ppt allergy march

7/25/2019 Ppt Allergy March

1/30

ALLERGY MARCHDEBORAH ORIONA VEGA/ G4A015089

Pembimbing : !" #$!i %&n'$(&) %*"A)M(i"Me"


2/30

LA+AR BELA,ANG

-!e.en(i *en&.i' &'$*i.) 'e!m&(. dermatitis atopiki.en&2 3g& (eb&g&i eem&6) rhinitis alergika dan asma)'e2&7 meningkat dalam dekade terakhir ini &n (e.&!&ngmengen&i .i!&.i!& 20% dari populasi &2&m neg&!&be!.emb&ng" ,$n(e* Allergy march be!.emb&ng n'.men3e2&(.&n perjalanan dari penyakit atopik &!i

e!m&'i'i( &'$*i. *&& b&i infant6 men3&i !7ini'i( &2e!gi.&&n &(m& *&& &n&.&n&." P&(ien eng&n e!m&'i'i( &'$*i.&*&' be!.emb&ng men3&i (e.en( 'i*i.&2 &!i e!m&'i'i(&'$*i. &n !7ini'i( &2e!gi.& &n &(m&) &ng &.&nberkembang pada umur tertentu) &'& &*&' bertahandalam beberapa tahun) im&n& &ng 2&in &*&' berubah

dengan bertambahnya umur


3/30

+&n& &&2 &!i *en&.i' &2e!gi &&2&7 e!m&'i'i( &'$*i. &n&2e!gi 'e!7&&* m&.&n) im&n& (e&!& 'i*i.&2 memi2i.i puncakangka insidensinya selama dua tahun pertama

kehidupan" H&m*i! setengah dari anak-anak eng&ndermatitis atopik meng&2&mi *e!.emb&ng&n ge3&2& &2&men&m b2&n *e!'&m& &!i .e7i*&nn& &n .i!&.i!& 85 &!iini;i eng&n e!m&'i'i( &'$*i. mem*n&i $n(e' ge3&2&*&& m! 2im& '&7n ,& et al) 19946" Sebesar 50%penderita dermatitis atopik akan menjadi asma &n


4/30

Pe!.emb&ng&n &2e!gi m&.&n&n 7&m*i! mi!i* eng&n *$2&em&'i'i( &'$*i.) eng&n *n&. (en(i'i(&(i m&.&n&n 3g&

'e!3&i *&& & '&7n *e!'&m& .e7i*&n" Ang.& insidensitertinggi 'e!3&i &!i alergi makanan &i' (e.i'&! 6-8%pada umur 1 tahun) ii.'i $2e7 penurunan insidensi(e&!& g!&&2 men3&i 1-2% pada saat dewasa"Pengemb&ng&n sensitisasi alergik terhadap alergeninhalan m2&i n'. mening.&' (e.i'&! umur tahun &n

(e!ing ii.'i eng&n allergic respiratory disease)'e!m&(. i&2&mn& asma dan rhinitis alergika" P&&.eb&n&.&n &n&.&n&. eng&n ge3&2& asma mem2i.i $n(e'*&& 5 tahun pertama kehidupannya Ynginge! et al)199?6) im&n& sensitisasi alergi 'e!7&&* alergen inhalan(e&!& mm meningkat &2&m *!e;&2en(i (e2&m& '&7n

*!e(7$$2) eng&n (en(i'i(&(i 'e!7&&* &2e!gen *e!enni&2$n'$7n& 'ng&) b2 .ing &n b2 &n3ing 'e!3&ii&n'&!& ? 7ingg& 5 '&7n 2&2 ii.'i eng&n (en(i'i(&(i'e!7&&* &2e!gen (e&($n&2 *&& m! @5 '&7n ,2ig et al)1998=>&7n) ?0006"


5/30

LA+AR BELA,ANG

Peneg&7&n *!ime! &2e!gi *&& &&2 .e7i*&n b&i (&ng&'*en'ing) .&!en& .e'i.& !e(*$n( IgE (&7 im2&i m&.&.&(.&e in&m&(i &2e!gi &.&n 'e!( be!2&ng(ng (e*&n3&ngm&(& b&i &n .emi&n (en(i'i(&(i 'e!7&&* &2e!gen 2&in&.&n 'e!3&i" Peneg&7&n *!ime! (eb&i.n& im2&i (ebe2m'e!3&i (en(i'i(&(i 'e!7&&* &2e!gen" Bebe!&*& in'e!;en(i&&2 &ng &*&' i2&..&n &&2&7 eng&n mengien'i.&(i*$*2&(i !i(i.$ 'inggi &n m&ni*2&(i 2ing.ng&n &n'&!& 2&in*eng7in&!&n &(&* !$.$. H&!($n$) ?0056" %&2&7 (&' &!&ien'i.&(i *$*2&(i !i(i.$ 'inggi i In$ne(i& &&2&7 me2&2i*enen'&n ni2&i &'$*i .e2&!g& 'e!7&&* 3&nin/b&i b&! 2&7i!

