D TEndosulfan (Endon, Sialan, Hektionex,

Thiodan, Thioluxan,

Endosulfan + Dimethoate (Aflix)

Heptachlor

Pharmacological Action or Site of Toxicitv

Hepatotoxic

Neurotoxic

Nephrotoxic

Routes of Absorption

Ingest ion

Dermal

Inhalation (negligl le)

WHO Hazard Classification

Class

svmotoms

Onset: Twenty minutes to four hours after exposure.Nausea, Vomit ing, Restlessness, Tremor, Apprehension,Convulsions. Coma, Respiratory Failure, Death.

The Biological and Environmental behaviour of Endosulfanis totally different to Chlorinated hydrocarbons but for medicalreasons the compound is grouped on Chlorinated hydrocarbons.

Chlorinated Hydrocarbon

Treatment

1 . Watch breathing closely. Aspirate. Give oxygen and or/artificialrespiration if needed.

2. Diazepam or barbiturates in appropriate dosages repeatedas necessary for restlessness or convulsions. (Phenobarbitone(100 mg) or diazepam (10 mg IM or IV), It may be necessary tocontinue treatment for up to two weeks after poisoning

3.

4.

AVOID OILS, OIL LAXATIVES AND EPINEPHRINE (ADRENALIN).DO NOT GIVE STIMULANTS OR ATROPINE.Give calcium gluconate (10% 0 ml ampules) intravenously everyfour hours.

5. Cholestyramine 4 gm 4 times/day (before meals and bedtime) toaccelerate biliary fecal excretion. Prolonged treatment(several weeks) may be needed.

6. Gastric lavage using activated charcoal (40 gm Charcoal) Chatharsiswith 30 gm, sodium sulphate.

7 DO NOT INDUCE EMESIS IF THE INGESTED POISON ISPRINCIPALLY A HYDROCARBON SOLVENT (e.g. KEROSENE).

8. If poisoning occurred via dermal route, skin and hair should bedecontaminated.

9 In case of “AFLIX” 2 mg Atropine sulphate IV (to be treated if necessary)

Lab TestsNo simple test. Only complex laboratory procedures. A high urine level of organicchlorine or especial or p-chlorophenyl acetic acid indicates exposure to DDTor to one of the analogous compounds. The level however is no indicative ofthe severity of exposure.

O R G A N O P H O S P H O R U S C O M P O U N D S

ExampIes of Commercial Products and Generic Names

Acephate

Azinophos Methyl

Cadusafos

ChlorfenvinphosChlorpyriphos

Chlorpyr iphos methyl

Dichlorvos

Dimethoate

(Asophate, Sephate, Orthene)

(Gusa!hion M)

(Birlanej(Lorsban, Nurel le-D, Kuri fast

Cyren)

(De De Vap. Dimetaxal, Foiek,Phosvit, Vapona, Nokovos,Vision, Nicavos)

(Chemathoate,Dimetaxal.Higonet, Luxagan, Perfekthion,Rogar, Roxion, Systoate, Stinger)

(Aflix)

(Agrilex, Disystone, Solvirex)

(Basudin)

(Ethion)

(Anthio)

(Sumithion)

Dimethoate + Endosulfan

Disulfoton

Diazinon

Ethion

Formathion

Fenitrothion

Mononcrotophos

Methidathion

Methamidophos

Methylparathion

Malathion

Methamidophos + Cyfluthr in

Methamidophos +

Oxydemetion Methyl

(Azodrin, Azofas Apadrin,Monophos, Nokout.Suncrotophos. Tiger. Titophos)

(Supracide)

(Grip, Monitor. Pandaphos,

Sundaphos, Shangnong,

Tamaron, Chaser, Jiangmen)

(Assomido, Folidol, Pi l laron,

Paramet. Jiashou)

(Emmatos, Fyfanon, MLT.)

(Baythriod, T.M.)

(Magnum)

(Metasystox R)

4

ORGANOPHOSPHORUSCOMPOUNDS

Profenofos (Curacron, Polytrin C)

Phorate (Thimet)

Pirimiphos (Actellic)

Pyrazophos (Afugan)

Phenthoate (Cidial)

Prothoate + Dimethoate (Facron-s)

Qunaiphos (Ekalux)

Trichlorfon (Dipterex)

Triazophos (Deltaphos, Hostathion)

Ant ichol inesterase

(Irreversible)


Ingest ion

Inhalation

Dermal

WHO Hazard Classificationclass

1 . MILD--anorexia, headache, dizzines, weakness anxiety, tremors oftongue and eyelids, miosis, impairment of visual

2. MODERATE--nausea, sal ivation, lacrimation, abdominal cramps.vomiting, sweating, slow pulse, muscular tremores.

3. SEVERE-diarrhoea. pinpoint and non-reactive puplis, respiratorydifficulty, pulmonary edema, cyanosis, loss of sphincter controlconvulsions. coma and heart block.

Organo Phosphorus compounds

TreatmentSPEED IS IMPERATIVE.Persons giving First aid should avoid contact with contaminated clothingand vomitus.1 .

2.

3.

4.

5.

6.

7.

8.

9.

Maintain adequate and cardiac functions. Keep airway open.Aspirate, use oxygen, insert endotracheal tube. Artificial respiration andtracheostomy in severe cases.

INJECT MASSIVE DOSES OF ATROPINE (l-3 mg) EVERY MINUTES UNTIL SIGNS OF ATROPINIZATION OCCUR. Signs ofatropininzation include dry, flushed skin, pupillary size of at least 4mm,& heart rate of 120/min. Do not give atropine to a cyanotic patient.Give artificial respiration first than administer atropine I.M. or S.C. Atropineprophylaxis is not recommended. Maintain atropinization for at least 24-48 hours and carefully observe the patient as the drug is withdrawn i tmay be necessary to recommence treatment if signs of poisoning returns.

Draw blood for cholinesterase test, preferably before Antidote (2 PAMor Toxogonin) are given.

If available, protopam chloride, (2-PAM or Toxogonin), 1 gm I.V. slowlyover a period of 5 minutes, Given second dose of 500 mg, in 30 minutesif muscle weakness persists. This drug must NOT be used as analternative or in preference to atropine the use of which is ESSENTIAL.

AVOID MORPHINE, TEHOPHYLLIN A M I N O P H Y L L I N E ,BARBITURATES OR PHENOTHIAZINES.

For skin contact, wash with soap and water, Wear rubber gloves whilewashing contact areas.

For ingestion, lavage with activated charcoal slurry (100 gm charcoal in150 ml water).

Because of reabsorption of these compounds from fatty tissue, treatmentof exposed people should continue for several days. Patient must remainatropinised for sufficient length of time (24-48 hrs.) Drug treatment maybe required for upto 10 days in sever cases.

Keep patient strictly at rest.

Lab TestsRed cell cholinesterase test.Levels 3050% of normal indicate exposure, although symptoms may not appearuntil the level falls to 20% or less, urine p-nitrophenol may indicate exposure toparathinon, chlorthion, ethion and EPN.Serum cholinesterase test to be done.

