Prof.Dr.HalukKülah

OrtaDoğuTeknikÜniversitesi– MikroBiyosistemler A.Ş.

ALab-on-a-Chip Platformfor Cancer Treatment

BioMEMS:MICROSYSTEMSfor BioMEDICAL APPLICATIONSResearchatProf.Külah’s Lab

CellSeparation CellCounting

BacteriaDetection

CMOS-BasedSensors

Microvalves &DrugAnalysis

FullyImplantableCochlearImplants

NeuralProbes

ChipScaleElectrophoresis

Ear Canal

Inner Ear

Pinna

Eardrum

Middle Ear

Rechargable Battery & Coil

Interface Electronics

Piezoelectric Devices

Cochlea

Interconnects

Signal conditioning and rectifier electronics

to battery & coil

Cochlear Electrode

Energy Harvester

Sound Detectors

Eustachian Tube

Cochlear Electrode

Piezoelectric Transducers

Flexible Substrate Carrying

Interconnects

DielectrophoresisElectrorotation

CoulterCountersGravimetricCounting

CellCountingDNASensing

MISSION

VISIONTo become a globally recognized biomedical microsystems company

To develop and commercialize tagCTC product family with competitive edge on performance, cost and time-to-result

Biomedical Microsystems Company

Established in 2015

TEAm

Prof. Dr. Haluk KülahCo-Founder, CEO

ODTÜ Electrical & Electronics Eng. Dpt.

Prof. Dr. Tayfun AkınCo-Founder, Board Member

Director @ ODTÜ-MEMS Center

Özge Zorlu, PhDCTO

Electrical & Electronics Engineer

Ebru Özgür, PhDDirector

Biochemist

Begüm Şen Doğan, MScR&D Engineer

Chemical Engineer

H. Ceren Ateş, BScR&D Engineer

Chemical Engineer

Nilüfer Afşar Erkal, PhDSenior

Researcher Biologist

Ender Yıldırım, PhDConsultant

Microfluidics Expert

Gürhan Özkayar, MScR&D Engineer

Biomedical Engineer

Taylan B. Töral, MScMicrofabrication Specialist

EE Engineering

Yağmur D. Yalçın, MScR&D Engineer EE Engineer

Engineering Directorate

Clinical Research Directorate

mikrobiyo.com.tr

Infrastructure

Fully-equipped laboratoriesMicrofluidic TestingCell CultureChemical ProcessingElectrical Testing

Engineering design and analysis toolsTanner Tools Layout EditorComsol MultiphysicsPADS PCB Design ToolMatlabSolidworksOrigin

mikrobiyo.com.tr

What we do?

PatientandphysicianawarenessHighquality&affordableEfficientNon-invasiveIncreasedlifequalityandexpectancy

mikrobiyo.com.tr

Circulating Tumor Cell

Isolation & Detection

Drug Resistance Detection

for Precision Medicine

Microfluidic Consultancy

for Device Design & Fabrication

CANCER14 million new cases/year

2nd leading cause of death (8.8 M 2015)Cause of 90% of human cancer deaths

CIRCULATINGTUMORCELLSImportant biomarkers for metastasisPromises early cancer diagnosis/screening

(CTCs)

CTCs

CTC count Direct correlation with disease progression, Monitoring of drug efficacy

CTC isolation Allow downstream analysis, mutation detection, NGS, functional analysis, biomarker analysis, etc.

To replace metastatic tissue biopsies

Clinical utility of CTCs

CTC MARKET OVERVIEW

SOCIAL ASPECTS

DRIVERSPatientandphysicianawarenessHighquality&affordableEfficientNon-invasiveIncreasedlifequalityandexpectancy

Growing cancer incidenceEarly detection

Minimally invasive disease monitoringRisk/benefit assessment & therapy

guidance

MEDICAL NEED

mikrobiyo.com.tr

APPLICATION SPECIFIC

RESTRAINTSSamplepreparationislengthywrt detectiontimeFarfrombeingPoC

Extreme rarity and heterogeneityCell loss during preparation

Statistical representativeness of collected bloodMisinterpretation, inaccurate detection

CONSIDERATIONS

mikrobiyo.com.tr

CTC MARKET OVERVIEW

2,9 3,33,8

4,35,0

5,76,6

7,68,7

10,0

11,6

0

2

4

6

8

10

12

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

Global Circulating Tumor Cells Market, 2012-2022 (USD Billion)

mikrobiyo.com.tr

Grand View Research, CTC market by technology and applications, 2016

CAGR: 15 % Market Launch

CTC MARKET OVERVIEW

Size-based enrichmentUnique Selling Propositions:High recovery rate & purity

Cascaded LoC platformPrompt cell count with clustering info

Online electrical countingPreserved cell viabilityMinimal pre-process

Whole blood process possiblePortability

Low footprint, low weightPlug&Play operation

Pre-filled cartridge

Antibody bindingImpedimetric counting

Size-based enrichmentUnique Selling Propositions:High recovery rate & purity

Cascaded LoC platformPrompt cell count with clustering info

Online electrical countingPreserved cell viabilityMinimal pre-process

Whole blood process possiblePortability

Low footprint, low weightPlug&Play operation

Pre-filled cartridge

Antibody bindingImpedimetric counting

mikrobiyo.com.tr

Partners and critical suppliers

DCP (TR, NL) – Seed investor Turkey’s first technology transfer and seed-stage venture capital fund managerHeadquarters in The Netherlands

Mikro Tasarım Inc. ASIC DesignMETU-MEMS Spin-off specialized in CMOS interface electronics design

Designnobis Industrial and mechanical designAward-winning design consultancy on product design

ODTÜ-MEMS Center MEMS FabricationFully equipped MEMS Clean room with close proximityFormer host of Mikro Biyosistemler’s key technologies

mikrobiyo.com.tr

Partners and critical suppliers

DCP (TR, NL) – Seed investor Turkey’s first technology transfer and seed-stage venture capital fund managerHeadquarters in The Netherlands

Mikro Tasarım Inc. ASIC DesignMETU-MEMS Spin-off specialized in CMOS interface electronics design

Designnobis Industrial and mechanical designAward-winning design consultancy on product design

ODTÜ-MEMS Center MEMS FabricationFully equipped MEMS Clean room with close proximityFormer host of Mikro Biyosistemler’s key technologies

M i k r o B i yo s i s t em l e r E l e k t r o n i k S a n ay i ve T i c a r e t AŞ

O D T Ü Te k n o k e n t M E T Ye r l e ş k e s iD u m l u p ı n a r B l v . N o : 2 8 0 - B O f i s 1 0

0 6 5 3 0 Ç a n k a y a /A n k a r a / Tü r k i y e

+ 9 0 3 1 2 2 8 5 0 5 3 0

h a l u k . k u l a h @ m i k r o b i y o . c o m . t ro z g e . z o r l u @ m i k r o b i y o . c o m . t r

www.m i k r o b i yo . c om . t r