eng&n .&!' e'e.(i ini !i(i.$ &2e!gi I.&'&n D$.'e! An&.In$ne(i& Pe!(&'&n Ob('e'!i &n Gine.$2$gi In$ne(i&IDAI POGI6" IDAI be.e!3& (&m& eng&n POGI 'e2&7me2&..&n ($(i&2i(&(i .&!' e'e.(i ini (e3&. '&7n ?005)&ng .emi&n i*e!b&7&!i *&& '&7n ?009 IDAI) ?0096"


6/30

+3&n

Men3e2&(.&n *!$(e( me'&b$2i(me &n7$me$('&(i( be(i

Men3e2&(.&n (i$2$gi '!&n(*$!' be(i &!i

*2&(en'& .e e'( Membe!i g&mb&!&n *!$(e( 7$me$('&(i(

be(i *&& m&(& .e7&mi2&n &n 2&.'&(i

Membe!i g&mb&!&n 'e!.&i' &nemi&e(ien(i be(i i'in3& &!i &.'$! e'(&n *2&(en'&"


7/30

!"#$ '&S!(


8/30

Me'&b$2i(me &n H$me$('&(i( Be(i

Be(i &2&m 'b7 (e2&2 (eimb&ng .e7i2&ng&n be(i7&!i&n 'e!g&n'i.&n $2e7 &(*&n be(i $!&2 7&!i&n

,e(eimb&ng&n be(i i&'! $2e7 *!$(e( &b($!*(i be(iin'e('in&2

%e&!& &2&mi&7 &' be(i i*e!$2e7 &!i m&.&n&n" &' be(i &ng be!(mbe! &!i *!$. 7e&ni i'em.&n

&2&m ben'. 7eme&ng &*&' i(e!&* 2&ng(ng $2e7'b7)

&!i *!$. '&n&m&n be!ben'. n$n 7eme / .$m*2e.(

e!!i -e@F6 'i&. i(e!&* 2&ng(ng $2e7 'b7 &g&!bi(& i(e!&* 2&ng(ng $2e7 'b7) eng&n b&n'&n&(&m .2$!i& i 2&mbng be(i i!e.(i men3&i ben'.e!!$ -e?F6


9/30

Be(i 7emei(e!&* en'e!$(i' me2&2i 7eme'!&n(*$!'e! Haem Carrier Protein 1 HCP16

Be(i e!!$ -e?F6 i(e!&* me2&2iDivalentMetal Transporter 1 DM+16

Be(i &ng 'e2&7 i(e!&* (eb&gi&n i(im*&ni &2&m en'e!$(i' &2&m ben'. e!!i'in)(eb&gi&n i.e2&!.&n .e *2&(m& me2&2ie!!$*$!'in i memb!&n b&(&2

Reg2&(i &b($!*(i be(i *enge2&!&n be(i&!i en'e!$(i' men3 *2&(m&


10/30

+i&. (em& be(i ign&.&n &2&m *!$(e(me'&b$2i(me 'b7"

Penggn&&n b&n&.*en*2&i &2&m

memben'. 7em$g2$bin) (eb&gi&n 2&inn&i(im*&n (eb&g&i &&ng&n) (eb&gi&ni&g$(i' i &2&m RE%) &n (eb&gi&n 2&inn&i2e*&( .e &2&m *2&(m& 2&2 be!i.&'&n.emb&2i eng&n '!&n(e!in n'. (in'e(i( 7eme&n *!$'ein"

,e2ebi7&n be(i &.&n i(im*&n i &2&m $!g&nRE% &2&m ben'. e!i'in m&*n 7em$(ie!in"


11/30


12/30


13/30

+!&n(e! be(i'!&n(*2&en'&2

+!&n(e! &' be(i 'e!3&i me2&2i & me.&ni(me&i' $2e7 en$(i'$(i( me2&2i !e(e*'$! be(i &ng'e!2e'&. i memb!&n '!$$b2&( *&& *2&en'&