6

CARBAMATES

Aldicarb

Carbosulfan

Carbofuron

Cartap

Carbary l

(Temik)

(Advantage)

(Brifur, Curaterr, Furadan,Sunfuran)

(Padan)

(Sevin)

Dithiocarbamate (Antroacol)

Furathiocarb (Del tanet)

Methomyl (Lannate, Nudrin)

Pir imicarb (Pirimor)

Thiofanox (Decamox)

Triazamate (Aztec)

Action or Site of Toxicity

Antichol inesterase

(Reversible)

Routes of

Ingest ion

Inhalation

Dermal

WHO Hazard ClassificationClass

Blurred Vision, disturbances of Retrobulbar pain, constrictionof pupils, Salivation, Profuse sweating, Lasstude, Muscle Incoordination,Nausea, Vomiting, Diarrhoea, Epigastric pain, Tightness in chest.

Carbamates

Treatment

SPEED IS IMPERATIVE

Persons giving first aid should avoid contact with contaminated clothing andvomitus.

1. Maintai adequate respiratory and cardiac functions. Keep airway open,aspirate, use oxygen, insert endotraceal tube. artificial respiration andtracheostomy in severe cases.

2. FOR EXTREME SYMPTOMS OF O.P. POISIONING INJECTATROPINE (1-3 mg) EVERY 5-10 MINUTES UNTILSIGNS OF ATROPINIZATION OCCURS.

Signs of atropinization includes dry flushed skin, pupillary size of at least4 mm, & heart rate of 120/min. Do not give atropine to a cyanoticpatient. Give artifical respiration first then administer atropine I.M. orS.C. Atropine prophylaxis is not recommended.

In case of “Padan” I.V. Injection of 100-200 mg L-cystine or I.M. injec-tion of 20-60 mg of BAL are recommended by the manufacturer.

For skin contact, wash with soap and water. Water rubber gloves whilewashing contact areas.

For ingestion, lavage with activated charcoal slurry (100 gm charcoal in150 ml water).

AVOID MORPHINE, THEOPHYLLINE, AMINOPHYLLINE, ORBARBITURATES

6. 2-PAM OR TOXOGONIN IS CONTRA-INDICATED therefore do not use

Lab Tests

Red cell cholinesterase test.

Levels 30-50% of normal indicate exposure, although symptoms may not ap-pear the level falls to 20% or less. Values may return to normol within 12to 72 hrs. depending on severity of poisoning.

1 -naphthol, normally found in traces, is excreted in urine in much higher con-centration following Carbaryl (Sevin) ingestion.

Serum cholinesterase test to be done.

8

PYRETHROIDS

of Commercial Products and Generic NamesAlpha-Cypermethrin (Bestox, Fastac, Alphafos, Skolix)

Bi fenthr in Talstar

Beta Cyfluthrin Bulldock

Beta Cyfulthrin + Methomidophos M a g n u m

Cypermeihr in

Cyfluthrin

Cyf lu th r in + Methamidophos

Cypermethr in + Dimethoate

Cypermethrin + Chlorpyriphos

Deltamethrin

Deltamethrin + Dimethoate

Flucythr inate

Fenpropathrin

Lambda-Cyhalothrin

(Arrivo, Cheeta, Cymbush,Cyperkill, Lucky Cypermethrin,Nurel le, Ripcord, Sherpa,S u n n m e r i n , Ustad)

(Baythr iod)

(Baythriod TM)

(Aimos-D, Laser)

(Nurelle-D)

(Decis)

(Decis-D)

(Pay-off)

(Danitol, Fenthrion)

(Karate, Labdathrin)

Permethrin

Fenvalerate

ES-Fenvalerate

Zeta-Cypermethr in

(Ambsh, Coopex, Permasect,Pounce, Talcord)

(Fenki l l , Sumicidin)

(Sumincidin Super)

(Fury)

Action or Site of ToxicityAllergnic

neurotoxic

Routes of AbsorotionIngest ion

Dermal

Inhalation

9

Pyrethroid


Class III

SymptomsAllergic reaction following pyrethroids exposure manifest themselves likeasthmatic symptoms (bronchospasm swelling of mucous membranes etc.) uptoanaphylaxis. Excessive salivation, choreoathetosis., convulsions, tremors.

Treatment1 . Severe allergic reactions have to be treaied wiih adrenalin

2. Less severe allergic reaction can be treated with antihistamines.

3. For ingestion lavage using activated charcoal slurry (100 gm in 150 ml

water). For skin contact wash exposed area.

Symptomat ic t reatment .

Atropine sulphate to suppress salivation & reduce severity of some of

the signs of poisoning.

Diazepam for convulsions.

Lab Tests

No simple test. Only complex laboratory procedure.

1 0

ARSENICALS (INORGANIC)

of Commercial Products and Generic NamesLead ArsenateParis GreenSodium Arsenite


Blocking of the functional thiol groups, especially on capillaries, epidermis and

nervous system.

of

Ingest ion

InhalationWHO Hazard ClassificationClass I

SymptomsIn acute arsenic poisoning a garlic odor to breath and feces helps to identifythe responsible toxicant. Arsenic inhalat ion causes Haemoglobin leading toacute tuber necrosis followed by anuria, Other symptoms are Chills, weaknesscramps, vomiting and prostration.

After thirty minutes to many hours profuse vomiting & painful diarrhoea whichmay become bloody later. Colicky pains in esophagus, stomach and bowel.Dehydration, thirst, muscular cramps, cyanosis, feeble pulse and coldextremities. Headache, Dizzines, Vertigo, Delirium or Stupor, Skin eruption,Convuls ions.

Three terminal signs.

C o m a

General paralysis

Death

INGESTION: Chief Initial symptoms are those of a violentgastroenteritis, burning esophageal pain, vomiting, watery orbloody diarrhoea containing much mucous, later collapse,shock, market weakness, Death generaly due to circulatoryfailure.

INHALATION: may cause pulmonary edema, restlessness, dyspensiacyanosis and foamy sputum.

1 1

Arseniclas (Inorganic)

Treatment

1 . For ingestion, gastric lavage followed by Instillation of activated charcoalslurry (40 gm charcoal).

2.

3.

4.

For skin contact wash with soap and water. Acute symptoms will notdevelop except for sodium arsenite

Saline catharitc (15 to 30 gm sodium sulfate).

BAL in a 10% solution in oil -- intra muscularly -- (see schedule) orD-Pencillamine 0.5 g q6 h given 30 to 60 minutes before meals and atbedt imes.

5.

6.

7.

Check blood pressure and treat shock.

Isotonic saline for Intravenous use to contract dehydration. Electrolyteinfusion might be necessary to substitute losses due to diarrhoea.

Morphine may be needed for abdominal pain.

BAL SCHEDULE

Day 1 2

D a y 2

Day 4-10

S E V E R EPOISONING

3 (6 Injectins)

3 (4 Injectins)

3 mglkg (2 Injectins)

MILD POISONING

2.5 (4 Injections)

2.5 mglkg (2 Injections)

2.5

BAL: Brithsh Anti Lewisite Compound. (2.3 Dimercapto-1 ordimercaprol)

Lab TestsNo simple test. Only complex laboratory procedures. Save initial stomachcontents and urine for arsenic analysis. Urine may show red blood cells, albuminand casts. After arsenic inhalation urine shows Haemoglobin relnsch Test.