&n *!$(e( 2&inn& me2&2i &g$(i'$(i( &' &ng'imb2 &!i ib (e*e!'i &!&7 e!i'!$(i'6(i'$*2&(m& ib) 3&!ing&n !&7im) (e!'& &!&7 &ng2!7 O2i;ei!&) ?01?6"


14/30

)omeostasis besi selama kehamilan


15/30


16/30

PENGARH IN+A,E MA,ANAN +ERHADAP,ADAR PLA%MA BE%I DAN ERI+RO%I+

P2&(m& be(i men!n (e&!& e*&' *&&(i& .e7&mi2&n 8 mingg (&m*&i ??mingg *&& *$*2&(i be(i 11 mg/7&!i

m&*n *&& in'&.e be(i &ng 2ebi7 'inggi+&m!&) ?0006"

%'i 2&inn& 3g& menn3.&n b&7&*en!n&n .&&! be(i 'i&. &*&' ieg&7

eng&n *embe!i&n 15 mg/7&!i (e2&m&.e7&mi2&nC&2e2 et al.,?0086"


17/30

Pene2i'i&n * &ni'& Pe!;i& (*2emen'&(i 15mg/7&!i &n &(&m $2&'meng7&(i2.&n .&&! be(i &ng 2ebi7 'inggi

(eb&n&. 5 ib&ning.&n eng&n &ng'i&. ibe!i.&n (*2emen'&(i be(i"

D&2&m ('i 2&in i'em.&n b&7& serumbesi umbilical lebih rendah pada

kelompok dengan intake besi yangtinggi C&2e2 et al.,?0086"


18/30

,e2$m*$. g in'&.e be(i &ng 2ebi7 !en&7(e&!& (igni.&n memi2i.i e!i'!$(i'methallothioneinm&'e!n&2 &ng !en&7

&n me'7&22$'7i$nein *2&en'& &ng 2ebi7'inggi

,e&&&n ini me!ee.(i.&n *e!*in&7&n /*e!ge(e!&n be(i &!i 3&!ing&n ib &!i ib

.e &n&. n'. mening.&'.&n '!&n(e! be(i*&& e'&2 D$n&nge2$ &n ,ing) ?01?6"


19/30

REGLA%I DAN) HOMEO%+A%I% BE%I PADA ,EHAMILAN


20/30

E,%RE%I BE%I DALAM RIN MA+ERNAL

E.(!e(i be(i &2&m !in '!' i*eng&!7i$2e7 be(i in'&.e"

D$n&nge2$ &n ,ing) ?01?6"

&ni'& 7&mi2 &ng meng.$n(m(i 11mg /7&!i) e.(!e(i !in mening.&' ? 2i*&'*&& &(e &.7i! .e7&mi2&n

Pening.&'&n e.(!e(i be(i 'i&. 'e!3&i*&& &ni'& 7&mi2 eng&n in'&.e be(i&ng !en&7 < (/ 9 mg/ 7&!i6


21/30

AB%ORB%I BE%I DIIN+E%+INAL

Pe!2&.&n : in'&.e be(i >&ni'& 7&mi2 C&2i$!ni&

1? mg/7&!i= B!&i2 9 mg/7&!i e*siensi dari absorbsi besi meningkat pada

wanita dengan intake besi yang rendah di+ase akhir kehamilan,


22/30

HOMEO%+A%I% BE%I %ELAMA MA%A LA,+A%I

,&&! be(i *&(& *e!(&2in&n 7ingg& J b2&n *e!'&m& m&(&

2&.'&(i meng&2&mi *en!n&n" Ab($!b(i be(i (ebe(&! ?4 mg/7&!i) '&mb&7&n be(i (eb&n&.

??< mg i*e!2.&n *&& J b2&n *e!i$e *e!'&m& 2&.'&(i

Be(i &ng 'inggi *&& &&2 2&.'&(i (eb&gi&n ign&.&n n'.mem$bi2i(&(i ib) men3&g& 7$me$('&(i( *&& m&(& (e'e2&7

*e!(&2in&n) (e!'& mem*e!(i&*.&n ib (ebe2m men('!&(i.emb&2i"

%e.i'&! @0 &!i '$'&2 be(i 'b7 i(im*&n &2&m 3&!ing&n'2&ng) &n i*e!.i!&.&n (eb&n&. 4 J &!i m&((& '2&ngib 7i2&ng (e2&m& J b2&n 2&.'&(i"

Penggn&&n be(i (e2&m& m&(& 2&.'&(i .* 'inggi" Be(i *&&A%I i(e.!e(i !&'& !&'& ?@mg/7&!i) (e2&n3'n& '!n 7ingg& 1mg/7&!i &2&m @ b2&n be!i.'n&) &n be!2&n3' 7ingg&men&*&i 0"5 mg/7&!i National Academic Press) ?0016"