HALOGEN FUMIGANTS

Examoles of Commercial Products and Generic Names

Methyl Bromide (Dofume, Bromomethan, Terabol, Saibrom, Brom-o-Gas)

Action or Site of ToxicityCNS depressantNephrotoxicLiver damage

Routes of AbsorotionIngest ionInhalationDermal

WHO Hazard ClassificationClass I

Svmptoms

Appears after four to twelve hours following inhalation. Symptoms includedizzines. headache, anorexia, nausea, vomiting, and abdominal pain, lassitude,weakness, slurring speech and staggering gait. Mental confusion, mania,tremors and epileptiform convulsions,

Bromides cause:Rapid respiration, pulmonary edema, cyanosis, collapse, coma, areflexiaand death due to respiratory or circulatory failure. Late manifestationmay include bronchopneumonia, pulmonary edema, and respiratoryfai lure.

Methyl bromide may produce cutaneous blisters and kill via dermal exposure.

TreatmentIN METHYL BROMIDE POISONING, EARLY TREATMENT WITH BAL MAY BECONSIDERED. GIVE BAL SOON AFTER LIFE THREATENING EXPOSURE.1. First remove patient from contaminated area.

2. Give BAL 3-5 for 4-6 doses.

3. Remove all contaminated clothing and wash contaminated skin canpenetrate ordinary rubber gloves.

4. Restrain confused and maniacal patients. Diazepam or barbiturates forconvuls ions.

5. May require specific therapy for acidosis, pulmonary edema,bronchospasm, (use epinephrine subcutaneously). Respiratory paralysisand/or kidney failure.

Lab TestNo simple test. Only complex laboratory procedures. Blood electrolytes to detectacidosis.Note: BAL British Anti Lewisite Compound. Dimercapto-1-proponal ordimercaprol).

CYANIDE FUMIGANTS


Acrylonitrite (Organic Bound Cyanides)Calcium Cyanide (Cyanogas)Hydrogen Cyanide (Hydrocyanic Acid)


Cell MetabolismCyanide fumigants affect cytochomoxidases primarily in heart and brain.


Ingest ionInhalationDermal


Class I

Symptoms

One of fastest acting known poisons.MASSIVE DOSE unconsciousness and death without warning.SMALLER DOSES illness may last one or more hours.FOLLOWING INGESTION: bitter, acrid, burning taste followed by constrictionof membrane in throat. Salivation and nausea without vomiting, anxiety,confusion, and dizziness. Variable respirations inspiration short and expirationprolonged. Order of bitter almonds in breath and vomitus. Initial increase inblood pressure and slowing of heart followed by rapid and irregular pulse.palpitation and constriction of chest. Unconsciousness, and deathfrom respiratory failure.

Treatment

SPEED IS IMPERATIVE

If apneic, start artificial respiration. Keep airway open.

INHALATION OF AMYL NITRITE (AMYL NITRITE PEARLS) every 1530 seconds of glycerol trinitrate (Nitrol) 1 inch applied on the non-halrypast of the chest near the heart.

Intravenous injection (even of non-sterile solution) of 10 ml of 3% sodiumnitrite over 2-4 minute period. DO NOT REMOVE NEEDLE.

Through same needle give 50 ml of 25% solution of sodium thiosulfateover 10 minutes.

14

Cvanide Fumiaants

ALTERNATIVE to sodium nitrate and sodium thiosulfate: 5 IV bolus, single dose.

5. If symptoms recur repeat the nitrite and thiosulfate.

6. In case of ingestion stomach lavage with 5% sodium bicarbonate shouldfollow the above procedure.

7. After lavage, Charcoal (40 gm) should be placed into the stomach.

8. Oxygen therapy end blood transfusions may be necessary if nitrite methemoglobinemia becomes severe.

Lab Tests

No simple tests. Only complex laboratory procedures. Send blood for cyanidelevels.Levels of 0.1 usually associated with symptoms.

1 5

PHOSPHINE FUMIGANTS

of Commercial Products and Generic Names

Aluminium Phosphide (Celphos, Quickphos, Phostoxin, Gastowin,Delitia, Detia gas, Agtoxin)

Action of Site or Toxicity

Toxic to lungsCNS depressantToxic to myocard


inhalation


Class I

Symptoms

Nausea, vomiting, diarrhea, great thirst, headache, vertigo, tinnitus, pressurein chest, back pains, dyspnea, a feeling of coldness. and stupor or attacks offainting.

May develop hemolytic icterus and cough with sputum of a green fluorescentcolor.

Tremors, convulsions, and coma leading to death. Hematuria and anurla dueto kidney damage. Acute pulmonary edema, hypertension, cardiac arrhythmlasand convulsions in severe cases.

TreatmentNo specific antidote. Symptomatic treatment

1 .

2.

3.

4.

5.

Control of convulsions with injection of diazepam (5-10 gm in adults).

Keep patient quiet and warm.

May need to treat incipient pulmonary edema with venesection. oxygen,and hypertonic glucose (50%) infusions.Intravenous isotonic solutions are contraindicated.

In case of ingestion, Copper Sulfate 0.25 gm in a glass of water, (Formsinsoluble Copper Phosphides)Monitor Calcium levels, Give 10% Calcium Gluconate 10 ml IV tomaintain Calcium level. Monitor heart rate while giving calcium.

Lab TestNone

COUMARIN INDANDIONES


Coumarin (Ratilan, Tomorin)Diphacinone (Diphasin, Ramik)Calci feron (Warfar in)Brodifacoum (Klerat)Coumate tralyl (Racumin)

Action or Site of

Anticoagulant


Ingest ionDermal

WHO Hazard ClassificationClass I-III

After repeated ingestion for several days, bleeding from nose, gums and intoconjunctive urine and stool.Possible pallor and petechial rash.Late massive ecchymoses or hematoma of skin, joints, brain hemorrhage,-(back pain, renal colic and weakness due to hemorrhage)Shock and death.

Treatment

Lavage stomach with tap water. Catharsis 30 gm, sodium sulfate in250 ml tap water.

Charcoal suspension should be instilled after gastric lavage.

To restore blood clotting give 10 to 20 mg Vitamin K (AquamephytonI.V. or Menaphthone Sodium Bisulfite KAPLIN) by oral. Intramuscularor intravenous route depending on severity of case. Vitamin C may bea useful adjunct.

Transfuse with fresh blood if bleeding is severe or until anemia iscorrected.

5.

6.

Iron (ferrous sulfate) by mouth for correction of secondary anemia0.3 gm t.i.d.

Treatment of intoxication with anticoagulants should be followed up forseveral weeks.

Lab TestsProthrombin activity of blood plasma, blood in urine and faeces.

1 7

CHLOROPHENOXY COMPOUNDS

Exarnoles of Commerdal Produas and Generic NamesDichlorophenoxyacetic acid (2. 4-D) DMA-6DSMA. MSMA(Sodium t&noananares)

Phannacoloqical Adion or Site of Totic@HepatototicNephrotoxicNewo Toxic

Routes of AbsorotionIngest ionDerrlMInhalation

WHO Hazard ClassificationCl&s III

Irritation of inhalation route (skin. nascpharynx. mouth throat, gastrointestinaltract). em&s. abdominal pain, muscle twitching and metabolic acidosis.Weakness. and p3haps lettmrgy. anorexia. diarrhea.Muscle weakness . may involve the muscles of mastication and swallowingVentricular fibrillaton and/or cardiac arrest and death

Treatmentt.

2 .

3 .4 .

5 .

For ingestion, lavage with activated charcoal slurry. For skin contact wash exposed area.

Metabolic addosis should be treated with infus&s of sodium biirbonate(Alkalinix the urine by IV scdwm bicarbonate lo-15 gm daily)Support ive treatment.

Ouinidine sulfale w calcium Mockers to svppress abmxmal ventricularcardiac rhythm.

For muscle and cardiac irritability give Lidocafne 50-l 00 gm IV. followedby l-4 mglmin by infusion as needed.

labTestsNo simple test. Only complex laboratory prccedures.

18

UREAS

Examples of Commercial Products of Generic NamesCinmethyl in (Argold)

Chlorotoluran (Dicuran)

Cyanazine (Bladex)

Dicamba (Banvi l )

Fluometuron (Cotogard)

Flufenoxuron (Cascade)

FIufenoxuron+alphacypermethrin (Casfas)

Isoproturan (Arelon, Graminon, Matrix,Tolkan. Proton, Swat)

Methabenzthiozuron (Tribunil)

Triasulfuran (Log ran)

Teflubenzuron (Nomolt)

Mocous membrane irritant

Routes of Absorotion

Ingest ion


Class

Svmptoms

During handling may cause irritation of eyes, nose, throat and skin ingestionmay cause gastroenteritis.

Treatment

1. For ingestion, lavage with activated charcoal slurry, for skin contact,wash exposed areas.

2. Support ive treatment.

3. Avoid contact with skin, eyes and clothing.

Lab TestsNo simple test. Only complex laboratory procedures.

1 9

HYDOXYBENZONITRILE


Bromoxyni l (Buctril, Quattro)


Increase cel lular metabol ism

Routes of AbsorptionIngest ionDermal

WHO ClassificationClass II Moderately Hazardous

SvmptomsMay cause irritation of eyes,

Ingestion may cause raised body temperature. increased heart and respiration.rate, sweating, disorientation, Stomach pain, Vomiting and Nausea.

TreatmentFor skin contact flood exposed skin with water. Remove contaminated clothingand wash skin with soap and water.

If swallowed the stomach should be emptied, ingestion should be treatedsymptomatically.

Lab Tests

No simple test. Only complex laboratory procedures.

2 0

BIPYRIDYLS


Paraquat (Gramoxone. Pil laroxone)


All Pharmacological actions are based on a generation of free radicals causedby bipyridyls. This happens in almost every tissue.NeurotoxicNephrotoxic Oculo toxicToxic to lungsHepatotoxic


Ingest ionInhalationDermal


Class II

Symptoms

Early symptoms stem from an injury of all epithelial tissues that have been incontact with the pesticide e.g. burning of mouth, oral ulcerations, substernal.abdominal pain, vomiting, diarrhea and myalgia.

INGESTION: burning in the mouth & throat, vomiting.

AFTER 2-5 DAYS: Hemolysis, oliguria, ulceration of the tongue, pharynx andesophagus.

AFTER 5-8 DAYS: Jaundice, fever, tachycardia, respiratory distress andcyanosis.

PROLONGED Inhalat ion of spray droplets: Nosebleed

EYE CONTAMINATION: Sever conjunctivitis & sometimes protracted & evenpermanent opacification.

2 1

Bipyridyls

Treatment

SPEED IS IMPERATIVE

1 .

2.

3.

4.

5.

For ingestion, lavage with activated charcoal (50-l 00 gm in 100 ml wa-ter) followed by 200 ml of 30% suspension of Fuller’s earth (Bentonite),repeated twice daily for the first 48 hours. if fullers earth is not availableuse activated charcoal. Also administer 200 ml of 20% mannitol in thegastric tube. Bentonite is the ideal absorbent (alternate Charcoal) whichshould be instilled after forced emesis or gastric lavage.

Decontaminate, Flush contaminated skin, hair and eyes with largeamounts of water.

Do not administer supplemental oxygen.

Forced diuresis, hemodialysis or peritoneal dialysis. Maintain urine output at 200 ml/hr. Furosemide 20 mg I.V. every 4-8 hrs may be necessary.

Charcoal hemoperfusion is most effective if begun within the first 12hours.

Lab Tests

Simple calorimetric (dithionite) test in the urine. Blue Colour indicates the pres--ence of paraquat in excess of 0.5 mg/l.

2 2

ALL


AtrazineAmetryn + AtrazineAmitrazBupir imateClodinafop PropargylChlor fenapyrCarbendazimCarfentrazone EthylCarfentrazone + lsoproturonClomazoneCinmethyl icCyanazineDimethormorptDiafenthiauronDazometEthalf lural inFlurochloridoneFenarmollmazamethabenzMetaolachlorMetalaxylPendimethalinPerclorazPerti lachlorPenconazole

(Primextra, Aatrax)(Gesapax)(Obasyn. Mitac)(Nimrod)(Topik)(Pirate)(Derosal)(Aim)(Affinity)(Commond)(Argold)(Bladex)(Acrobat)(Polo)(Basamid)(Sonalan)(Racer)(Rubigan)(Asser t )(Dual Gold)

(Octave)(Rifit)

Terbuthylazine + Terbutryn (Topogard)Thiamethoxam (Actara, ‘Cruiser)Tri fural in (Treflan, Drifan, Orifan. lpiflour

Action or Site of ToxicityMucous memberane and skin irritant

Routes of AbsorptionIngest ionDermalInhalation


During handling many cause irritation of eyes, nose, throat and skin ingestiomay cause gastroenteritis.

2 3

Treatment1. Eyes:

2. Skin:

3. Ingestion:

4. inhalation:

Lab Test

Flush eyes with plenty of water. a physician if irritationdevelops.Wash ail exposed areas with plenty of soap and water.Contact a physician if irritation develops.If swallowed, do not induce vomiting. Call a physician,administer act ivated charcoal (6-8 heaping teaspoonfuls)with plenty of water. Do not give anything by mouth to anunconscious patient. Transport to medical care facility andsee a physician.Remove individual to fresh air. If breathing difficulty occurs,call a physician.


24

THIOCARBAMATES


Captan (Thalamide group)DithianonM a n e bMancozeb

Thiobencarb

(Captan)(Delan)(Dithene, Polytram)(Manzate, Nemispor, Pencozeb,Sancozeb)(Saturn)

NeurotoxicSkin irritantInhibi t ion of aldehyde dehydogenase


Ingest ionDermalInhalation


WITHOUT ALCOHOL INGESTION. I tching, redness, dermati t is, hoarseness,coughing, nausea, vomiting, ataxia, muscle weakness, paralysis.

WITH ALCOHOL INGESTION. (Due to aldehyde dehydrogenase inhibition).Flushing sweating shortness of breath, chest pain, hypotension.

Treatment

1. Decontaminate, Wash skin and hair for ingestion, lavage using acti-vated charcoal.

2. Supportive therapy

3. If complicated with alcohol, oxygen as needed and Vitamin C.

4 . No alcohol for three weeks in any case.

Lab Tests


25

ACETAMIDE

Name of Commercial Products and Generic Names

Butachlor (Machete, Bandox)

Action or Site of

information not available at present.


Information not available at present.