23/30

PENGARH IN+A,E BE%I MA+ERNAL DAN ,ON%EN+RA%I BE%I PADA A%I


24/30

#." /"S"#S" S" /"!"#$&/" (!3 !&S /# '4S#!,

P!ee.2&m*(i&

mem*eng&!7i .&&! be(i i &2&mne$n&'( .&!en& 'e!g&nggn& (i!.2&(i

&!&7 '!&n(*2&(en'&2 &!i ib .e 3&nin ,e2&in&n be!*& ;&($(*&(me *&& &!'e!i

(*i!&2i() &n .!&n i&me'e! &!'e!i(*i!&2i( &ng 2ebi7 .ei2 &!i n$!m&2&.ib&' 'e!7&mb&'n& in;&(i '!$$b2&(


25/30

C$nK '

Di&be'e( me22i'(

,eb'7&n be(i &ng mening.&' *&&.e7&mi2&n meneb&b.&n *ening.&'&n

!e(e*'$! be(i i *e!m.&&n *2&(en'&" ,$m*en(&(i ini 'i&. (em*!n& .&!en& *&&

ib eng&n i&be'e( terjadi penurunana*nitas trans+erin terhadap reseptor di

permukaan *2&(en'& .&!en& &&n&g2i.$(i2&(i &n 7&(i2n& 7&n& (ebe(&! 11be(i &ng &*&' i'!&n(*$!' .e e'("


26/30

C$nK'

%$2(i$ P2&(en'&

+e!2e*&(n& *2&(en'& &!i 'em*&'*e!2e.&'&n meneb&b.&n hipoksemia

pada +etus e'( menggn&.&n(im*&n&n be(i &n me2&..&ne!i'!$*$ie(i( n'. meng.$m*en(&(i'e!3&in& 7i*$.(emi&"


27/30

-&.'$! e'&2

B&i *!em&'!

C&&ng&n be(i e'( iben'. *&2ingb&n&. *&& '!ime('e! .e'ig& (e7ingg&

*&& b&i &ng 2&7i! *!em&'! !en'&nmeng&2&mi &nemi& e(ien(i be(i" B&i&'e!m n$!m&2 &*&' memen7i.eb'7&n be(in& (&m*&i (i& 4 J

b2&n R&$) ?00


28/30

(S".'&4#

Ag&! be(i 'e'&* &2&m .e&&&n &ng (eimb&ng) 'b7 'e2&7memi2i.i me.&ni(me n'. meng.$m*en(&(i .e.!&ng&n&n .e2ebi7&n be(i eng&n *e!b&7&n 7$me$('&'i( (e2&m&bebe!&*& .e&&&n (e*e!'i m&(& .e7&mi2&n &n 2&.'&(i"

(e2&m& .e7&mi2&n) !&.(i &b($!b(i be(i &ng mening.&'&n .&&! *2&(m& in men!n 2ebi7 'e!2i7&' *&& &ni'&eng&n &(*&n be(i &ng !en&7

A(*&n in ib &'& ('&'( memi2i.i ee. .ei2 *&&

.$n(en'!&(i be(i *&& A%I" %e2&n3'n&) i*e!2.&n ('i 2ebi7 2&n3' 'e!.&i' ee.

g&bng&n &!i in'&.e be(i &ng !en&7 &n ine.(i (b.2ini( *&& &ni'& 7&mi2 &n men(i


29/30

/! '&S!(

Be&! ) eReigne! RA) %7& MD) e' &2" ?00


30/30

C$n'K

H&mbige) ,"M"= Abebe) Y"= Gib($n) R"%"= >e('$'') "E"= Mi22e!) L"V"= Lei) %"= %'$e.e!) B""= A!bie) I"=+e(7$me) A"= B&i2e) ,"B"= et al. in &b($!*'i$n !ing 2&'e *!egn&n in !!&2 ($'7e!n E'7i$*i&"Am.'. Clin. Ntr. 2006) (") 110?110J"

,e22e7e!) %"L"= Lnne!&2) B" L$ng'e!m m&!gin&2 in'&.e( $ in &n !e'in$2 &e' !e'in$2 7$me$('&(i(i'7$' $m*!$mi(ing i!2&'ing 2e;e2( !ing 2&'&'i$n in !&'(" '. Ntr. 2001) 1-1: @?@ine(( A) Ge$!gie M," ?00

ppt allergy march

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