Class Ill

Svmotoms

There are no diagnostic symptoms of poisoning associated with the product other than to know that if actually got into eyes or was ingested.

Treatment1. Eyes: Flush eyes with plenty of water. Call a physician if irritation

develops.2. Skin: Wash all exposed areas with plenty of soap and water.

Contact a physician if irritation develops.3. Ingestion: If swallowed, induce vomiting and treat symptomatically. Call

a physician. Do not give anything by mouth to anunconscious pat ient.

4. Inhalation: Remove individual to fresh air. If breathing difficulty occurs,call a doctor.

Lab TestNot applicable.

DERIVATIVES

of Commercial Product and Generic Names

Metribuzin

Action or Site of

Neurotoxic


Ingest ion

WHO Hazard ClassificationClass III

Svmotoms

Not Known as yet.

Treatment

1.

2.

Antidote not known, symptomatic treatment is recommended.

Check blood pressure and pulse rate frequently since brady cardia andhypstonia are possible.

3. Supportive measures for re-enforcement of breathing and heart action.Give artificial respiratory if signs of Paralysis appear.

4. Additional therapeutic measures involve elimation of the substancesfrom the body acceleration of its excretion (gastrolavage.Saline laxatives).

5. On oral ingestion give plenty of water (no milk no alcohol) to drink, anda suspension of 1 Og or more of medical charcoal in 150-200 ml water.

Take care before inducing vomiting (should be done if chemical swallowed is highly toxic and if medical assistance is not readily available),as there is a danger of aspiration of the solvent, with possible inductionof pneumonid or pneumonitis. Only in fully conscious persons may vomiting be induced by stimulation of the back of the throat, e.g. with a fingertip. Give plenty of liquid to drink (several litres in the course of hours)to cause forced diuresis. If sodium bicarbonate is added to infusionsfollow the dosage instructions exactly because of the danger of respiratory depression.

6. Eyes: Open the eyelids with fingers and wash the conjunctiva withrunning water for several minutes or wash the conjunctiva with anappropriate eyewash device (e.g. plastic wash bottle filled with water).

27

T~zenona Derivatives

7 . Gastric lavage should only be carriad out by a doctor and requires thepresence of 2 other qualified people. It rS a mea.wre indiited for allorally ingested life-threatening quantities of poison. even after earliervomMg and in unconsaouapersons.

In convu:sions first injact 10 mg Diazepam (other banzodiarepine derivatives may al.50 be used) intravenously as a spasmo&tiic. and to pravent vagal reflex aIs0 first 14 administer 1 mg atropine. again by an ix.I#XtiOtl.The lavage itsetf should be carried out with wata$’ suspension of activated charcoal if possible.Adults and children over 12 years: 50-100 g activated charcoal in every300 to 800 ml of water (lukewan).Children under 12 years: 50-30 g activated charcoal in every 100-300ml of water (lukewan).If actlvatad charcoal is not available. the lavage may be carried out Wimlukewarm water alana.

a. Ii poisoning occur& via dermal route. skin and hair should be dawntaminated.

LabTWSSNot applicable.

NITROGUANIDINE

tiamoles of Commercial Products and Generic Nameslmldacloprld (Confider)

Pharmacolooical Action or Site of ToxicityNeUrOtOXiC

Routes of AbsorptionIngestIonDermalInhalation (negligible)

WHO Hazard ClassificationClass II

Svmotoms(Similar to those caused by nicotine poisoning) Apathetic state. depressedmuscular tone. respiratory disturbance & trembling, muscular cramps insevere cases of poisoning.

Treatment1 .2.

Antldote not known, symptomatic treatment is recommended.


3. Supportive measures for re-enforcement of breathing and heal action.Give artificial respiratory if signs of Paralysis appear.

4. AddItional therapeutic measures involve elimation of the substancesfrom the body acceleration of its excretion (gastrolavage,Salmelaxatives).

5. On oral ingestron gwe plenty of water (no milk, no alcohol) to drink, anda suspension of log or more of medrcal charcoal in 150-200 ml water.

Take care before inducing vomiting (should be done if chemical swallowed is highly toxic and if medical assistance is not readily available),as there is a danger of aspiration of the solvent. with possible inductionof pneumonid or pneumonitis. Only in fully conscious persons may vomsting be induced by stimulation of the back of the throat, e.g. with a fing&p. Give plenty of liquid to drink (several litres in the course of hours)to cause forced diuresis. If sodium bicarbonate is added to infusionsfollow the dosage instructions exactly because of the danger of respiratory depresson.

29

Nitroauaniding

6. Eyes Open the eyelii with fingers and wash ~Jw conjunUiva withrunning water for several minutes or wash the conjunct~va with anappropriate eyewash device (e.g. plastic wash bottfe filled with water)

7 . Gasaiclavageshould~becamedoutbyaboQocandrequiresmepresence of 2 other qualified people. If is a measure indicated for allorally ingested life-threatening quanMies of poison. even after earliervomiting and in uwxnsciws persors.

In wnvulsions first inject 10 mg Diazepam (other banzodiiepme derivatives may also be used) intravenously as a apasmofytic. and to ptevent vegal reflex afso first 14 administer 1 mg atropine. again by an i.v.l+CtiOfl.

The &age itseff should be carried out wilt? watery suspension of actfvated charcoal if possible.

Adults and children over 12 years: 60-100 g abated charcoal in avew J300 to 800 ml of water (lukewarm).

Children wdef 12 years: 50-30 g activated charcoal in every 1 W-300ml of water flukewarm).

ff activated chmwal is not available. tha lavaga may be carried out wimlukewarm water alone.

8 . If poisoning ccu~ned via darmaf route. skin and hair should be decontaminated.

I=lbTTesf.Not applicable.

30

TRIASOLE DERIVATIVES


TriadimenolTriadimetion (Bayletan)

Action or Site of

Neurotoxic


ingestionDermalinhalation


Class III

Effects CNS and at highdose, stomach & liver symptoms.

Treatment

1 .

2.

3.

4.

5.

6.

3 1

Antidote not known, symptomatic treatment is recommended.


Supportive measures for re-enforcement of breathing and heart action.Give artificial respiration if signs of Paralysis appear.

Additional therapeutic measures involve elimation of the substancesfrom the body acceleration of its excretion (gastrolavage,Salinelaxatives).

On oral ingestion give plenty of water (no milk no alcohol) to drink, anda suspension of 1 Og or more of medical charcoal in 150-200 ml water.

Take care before inducing vomiting (should be done if chemical swallowed is highly toxic and if medical assistance is not readily available),as there is a danger of aspiration of the solvent, with possible inductionof pneumonid or pneumonitis. Only in fully conscious persons may vomiting be induced by stimulation of the back of the throat, e.g. with a fingertip. Give plenty of liquid to drink (several litres in the course of hours)to cause forced diuresis. If sodium bicarbonate is added to infusionsfollow the dosage instructions exactly because of the danger of respiratory depression.

Eyes: Open the eyelids with fingers and wash the conjunctiva withrunning water for several minutes or wash the conjunctiva with anappropriate eyewash device (e.g. plastic wash bottle filled with water).

Triasole Defivaties

7. Gash lavage should only be carried wt by a doctor anf rWJireS tf~presmca of 2 other quafiii people. lf is a measure indhzated for allorally ingested life-threatening quantities of poison. even after earliervomiting and in unconscious persNSIn convulsions first inject 10 rng Diazepam (0tfEr banZ0diiazePirW derivaties may also be used) intrwenOusly as a spasmdytic. and to prevent vegaI reflex also first 14 administer 1 mg atropine. again by an i-v.lnjeclion.

The lavage itseii should be carried out with watery suspension Of tivated charcoal if possible.Aduits and children over 12 years: 50-100 g activated charcoal in every300 to 800 ml of water (lukewarm).Chlkiren under 12 years: 50-30 g activated charcoal in every 100-300ml of water (lukewarm).If bated charcoal is not available. the Wage may be carried out wimlukewarm water $qw.

a If poisoning occurred via dennal route. skin and hair should be deccmtaminatad.

I?bTasr.Not applicable.

WHO OF PESTICIDEBASED ON TOXICITY AND HAZARD

CLASS

ACUTE LD50 (RAT) body weight

TOXIC RING

C O L O U R ORAL DERMAL

laExtremely Hazardous

l bHighly Hazardous

SOLID LIQUID SOLID LIQUID

R E D 5 OR 20 OR 10 OR 40 ORLESS LESS LESS LESS

B L U E lo- loo 40-400

I IModerately Hazardous

Y E L L O W

B R O W N OVER O V E R OVER OVERSlightly Hazardous 2ooo 1 0 0 0

INDEX

PRODUCT GROUP PRODUCT USE PAGE NO.

2,4-D Chiorophenoxy Compounds H 1 8

AAatraxAcephateAcrobatAcrylonitriteActel l icA d v a n t a g e

AfuganAgrllexAgtoxinAldicarbAirnos-DAlphacypermethrinAluminum PhosphideAmbushAmettynAnthioAntracolApadimArelonArgoldArrivo A s o r n i d o AtrazineAzinophosAzodrinAzofosActaraAmitrazAztec

BBanvilBasudinBayie fonBaylanBaythorid TMBaythroiaBestoxBeta CyfluthrinBHC

Triazine phosphorus

All OthersCyanide Fumigants

phosphorusCarbamtesChlorinated hydrocar

phosphorus phosphorus

Phospine FumigantsCarbamatesPhrethroidsPhrethroidsPhosphine FumigantsPhyrethroidsAll Others

phshorusCarbamatesOrgno phosphorusUrteasAll OthersPyrethrolds

phosphor&All Others

phosphorus phosphorus phosphorus

NeonicotinoidAll OthersCarbamate

7

1 6

H4

H 2 31 4

F

F

HH

H

23

7

23

234

23237

Ureas phosphorus

Tr iazole Der ivat iveTr iazole Der ivat ive

phosphorusPyrethroidsPyrethroidsPyrethroidsChlorinated Hydrocarbons

H 1 95

FF

2

34


BifenthrinBirlaneBladexBootachlorBrifurBrodifacoumBromoxyni lBromomethanBuctrillBulldockBupir imate

CCalcl feronCalcium CyanideCaptanCarbarylCarbendazineCarfentrazone EthylCarfentrazoneCarbofuronCarbosulfanCartapCelphosCheetaChemathoateChlorfenivnphosChlorothalonii ChlorotbluranChlorpyriphosChlorfenapyrChlorpyr iphos MethylCadialCinmethyl inClodinafopClomazoneCodusafosConf idorCoopexCoumarinCoumate tralylCuracronCuraterrCyanogasCyfluthrinCymbughCyanides

Pyrethroids phosphorus

UreasAcetamideCarbamatesCoumarin lndandionesHydrooxybenzonitr i l leHalogen FumigantshydrooxybenzonitrillePytethrordsAll Others

I

HH

RH

HI

F

Coumarin lndandiones RCyanide FumigantsThiocarbamates FCarbamatesAll OthersAll OthersAll OthersCarbamatesCarbamatesCarbamates APhsphine Fumigants APyrethroids I

Phosphorus I Phosphorus I

C h l o r i n a t e d FUreas H

Phosphorus AAll Others H

phosphorus Phosphorus

All OthersAll Others HAll Others

phosphorusNitroguanidinePyrethroidsCoumarin lndandionesCoumarin lndandiones

phosphorus ICarbamates ICyanide FumigantsPyrethroids IPyrethroidsCyanide Fumigants

9

1 7

2 3

1 71 42 57

2 32 32 3777

421 9

2 34

2 32 3

234

1 71 7

3 5

D i c a m b a

Dimetaxal DimethormorptDimethlocarbamateDimethoateDimethomorphDiphacinoneDiphasinDipterexDisulfotonDisystonDithaneDMA-6Dofume

EEkaluxEmmatosEndonEndosulfanES-Fenvalerate

PRODUCT USE PAGE NO.

H 2 3

92 3

PRODUCT GROUP

Cyanazine All OthersCyperk i l l PyrethroidsCypermethr in PyrethroidsCruiser NeonicotinoidChlor fenapyr All Others

DDaconil Chiorinated Hydrocarbons FDannitol PyrethroidsDazomet All Others

Chlorinated HydrocarbonsDDVP phosphorusDecamox CarbamatesDecis PyrethroidsDecis-D PyrethroidsDell t ia Phoshine FumigantsDeltamethrin PyrethroidsDeltanet CarbomutesDeltaphos phosphorusDetia gas Phosphine FumigantsDiazinon phosphorusDual Gold Acetanil ide HDiafenthiuron All OthersDithiocarbamate Carbamate

HHUreas


All OthersCarbamates

phosphorusAll OthersCoumarin lndandiones RCoumarin’lndandiones R


Thiocarbamates FChiorophenoxy HHalogen Fumigants


Chiorinated HydrocarbonsChiorinated HydrocarbonsPyrethroids

2 32

9

42 32 37

1 81 9

2 3

1 71 7

44

9

3 6

PRODUCT

EthalfluralinEthion

FFacron-SFastacFatekFenitrothionFenkillFenpropathrinFentlfothionFenvale ta teFlucythr inateFluometuronFlufenoxuronFlurochlorideneFolidolFormathionFuradanFurathiocarbFyfanon

GGastoxinGesapexGranmoxoneGripGusathion M

HHeptachiorHigonetHostathionHydrocyanic AcidHygrogen Cyanide

IImidaciopridlmazamethabenzlsoproturanlpi f luor

KKarateKleratKumulus

GROUP

All Others phosphorus

PRODUCT USE PAGE NO.

2 3I 4

phosphorusPyrethroids


PyrethroidsPyrethroids

phosphorusPyrethroidsPyrethroidsUreasUreasAll Others


CarbamatesCarbamates

phosphorus

HHH

Phosphine FumigantsAll OthersBipyridyis

phosphorus-. phosphorus

IH

II

Chiorinated Hydrocarbons phosphorus phosphorus

Cyanide FumigantsCyanide Fumigants

NitroguanidineAll OthersUreas H

PyrethroidsCoumarin lndandiones R

4

9

991 91 9

4

7

292 3

19.23

1 7

3 7


LLambda-CyhalothrinLannateLaserLead ArsenateLogranLorsbanLucky cypermethr inL u x a g a n

MMacheteMagnumMalathionMancozebM a n e bManeb + ZinebManzarteMatrixMethamidophosMethabenzthiozuromMetolachlorMetalxylMetasystox RMethidathionMethomylMethyl Bromide:Methylparathion’MetribuzinM L TMonitor

MonocrotophosMonophosMSMAMitac

NNemisporNimrodNokoutNokovosNudrinNurelleNurelle-D

PyrethroidsCarbamatesPyrethroidsArsenicals InorganicUreas

phosphorusPyrethroids

phosphorus

AcetamidePyrethroids

phosphorusThiocarbamatesThiocarbamatesThiocarbamatesThiocarbamatesUreas

phosphorusUreasAll OthersAll Others


CarbamatesHologen Fumigants

phosphorus Trizenone Derivatae

phosphorus phosphorus phosphorus phosphorus

Chlorophenoxy Compounds

9

911

H

H

HF

42 52 52 52 5

41 92 32 3

47

42 7

4

H

ThiocarbamatsAll Others


Carbamates PyrethroidsPyrethroids

FF

A


0Organic BoundOxydemeton MethylO c t a v e

PPadanPandaphosParametParaquatParis GreenPay-offPencozebPendimethalinPerclorazPenconazolePhenoxyacet ic acidPhenthoatePermasectPermthrinPhoratePhostoxinPhosv i tPillaronPil laroxonePirimicarb .P i r i m o rPolo Polyt ramPolytrin CPuma SuperPouncePrimextraPrimiphosProfenofosProthoatePropargylPreti lachlor

QQuickphosQunaiphos

phosphorus 4

Carbamates phosphorus phosphorus

Bipyridyis HArsenicals Inorganic APyrethroidsThilcoarbamates FAll OthersAll OthersAll Others FChiorophenoxy Compounds H

phosphorusPyrethroidsPyrethroids

phosphorusPhasphine Fumigants


Bipyridyls HCarbamtesCarbamates All OthersThiocarbomates F

phosphorus

PyrethroidsAll Others


All OthersAll Others

phosphorus

Phosphine Fumigants phosphorus

7

2 11 1

232 323

7

H

HH

23555

23235

PRODUCT USE PAGE NO.PRODUCT GROUP

RRacer All OthersRacumin Coumarin lndandionesRamilk Coumarin lndandionesRati lan Coumarin lndandionesReldan phosphorusRidomil All OthersRifit Others‘Ripcord PyrethroidsRogor phosphorusRoxion phosphorus

SSalbrom Halogen FumigantsSaturn ThiocarbamatesSencor Trizehone DerivateSevin CarbamatesShangnong phosphorusSherpa PyrethroidsSialan HydrocarbonsSodium Arsenite Arenicals InorganicSodium Monoarsonates Chlorophenoxy Compounds

HR 1 7R 1 7R 1 7

F 23H 2 3

1 1

SolvirexStingerSumicidinSumicidon SuperSumithionSuncrotophos SundaphosSunfuranSunmerinSupracideSys toa tescout

TTaicordTaistarTamaronTemikTerabolTeflubenzuronTerbuthylazineTerbut rynThiamethoxamThimetThiobencarb



phosphorus phosphorus -- phosphorus

CarbamatesPyrethroids



phosphorusCarbamatesHalogen FumigantsUreasAll OthersAll OthersAll Others

phosphorusThiocrbamates

1 9H 23H 23

2 3

2 5


ThiodanThiofanoxThioluxanTigerTolkonTomorinTopasTopikTopogardTriadimenolTriadimetonTriasuiforanXazophosTriazamateTribunilTrichlorfonTrifural in

Chlorinated CarbamatesChlorinated Hydrocarbons

phosphorusUreasCoumarin lndandionesAll OthersAll OthersAll OthersTriazole DerivativeTriazole DerivativeUreas

phosphorusCarbamateUreas

phosphorusAll Others

UUstad Pyrethroids

VVaponaVitigran

phosphorus

Warfar in Coumarin lndandiones

Exolanation oftermsH = HerbicidesI Insect ic ides

= RodenticidesF = Fungicides Acaricides

IHRFHHFFHA

H

R

7

1 72 32 32 33 13 11 9571 95

2 3

1 7

4 1

EMERGENCY RESPONSE ADDRESSAND TELEPHONE NUMBERS

BhawalpurNovartis (Pakistan) Ltd.

Edgro (Private) LimitedJaffer Brothers (Private)L t d .

Granulars (Pvt) Ltd..

United DistributorsPakistan Ltd.Pakistan AgroChemicals Ltd.Cyanamid (Pakistan) Ltd

FMC United (Pvt) Ltd.

NICL

D-G. KhanFMC United Ltd.

United DistributorsPakistan Ltd.

Granulars (Pvt) Ltd.

Pakistan AgroChemicals (Pvt) Ltd.

Faisalabad (Private) Ltd.

Granulars (Pvt) Ltd

Opposite Zakhira,Ahmedpur Sharqia Road,

6-B, Model Town AHouse No. B-4,329,Karbala Road, Model Town-B,

Rainbow Shopping Centre,F-3, Chowk

13-A, Block-V,Model Town C

Model Town B, ChowkSaith Abaii-ur-RehmanHouse No. 22-A,Satellite TownHouse No. Model Town

Bypass Karachi Road,Model Town

272-C Khyaban-e-Sarwar

241 -A, Khyaban-e-Sarwar

Laskani Manzil, ChowkChorhatta, Road.

Khyaban-e-Sarwar

Engro near Chowk Churhatta

Shop 13, Market, Gulistan Colony-3

88, Commercial Centre No.2, Gulistan Colony,

877762882664

66216176

645884123875611

8189480635874974

874129

62438

61236

783939

56501

Mehran Ltd.

AgroChemicals (Pvt) Ltd.

Cyanamid (Pakistan) Ltd.

GujranwalaGranulars (Pvt) Ltd.

Jaff er Brothers (Pvt) Ltd

PakistanAgrochmicals (Pvt) Ltd.

Hyderabad (Private) Limited

(Pakistan) Limited

Pakistan Ltd.

ICI Pakistan Ltd.

Jaffer Brothers (Private)L t d .


Pakistan AgroChemicals Ltd.


Cyanamid (Pakistan) Ltd

KarachiAG Services andSupplies

Agticides (Private) Limited.

112, Madina Town 27554

70-Shahzad Market 716483 Road

243-C Colony No. 2 730818

18, Mohallah Faisalabad, 8 4 8 3 1Ghalla Mahdi, Near Deen Plaza.

Mir Nazir Street, 43069Road, Satellite Town.

Road Eimnabad 263717

A/22/A-2, S.I.T.E.,

Plot A/66-A, S.I.T.E.,,

A-25, S.I.T.E.,

24 Lines, OppositeT&T TowerPlot No. S.I.T.E.,

41787

880530880441

880820

780771

880011880012

430 Haji Shah Chowk, Saddar. 782746

577, Unit No. 2Latifabad.

A-51QS.I.T.E.

House No. B-50,Block-B, Latifabad No.2

ManzilGarikhata

18-20, Naval Fleet Club,lnverarity Road

Marine Trade Centre, BC 3,Kehkashan Block-9, Clifton

862809

880011810351

782921

778162677837417781626570941570942

Chemdyes Pakistan(Pvt) Ltd.

Novartis (Pakistan) Ltd.


D. E. United (Pvt) Ltd.

Edgro (Private) Limited

(Pvt) Ltd.

GHR (Pvt) Limited

Pakistan Ltd.

Mehran Ltd.

National Agro Trading(Pvt)

National Insecticides Ltd. (NICL)



LahoreNovartis (Pakistan) Ltd.

Granulars (Pvt) Ltd..

Block-6.P.E.C.H.S.

S-50, S.I.T.E., Hawks BayRoad

S-33, S.I.T.E., Hawks BayRoad

11, StreetCivil Lines,

Marine Trade Centre, BC-3,Kehkashan Block-9, Clifton1 st Floor, Kassam Manzil,

Road.

303, Kassam Court, BC-9Block-5, Clifton

Hoechst House, Plot No. 23Sector No. 22, KorangiIndustrial Area

At-Syed Arcade, 2ndfloor, Minhas Road,

208 Swami Building, 1 st Floor,

F-52, S.I.T.E.

9th Floor NIC Building,Abassi Shaheed Road.

P.E.C.H.S.

Plot No. 90, Industrial Area,Kot Lakhpat

1 Lahore-3

430184430185430186

25649404325649470300 2413960300 241397

2567411-34111-777-333

567226265

570943570944772804677280477728048

575041575042

5060721-23

4698434971812

21820026205292623072

2576441

519051-54

51185825116760

75869827586955

AgrEvo Pakistan Ltd.

ICI Pakistan Ltd.






Pakistan AgroChemicals Ltd.Granulars Ltd.

MultanAgricides (Pakistan) Ltd

(Pakistan) Ltd.

D.E. United (Pvt) Ltd.

Edgro (Private) Limited.

Ltd.

Pakistan Ltd.

ICI Pakistan Ltd..

13 Kilometer Multan Road,Hanjarwal

63 Mozang Road

Flat No. Floor,Eden Center, jail Road.18 Sikander Block, lqbal Town

18 km Multan Road

2-A, PlazaMain lqbal Road

House No. NearNawab Aziz Adam Town Road.

C-7, Block 14, Unit No. Satellite Town

Satellite Town.

Park, KahnewalRoad

Mouza Abdul Fateh,Near Industrial Estate, OffBypass Road.

En. En. Building, 1st FloorKhanewal Road.

757 A3 Nawan Abdali Road

Gulgusht Colony,Bosan Road.

7-C/1, Industrial Estate

Ginning Factory,1 -A, Industrial Estate.

541389154138925417993

631127181

7588329

5414249

751009596

7842491

551276551277

537071539658539659556494

43009573928511218

520640

538251-56

539063Emergency No.539636539212


Mehran Agro-Chem(Pvt) Ltd.United DistributorsPakistan Ltd.

Pakistan (Pvt) Ltd.


Madina Palace, Ex-9 Colony,

Khanewal Road.Mehran House, 25-Y, NewMuitan Colony

33-A, Gulgasht Colony


ColonyHumayun Road.

near Pasco Industrial Estate

21 -A, Gulgast Colony

37-C, 15 Industrial Estate

PeshawarAg ricides (Pvt)Limited

Edgro (Pvt) Limited

Pakistan Ltd.

ICI Pakistan Ltd.

Mehran Agro-Chem(Pvt) Ltd.United DistributorsPakistan Ltd.



Zinat Plaza, haji Camp, Road.

Jan Market, Industrial Estate, Kohat Road.Sardar Garhi, MalikGoods, Road

Plaza, University Road.

Room No. Floor,

3358434925

5534585 7 3 5 4 65 2 4 5 6 65 5 5 1 2 55 8 4 0 2 35734115 3 9 8 2 2539321

521321221319

5382025 6 3 5 6 9

2 5 3 0 4 3

2616852 6 3 6 3 08 4 1 7 8 46 4 1 7 8 5

Hotel, l/S, Road.

6-C Plaza, Charsadda 2 4 0 0 4 3RoadShakeel Mansion, Jamrud 40664Road, Wahidabad,Opposite lslamia College

Mag Agro Chemicals,11 -A, 2 7 3 3 7 0 Officers Colony

House No. 817690Phase-l, Hayatabad

Agricides (Pvt)Limited

Novartis (Pakistan) Ltd


Granulars Ltd.


ICI Pakistan Limited

Jaffer Brothers (Private)L t d .Pakistan AgroChemicals (Pvt) Ltd.

Mehran (Pvt) Ltd.

United DistributorsPakistan Ltd.FMC United (Pvt) Ltd


Shaiwal

Agricides (Private)Limited

Novartis (Pakistan)L t d .


Granulars (Pvt) Ltd


Khanpur Road

By Pass Road

House No. 1 -A, Street No. 9,Jugnoo Chowk, Jinnah Park

Khanpur Road

7 km, Shehbazpur Road

Shehbazpur Road 70768

House No. 301 Satellite 76272

4 New Colony,Shahrah-e-Sheikh Zaid BinSultan Road.

10 Complex, OppJinnah Hall

Behind Punjad Tractors,Shah Road.

558-A, College RoadSatellite Town

8-D, Commercial Area

21-22, Factory Area Pur Road

11 -J. Town 52287

United Farms, Pak Road.

51 O/B-VII, Road, CivilRoad.

166-A, Govt. ServantsHousing

United Farm, Pak Sharif Road.

7286372763

7892871913

7796

78138

74831

7375574200

72409

463674082

7576575706

2956

52972

630454663148

ICI Pakistan Ltd


Mehran Ltd.


Pakistan AgroChemicals Ltd.


Cyanamid (Pakistan) Ltd

S u k k u rGranulars Ltd.

ICI Pakistan Ltd.

United DistributorsPakistan Ltd. . .

Pakistan AgroChemicals (Pvt) Ltd.Cyanamid (Pakistan) Ltd.

Vehari

Agricides (Private)Limited

Novartis (Pakistan)Limited.

Edgro (Private) Ltd.

(Pvt) Ltd.

Pakistan Ltd

ICI Pakistan Ltd

United Farm, Pak 78969Road. 78264

1 Bin Colony 77832

147, Railway Road

6-B, Ciil tines, StadiumRoad

Road 74764

House No. 8, Katchehri RoadNew Civil tines

Saeed Moukal ColonyGulberg Road

Rohail Oil Mill No.

65954574476

5388953681

F-l Barrage Colony,Workshop Road

A/l Workshop Road,Barrage Colony

F-331415, Workshop Road

Agro House, VIP/MilitaryHouse

House No. W-l 66,Auqaf Plots, Waritar Road

82987

86385177689

39855

612687

407 Sharqi

Khanewal Road

17 ‘H’ Block,

32-B, Grain Market

4th Kilometer, BurewalaRoad

Burewala Road

6257363573

62561

619742181

6243362434

62596

Brothers (Private)L t d .




FMC United (Pvt) Ltd

Quetta


Chishtian

FMC United Ltd.

FMC Ltd.

House No. 174-F, Street No. 6130110, Block-F.

Road 3159

2 km, Khanewal Road 62874

Oil Mills, Chak 61675Vehati Burewala Road 65675

House No. 63748

22, Rahim Colony

2, Pohan ColonyMalakand Road

4-X. Satellite Town

5, Civil LinesChak Road

832693

66271

5227451993

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